Identification of intracellular markers in induced sputum and bronchoalveolar lavage samples in patients with respiratory disorders and healthy persons.

abstract：:Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

journal_title：Respiratory medicine

authors： Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

更新日期：2013-09-01 00:00:00

abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...

journal_title：Respiratory medicine

authors： Levine M,Taylor R,Ryan M,Sculpher M

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Dipyrone (Novalgin) is an effective analgesic, antipyretic agent also with spasmolytic effects on various types of smooth muscles. It has recently been reported that dipyrone relaxes tracheal smooth muscle of guinea pig. In this present study, we aimed to investigate whether this and previously reported in vi...

journal_title：Respiratory medicine

authors： Gulmez SE,Tulunay FC,Beder S,Kayacan O,Karnak D

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Smoking and obesity might alter the risk of sarcoidosis. However, the data remained inconclusive. METHODS:A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified based on individual medical record review. For each sarcoidosis su...

journal_title：Respiratory medicine

authors： Ungprasert P,Crowson CS,Matteson EL

更新日期：2016-11-01 00:00:00

abstract：:The results of pulmonary function testing with a turbine spirometer (TS) and a bell spirometer (BS) of a randomized group of 275 patients aged 4-18 years were compared. In the TS, an inexpensive device without graphical display was used. The difference BS minus TS (d) for forced expiratory volume in 1 s (FEV1) was cal...

journal_title：Respiratory medicine

authors： Paul KP,Schultz T

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVES:To compare the prognostic value of FENO with bronchoprovocation testing when the clinical course within the first year after assessment was taken into account; to compare the prognostic values with respect to eosinophilic versus non-eosinophilic inflammatory pattern. METHODS:Cross-sectional diagnostic study...

journal_title：Respiratory medicine

authors： Schneider A,Faderl B,Schwarzbach J,Welker L,Karsch-Völk M,Jörres RA

更新日期：2014-01-01 00:00:00

abstract：:Summary beta2-adrenoreceptor agonists are able to modulate various aspects of airway cell functions involved in the inflammatory and repair processes characterizing a variety of respiratory disorders. Human bronchial epithelial cells (HBECs), which can act as immune effector cells and express beta2-adrenoreceptors, we...

journal_title：Respiratory medicine

authors： Sabatini F,Silvestri M,Sale R,Serpero L,Di Blasi P,Rossi GA

更新日期：2003-09-01 00:00:00

abstract：:In a double-blind study of 60 patients undergoing fibreoptic bronchoscopy we have compared the local anaesthetic effects of intratracheal injections of cocaine (4 ml, 2.5%) and lignocaine (4 ml, 4%). The two local anaesthetics were equally effective in terms of cough suppression, requirement for extra local anaestheti...

journal_title：Respiratory medicine

authors： Teale C,Gomes PJ,Muers MF,Pearson SB

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVES:To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). METHODS:Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD. RESULTS:Twenty rand...

journal_title：Respiratory medicine

authors： Ram FS,Jardin JR,Atallah A,Castro AA,Mazzini R,Goldstein R,Lacasse Y,Cendon S

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Asthmatic symptoms usually can be controlled with corticosteroids, but partly asthmatic patients do not respond to corticosteroids, steroid resistance (SR) play a significant role in the poorly responding. However, no approach can accurately predict steroid responsiveness in asthma patients, so prediction of...

journal_title：Respiratory medicine

authors： Jiang H,Chi X,Zhang X,Wang J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Individuals with chronic respiratory conditions are at-risk for depression and anxiety. In the largest mental health screening study of over 6000 people with cystic fibrosis (CF) and 4000 parent caregivers (TIDES, 2014), rates of symptomatology were two to three times higher than in the general population. I...

journal_title：Respiratory medicine

authors： Graziano S,Spanò B,Majo F,Righelli D,Vincenzina L,Quittner A,Tabarini P

更新日期：2020-10-01 00:00:00

abstract：:We have recently found that changes in lung sounds correspond well with a 20% fall in the forced expiratory volume in 1 s (FEV1) after methacholine challenge in asthmatic children. Up to now, little was known about the agreement between a 20% fall in FEV1 and a change in lung sounds after repeated bronchial challenge....

