Are the results of early long-term trials of sodium cromoglycate valid?

abstract：BACKGROUND:Severe asthma is a heterogeneous disease. Patients with both eosinophilic and allergic asthma phenotypes may be eligible for treatment with mepolizumab and omalizumab. Evidence on the relative effectiveness of these treatments in this 'overlap' population would be informative for clinical and payer decision ...

journal_title：Respiratory medicine

authors： Cockle SM,Stynes G,Gunsoy NB,Parks D,Alfonso-Cristancho R,Wex J,Bradford ES,Albers FC,Willson J

更新日期：2017-02-01 00:00:00

abstract：:Intrapulmonary percussive ventilation (IPV) is a ventilatory technique that delivers bursts of high-flow respiratory gas into the lung at high rates, intended for treating acute respiratory failure and for mobilization of secretions. We performed a study, aimed at assessing the physiological response to IPV, on patien...

journal_title：Respiratory medicine

authors： Nava S,Barbarito N,Piaggi G,De Mattia E,Cirio S

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Local and systemic inflammation is implicated in the pathophysiology of Obstructive Sleep Apnea (OSA). Exhaled breath condensate (EBC) is a non-invasive sampling method for the lower airways. However, it is important to consider the potential effect of the systemic origin whereas systemic inflammation is sig...

journal_title：Respiratory medicine

authors： Antonopoulou S,Loukides S,Papatheodorou G,Roussos C,Alchanatis M

更新日期：2008-10-01 00:00:00

abstract：:The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with chemoimmunotherapy wh...

journal_title：Respiratory medicine

authors： Metintas M,Metintas S,Ucgun I,Gibbs AR,Harmanci E,Alatas F,Erginel S,Tel N,Pasaoglu O

更新日期：2001-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a condition characterized by progressive airflow limitation, with symptoms of dyspnoea, cough, and sputum production. Aside from information on prevalence, mortality and hospital resource utilization arising from COPD in Canada, there is a lack of data on the impact of t...

journal_title：Respiratory medicine

authors： Chapman KR,Bourbeau J,Rance L

更新日期：2003-03-01 00:00:00

abstract：:Inhalation of dust in swine confinement buildings causes airway inflammation and systemic symptoms. The proinflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) increase in bronchoalveolar and nasal lavage fluid, and in serum. The aim of this investigation was to study changes in the...

journal_title：Respiratory medicine

authors： Wang Z,Manninen A,Malmberg P,Larsson K

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Current evidence suggests that blood eosinophil levels (Eos) are associated with chronic obstructive pulmonary disease (COPD) treatment response and natural history. This analysis investigated the relationship between Eos levels and clinical characteristics in a representative cohort of US subjects with spir...

journal_title：Respiratory medicine

authors： DiSantostefano RL,Hinds D,Le HV,Barnes NC

更新日期：2016-03-01 00:00:00

abstract：:Inhalation of on-demand salbutamol (ODS) several times daily is sometimes the only beta2-agonist prescribed in moderate persistent asthma, whereas a long-acting beta2-agonist should be added. This trial aimed to compare the efficacy of formoterol dry-powder capsule 12 microg b.i.d. (Foradil) and ODS in patients with m...

journal_title：Respiratory medicine

authors： Molimard M,Bourcereau J,Le Gros V,Bourdeix I,Leynadier F,Duroux P,French FOR-F-01 Study Group.

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is the most common life limiting genetic disorder, characterized by chronic respiratory failure secondary to inflammation and chronic bacterial lung infection. Pseudomonas aeruginosa lung infection is associated with more severe lung disease and rapid progression of respiratory failure w...

journal_title：Respiratory medicine

authors： Fesen K,Silveyra P,Fuentes N,Nicoleau M,Rivera L,Kitch D,Graff GR,Siddaiah R

更新日期：2019-05-01 00:00:00

abstract：:Several clinical trials have shown that the inhaled beta2-agonists with long-acting properties, formoterol and salmeterol, may be effective in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, there is a great deal of controversy regarding the timing and optimal dose of inhaled beta2-agonis...

