Neurological and endocrinological disorders: orphans in chronic obstructive pulmonary disease.


:Patients with chronic obstructive pulmonary disease (COPD) are often characterised by a range of characteristic co-morbidities that interfere with their pulmonary disease. In addition to a mere association with co-morbidities, a complex pathophysiological interaction and mutual augmentation occurs between COPD and its co-morbidities that may result in disease progression and increased morbidity and mortality. An interdisciplinary approach is required both for diagnosis and treatment to target co-morbidities early in the course of the disease. This review summarizes the current knowledge of the interaction with cerebrovascular disease and endocrinological co-morbidities in COPD patients. There is growing evidence that COPD is an independent risk factor for ischemic stroke, increasing the risk about twofold. Stroke risk in COPD patients increases with the severity of the disease as measured by the degree of airflow limitation. The presence of cardiovascular risk factors is of particular importance for stroke prevention in COPD patients. Endocrinological co-morbidities are also important and many are associated with increased cardiovascular risk. Impaired glucose metabolism ranges from insulin resistance to overt diabetes mellitus, which is a frequent finding and is associated with worse outcome.


Respir Med


Respiratory medicine


Doehner W,Haeusler KG,Endres M,Anker SD,MacNee W,Lainscak M




Has Abstract


2011-10-01 00:00:00










105 Suppl 1


  • Pulmonary alveolar proteinosis: new insights from a single-center cohort of 70 patients.

    abstract:BACKGROUND:Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the intra-alveolar accumulation of surfactant lipids and proteins. The aim of the study is to describe the epidemiologic, clinical, physiologic, and laboratory features of PAP in a large single-center cohort of patients with PAP. STUDY...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Bonella F,Bauer PC,Griese M,Ohshimo S,Guzman J,Costabel U

    更新日期:2011-12-01 00:00:00

  • Completion rate of latent tuberculosis infection treatment in patients aged 65 years and older.

    abstract:INTRODUCTION:There are insufficient data on the treatment of latent tuberculosis infection (LTBI) in elderly patients. We investigated the completion rate of treatment in elderly LTBI patients. METHODS:A retrospective multicentre study was conducted at five university hospitals in South Korea. We reviewed the electron...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Noh CS,Kim HI,Choi H,Kim Y,Kim CH,Choi JH,Hyun IG,Baek MS

    更新日期:2019-10-01 00:00:00

  • Using laboratory measurements to predict in-flight desaturation in respiratory patients: are current guidelines appropriate?

    abstract::In an attempt to guide physicians asked by respiratory patients for advice on flight fitness, the British Thoracic Society (BTS) have published guidelines on fitness to fly. The main potential hazard is hypobaric hypoxia, and efforts have focused on the prediction of hypoxia in individuals. The present study examines ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Robson AG,Lenney J,Innes JA

    更新日期:2008-11-01 00:00:00

  • The disease management approach to controlling asthma.

    abstract::Asthma has become an important public health issue worldwide and certain groups, such as children, are at particular risk of the disease. Often asthma remains under-diagnosed and under-treated. Despite these worrying trends, the disease management approach to asthma control can help most asthma patients achieve a 'nor...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Haahtela T

    更新日期:2002-02-01 00:00:00

  • Serum and bal beta-D-glucan for the diagnosis of Pneumocystis pneumonia in HIV positive patients.

    abstract:BACKGROUND/PURPOSE:The diagnosis of patients with pulmonary infiltrates and human immunodeficiency virus (HIV) infection remains a challenge. In current clinical practice the gold standard for Pneumocystis jirovecii pneumonia (PCP) diagnosis remains the identification of the organism in bronco alveolar lavage (BAL) usi...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Salerno D,Mushatt D,Myers L,Zhuang Y,de la Rua N,Calderon EJ,Welsh DA

    更新日期:2014-11-01 00:00:00

  • Inhaled corticosteroids for adult asthma: impact of formulation and delivery device on relative pharmacokinetics, efficacy and safety.

    abstract::Metered dose inhalers (MDIs) are the mainstay of inhaled steroid therapy for asthma. With the phasing out of traditional chlorofluorocarbon (CFC) propellants and their replacement with a new generation of CFC-free products, it is becoming clear that formulation and inhaler characteristics can markedly affect the drug ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Shaw RJ