journal_title：Respiratory medicine

authors： Sprikkelman AB,Schouten JP,Lourens MS,Heymans HS,van Aalderen WM

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease with chronic respiratory failure (COPD-CRF) experience high mortality and healthcare utilization. Non-invasive home ventilation (NIVH) is increasingly used in such patients. We examined the associations between NIVH and survival, hospitalizations, and emerg...

journal_title：Respiratory medicine

authors： Frazier WD,Murphy R,van Eijndhoven E

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:The synergistic interactions between pharmacotherapy and pulmonary rehabilitation has been provided, but it remains to be established whether this may also apply to more severe patients. OBJECTIVES:We have examined whether tiotropium enhances the effects of exercise training in patients with advanced COPD (...

journal_title：Respiratory medicine

authors： Pasqua F,Biscione G,Crigna G,Auciello L,Cazzola M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Bleach is widely used for household cleaning. Although it is recognized that occupational use of bleach may have adverse respiratory health effects, it is unknown whether common domestic use of bleach may be a risk factor for asthma. AIM:To assess whether the domestic use of bleach for home cleaning is asso...

journal_title：Respiratory medicine

authors： Matulonga B,Rava M,Siroux V,Bernard A,Dumas O,Pin I,Zock JP,Nadif R,Leynaert B,Le Moual N

更新日期：2016-08-01 00:00:00

abstract：:Nasal mucociliary system is the first line of defense of the upper airways and may be affected acutely by exposure to particulate matter (PM) from biomass burning. Several epidemiologic studies have demonstrated a consistent association between levels of air pollution from biomass burning with increases in hospitaliza...

journal_title：Respiratory medicine

authors： Ferreira-Ceccato AD,Ramos EM,de Carvalho LC Jr,Xavier RF,Teixeira MF,Raymundo-Pereira PA,Proença Cdos A,de Toledo AC,Ramos D

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Mortality rates from lung cancer are known to vary considerably between countries. Differences in patients, disease, investigation and treatment are thought to account for some survival shortfalls but it is not known whether differences in collection or processing of data also contribute. METHODOLOGY:We sea...

journal_title：Respiratory medicine

authors： Butler CA,Darragh KM,Currie GP,Anderson WJ

更新日期：2006-09-01 00:00:00

abstract：:The Spacehaler is a new, compact, pressurized aerosol device that uses the same canister as a conventional metered-dose inhaler (MDI). Its design, however, reduces the velocity of the aerosol cloud that emerges from the inhaler, thereby reducing the amount of the non-respirable fraction of the drug delivered to the pa...

journal_title：Respiratory medicine

authors： Gunawardena KA,Sohal T,Jones JI,Upchurch FC,Crompton GK

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost-utility of the treatment with a long acting beta-agonist (LABA) and inhaled corticosteroid (ICS) combination inhaler [salmeterol xinafoate (SAL)/fluticasone propionate (FP) combination inhaler (SFC) (Advair(®))] to continuing on current ICS dose (no ICS dose change) or increased ICS dose ...

journal_title：Respiratory medicine

authors： Ismaila AS,Risebrough N,Li C,Corriveau D,Hawkins N,FitzGerald JM,Su Z

更新日期：2014-09-01 00:00:00

abstract：:Assessment of asthma severity is important for disease management. Analysis of symptoms past and present, and previous and actual lung function measurements (including variability) is the usual method of evaluation and classification of asthma disease severity and activity. However, symptoms and lung function alterati...

journal_title：Respiratory medicine

authors： Dahl R,Martinati LC,Boner AL

更新日期：1997-11-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common and highly contagious pathogen that infects nearly all children by the age of 2 years. It is responsible for significant morbidity and mortality worldwide among certain high-risk paediatric populations. Therapy is sub-optimal for RSV, thus treatment focuses on ameliorating...

