当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Lymphocytic focus score is positively related to airway and interstitial lung diseases in primary Sjögren's syndrome.

Lymphocytic focus score is positively related to airway and interstitial lung diseases in primary Sjögren's syndrome.

Abstract：

OBJECTIVE:Although high-resolution computed tomography (HRCT) is useful for the characterization of minute morphological changes in the lungs, no study has investigated risk factors for lung involvement detected by HRCT in patients with Sjögren's syndrome with or without respiratory symptoms. The aim of the current study was to investigate risk factors for lung involvement in patients with primary Sjögren's syndrome detected by HRCT, with a particular focus on airway and interstitial lung diseases. METHODS:We performed a retrospective cohort study of patients with primary Sjögren's syndrome and investigated risk factors for lung involvement detected by HRCT. A total of 101 patients with primary Sjögren's syndrome with initial HRCT examinations were enrolled. RESULTS:Higher age, dry mouth, and higher labial gland biopsy focus scores (≥4) were risk factors for airway diseases (odds ratio [OR] 1.064 confidence interval [CI] 1.026-1.102, OR 8.795 CI 2.317-33.378 and OR 3.261 CI 1.100-9.675, respectively) in the multivariable analysis. Higher age, male sex, and higher labial gland biopsy focus scores (≥4) were risk factors for interstitial lung diseases (OR 1.078 CI 1.032-1.127, OR 12.178 CI 1.121-132.307 and OR 3.954 CI 1.423-10.987, respectively) in the multivariable analysis. The presence of anti-T-lymphotropic virus type 1 antibodies was significantly more common in patients with airway diseases. CONCLUSIONS:This study showed significant associations of labial gland biopsy focus scores and dry mouth with pulmonary manifestations in patients with primary Sjögren's syndrome. Focus scores as well as dry mouth may reflect lymphoproliferative activity in the lungs in patients with primary Sjögren's syndrome.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Kakugawa T,Sakamoto N,Ishimoto H,Shimizu T,Nakamura H,Nawata A,Ito C,Sato S,Hanaka T,Oda K,Kido T,Miyamura T,Nakashima S,Aoki T,Nakamichi S,Obase Y,Saito K,Yatera K,Ishimatsu Y,Nakayama T,Korogi Y,Kawakami A,T

doi

10.1016/j.rmed.2018.02.023

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

95-102

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(18)30062-3

journal_volume

137

pub_type

杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • Smoking cessation in chronic obstructive pulmonary disease.

    abstract：:Chronic obstructive pulmonary disease (COPD) is increasing in prevalence, and is predicted to become the third leading cause of deaths worldwide by 2020. The precise prevalence of COPD is not known, as many individuals with the disease are left undiagnosed, despite the requirement of only simple spirometry testing for...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2009.02.013

    authors： Tashkin DP,Murray RP

    更新日期：2009-07-01 00:00:00

  • Staging of non-small cell lung cancer (NSCLC): a review.

    abstract：:Lung cancer remains the most common cause of cancer-related mortality in Scotland, accounting for 28.9% of all cancer deaths in 2007. (1) Current guidelines recommend assessment of patient fitness and operability by a multi-disciplinary team when selecting management options. (2-6) Two of the most important prognostic...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2010.08.005

    authors： Tsim S,O'Dowd CA,Milroy R,Davidson S

    更新日期：2010-12-01 00:00:00

  • Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosis.

    abstract：:Pulmonary hypertension is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome. The aim of this study was to further characterize the exercise intolerance, dyspnoea and ventilatory inefficiency of patients with pulmonary fibrosis in the pres...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.08.005

    authors： Gläser S,Noga O,Koch B,Opitz CF,Schmidt B,Temmesfeld B,Dörr M,Ewert R,Schäper C

    更新日期：2009-02-01 00:00:00

  • The prevalence of undiagnosed renal failure in a cohort of COPD patients in western Norway.

    abstract：:Patients with COPD are at risk for other comorbid diseases, like heart failure, coronary heart disease, and depression. However, little is known about COPD phenotypes and prevalence of sub-clinical renal failure. 433 COPD patients and 233 subjects without COPD, from Western Norway, age 40-75, GOLD stage II-IV, were ex...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.10.004

    authors： Gjerde B,Bakke PS,Ueland T,Hardie JA,Eagan TM

    更新日期：2012-03-01 00:00:00

  • Cost-effectiveness analysis of budesonide/formoterol compared with fluticasone in moderate-persistent asthma.

