Abstract：
:It is logical to look upon the nose and the bronchi as integrated parts of one 'united airway' and we would like to advance the hypothesis that optimal management of airway disease, caused by inhaled allergens, may necessitate control of inflammation in all parts of the airways. Nasal inflammation can aggravate asthma symptoms, and there is a rationale for giving intranasal anti-inflammatory treatment to patients with asthma. (i) Inhaled allergens are predominantly deposited in the nose, whether a patient suffers from rhinitis, asthma or both. (ii) Antigen presentation consequently takes place in the nose, and the response of the airway immune system is thus initiated in the nasal mucous membrane. (iii) Antigen presentation in the nose may possibly induce cell recruitment and activation not only in the nasal mucosa but also in the lower airways. (iv) Suppression of nasal inflammation may therefore be necessary for optimal management of asthma.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Mygind N,Dahl R,Nielsen LPdoi
10.1016/s0954-6111(98)90306-7subject
Has Abstractpub_date
1998-03-01 00:00:00pages
547-9issue
3eissn
0954-6111issn
1532-3064pii
S0954-6111(98)90306-7journal_volume
92pub_type
杂志文章,评审abstract：BACKGROUND:Asthma is a common chronic disease in childhood, resulting in high costs for health care systems and society. As of June 2011, the Brazilian Unified Health System (SUS) provides free asthma medications for the population. This study evaluated the impact of this program on asthma admissions in the population ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.105915
更新日期：2020-04-01 00:00:00
abstract：:Seventy-seven patients with morbid obesity, body mass index (BMI) 40-69.9 kg m(-2), who were candidates for gastroplasty, were studied in our laboratory as part of a pre-operative survey. They had no complaints other than obesity and were not cyanotic. A group of 28 lean subjects (BMI 20-29.8 kg m(-2)) who were candid...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2001.1035
更新日期：2001-04-01 00:00:00
abstract：:Measurement of exhaled nitric oxide is widely used in respiratory research and clinical practice, especially in patients with asthma. However, interpretation is often difficult, due to common interfering factors, and little is known about interactions between factors. We assessed the influences and interactions of fac...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.02.012
更新日期：2008-07-01 00:00:00
abstract：:In a double-blind study of 60 patients undergoing fibreoptic bronchoscopy we have compared the local anaesthetic effects of intratracheal injections of cocaine (4 ml, 2.5%) and lignocaine (4 ml, 4%). The two local anaesthetics were equally effective in terms of cough suppression, requirement for extra local anaestheti...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(08)80076-5
更新日期：1990-09-01 00:00:00
abstract：:Vocal cord dysfunction (VCD) is characterised by paradoxical vocal cord adduction during inspiration or throughout the respiratory cycle, it results in wheeze, stridor, cough and dyspnoea. Although asthma and VCD can coexist, patients with VCD are frequently misdiagnosed with refractory asthma. It can severely restric...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.08.009
更新日期：2007-04-01 00:00:00
abstract：:The objective of this study was to evaluate the effect of lateral body position on gas exchange in patients with unilateral pleural effusion, with special reference to the influence of effusion volume. Thirty consecutive patients with unilateral pleural effusion, without evidence of parenchymal pulmonary involvement, ...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0954-6111(95)90091-8
更新日期：1995-04-01 00:00:00
abstract：:The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with chemoimmunotherapy wh...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2001.1178
更新日期：2001-10-01 00:00:00
abstract：:A survey was undertaken to determine the current practice in the Yorkshire Health Region for the assessment and provision of home nebulizers for adults with chronic obstructive pulmonary disease (COPD). A detailed postal questionnaire on assessment methods was sent to each of the 22 consultant physicians in respirator...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/0954-6111(95)90070-5
更新日期：1995-01-01 00:00:00
abstract：:The purpose of this randomized, double-blind parallel group study was to compare the safety, tolerability and acceptability of Easyhaler and Turbuhaler dry powder inhalers for the delivery of budesonide 800 microg day(-1) in adult asthmatic patients who had already been treated with inhaled corticosteroids for at leas...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/rmed.2001.1261
更新日期：2002-04-01 00:00:00
abstract：:Prolonged cough is a common problem in patients seen in general practice. Using a simple method of sputum induction and processing of sputum samples, we determined whether eosinophilic airway inflammation could be a cause of undiagnosed prolonged cough. Eighty-two patients who had had cough for more than 1 month were ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2001.1215
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:COPD patients who remain hypercapnic after acute respiratory failure requiring mechanical ventilation have a poor prognosis. Long-term nocturnal non-invasive ventilation (NIV) may be beneficial for these patients. We hypothesized that stable patients on long-term NIV would experience clinical worsening after...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2010.09.005
更新日期：2011-03-01 00:00:00
abstract：:A multiplex polymerase chain reaction (PCR) was developed for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. Oligonucleotide primers for the amplification of the DNA of these three organisms were optimized for use in combination in the same reaction. PCR products ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2003.11.012
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Neurocognitive impairment has been described in COPD patients, but little is known about its relationship with physical functioning and health-related quality of life (HRQL) in this chronically ill patient group. METHODS:301 stable COPD patients completed the Trail Making Test (TMT-A: psychomotor speed and ...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.rmed.2016.03.005
更新日期：2016-05-01 00:00:00
abstract：:The mandatory requirement to eliminate chlorofluorocarbons (CFCs) as propellants in pharmaceutical aerosols has provided the opportunity to enhance significantly the delivery of aerosol drugs to the respiratory tract. This randomized, parallel-group, double-blind, double-dummy, multicentre study was undertaken to asse...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0954-6111(98)90214-1
更新日期：1998-06-01 00:00:00
abstract：:The aim of this study was evaluate the predictive value of a 2 week course of prednisolone on the effect of 6 months treatment with inhaled budesonide in patients with stable chronic obstructive pulmonary disease (COPD). Forty patients with stable COPD entered the study, and received prednisolone (37.5 mg o.d.) for 2 ...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0954-6111(99)90038-0
更新日期：1999-10-01 00:00:00
abstract：INTRODUCTION:To date endurance and strength training are established and evidence-based exercise methods in patients with chronic obstructive pulmonary disease (COPD). There is an unmet need for further research in new and complementary exercise modalities. Additional whole body vibration training during pulmonary reha...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2011.10.021
更新日期：2012-01-01 00:00:00
abstract：:The diagnostic value of isocapnic hyperventilation of cold air (IHCA) is not fully established. All 342 adult patients in whom IHCA had been performed because of a clinical suspicion of asthma between 1992 and 1994 were analysed retrospectively in the authors' hospital. In addition, 26 healthy subjects were recruited....
