Abstract:
:Clinically there are several different types of eosinophilic pneumonia (EP), but other than for tropical pulmonary eosinophilia, the humoral immune response between different types of EP, such as acute eosinophilic pneumonia (AEP), chronic EP, drug-induced EP, allergic bronchopulmonary aspergillosis, and Churg-Strauss syndrome, has not been examined. Immunoglobulin G (IgG) and E (IgE) serum concentrations were analyzed in patients with EP, or bacterial pneumonia, and in age-matched controls. Patients with AEP had lower IgG levels than the age-matched controls. Serum IgG levels in patients with AEP were significantly lower than in patients with other types EP or bacterial pneumonia. IgG2 and IgG4 were also significantly decreased in AEP, compared to age-matched controls. In AEP, the serum IgG levels were significantly decreased during active disease and increased during remission, but the serum IgE levels did not change significantly, indicating a decrease in serum IgG is a common feature of AEP. Low IgG levels were significantly correlated with serum surfactant protein D and absolute eosinophil counts in the bronchoalveolar lavage fluid of patients with AEP. This is the first reported study of immunoglobulin levels in AEP. The pathogenesis of AEP might negatively affect serum IgG levels, but not IgE levels. The present findings might indicate that serum IgG reflects the inflammatory response in AEP.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Matsuno O,Takenaka R,Hiroshige S,Ono E,Nishitake T,Ueno T,Miyazaki E,Kumamoto Tdoi
10.1016/j.rmed.2008.01.004subject
Has Abstractpub_date
2008-06-01 00:00:00pages
899-903issue
6eissn
0954-6111issn
1532-3064pii
S0954-6111(08)00017-6journal_volume
102pub_type
杂志文章,多中心研究abstract:BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is now the generally preferred surgical treatment for spontaneous pneumothorax but is more difficult once pleural adhesions have developed. To test the hypothesis that VATS is under-used because of prolonged pleural intubation, we have audited the effect of preoper...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(98)90103-2
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2019.01.013
更新日期:2019-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.04.021
更新日期:2013-09-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(97)90112-8
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.1999.0720
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1053
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pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2003.08.003
更新日期:2004-01-01 00:00:00
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2014.04.014
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Respiratory medicine
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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