    更新日期:1999-03-01 00:00:00

  • Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics.

    abstract:BACKGROUND:Computed tomography (CT) has been used for non-invasive quantitative assessment of airway dimensions, potentially showing airway remodeling, in asthma. However, most studies have examined either only one airway or only airways in anatomically unidentified cross-sections. Using software capable of precisely i...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Shimizu K,Hasegawa M,Makita H,Nasuhara Y,Konno S,Nishimura M

    更新日期:2010-12-01 00:00:00

  • Referral to palliative care in COPD and other chronic diseases: a population-based study.

    abstract:AIM:To describe how patients with COPD, heart failure, dementia and cancer differ in frequency and timing of referral to palliative care services. METHODS:We performed a population-based study with the Sentinel Network of General Practitioners in Belgium. Of 2405 registered deaths respectively 5%, 4% and 28% were iden...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Beernaert K,Cohen J,Deliens L,Devroey D,Vanthomme K,Pardon K,Van den Block L

    更新日期:2013-11-01 00:00:00

  • Artificial pneumothorax by the Veress cannula: efficacy and safety.

    abstract::In 16 patients with pulmonary fibrosis, an artificial pneumothorax was introduced using the Veress cannula and the Saugman water manometer. Atmospheric air was introduced by fractionated insufflation to a total volume of 800 ml (median). The interpleural space was found on the first attempt, and in all cases, fraction...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章


    authors: Faurschou P,Viskum K

    更新日期:1997-08-01 00:00:00

  • Non-reversible airway obstruction in never smokers: results from the Austrian BOLD study.

    abstract:BACKGROUND:The presence of non-reversible airway obstruction (AO) in never smokers has only received limited attention until now. METHODS:We analyzed data from the Austrian Burden of Obstructive Lung Disease (BOLD) study. We defined non-reversible AO as post-bronchodilator FEV(1)/FVC <0.7 which corresponds to COPD I a...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Lamprecht B,Schirnhofer L,Kaiser B,Buist S,Studnicka M

    更新日期:2008-12-01 00:00:00

  • Home-made spacer as an auxiliary device in administration of beclomethasone via pressurized metered dose inhaler for asthma control. A randomized controlled pragmatic trial.

    abstract:BACKGROUND:Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE:...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Schor D,Rizzo JÂ,Medeiros D,Dela Bianca AC,Silva AR,Nunes C,Morais-Almeida M,Sarinho E

    更新日期:2017-05-01 00:00:00

  • Restless legs syndrome: A new comorbidity in idiopathic pulmonary fibrosis.

    abstract:OBJECTIVE:Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical feature...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Varone F,Friello L,Di Blasi C,Sgalla G,Luigetti M,Iovene B,Richeldi L,Della Marca G,Brunetti V

    更新日期:2020-01-01 00:00:00

  • A study of loculated tuberculous pleural effusions treated with intrapleural urokinase.

    abstract:AIM:To assess the effect of intrapleural urokinase, vis-à-vis simple pleural drainage, on residual pleural thickening in a series of patients suffering from loculated tuberculous pleural effusion. PATIENTS AND METHOD:Twenty-nine patients (21 males and 8 females) with loculated pleural effusion were studied. These pati...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Cases Viedma E,Lorenzo Dus MJ,González-Molina A,Sanchis Aldás JL

    更新日期:2006-11-01 00:00:00

  • Population-based estimates of transbronchial lung biopsy utilization and complications.

    abstract:BACKGROUND:Little is known about trends in the utilization or complication rates of transbronchial lung biopsy, particularly in community hospitals. METHODS:We used the Healthcare Cost and Utilization Project Florida State Inpatient and State Ambulatory Surgical Databases to assess trends in transbronchial lung biopsy...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Tukey MH,Wiener RS

    更新日期:2012-11-01 00:00:00

  • Chest low-dose computed tomography in neutropenic acute myeloid leukaemia patients.

