Abstract:
:Various cells including polymorphonuclear leukocytes, alveolar macrophages and type-II pneumocytes may be a source of exhaled hydrogen peroxide (H2O2) in airways of humans. H2O2 can convert into hydroxyl radicals leading to peroxidative damage of airways structures and formation of volatile thiobarbituric acid-reactive substances (TBARs). We tested whether exhalation of H2O2 and TBARs by healthy subjects depends on reactive oxygen species generation from blood phagocytes. The expired breath condensate (EBC) and blood specimens were collected from 41 healthy, never smoked subjects (mean age 20.7 +/- 0.8 years, 18 men, 23 women) and then the EBC concentration of H2O2 and TBARs and 2 x 10(-5) M fMLP-provoked whole blood chemiluminescence response was measured. The mean concentration of H2O2 and TBARs in EBC was 0.28 +/- 0.17 and 0.04 +/- 0.13 microM with ratio of positive readings reaching 36/41 and 4/41, respectively. The chemiluminescence response to n-formyl-methionyl-leveyl-phenylalanine stimulation was obtained in all cases and the following parameters were estimated: basal chemiluminescence (bCl); peak chemiluminescence (pCl); absolute light emission (aCl); and peaktime. H2O2 levels in EBC positively correlated (Spearmann test) with bCl (r=0.41, P<0.01), pCl (r=0.47, P<0.01), aCl (r=0.49, P<0.001), peaktime (r=0.52, P<0.001) in the whole group and with bCl (r=0.56, P<0.01), pCl (r=0.67, P<0.01), aCl (r=0.66, P<0.01) in men and with aCl (r=0.41, P<0.05) and peaktime (r=0.48, P<0.05) in women. No association between exhaled TBARs and blood phagocytes activity was found. These results indicate that H2O2 exhalation in healthy never smoked subjects depends on ability of blood phagocytes to generate reactive oxygen species.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Szkudlarek U,Maria L,Kasielski M,Kaucka S,Nowak Ddoi
10.1053/rmed.2003.1506subject
Has Abstractpub_date
2003-06-01 00:00:00pages
718-25issue
6eissn
0954-6111issn
1532-3064pii
S0954-6111(03)91506-Xjournal_volume
97pub_type
杂志文章abstract::Specific targeting of patients with a previous asthma hospitalisation could be more focused if predictors could be identified. This study was an observational retrospective analysis using ridge and linear multivariate regression analysis. Patient asthma management data were extracted from the hospital and general prac...
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journal_title:Respiratory medicine
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
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更新日期:2006-02-01 00:00:00
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doi:10.1016/j.rmed.2016.11.017
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2003.11.012
更新日期:2004-06-01 00:00:00
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更新日期:1990-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.04.029
更新日期:2009-11-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2018.06.017
更新日期:2018-08-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.03.025
更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.02.024
更新日期:2007-08-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1215
更新日期:2002-01-01 00:00:00
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更新日期:2008-12-01 00:00:00
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2003.10.009
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2020.105943
更新日期:2020-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1053/rmed.1999.0720
更新日期:2000-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-10-01 00:00:00