journal_title：Respiratory medicine

authors： Simoes EA,Groothuis JR

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Primary spontaneous pneumothorax (PSP) remains a significant global health problem. Despite general agreement, an official algorithm for the management of PSP still does not exist. OBJECTIVES:Evaluating the efficacy of all available treatments in PSP. METHODS:A systematic search of 12 electronic databases ...

journal_title：Respiratory medicine

authors： Vuong NL,Elshafay A,Thao LP,Abdalla AR,Mohyeldin IA,Elsabaa K,Omran ES,Yu F,Hirayama K,Huy NT

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Nitrite in exhaled breath condensate (EBC) has been shown to be elevated in cystic fibrosis (CF), while exhaled nitric oxide (FENO) is paradoxically low. This has been argued to reflect increased metabolism of NO while its diffusion is obstructed by mucus. However, we wanted to study the possible influence o...

journal_title：Respiratory medicine

authors： Zetterquist W,Marteus H,Kalm-Stephens P,Näs E,Nordvall L,Johannesson M,Alving K

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:In vivo, the airway epithelium stretches and relaxes with each respiratory cycle, but little is known about the effect this pattern of elongation and relaxation has on bronchial epithelial cells. We have used a model of cell deformation to measure the effect of stretch on inflammatory cytokine release by t...

journal_title：Respiratory medicine

authors： Thomas RA,Norman JC,Huynh TT,Williams B,Bolton SJ,Wardlaw AJ

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The efficacy and safety of 750-mg, 5-day levofloxacin was recently shown to be comparable to 500-mg, 10-day levofloxacin in a randomized, double-blind, multicentre clinical trial for mild-to-severe community-acquired pneumonia (CAP). This subgroup analysis attempted to compare the safety and efficacy of a sh...

journal_title：Respiratory medicine

authors： Shorr AF,Khashab MM,Xiang JX,Tennenberg AM,Kahn JB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Systemic inflammation is associated with impaired lung function in healthy adults as well as in patients with lung disease. The mechanism for this association is unknown and it is unclear if systemic inflammation leads to impaired lung function or if poor lung function leads to inflammation. We explored the ...

journal_title：Respiratory medicine

authors： Hancox RJ,Gray AR,Sears MR,Poulton R

更新日期：2016-02-01 00:00:00

abstract：:Beclometasone dipropionate (BDP) extrafine is a hydrofluoroalkane-based, chlorofluorocarbon (CFC)-free inhalation aerosol. This study was conducted to determine whether BDP extrafine and CFC-fluticasone proprionate (FP) aerosols were equivalent in terms of efficacy and tolerability in children with symptomatic mild-to...

journal_title：Respiratory medicine

authors： van Aalderen WM,Price D,De Baets FM,Price J

更新日期：2007-07-01 00:00:00

abstract：:Anxiety and depression can increase the intensity of dyspnea out of proportion to the impairment in cardiorespiratory function and may contribute to the degree of disability associated with dyspnea. The effect of anxiety/depression on the sensory and affective components of reported dyspnea in patients with respirator...

journal_title：Respiratory medicine

authors： Scano G,Gigliotti F,Stendardi L,Gagliardi E

更新日期：2013-05-01 00:00:00

abstract：:Prolonged cough is a common problem in patients seen in general practice. Using a simple method of sputum induction and processing of sputum samples, we determined whether eosinophilic airway inflammation could be a cause of undiagnosed prolonged cough. Eighty-two patients who had had cough for more than 1 month were ...

journal_title：Respiratory medicine

authors： Rytilä P,Metso T,Petäys T,Sohlman A,Työlahti H,Kohonen-Jalonen P,Kiviniemi P,Haahtela T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Impaired cardiac function and sleep-disordered breathing (SDB) are associated with progression of chronic kidney disease (CKD) in heart failure (HF) patients. Adaptive servo-ventilation (ASV) therapy improves cardiac function in HF patients regardless of the SDB severity through hemodynamic support and preve...

journal_title：Respiratory medicine

authors： Koyama T,Watanabe H,Terada S,Makabe S,Igarashi G,Nobori K,Ito H

更新日期：2011-12-01 00:00:00