Abstract:
:Both albuterol and nedocromil sodium have been recognized to possess certain anti-inflammatory properties. However, there are no data on the impact of these drugs on the pathophysiology of the bronchial extracellular matrix in asthma characterized by enhanced tenascin (Tn) expression, known to occur proportional to the severity of asthma. This paper reports data from a morphometric study on the effects of regular treatment with inhaled albuterol or nedocromil sodium on the extent of bronchial subepithelial deposition of Tn, collagen types III, IV, and VII and mucosal infiltration with macrophages. Thirty-two patients (14 women) with chronic asthma, aged 38.7 years (median) with a median forced expiratory volume in 1 sec (FEV1) of 74.4% predicted, were selected to undergo fibre-optic bronchoscopy with bronchial biopsies before and after 12 weeks of treatment with either inhaled albuterol 0.2 mg or nedocromil sodium 4 mg four times daily according to a double-blind protocol. Cryostat sections of the biopsy specimens were studied by indirect immunostaining techniques using monoclonal antibodies and computer-assisted quantitative image analysis. Albuterol treatment significantly reduced the median thickness of subepithelial Tn expression from 9.7 to 6.3 microns (P = 0.023) and macrophage numbers in the epithelium (P = 0.034), lamina propria (P = 0.039) and entire mucosa (P = 0.033), whereas nedocromil sodium had no effect. Expression of the collagen types was not affected by either treatment. There was no identifiable statistical difference between the two treatments for any of the outcome variables measured. Nevertheless, the results demonstrate that even a short-acting beta 2-agonist may exert anti-inflammatory potential sufficient to interfere with the basic mechanisms of asthma as shown by reduction of subepithelial Tn content and mucosal macrophage count.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Altraja A,Laitinen A,Meriste S,Marran S,Märtson T,Sillastu H,Laitinen LAdoi
10.1016/s0954-6111(99)90086-0subject
Has Abstractpub_date
1999-07-01 00:00:00pages
445-53issue
7eissn
0954-6111issn
1532-3064pii
S0954-6111(99)90086-0journal_volume
93pub_type
临床试验,杂志文章,随机对照试验abstract::In the Department of Respiratory Medicine, North Staffordshire Hospital, patients fulfilling the Department of Health criteria for long-term oxygen therapy (LTOT) attend a practical teaching session on the use of their oxygen concentrator before commencing therapy. In the present study, we have audited the prescribing...
journal_title:Respiratory medicine
pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
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journal_title:Respiratory medicine
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pub_type: 杂志文章,meta分析
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2007.11.010
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2009.11.006
更新日期:2010-05-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/S0954-6111(11)70005-1
更新日期:2011-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/0954-6111(93)90090-m
更新日期:1993-04-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.09.013
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(99)90010-0
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Respiratory medicine
pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2004.11.012
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.07.006
更新日期:2006-03-01 00:00:00
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更新日期:2014-03-01 00:00:00
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