Abstract：
:In an attempt to establish the protection afforded by regular salmeterol use against induced bronchoconstriction in asthmatic patients, a meta-analysis was conducted on nine double-blind clinical trials that fulfilled the inclusion criteria. In each trial, subjects were randomly assigned to receive either salmeterol 50 micrograms twice daily or a comparator (placebo or salbutamol). Two hundred and twenty-five asthmatic subjects had at least one PC20 or PD20 (histamine or methacholine concentration or dose producing 20% fall in forced expiratory volume in 1 s) measurement recorded within 1 h to 16 weeks after the first dose, and up to 31 days after the last dose, of medication. One hour after the first dose of salmeterol, there was a 3.5-fold increase in doubling dose compared to baseline. Within 12 h of the first dose, the level of protection was 1.5 doubling doses, and protection was maintained at 0.5-1.5 doubling doses over 16 weeks' treatment. This level of protection was maintained for up to 60 h after the last dose. At no time during the washout period did the level of protection fall below zero. Salmeterol afforded significantly greater protection at all time points during the treatment period than comparator agents, but there was no significant difference during the washout period. In conclusion, salmeterol affords protection against bronchoconstrictor stimuli, and any reduction in this bronchoprotective effect occurred during the first few days of treatment. During long-term salmeterol treatment, there was maintained significant protection that showed no evidence of attenuation after 16 weeks' treatment. Furthermore, there was no evidence of rebound deterioration in bronchial responsiveness after cessation of salmeterol treatment.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Verberne AA,Fuller Rdoi
10.1016/s0954-6111(98)90012-9subject
Has Abstractpub_date
1998-05-01 00:00:00pages
777-82issue
5eissn
0954-6111issn
1532-3064pii
S0954-6111(98)90012-9journal_volume
92pub_type
杂志文章,meta分析abstract：BACKGROUND:IL-4 receptor alpha chain is crucial for the binding and signaling of IL-4, which mediates isotype switching and IgE production. The gene of IL-4 receptor alpha chain is a candidate gene for asthma and atopy. OBJECTIVES:To determine whether Ile50Val and Q576R polymorphisms of IL-4 receptor alpha chain gene ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.04.004
更新日期：2007-01-01 00:00:00
abstract：:In patients with asthma, exercise-induced symptoms are well recognized and frequently limiting. Currently available beta 2-receptor agonists have a short duration of action and breakthrough symptoms may occur. We studied the efficacy of the recently developed long acting inhaled beta 2-agonist salmeterol with respect ...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0954-6111(93)90070-g
更新日期：1993-08-01 00:00:00
abstract：:Pulmonary hypertension is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome. The aim of this study was to further characterize the exercise intolerance, dyspnoea and ventilatory inefficiency of patients with pulmonary fibrosis in the pres...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.08.005
更新日期：2009-02-01 00:00:00
abstract：:Increased levels of exhaled nitric oxide (FeNO) and airway hyperresponsiveness (AHR) to inhaled mannitol are related to allergic inflammation characterized by eosinophil infiltration and a clinical response to treatment with anti-inflammatory agents in subjects with asthma. This study determines the diagnostic accurac...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2012.09.004
更新日期：2013-01-01 00:00:00
abstract：:Clinically there are several different types of eosinophilic pneumonia (EP), but other than for tropical pulmonary eosinophilia, the humoral immune response between different types of EP, such as acute eosinophilic pneumonia (AEP), chronic EP, drug-induced EP, allergic bronchopulmonary aspergillosis, and Churg-Strauss...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmed.2008.01.004
更新日期：2008-06-01 00:00:00
abstract：:Patients using domiciliary nasal ventilation, or long-term oxygen, require regular assessment which could be carried out in the home. Blood gas analysis may be regarded as an essential part of the assessment. The present study investigated the effect of a 1-h time delay on the measurement of capillary blood gases. Fou...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(96)90207-3
更新日期：1996-02-01 00:00:00
abstract：:The aims of this study were to describe asthma management and morbidity in patients attending general practitioners in Australia, and to assess the relationship between patient reports and those of their general practitioner (GP). The sample comprised consecutive patients attending 46 general practitioners chosen at r...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/0954-6111(95)90133-7
更新日期：1995-11-01 00:00:00
abstract：:Eighteen patients with community acquired pneumonia required intensive care for severe or progressive hypoxaemia, rising arterial carbon dioxide tension or respiratory arrest, and 17 received intermittent positive pressure ventilation. Thirteen survived to leave hospital and 12 are long term survivors. Ventilation was...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(08)80087-x
更新日期：1990-01-01 00:00:00
abstract：:The efficacy of a non-steroidal anti-inflammatory agent (nedocromil sodium, NS) has been assessed in young children born prematurely who had recurrent respiratory symptoms at follow-up. In a randomized, double-blind cross-over trial, either two puffs of NS (2 mg puff-1) or placebo were administered three times a day v...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(96)90173-0
更新日期：1996-09-01 00:00:00
abstract：:The objective of this study was to compare surfactant (SF) distribution and physiological effects after standard SF delivery during conventional mechanical ventilation (CMV) with that using partial liquid ventilation (PLV). A model of meconium aspiration syndrome (MAS) was developed using two groups of adult rats (n =...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2001.1114
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Supplemental oxygen is a recommended therapy option in stable hypoxemic COPD patients. Often, supplemental oxygen is provided by continuous flow (CF). However, demand oxygen delivery systems (DODS) that provide an oxygen bolus only during inspiration have gained increasing use as they prolong oxygen cylinder...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2019.08.001
更新日期：2019-09-01 00:00:00
abstract：:Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2007.11.002
更新日期：2008-03-01 00:00:00
abstract：:Although in the clinic the presence of mucus in the airways is known to be an important factor influencing the sound of coughing in pathological conditions, this observation has not been established experimentally. We have substituted mucus in the airways of anaesthetized cats with 0.5 ml of natural undiluted egg albu...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(05)80313-0