    abstract:BACKGROUND:We aimed to compare chest low-dose computed tomography (LDCT) with chest radiography (CXR) in the assessment of febrile acute myeloid leukaemia neutropenic patients. METHODS:A prospective non-randomized study was carried out between 30 May, 2003 and 3 June, 2004 in consecutive neutropenic patients who requi...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Patsios D,Maimon N,Chung T,Roberts H,Disperati P,Minden M,Paul N

    更新日期:2010-04-01 00:00:00

  • HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody.

    abstract:BACKGROUND:Anti-CADM-140 antibody (anti-CADM-140), also referred to as anti-melanoma differentiation-associated gene 5 (MDA5) antibody, is a myositis-specific antibody identified in the sera of patients with clinically amyopathic dermatomyositis (C-ADM) and is associated with a worse prognosis in dermatomyositis-associ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Tanizawa K,Handa T,Nakashima R,Kubo T,Hosono Y,Watanabe K,Aihara K,Oga T,Chin K,Nagai S,Mimori T,Mishima M

    更新日期:2011-09-01 00:00:00

  • Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A.

    abstract::Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the tre...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Alton EW,Johnson M,Turner-Warwick M

    更新日期:1989-07-01 00:00:00

  • Comparative study of two different modes of noninvasive home mechanical ventilation in chronic respiratory failure.

    abstract:STUDY OBJECTIVE:Two modes of noninvasive home mechanical ventilation (NIHMV) with volumetric ventilators were compared in patients with chronic respiratory failure. DESIGN:Retrospective, parallel-group, comparative study. SETTING:Third-level teaching Hospital in Barcelona (Spain). PATIENTS AND METHODS:We studied 110...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Muñoz X,Crespo A,Marti S,Torres F,Ferrer J,Morell F

    更新日期:2006-04-01 00:00:00

  • Bronchial responsiveness to histamine and methacholine measured with forced expirations and with the forced oscillation technique.

    abstract::The objective of this study was to compare bronchial challenge tests with two substances [histamine (H) and methacholine (M)] and two methods of measuring the effect parameter FEV1 and pulmonary impedance [with the forced oscillation technique (FOT)] in order to determine which test is the shortest, and gives the leas...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weersink EJ,vd Elshout FJ,van Herwaarden CV,Folgering H

    更新日期:1995-05-01 00:00:00

  • Emerging concerns of infectious diseases in lung cancer patients receiving immune checkpoint inhibitor therapy.

    abstract:BACKGROUNDS:Cancer immunotherapy using immune checkpoint inhibitors has received a remarkable amount of attention in patients with non-small cell lung cancer (NSCLC). The unique adverse effects known as immune-related adverse events (irAEs) associated with immune checkpoint inhibitors are not known however, and neither...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Fujita K,Kim YH,Kanai O,Yoshida H,Mio T,Hirai T

    更新日期:2019-01-01 00:00:00

  • IL-5, IL-8 and MMP -9 levels in exhaled breath condensate of atopic and nonatopic asthmatic children.

    abstract:RATIONALE:Asthma is a heterogeneous disease, and a great majority of pediatric patients with asthma demonstrate atopic characteristics and develop a Th2 type cytokine response. Nonatopic asthma, on the other hand, is seen more rarely. METHODS:In this study, levels of IL-5, IL-8 and MMP-9 were measured in exhaled breat...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Turkeli A,Yilmaz O,Taneli F,Horasan GD,Kanik ET,Kizilkaya M,Gozukara C,Yuksel H

    更新日期:2015-06-01 00:00:00

  • Energy expenditure during daily activities as measured by two motion sensors in patients with COPD.

    abstract:BACKGROUND:In patients with chronic obstructive pulmonary disease (COPD), energy expenditure (EE) assessment during the performance of daily activities is not yet studied in depth. The aim of this study was to determine which daily activities are more demanding to patients with COPD and to compare the accuracy of EE es...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Cavalheri V,Donária L,Ferreira T,Finatti M,Camillo CA,Cipulo Ramos EM,Pitta F

    更新日期:2011-06-01 00:00:00

  • Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients.

