Abstract：
OBJECTIVE:To quantify persistence with inhaled corticosteroids (ICS) among new users in daily practice and identify determinants of persistence. METHODS:A retrospective cohort study was performed with data from the Dutch PHARMO system. This system consists of medication and hospital admission records of 325,000 inhabitants of 12 Dutch cities. In patients who were already using other drugs with a labeled indication of obstructive lung diseases (ATC: R03), individuals with a first dispensing of ICS between January 1, 1994 and December 31, 2000 were identified. Persistence with ICS was defined as the number of days on ICS treatment in the first year of use. Determinants of persistence were identified one year before start of the first dispensing of ICS. RESULTS:Approximately 50% of the patients used inhaled corticosteroids (ICS) for less than 200 days, while 18% continued treatment for one year. One-year persistence rates increased to 40% in patients with a history of multiple respiratory disease related drugs. Persistence rates also increased with lower initial doses, if the initial prescription was instituted by a medical specialist, if a patient was previously hospitalized for obstructive lung diseases, and with increasing age. CONCLUSION:The persistence rate of ICS is poor. Preventing early treatment discontinuation may be important to ensure maximal benefit from ICS treatment.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Breekveldt-Postma NS,Gerrits CM,Lammers JW,Raaijmakers JA,Herings RMdoi
10.1016/j.rmed.2004.01.014subject
Has Abstractpub_date
2004-08-01 00:00:00pages
752-9issue
8eissn
0954-6111issn
1532-3064pii
S0954-6111(04)00055-1journal_volume
98pub_type
杂志文章abstract：BACKGROUND:Susceptibility to Chronic Obstructive Pulmonary Disease (COPD) has a genetic component. We undertook a study to determine if a genetic variant of the gene encoding the cyclooxygenase-2 gene influences the likelihood of developing COPD. METHODS:In a case control study the frequency of a single nucleotide pol...
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究
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更新日期：1992-05-01 00:00:00
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更新日期：2003-03-01 00:00:00
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更新日期：2010-05-01 00:00:00
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更新日期：2014-05-01 00:00:00
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更新日期：2015-02-01 00:00:00
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-03-01 00:00:00