更新日期：1993-01-01 00:00:00
abstract：:From about 1190 to the present day opposing views have been expressed about the effects of coughing in patients with asthma. Some accounts have stated that it brought relief and others that it exacerbated asthma, whereas others thought that it could have both effects. In the present investigation, 187 patients with a ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(06)80246-5
更新日期：1991-01-01 00:00:00
abstract：:In response to the introduction of ethnic monitoring within the U.K. hospital inpatient data set, this study investigates the variations in secondary healthcare utilization by Black and minority ethnic communities whose cause of admission is related to asthma. The study examines all residents of the West Midlands: ove...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90511-x
更新日期：1998-04-01 00:00:00
abstract：:The need for efficient use of resources in the provision of health care is now an accepted reality. Despite its economic significance, respiratory disease has been the subject of very few examples of the application of techniques of economic evaluation. There are a number of examples of cost-minimization studies, and ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(06)80169-1
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:Limited data are available as to the relationship between computed tomography (CT) derived data on emphysema and airway wall thickness, and quality of life in subjects with chronic obstructive pulmonary disease (COPD). Such data may work to clarify the clinical correlate of the CT findings. METHODS:We inclu...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2013.04.016
更新日期：2013-08-01 00:00:00
abstract：:The sputum smear-negative patients have been a diagnostic challenge for health professionals. Adenosine deaminase (ADA) activity has been shown to rise in various body fluids of patients with tuberculosis (Tb). A prospective clinical trial was conducted to determine the diagnostic value of ADA activity in bronchoalveo...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2001.1284
更新日期：2002-07-01 00:00:00
abstract：RATIONALE:Mounting data suggest that immune cell abnormalities participate in the pathogenesis of pulmonary arterial hypertension (PAH). OBJECTIVE:To determine whether the T lymphocyte subset composition in the systemic circulation and peripheral lung is altered in PAH. METHODS:Flow cytometric analyses were performed...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.10.004
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:Idiopathic bronchiectasis is a poorly defined disease characterised by persistent inflammation, infection and progressive lung damage. Natural killer (NK) cells provide a major defense against infection, through the interaction of their surface receptors, including the activating and inhibitory killer immu...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2014.05.017
更新日期：2014-08-01 00:00:00
abstract：:To document the rate and cost of antibiotic prescribing for patients diagnosed only with influenza during US ambulatory care visits. Federal survey data for 1997-2001 were used to estimate outpatient trends for all patients and healthy people age 5-49 years. Cost estimates were based on Medicare payments and Red Book ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.03.021
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Sarcoidosis patients often are troubled by dyspnea, exercise limitation, and fatigue. Many patients (up to 50-81%) suffer from sarcoidosis-associated fatigue. The etiology of fatigue in sarcoidosis is still unclear. OBJECTIVE:The aim of this study was to assess the relationship between fatigue and both exer...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2016.05.010
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The prevalence of asthma appears to be on the increase, and risk factors are not well established. To investigate risk factors for the development of asthma, a population sample of children and adolescents, aged 7-17 years at enrolment, were studied in 1986. Initial examinations were repeated at follow-up in...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(96)90021-9
更新日期：1996-11-01 00:00:00
abstract：:The present study investigated, for the first time, the long-term prognosis of hypersensitivity type of occupational laryngitis (OL). Thirteen patients with OL diagnosed in 1990-1993 at the Finnish Institute of Occupational Health participated in a questionnaire follow-up study. The records of the primary diagnostic i...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.07.015
更新日期：2009-01-01 00:00:00
abstract：:Active smoking is an increasing problem amongst U.K. teenagers. The smoking habits of a cohort of 14-16-year-olds were determined and the association between regular active smoking and domestic and social factors investigated. Current smoking habits of a cohort of 2289 14-16-year-olds were assessed using a simple post...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.1999.0746
更新日期：2000-04-01 00:00:00
abstract：INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2012.08.019
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Fluticasone propionate and formoterol fumarate have been combined in a single inhaler (fluticasone/formoterol; flutiform(®)) for the maintenance treatment of asthma. This pooled analysis assessed the efficacy of fluticasone/formoterol versus fluticasone in patients who previously received inhaled corticoster...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2014.10.019
更新日期：2015-02-01 00:00:00
abstract：:The purpose was to compare the short-term cost-effectiveness of intensive vs conventional education and supervision for the self-management of mild asthmatic patients. Consecutive newly diagnosed asthmatic patients (n = 162) were randomized into an intervention group (IG) and a control group (CG) with 1 yr of treatmen...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(98)90113-5
更新日期：1998-02-01 00:00:00
abstract：:Viozan (sibenadet HCl, AR-C68397AA) is a novel dual D2 dopamine receptor, beta2-adrenoceptor agonist that has been investigated for efficacy in alleviating the symptoms of chronic obstructive pulmonary disease (COPD). The slowly progressive nature of this disease means that patients will require ongoing therapeutic ma...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2003-01-01 00:00:00
abstract：RATIONALE:Combination therapy with corticosteroid and long-acting β(2)-agonists (LABA) in a single inhaler is associated with superior effects on airway function and exercise performance in COPD compared with LABA monotherapy. The physiological effects of adding inhaled corticosteroid monotherapy to maintenance broncho...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2011.08.021
更新日期：2011-12-01 00:00:00