    abstract：:In this economic evaluation, conducted alongside a randomized, double-blind clinical trial, economic data were collected from 339 patients with moderate-persistent asthma randomized to receive twice-daily, double-blind treatment with budesonide/formoterol 160/4.5 microg in a single inhaler (n=166) or fluticasone propi...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2005.09.032

    authors： Ericsson K,Bantje TA,Huber RM,Borg S,Bateman ED

    更新日期：2006-04-01 00:00:00

  • Effect of adjunct fluticasone propionate on airway physiology during rest and exercise in COPD.

    abstract：RATIONALE:Combination therapy with corticosteroid and long-acting β(2)-agonists (LABA) in a single inhaler is associated with superior effects on airway function and exercise performance in COPD compared with LABA monotherapy. The physiological effects of adding inhaled corticosteroid monotherapy to maintenance broncho...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2011.08.021

    authors： Guenette JA,Raghavan N,Harris-McAllister V,Preston ME,Webb KA,O'Donnell DE

    更新日期：2011-12-01 00:00:00

  • Clinical and radiological features of Mycobacterium kansasii and other NTM infections.

    abstract：BACKGROUND:Mycobacterium kansasii infection is one of the most common causes of nontuberculous mycobacterial lung disease in the world. However, it is not possible to differentiate completely between M. kansasii and other nontuberculous mycobacteria (NTM) because of a lack of direct comparative studies. This retrospect...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.06.023

    authors： Matveychuk A,Fuks L,Priess R,Hahim I,Shitrit D

    更新日期：2012-10-01 00:00:00

  • Effect of maternal moderate to severe asthma on perinatal outcomes.

    abstract：BACKGROUND/OBJECTIVES:It has been reported that adverse fetal outcomes are more prevalent in pregnant women with asthma than they are in women without asthma. In our study, we investigated the effect that the severity of asthma during pregnancy has on the risk of a small for gestational age (SGA) infant, low birth weig...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.03.010

    authors： Firoozi F,Lemière C,Ducharme FM,Beauchesne MF,Perreault S,Bérard A,Ferreira E,Forget A,Blais L

    更新日期：2010-09-01 00:00:00

  • Elevated level of circulating matrix metalloproteinase-9 in patients with lung cancer.

    abstract：:The 72 kDa matrix metalloproteinase (MMP-2) and the 92 kDa matrix metalloproteinase (MMP-9), are type IV collagenases that have been implicated as important factors in cancer invasion and metastasis formation. We have used quantitative zymography and computer-assisted image analysis to measure the levels of MMP-9 and ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2000.0923

    authors： Hrabec E,Strek M,Nowak D,Hrabec Z

    更新日期：2001-01-01 00:00:00

  • Characteristics of asthmatics with detectable IL-32γ in induced sputum.

    abstract：BACKGROUND:Interleukin-32(IL-32)γ is a pro-inflammatory cytokine involved in the development and severity of chronic inflammatory diseases, but its role in asthma is unclear. OBJECTIVE:This study was conducted to evaluate the relationship of IL-32γ levels in sputum with the severity of asthma. METHODS:IL-32γ levels i...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.06.005

    authors： Kwon JW,Chang HS,Heo JS,Bae DJ,Lee JU,Jung CA,Son JH,Park JS,Kim SH,Min KU,Park CS

    更新日期：2017-08-01 00:00:00

  • Severe vocal cord dysfunction resistant to all current therapeutic interventions.

    abstract：:Vocal cord dysfunction (VCD) is characterised by paradoxical vocal cord adduction during inspiration or throughout the respiratory cycle, it results in wheeze, stridor, cough and dyspnoea. Although asthma and VCD can coexist, patients with VCD are frequently misdiagnosed with refractory asthma. It can severely restric...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.08.009

    authors： Goldstein R,Bright J,Jones SM,Niven RM

    更新日期：2007-04-01 00:00:00

  • Short-term effects of air pollution from biomass burning in mucociliary clearance of Brazilian sugarcane cutters.

    abstract：:Nasal mucociliary system is the first line of defense of the upper airways and may be affected acutely by exposure to particulate matter (PM) from biomass burning. Several epidemiologic studies have demonstrated a consistent association between levels of air pollution from biomass burning with increases in hospitaliza...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.08.003

    authors： Ferreira-Ceccato AD,Ramos EM,de Carvalho LC Jr,Xavier RF,Teixeira MF,Raymundo-Pereira PA,Proença Cdos A,de Toledo AC,Ramos D

    更新日期：2011-11-01 00:00:00

  • Cost of influenza and influenza-like syndromes (I-LSs) in Italy: Results of a cross-sectional telephone survey on a representative sample of general population.

