Abstract：
INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However, a large part of these exacerbations have an unknown cause. In the present study we evaluated the presence of mimivirus in sputum samples of COPD patients. METHODS:From March 2009 until January 2010 all sputum samples collected during stable conditions and during exacerbations of COPD patients, referred for pulmonary rehabilitation, were included. All sputum samples were analysed by real-time PCR targeting mimivirus. Furthermore, serum samples were analysed for the presence of antibodies against mimivirus. RESULTS:A total of 220 sputum samples from 109 patients were eligible for inclusion. None of the sputum samples showed the presence of mimivirus DNA. Antibodies against mimivirus were detected in 3 serum samples from 3 patients, of which one showed an increase in antibody-titre. CONCLUSIONS:Although mimivirus was suggested as a potential respiratory pathogen, its presence could not be confirmed in the present study-population of patients with COPD.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Vanspauwen MJ,Franssen FM,Raoult D,Wouters EF,Bruggeman CA,Linssen CFdoi
10.1016/j.rmed.2012.08.019subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1690-4issue
12eissn
0954-6111issn
1532-3064pii
S0954-6111(12)00315-0journal_volume
106pub_type
杂志文章abstract：INTRODUCTION:Multiple Breath Washout (MBW) to measure Lung Clearance Index (LCI) is increasingly being used as a secondary endpoint in multicentre bronchiectasis studies. LCI data quality control or "over-reading" is resource intensive and the impact is unclear. OBJECTIVES:To assess the proportion of MBW tests deemed ...
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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