    abstract:BACKGROUND:Combination therapy with inhaled corticosteroids (ICS) and long-acting β(2)-adrenergic agonists (LABA) is reported to have superior effects on controlling asthma symptoms to ICS alone; however, there is no molecular-based evidence to explain the clinical effects. Here, the effect of the ICS/LABA combination ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Essilfie-Quaye S,Ito K,Ito M,Kharitonov SA,Barnes PJ

    更新日期:2011-12-01 00:00:00

  • Light smoking and dependence symptoms in high-school students.

    abstract::In high-school students, prevalence of smoking is high but few studies analyzed smoking in the student population according to nicotine content of smoked cigarettes and gender. We analyzed the responses to a questionnaire, including the modified Fagerström Tolerance Questionnaire (FTQ), administered to 555 students (3...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Soresi S,Catalano F,Spatafora M,Bonsignore MR,Bellia V

    更新日期:2005-08-01 00:00:00

  • Exercise testing as a predictor of surgical risk after pneumonectomy for bronchogenic carcinoma.

    abstract::The aim of the present investigation was to evaluate the predictive value of a symptom-limited exercise test in predicting postoperative morbidity and mortality in patients submitted to pneumonectomy. The study was conducted in 150 patients (mean age, 57.1). Forty-four patients (29.3%) had postoperative complications....

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Villani F,De Maria P,Busia A

    更新日期:2003-12-01 00:00:00

  • Comparison between formoterol 12 microg b.i.d. and on-demand salbutamol in moderate persistent asthma.

    abstract::Inhalation of on-demand salbutamol (ODS) several times daily is sometimes the only beta2-agonist prescribed in moderate persistent asthma, whereas a long-acting beta2-agonist should be added. This trial aimed to compare the efficacy of formoterol dry-powder capsule 12 microg b.i.d. (Foradil) and ODS in patients with m...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Molimard M,Bourcereau J,Le Gros V,Bourdeix I,Leynadier F,Duroux P,French FOR-F-01 Study Group.

    更新日期:2001-01-01 00:00:00

  • Inhaled nedocromil sodium in symptomatic young children born prematurely.

    abstract::The efficacy of a non-steroidal anti-inflammatory agent (nedocromil sodium, NS) has been assessed in young children born prematurely who had recurrent respiratory symptoms at follow-up. In a randomized, double-blind cross-over trial, either two puffs of NS (2 mg puff-1) or placebo were administered three times a day v...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yüksel B,Greenough A

    更新日期:1996-09-01 00:00:00

  • Measurement of agreement on health-related quality of life changes in response to respiratory rehabilitation by patients and physicians--a prospective study.

    abstract:INTRODUCTION:To provide optimal care for patients with chronic obstructive pulmonary disease physicians need to understand if their patients benefit from an intervention. The objective of this study was to assess agreement between patients and physicians on health-related quality of life (HRQL) changes in response to r...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Puhan MA,Behnke M,Devereaux PJ,Montori VM,Braendli O,Frey M,Schünemann HJ

    更新日期:2004-12-01 00:00:00

  • A review of the etiology and clinical presentation of non-cystic fibrosis bronchiectasis: A tertiary care experience.

    abstract:INTRODUCTION:Non-cystic fibrosis(CF) bronchiectasis has been recognized in children for the past 200 years. Early childhood pneumonia and underlying conditions such as immunodeficiency, primary ciliary dyskinesia(PCD), and congenital lung pathology should be considered in the etiology. The aim of our study was to descr...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Satırer O,Mete Yesil A,Emiralioglu N,Tugcu GD,Yalcın E,Dogru D,Kiper N,Ozcelik U

    更新日期:2018-04-01 00:00:00

  • Incidence of tuberculosis among anti-tumor necrosis factor users in patients with a previous history of tuberculosis.

    abstract:BACKGROUND:We aimed to investigate the results of anti-tumor necrosis factor (TNF) therapy in patients with a previous history of tuberculosis (TB). METHODS:A total of 101 patients with a previous history of TB receiving TNF antagonists between December 2004 and September 2012 at the Asan Medical Center in South Korea...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Jo KW,Hong Y,Jung YJ,Yoo B,Lee CK,Kim YG,Yang SK,Byeon JS,Kim KJ,Ye BD,Lee SD,Kim WS,Kim DS,Shim TS

    更新日期:2013-11-01 00:00:00