journal_title：Respiratory medicine

authors： Cazzola M,Santus P,Matera MG,Carlucci P,Belloli E,Di Marco F,Centanni S

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Natriuretic peptides are considered as reliable indicators of left-heart failure (HF) and are useful for differential diagnosis of dyspnoea. AIM:We evaluated the clinical significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic hypercapnic respiratory failure (CHRF). ME...

journal_title：Respiratory medicine

authors： Budweiser S,Luchner A,Jörres RA,Heinemann F,Hitzl AP,Schmidbauer K,Riegger G,Pfeifer M

更新日期：2007-09-01 00:00:00

abstract：:Metered dose inhalers (MDIs) are the mainstay of inhaled steroid therapy for asthma. With the phasing out of traditional chlorofluorocarbon (CFC) propellants and their replacement with a new generation of CFC-free products, it is becoming clear that formulation and inhaler characteristics can markedly affect the drug ...

journal_title：Respiratory medicine

authors： Shaw RJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Mortality correlates with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria of airway obstruction. Yet, little data exist concerning the long-term survival of patients presenting with different levels of obstruction. METHODS:We studied the association between all-cause and cause-spe...

journal_title：Respiratory medicine

authors： Mattila T,Vasankari T,Kanervisto M,Laitinen T,Impivaara O,Rissanen H,Knekt P,Jousilahti P,Saarelainen S,Puukka P,Heliövaara M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate the efficacy and safety of ciclesonide compared with budesonide in adolescents with severe asthma. METHODS:In this randomized, double-blind, double-dummy, parallel-group study, patients aged 12-17 years with severe asthma were treated with budesonide 400 microg once d...

journal_title：Respiratory medicine

authors： Vermeulen JH,Gyurkovits K,Rauer H,Engelstätter R

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is now the generally preferred surgical treatment for spontaneous pneumothorax but is more difficult once pleural adhesions have developed. To test the hypothesis that VATS is under-used because of prolonged pleural intubation, we have audited the effect of preoper...

journal_title：Respiratory medicine

authors： Waller DA,McConnell SA,Rajesh PB

更新日期：1998-02-01 00:00:00

abstract：:Although pleural manometry is a relatively simple medical procedure it is only occasionally used to follow pleural pressure (Ppl) changes during a therapeutic thoracentesis and pneumothorax drainage. As some studies showed that pleural pressure monitoring might be associated with significant advantages, pleural manome...

journal_title：Respiratory medicine

authors： Grabczak EM,Krenke R,Zielinska-Krawczyk M,Light RW

更新日期：2018-12-01 00:00:00

abstract：:In a double-blind study of 60 patients undergoing fibreoptic bronchoscopy we have compared the local anaesthetic effects of intratracheal injections of cocaine (4 ml, 2.5%) and lignocaine (4 ml, 4%). The two local anaesthetics were equally effective in terms of cough suppression, requirement for extra local anaestheti...

journal_title：Respiratory medicine

authors： Teale C,Gomes PJ,Muers MF,Pearson SB

更新日期：1990-09-01 00:00:00

abstract：:Lung function (FEV1 before and after bronchodilatation) was studied prospectively over five visits in 55 asthmatic children (28 boys) from childhood to adulthood (age 30). At the last follow-up recordings were made at rest, after cold air challenge (CACh), and after bronchodilatation. Results were related to clinical ...

journal_title：Respiratory medicine

authors： Gustafsson PM,Kjellman B

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Although athletes have a high prevalence of airway hyperresponsiveness (AHR) and asthma, little is known about possible gender differences in regard to these features. We looked at the comparative prevalence of AHR, physician-diagnosed asthma and respiratory symptoms during exercise in female (F) and male (M...

journal_title：Respiratory medicine

authors： Langdeau JB,Day A,Turcotte H,Boulet LP

更新日期：2009-03-01 00:00:00

abstract：:There is an increasing body of evidence suggesting that altered vascular permeability may be an important component of the pathogenesis of acute mountain sickness (AMS). Vascular endothelial growth factor (VEGF) is a potent permeability factor subject to hypoxic regulation but its role in the pathogenesis of AMS is ye...