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(97)90112-8
更新日期：1997-09-01 00:00:00
abstract：:The value of continuous positive airway pressure (CPAP) ventilation via a tight fitting face mask was assessed in eight HIV-1 antibody-positive patients with Pneumocystis carinii pneumonia who were in hypoxaemic respiratory failure. All patients were conscious, able to protect their airway and not hypercapnic. Treatme...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(06)80291-x
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:There has not been a comprehensive multi-center study investigating the microbial profile of community acquired pneumonia (CAP) in Taiwan. METHODS:A prospective study of adult CAP patients requiring hospitalization between December 2001 and April 2002 was carried out in 13 hospitals in Taiwan. Etiology was ...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmed.2005.02.026
更新日期：2005-09-01 00:00:00
abstract：:Induced sputum and bronchoalveolar lavage (BAL) are widely used for retrieving cells and soluble materials for studies of airway inflammation. Centrifuged cell samples are suitable for immunochemical identification of cellular products. The aim was to determine the optimal fixation procedure to detect intracellular an...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2002.1373
更新日期：2002-11-01 00:00:00
abstract：:Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for ...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2015.10.006
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Systemic inflammation is associated with impaired lung function in healthy adults as well as in patients with lung disease. The mechanism for this association is unknown and it is unclear if systemic inflammation leads to impaired lung function or if poor lung function leads to inflammation. We explored the ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2015.12.007
更新日期：2016-02-01 00:00:00
abstract：:Inhaled lignocaine appeared to have considerable steroid sparing properties in an uncontrolled trial in 20 patients with oral-steroid-dependent asthma. Since it can also cause bronchoconstriction, safety needs to be studied under controlled conditions. We have performed a randomized, double-blind, placebo-controlled s...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(98)90142-1
更新日期：1998-12-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition worldwide and is associated with significant mortality. This paper gives an overview of the relevant literature regarding care needs in advanced COPD from the perspective of the patient or carer, and aims to explore the appropriateness of a p...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2009.09.007
更新日期：2010-02-01 00:00:00
abstract：:Antifibrotic drugs for idiopathic pulmonary fibrosis patients in England and Scotland are only available to those with FVC percent predicted (FVC%pred) less than or equal to 80%. The prescribing guidance does not state which set of reference values should be used and we show that a patient's FVC%pred can change by 4-6...
journal_title：Respiratory medicine
pub_type： 信件
doi：10.1016/j.rmed.2016.10.007
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:This study investigated the accuracy of impulse oscillometry (IOS) combined with fractional exhaled nitric oxide (FeNO) to assess asthma control among preschool children. METHODS:A total of 79 preschool children(3-6 year old) with asthma and 25 healthy preschool children who visited a paediatrician were enro...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.10.009
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient characteristics associated with all-cause mortality in asthma. METHODS:Asthma patients aged ≥18 years and...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.105919
更新日期：2020-01-01 00:00:00
abstract：:Limited knowledge exists about development of bronchial hyperresponsiveness (BHR) through adolescence. We aimed to assess changes in and risk factors for BHR in adolescence. From a Norwegian birth cohort 517 subjects underwent clinical examinations, structured interviews and methacholine challenges at age 10 and 16. B...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2011.09.013
更新日期：2012-02-01 00:00:00
abstract：:Antigen detection is a useful adjunct for the diagnosis of histoplasmosis. The purpose of this study was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83.3%) b...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.04.017
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To quantify persistence with inhaled corticosteroids (ICS) among new users in daily practice and identify determinants of persistence. METHODS:A retrospective cohort study was performed with data from the Dutch PHARMO system. This system consists of medication and hospital admission records of 325,000 inhabi...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.01.014
更新日期：2004-08-01 00:00:00
