Abstract:
BACKGROUND:Discrepancies have been observed between clinical, physiological, and inflammatory asthma control criteria, mostly in asthmatic subjects using regular inhaled corticosteroids (ICS) treatment. This study compared the prevalence of discrepancies between these 3 control parameters in mild asthmatic subjects not taking ICS. METHODS:A retrospective analysis of demographic data and results from the Asthma Control Scoring System tool was performed in mild patients with asthma not taking ICS. The % score obtained for the clinical (symptoms), physiological (FEV1), and inflammatory (sputum eosinophil percentage) criteria were compared. Discrepancy was defined as a >20% difference between any 2 scores. FINDINGS:Data from 213 subjects with mild asthma were analysed. Discrepancies between clinical and inflammatory scores were observed in 32% of subjects, whereas 31% showed discrepancies between physiological and inflammatory scores, and 20% between clinical and physiological scores. Sub-analysis of the discrepancy groups showed that respectively 88% and 89% of subjects had a higher clinical or physiological score than inflammatory score. Twenty-seven percent of subjects had residual airway inflammation despite adequate clinical control and optimal pulmonary function. INTERPRETATION:There are significant discrepancies between scores of subjective and objective asthma control criteria. Airway inflammation often persists in subjects with good clinical or physiological asthma control scores. The consequences of this persisting airway inflammation in mild patients remain to be further studied.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Boulay ME,Boulet LPdoi
10.1016/j.rmed.2012.12.015subject
Has Abstractpub_date
2013-04-01 00:00:00pages
511-8issue
4eissn
0954-6111issn
1532-3064pii
S0954-6111(12)00502-1journal_volume
107pub_type
杂志文章abstract:BACKGROUND:Myeloid and plasmacytoid dendritic cell (DC) subsets have been recently identified in the human lung based on their differential expression of Blood DC Antigens 1-3 (BDCAs). We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells. METHODS:Using an i...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.02.006
更新日期:2009-06-01 00:00:00
abstract::The fraction of the emitted dose from an inhaler that has the potential to be deposited into the lungs is known as the fine particle dose (also the respirable dose). During inhalation all dry powder inhalers require a 'force' to be created inside the device so that a fine particle dose is generated from the formulatio...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2003.1351
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:The synergistic interactions between pharmacotherapy and pulmonary rehabilitation has been provided, but it remains to be established whether this may also apply to more severe patients. OBJECTIVES:We have examined whether tiotropium enhances the effects of exercise training in patients with advanced COPD (...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2009.10.005
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Multiple criteria have been proposed to define community-acquired pneumonia (CAP) severity and predict ICU admission. Validity studies have found differing results. We tested four models to assess severe CAP built upon the criteria included in the 2007 IDSA/ATS guidelines, hypothesizing that a model providin...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2019.07.007
更新日期:2019-08-01 00:00:00
abstract::In developing countries, many sputum-negative suspects of pulmonary tuberculosis (PTB) are given antituberculous medication just because tuberculosis (TB) could not be excluded in them. Many studies have shown that BCG test is nearly 100% sensitive, except in those with severe malnutrition, steroid therapy and other c...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2003.1478
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Respiratory complaints after exercise are common in patients with rhinitis. Exercise-induced bronchospasm (EIB) may be one of the causes. OBJECTIVES:To evaluate EIB prevalence in a group of children and adolescents with allergic rhinitis, to compare the treadmill running (TR) and eucapnic voluntary hyperven...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2018.04.001
更新日期:2018-05-01 00:00:00
abstract::The objective of this study was to compare surfactant (SF) distribution and physiological effects after standard SF delivery during conventional mechanical ventilation (CMV) with that using partial liquid ventilation (PLV). A model of meconium aspiration syndrome (MAS) was developed using two groups of adult rats (n =...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2001.1114
更新日期:2001-07-01 00:00:00
abstract::Chlorofluorocarbon (CFC)-containing inhalers for use in the treatment of asthma are to be phased out under the terms of the Montreal Protocol (1). In this multi-centre, randomized, double-blind study, the therapeutic equivalence of two formulations of beclomethasone dipropionate (BDP) containing CFC or non-CFC (HFA134...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/rmed.1999.0678
更新日期:2000-01-01 00:00:00
abstract::The aim of this study was evaluate the predictive value of a 2 week course of prednisolone on the effect of 6 months treatment with inhaled budesonide in patients with stable chronic obstructive pulmonary disease (COPD). Forty patients with stable COPD entered the study, and received prednisolone (37.5 mg o.d.) for 2 ...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0954-6111(99)90038-0
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:The 6-min walk test (6MWT) is a submaximal exercise test used to assess functional status in patients with cardiopulmonary diseases. Regression equations have previously been published as a normal reference for 6-min walk distance (6MWD) in healthy Caucasian adults. However, a recent study showed that the no...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.01.012
更新日期:2009-07-01 00:00:00
abstract::Long-acting bronchodilators in combination with inhaled corticosteroids (ICS) are recommended to decrease the risk of recurrent exacerbations in patients with Global initiative for chronic Obstructive Lung Disease (GOLD) stage 3-4 chronic obstructive pulmonary disease (COPD). There is increasing concern about the clin...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rmed.2014.01.002
更新日期:2014-04-01 00:00:00
abstract::Recent developments in intrabronchial administration of insulin raise lung function in patients with type I diabetes as important issue. Several studies in adults report abnormalities of lung function of these patients. The aim of this study was to investigate lung function in children with type I diabetes. Twenty-sev...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1053/rmed.2002.1402
更新日期:2002-12-01 00:00:00
abstract::In response to the introduction of ethnic monitoring within the U.K. hospital inpatient data set, this study investigates the variations in secondary healthcare utilization by Black and minority ethnic communities whose cause of admission is related to asthma. The study examines all residents of the West Midlands: ove...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(98)90511-x
