Abstract:
:Limited knowledge exists about development of bronchial hyperresponsiveness (BHR) through adolescence. We aimed to assess changes in and risk factors for BHR in adolescence. From a Norwegian birth cohort 517 subjects underwent clinical examinations, structured interviews and methacholine challenges at age 10 and 16. BHR was divided into four categories: no BHR (cumulative methacholine dose required to reduce FEV(1) by 20% (PD(20)) >16 μmol), borderline BHR (PD(20) ≤16 and >8 μmol), mild to moderate BHR (PD(20) ≤8 and >1 μmol), and severe BHR (PD(20) ≤ 1 μmol). Logistic regression analysis was used to assess risk factors and possible confounders. The number of children with PD(20) ≤ 8 decreased from 172 (33%) to 79 (15%) from age 10-16 (p < 0.001). Most children (n = 295, 57%) remained in the same BHR (category) from age 10-16 (50% with no BHR), whereas the majority 182 (82%) of the 222 children who changed BHR category, had decreased severity at age 16. PD(20) ≤ 8 at age 10 was the major risk factor for PD(20) ≤ 8 6 years later (odds ratio 6.3), without significant confounding effect (>25% change) of gender, active rhinitis, active asthma, height, FEV(1)/FVC, or allergic sensitization. BHR decreased overall in severity through adolescence, was stable for the majority of children and only a minority (8%) had increased BHR from age 10 to 16. Mild to moderate and severe BHR at age 10 were major risk factors for PD(20) ≤ 8 at 16 years and not modified by asthma or body size.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Riiser A,Hovland V,Mowinckel P,Carlsen KH,Carlsen KLdoi
10.1016/j.rmed.2011.09.013subject
Has Abstractpub_date
2012-02-01 00:00:00pages
215-22issue
2eissn
0954-6111issn
1532-3064pii
S0954-6111(11)00338-6journal_volume
106pub_type
杂志文章abstract::Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.04.021
更新日期:2013-09-01 00:00:00
abstract:QUESTION OF THE STUDY:We studied whether prophylactic use of noninvasive pressure support ventilation (NIPSV) administered pre- and postoperatively may reduce the postoperative pulmonary function impairment. PATIENTS AND METHODS:Prospective randomized clinical trial. Thirty-nine patients with a preoperative FEV(1) <70...
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abstract:INTRODUCTION:Idiopathic bronchiectasis is a poorly defined disease characterised by persistent inflammation, infection and progressive lung damage. Natural killer (NK) cells provide a major defense against infection, through the interaction of their surface receptors, including the activating and inhibitory killer immu...
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2010.09.020
更新日期:2011-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
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更新日期:2018-01-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2020.105943
更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2006.01.010
更新日期:2006-09-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2001-06-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.1999.0763
更新日期:2000-05-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.04.017
更新日期:2007-09-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.rmed.2013.05.005
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Dental caries and respiratory tract infections are among the most common infectious diseases worldwide and they both are appearing in the respiratory system. However, their relations are still unclear. This study investigated the association of dental caries on the risk of lower respiratory tract infection...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2019.09.002
更新日期:2019-01-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.09.013
更新日期:2008-02-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2014.07.003
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2013.12.012
更新日期:2014-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2014.01.014
更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0954-6111(06)80246-5
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0954-6111(03)00255-5
更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2008.05.001
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-02-01 00:00:00