journal_title：Respiratory medicine

authors： Dorward DA,Thompson AA,Baillie JK,MacDougall M,Hirani N

更新日期：2007-03-01 00:00:00

abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...

journal_title：Respiratory medicine

authors： Levine M,Taylor R,Ryan M,Sculpher M

更新日期：2002-08-01 00:00:00

abstract：:Aminophylline administration was compared in 43 patients who died from asthma and 43 matched controls who were admitted, suffering from acute asthma, to hospitals in the North East Thames Region. A computer program, which used information about individual characteristics, medical history and drug intake, was employed ...

journal_title：Respiratory medicine

authors： Eason J,Markowe HL

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Acute exacerbation of COPD (AECOPD) is one of the leading causes for hospitalization and readmission in developed countries. No laboratory indices were consistently found to be associated with readmission risk. Recent evidence attests that red blood cell distribution width (RDW), conveys important informatio...

journal_title：Respiratory medicine

authors： Epstein D,Nasser R,Mashiach T,Azzam ZS,Berger G

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Exercise-induced bronchoconstriction (EIB) increases in cold and dry air and decreases in humid air in subjects with asthma. Few reports have reported on the effect of humid environment upon exercise capacity in subjects with EIB. OBJECTIVE:The primary aim of the present study was to examine the effect of ch...

journal_title：Respiratory medicine

authors： Stensrud T,Berntsen S,Carlsen KH

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Interstitial lung disease is a common extra-articular manifestation of rheumatoid arthritis (RA-ILD) and is associated with significant morbidity and mortality. However, limited data exist regarding predictors of mortality. We sought to examine the prognostic value of the high-resolution computed tomography (HR...

journal_title：Respiratory medicine

authors： Yunt ZX,Chung JH,Hobbs S,Fernandez-Perez ER,Olson AL,Huie TJ,Keith RC,Janssen WJ,Goldstein BL,Lynch DA,Brown KK,Swigris JJ,Solomon JJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease (COPD) are at higher risk of developing Community-Acquired Pneumonia (CAP) than patients in the general population. However, no studies have been performed in general practice assessing longitudinal incidence rates for CAP in COPD patients or risk factors f...

journal_title：Respiratory medicine

authors： Müllerova H,Chigbo C,Hagan GW,Woodhead MA,Miravitlles M,Davis KJ,Wedzicha JA

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Supplemental oxygen is a recommended therapy option in stable hypoxemic COPD patients. Often, supplemental oxygen is provided by continuous flow (CF). However, demand oxygen delivery systems (DODS) that provide an oxygen bolus only during inspiration have gained increasing use as they prolong oxygen cylinder...

journal_title：Respiratory medicine

authors： Gloeckl R,Jarosch I,Schneeberger T,Fiedler C,Lausen M,Weingaertner J,Hitzl W,Kenn K,Koczulla AR

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Gas trapping suggesting small airway disease is observed in adult asthmatic suffering from severe asthma. The aim of the study was to assess whether gas trapping could be evidenced in asthmatic children with/without severe exacerbation and with/without symptoms during the past three months. METHODS AND PATI...

journal_title：Respiratory medicine

authors： Mahut B,Peiffer C,Bokov P,Beydon N,Delclaux C

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:It has been shown that interleukin (IL)-18 levels in induced sputum are reduced in asthmatic and healthy smokers. However, in chronic obstructive pulmonary disease (COPD) patients, recent data show an overproduction in the lungs and increased serum levels of IL-18, suggesting that IL-18 may be involved in th...

journal_title：Respiratory medicine

authors： Rovina N,Dima E,Gerassimou C,Kollintza A,Gratziou C,Roussos C

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE:...

journal_title：Respiratory medicine

authors： Schor D,Rizzo JÂ,Medeiros D,Dela Bianca AC,Silva AR,Nunes C,Morais-Almeida M,Sarinho E

更新日期：2017-05-01 00:00:00