    abstract：OBJECTIVES:Influenza and Influenza-like syndromes (I-LSs) are very common events in general practice, and their relevance is frequently underestimated. Aim of the study was to assess the economic impact of influenza and Influenza-like syndromes (I-LSs) in the Italian general population by using real-world data from a r...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.07.001

    authors： Dal Negro RW,Turco P,Povero M

    更新日期：2018-08-01 00:00:00

  • Prophylactic use of tranexamic acid for prevention of bleeding during transbronchial lung biopsies - A randomized, double-blind, placebo-controlled trial.

    abstract：BACKGROUND:Although massive bleeding following transbronchial lung biopsies (TBLB) is rare, even minor hemorrhage may prolong the procedure and result in inadequate sampling. Tranexamic acid (TXA) is an antifibrinolytic agent, which reduces bleeding in numerous scenarios, however, its prophylactic use in mitigating pos...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106162

    authors： Kuint R,Levy L,Cohen Goichman P,Huszti E,Abu Rmeileh A,Shriki O,Abutbul A,Fridlender ZG,Berkman N

    更新日期：2020-11-01 00:00:00

  • Effects of allergen exposure on methacholine and AMP-induced air trapping in pollen-sensitive subjects.

    abstract：BACKGROUND:The effect of pro-inflammatory stimuli on bronchoconstrictor-induced air trapping has not been studied. OBJECTIVE:To determine the effect of natural allergen exposure, a pro-inflammatory stimulus, on methacholine- and adenosine 5'-monophospate (AMP)-induced air trapping. METHODS:Airway responsiveness to me...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.11.023

    authors： Lopez V,Prieto L,Perez C,Barato D,Marin J

    更新日期：2011-06-01 00:00:00

  • Needle-track metastases and prophylactic radiotherapy for mesothelioma.

    abstract：BACKGROUND:Mesothelioma invades the tracts made by chest instrumentation. Prophylactic radiotherapy is effective at preventing malignant seeding at these sites. METHODS:We assessed the use and effectiveness of radiotherapy at our centre in 39 of the 40 patients identified with mesothelioma between January 2000 and Sep...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.09.034

    authors： West SD,Foord T,Davies RJ

    更新日期：2006-06-01 00:00:00

  • HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody.

    abstract：BACKGROUND:Anti-CADM-140 antibody (anti-CADM-140), also referred to as anti-melanoma differentiation-associated gene 5 (MDA5) antibody, is a myositis-specific antibody identified in the sera of patients with clinically amyopathic dermatomyositis (C-ADM) and is associated with a worse prognosis in dermatomyositis-associ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.05.006

    authors： Tanizawa K,Handa T,Nakashima R,Kubo T,Hosono Y,Watanabe K,Aihara K,Oga T,Chin K,Nagai S,Mimori T,Mishima M

    更新日期：2011-09-01 00:00:00

  • Cytokine levels in the sera of patients with idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder. Cytokines contribute an important but yet undefined role to its pathogenesis. OBJECTIVES:The present study aims to compare serum levels of cytokines involved in Th-1 and Th-2 immunity, such as interleukins (IL) IL-2, IL-4, IL-8, IL-10, in...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.06.016

    authors： Tsoutsou PG,Gourgoulianis KI,Petinaki E,Germenis A,Tsoutsou AG,Mpaka M,Efremidou S,Molyvdas PA

    更新日期：2006-05-01 00:00:00

  • Use of a portable device to record maximum inspiratory flow in relation to dyspnoea in patients with COPD.

    abstract：:Forced inspiratory measures have been described to reflect the reduction in dyspnoea upon bronchodilation in severe COPD. Based on this we evaluated the applicability and usefulness of a portable device for the assessment of forced inspiration. In 37 patients with COPD (GOLD II/II/IV n = 16/15/6, mean ± SD FEV(1) 46.2...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.11.017

    authors： Taube C,Rydzy L,Eich A,Korn S,Kornmann O,Sebastian M,Jörres RA,Buhl R

    更新日期：2011-02-01 00:00:00

  • Managing malnutrition in COPD: A review.

    abstract：:In the UK approximately 1.2 million people have COPD with around 25-40% being underweight and 35% have a severely low fat-free mass index. Measuring their body mass index is recommended and Health care professionals should endeavour to ensure that COPD patients are achieving their nutritional requirements. A narrative...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2020.106248

    authors： Keogh E,Mark Williams E

    更新日期：2020-11-21 00:00:00

  • Relative therapeutic index between inhaled formoterol and salbutamol in asthma patients.

