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IL-8 and airway neutrophilia in children with gastroesophageal reflux and asthma-like symptoms.

Abstract：

:Gastroesophageal reflux (GER) may induce respiratory symptoms (RS) through inhalation of acid gastric contents. To characterize the airway inflammation associated with this condition, 20 children [7.4 (0.9) yr old] with "difficult to treat" RS and a positive 24-h oesophageal pH monitoring (pHm) were studied and bronchoalveolar lavage (BAL) performed. The control group included 10 children [7.3 (1.3) yr], non-atopics, with a respiratory clinical history similar to the cases but no reflux, as demonstrated by a negative 24-h oesophageal pHm. On BAL samples, in addition to inflammatory indexes, the lipid-laden macrophage (LLM) index was determined as index of gastric content inhalation. As compared to controls, GER children had higher neutrophil proportion (P=0.002), higher LLM index (P=0.004) and higher concentrations of interleukin (IL)-8 (P=0.005), myeloperoxidase (MPO) (P=0.001) and elastase (P=0.045) in BAL fluid. In GER children, but not in controls, neutrophil proportion significantly correlated with LLM index (r=0.65, P=0.002), with IL-8 (r=0.62, P=0.003) and MPO levels (r=0.54, P=0.014) but not with elastase concentrations. These results suggest an active pathogenetic role of IL-8 in the recruitment and activation of neutrophils in the airways of children with GER, respiratory symptoms and BAL findings suggestive of gastric content aspiration.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Sacco O,Silvestri M,Sabatini F,Sale R,Moscato G,Pignatti P,Mattioli G,Rossi GA

doi

10.1016/j.rmed.2005.05.011

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

307-15

issue

2

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(05)00237-4

journal_volume

100

pub_type

杂志文章

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