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Asthma is a common chronic disease in childhood, resulting in high costs for health care systems and society. As of June 2011, the Brazilian Unified Health System (SUS) provides free asthma medications for the population. This study evaluated the impact of this program on asthma admissions in the population ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2020.105915
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Reduction in 30-day readmission rate after chronic obstructive pulmonary disease (COPD)-related hospitalization is a national objective. However, little is known about trends in readmission rates in recent years, particularly in priority populations defined by the Agency for Healthcare Research and Quality (...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2017.07.058
更新日期:2017-09-01 00:00:00
abstract::Pulmonary hypertension is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome. The aim of this study was to further characterize the exercise intolerance, dyspnoea and ventilatory inefficiency of patients with pulmonary fibrosis in the pres...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2008.08.005
更新日期:2009-02-01 00:00:00
abstract::The aims of this study were to describe asthma management and morbidity in patients attending general practitioners in Australia, and to assess the relationship between patient reports and those of their general practitioner (GP). The sample comprised consecutive patients attending 46 general practitioners chosen at r...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/0954-6111(95)90133-7
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:International guidelines recommend simple spirometry for bronchiectasis patients. However, pulmonary pathophysiology of bronchiectasis is very complex and still poorly understood. Our objective was to characterize lung function in bronchiectasis and identify specific functional sub-groups. METHODS:This was ...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rmed.2018.10.031
更新日期:2018-12-01 00:00:00
abstract::Heart-lung transplantation involves denervation of the lungs below the tracheal anastomosis, with associated permanent loss of all pulmonary innervation except post-ganglionic efferent nerves. This is supported by loss of the cough reflex to inhaled USNDW, which also implies that the RARs which mediate this cough mech...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(06)80248-9
更新日期:1991-01-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) may be one of the pathophysiologic links in the association between obstructive sleep apnea-hypopnea and cardiovascular disease. Morning serum VEGF levels are increased in children with obstructive sleep apnea. However, release of VEGF by platelets and leukocytes during blood ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.09.003
更新日期:2006-05-01 00:00:00
abstract:QUESTION OF THE STUDY:We studied whether prophylactic use of noninvasive pressure support ventilation (NIPSV) administered pre- and postoperatively may reduce the postoperative pulmonary function impairment. PATIENTS AND METHODS:Prospective randomized clinical trial. Thirty-nine patients with a preoperative FEV(1) <70...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2006.12.002
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Little is known about trends in the utilization or complication rates of transbronchial lung biopsy, particularly in community hospitals. METHODS:We used the Healthcare Cost and Utilization Project Florida State Inpatient and State Ambulatory Surgical Databases to assess trends in transbronchial lung biopsy...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2012.08.008
更新日期:2012-11-01 00:00:00
abstract:AIM:A high rate of seropositivity for antibodies against Helicobacter pylori has been found in many extra-gastrointestinal diseases. In addition, it has been reported that the risk of chronic bronchitis may be increased in subjects infected with H. pylori. This study was designed to determine the H. pylori seroprevalen...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2005.02.036
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:There are chronic forms of hypersensitivity pneumonitis (cHP) that can progress to pulmonary fibrosis. There is no recommended treatment for patients whose respiratory condition continues to deteriorate in spite of antigen avoidance. Whether rituximab may be beneficial to patients with cHP is unknown. The ai...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2020.106146
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:During military service young men (age 19-21 years) are exposed to many predisposing factors for asthma. We aimed to study the short-term prognosis of asthma after the military service. METHODS:All 216 men with verified asthma in 2004-2005 from the register of the Central Military Hospital were included in ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2009.05.022
更新日期:2009-12-01 00:00:00
abstract::From about 1190 to the present day opposing views have been expressed about the effects of coughing in patients with asthma. Some accounts have stated that it brought relief and others that it exacerbated asthma, whereas others thought that it could have both effects. In the present investigation, 187 patients with a ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(06)80246-5
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Patients with amyopathic dermatomyositis (ADM) sometimes develop rapidly progressive interstitial lung disease (ILD) predominantly in Asia. Although anti-CADM-140/MDA5 antibody titer could correlate with disease activity and predict the course of ILD associated with ADM, it is not clear how this antibody is ...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2015.07.004
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Previous research indicates a high prevalence of untreated anxiety and depression in patients with chronic obstructive pulmonary disease (COPD). The current study examined the effect of cognitive behavioral therapy (CBT) in groups for co-morbid, clinically significant anxiety and depression in COPD outpatien...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2010.02.020
更新日期:2010-07-01 00:00:00
abstract::Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction (EIB). It has been shown that an in vitro hyperosmolar stimulation of basophils and mast cells with mannitol can induce the release of histamine and leukotrienes. The aim of thi...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(03)00119-7
更新日期:2003-08-01 00:00:00
abstract::There is an increasing body of evidence suggesting that altered vascular permeability may be an important component of the pathogenesis of acute mountain sickness (AMS). Vascular endothelial growth factor (VEGF) is a potent permeability factor subject to hypoxic regulation but its role in the pathogenesis of AMS is ye...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.06.014
更新日期:2007-03-01 00:00:00