    abstract：:A double-blind, randomized crossover study in 28 asthmatic patients assessed the relative therapeutic index for inhaled formoterol and salbutamol. Pre-drug administration FEV1 (mean 2.08 l) was 49-93% of predicted and reversibility 16-82% after inhalation of salbutamol. Patients inhaled single doses of formoterol (Oxi...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/rmed.2002.1291

    authors： Rosenborg J,Larsson R,Rott Z,Böcskei C,Poczi M,Juhász G

    更新日期：2002-06-01 00:00:00

  • Defective efferocytosis by alveolar macrophages in IPF patients.

    abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.08.020

    authors： Morimoto K,Janssen WJ,Terada M

    更新日期：2012-12-01 00:00:00

  • Beclometasone dipropionate extrafine aerosol versus fluticasone propionate in children with asthma.

    abstract：:Beclometasone dipropionate (BDP) extrafine is a hydrofluoroalkane-based, chlorofluorocarbon (CFC)-free inhalation aerosol. This study was conducted to determine whether BDP extrafine and CFC-fluticasone proprionate (FP) aerosols were equivalent in terms of efficacy and tolerability in children with symptomatic mild-to...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2006.11.020

    authors： van Aalderen WM,Price D,De Baets FM,Price J

    更新日期：2007-07-01 00:00:00

  • Are the results of early long-term trials of sodium cromoglycate valid?

    abstract：:The first long-term study of sodium cromoglycate, reported in 1972, demonstrated the effectiveness of sodium cromoglycate in controlling asthma. The trial had various limitations, but more recent trials have been designed so that they overcome some of these problems. Results of these trials validate the results obtain...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0954-6111(89)80244-6

    authors： Turner-Warwick M

    更新日期：1989-05-01 00:00:00

  • Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection.

    abstract：:Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.08.015

    authors： Bresser P,Cornelissen MI,van der Bij W,van Noesel CJ,Timens W

    更新日期：2007-04-01 00:00:00

  • Statins: cause of fibrosis or the opposite? Effect of cardiovascular drugs in idiopathic pulmonary fibrosis.

    abstract：BACKGROUND AND OBJECTIVE:Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with poor prognosis despite the recent availability of two antifibrotic drugs. Patients are more susceptible to cardiovascular comorbidities. In this study, we aimed to determine the impact of concom...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106259

    authors： M Lambert E,A Wuyts W,Yserbyt J,De Sadeleer LJ

    更新日期：2020-11-26 00:00:00

  • Angiopoietin-2 expression in patients with an acute exacerbation of idiopathic interstitial pneumonias.

    abstract：BACKGROUND AND OBJECTIVE:We hypothesized that increased pulmonary vascular permeability may play a role in the pathogenesis of an acute exacerbation of the idiopathic interstitial pneumonias (AE-IIPs). Angiopoietin-2 (Ang-2) promotes endothelial activation, destabilization, and inflammation. The purpose of this study w...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.05.012

    authors： Ando M,Miyazaki E,Abe T,Ehara C,Goto A,Masuda T,Nishio S,Fujisaki H,Yamasue M,Ishii T,Mukai Y,Ito T,Nureki SI,Kumamoto T,Kadota J

    更新日期：2016-08-01 00:00:00

  • Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking.

    abstract：:The imbalance between oxidants and antioxidants is known to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most frequent factor responsible for development of COPD by leading to oxidant overload in the lower airways, due to presence of its own oxida...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0574

    authors： Nowak D,Kasielski M,Antczak A,Pietras T,Bialasiewicz P

    更新日期：1999-06-01 00:00:00

  • A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma.

    abstract：OBJECTIVE:To compare the effects of once-daily ciclesonide and twice-daily fluticasone propionate in patients with moderate persistent asthma. METHODS:Patients aged 12-75 years with moderate bronchial asthma entered a 1-4 week run-in period. For inclusion into the 12-week, randomized, open-label treatment period, pati...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2007.03.001

    authors： Boulet LP,Bateman ED,Voves R,Müller T,Wolf S,Engelstätter R

    更新日期：2007-08-01 00:00:00

  • Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer - a retrospective single institution analysis.

    abstract：PURPOSE:The aim of this retrospective study is to present data on clinical significance of lactate dehydrogenase (LDH) serum levels in an unselected contemporary patient population with small cell lung cancer (SCLC) in limited disease (LD) and extensive disease stage (ED). PATIENTS AND METHODS:From June 2004 to June 2...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2010.07.013

    authors： Hermes A,Gatzemeier U,Waschki B,Reck M

    更新日期：2010-12-01 00:00:00