Abstract:
BACKGROUND:Current evidence suggests that blood eosinophil levels (Eos) are associated with chronic obstructive pulmonary disease (COPD) treatment response and natural history. This analysis investigated the relationship between Eos levels and clinical characteristics in a representative cohort of US subjects with spirometry-defined COPD. METHODS:Cross-sectional data from the National Health And Nutrition Examination Survey (NHANES 2007-2010) of subjects ≥ 40 years with spirometry-defined COPD and Eos data (n = 948) were analyzed. Differences in clinical characteristics by Eos level (≤ 2%, > 2%) were compared using chi-square tests. Characteristics associated with Eos > 2% were identified using multivariate logistic regression modeling. Characteristics associated with Eos >2% among subjects with normal lung function, plus other cut-points among the COPD population, were evaluated post hoc. FINDINGS:Most participants had Eos >2%; 70.7% with spirometry-defined COPD and 65.5% with normal lung function. Older age, male gender, and severe current asthma were significantly associated with Eos >2% in COPD subjects. The Eos ≤ 2% COPD group had higher reported rates of previous heart attack and anemia. Among participants with normal lung function, Eos > 2% was associated with being male, being overweight/obese, older age, hay fever, and congestive heart failure. INTERPRETATION:In this large US-based cohort, Eos > 2% was prevalent in participants with COPD and normal lung function. Among participants with COPD, Eos > 2% was associated with specific characteristics including lower rates of some co-morbidities; however, the clinical implications and relationships between Eos levels, COPD mechanisms, and risk of outcomes require further evaluation.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
DiSantostefano RL,Hinds D,Le HV,Barnes NCdoi
10.1016/j.rmed.2016.01.013subject
Has Abstractpub_date
2016-03-01 00:00:00pages
88-96eissn
0954-6111issn
1532-3064pii
S0954-6111(16)30010-5journal_volume
112pub_type
杂志文章abstract:BACKGROUND:Pulmonary function testing is not feasible in many adults with intellectual disabilities, because of difficulties with understanding and cooperation. AIMS:To investigate feasibility, repeatability and reproducibility of measuring airway resistance using the interrupter technique (MicroRint) in people aged 5...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1053/rmed.2000.0869
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doi:10.1016/j.rmed.2004.11.003
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pub_type: 临床试验,杂志文章
doi:10.1016/j.rmed.2018.01.003
更新日期:2018-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.rmed.2020.106146
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doi:10.1016/j.rmed.2007.10.001
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.rmed.2012.04.008
更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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