Abstract:
:Heart-lung transplantation involves denervation of the lungs below the tracheal anastomosis, with associated permanent loss of all pulmonary innervation except post-ganglionic efferent nerves. This is supported by loss of the cough reflex to inhaled USNDW, which also implies that the RARs which mediate this cough mechanism lie in the central airways. Bronchoconstriction following inhalation of USNDW developed only in those HLT recipients with acute lung rejection; this was not related to methacholine responsiveness and may therefore represent a pathologic vascular response. Hyperresponsiveness to methacholine has been reported following HLT, which we found unrelated to inflammation or acute rejection. A similar hyperresponsiveness to histamine was seen, which correlated with the response to methacholine. This also implies that histamine may act directly on smooth muscle receptors, and not solely via a cholinergic reflex. Hyperresponsiveness following HLT may be due to development of a generalized denervation hypersensitivity. Bronchodilation following capsaicin inhalation has been observed in HLT recipients, and may be due to unopposed release of VIP from retained post-ganglionic efferent nerves.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Hathaway T,Higenbottam T,Lowry R,Wallwork Jdoi
10.1016/s0954-6111(06)80248-9subject
Has Abstractpub_date
1991-01-01 00:00:00pages
17-21eissn
0954-6111issn
1532-3064pii
S0954-6111(06)80248-9journal_volume
85 Suppl Apub_type
杂志文章abstract::Specific targeting of patients with a previous asthma hospitalisation could be more focused if predictors could be identified. This study was an observational retrospective analysis using ridge and linear multivariate regression analysis. Patient asthma management data were extracted from the hospital and general prac...
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更新日期:2002-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-08-01 00:00:00
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1995-08-01 00:00:00
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doi:10.1016/j.rmed.2020.105943
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2019.01.013
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2012.11.018
更新日期:2013-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0954-6111(98)90286-4
更新日期:1998-03-01 00:00:00