Abstract：
:The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case control study. Twenty-two patients with idiopathic chronic cough and 65 community-matched controls for age and sex who responded to a self-administered questionnaire were asked about the presence of autoimmune disease, other medical problems and drug history. All subjects were invited to have a blood test for an autoimmune screen. Thirteen out of 22 (59%) patients with idiopathic chronic cough and eight out of 65 (12%) age- and sex-matched controls reported organ-specific autoimmune disease (odds ratio 8.8; 95% confidence interval 2.4-31.8, P<0.001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40% vs. 13%; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Birring SS,Murphy AC,Scullion JE,Brightling CE,Browning M,Pavord IDdoi
10.1016/j.rmed.2003.10.005subject
Has Abstractpub_date
2004-03-01 00:00:00pages
242-6issue
3eissn
0954-6111issn
1532-3064pii
S0954-6111(03)00365-2journal_volume
98pub_type
杂志文章abstract：BACKGROUND:Impaired cardiac function and sleep-disordered breathing (SDB) are associated with progression of chronic kidney disease (CKD) in heart failure (HF) patients. Adaptive servo-ventilation (ASV) therapy improves cardiac function in HF patients regardless of the SDB severity through hemodynamic support and preve...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2011.09.001
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:SLS COPD was the first open-label randomised controlled trial demonstrating a reduction in moderate/severe COPD exacerbations with once-daily inhaled fluticasone furoate/vilanterol (FF/VI) in everyday clinical practice. Here we report FF/VI effectiveness and safety in predefined patient subgroups. METHODS:P...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2018.12.016
更新日期：2019-02-01 00:00:00
abstract：:Pneumocystis carinii colonization was studied in 90 men using the polymerase chain reaction. These comprised ten heterosexual controls; ten HIV-seronegative homosexual controls; 20 HIV-seropositive homosexuals with blood CD4 count > 400 x 10(6) l-1; 20 HIV-seropositive homosexuals with CD4 < 400 x 10(6) l-1; ten HIV-s...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/0954-6111(93)90008-n
更新日期：1993-10-01 00:00:00
abstract：BACKGROUND:Tracheal collapse is a weakness of the tracheal wall leading to expiratory central airway collapse of more than 50% compared to inspiration. It has previously been discussed whether the collapsibility of the greater airways is a stable or a dynamic condition. Indeed, other well-known lung diseases such as as...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.11.018
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease (COPD) are at higher risk of developing Community-Acquired Pneumonia (CAP) than patients in the general population. However, no studies have been performed in general practice assessing longitudinal incidence rates for CAP in COPD patients or risk factors f...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2012.04.008
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Lung fibrosis is attributed to derangements in extracellular matrix remodeling, a process driven by collagen turnover. We examined the association of two collagen biomarkers, carboxy-terminal telopeptide of collagen type I (ICTP) and amino-terminal propeptide of type III procollagen (PIIINP), with subclinica...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmed.2018.06.001
更新日期：2018-07-01 00:00:00
abstract：:To clarify the clinical features of pulmonary Mycobacterium avium-intracellulare complex (MAC) infection, we retrospectively evaluated clinical manifestations, laboratory data, chest and maxillary sinus computed tomographic scans and induced sputum findings in 26 with MAC infection in comparison with 104 patients with...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2003.1496
更新日期：2003-06-01 00:00:00
abstract：:In recent years, it has become increasingly important to get as much as possible information on clinical efficacy already in the early phases of drug development. For proof of concept (POC) studies testing novel anti-inflammatory drugs in asthma, there are several validated exacerbation models, inducing various aspect...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2007.10.018
更新日期：2008-03-01 00:00:00
abstract：:The degree of risk of cross-infection of patients via lung function testing equipment has yet to be quantified. Based on current evidence, elaborate precautions are not justified for the majority of patients attending the laboratory, but attention to appropriate routine cleaning and disinfection protocols is important...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(03)00223-3
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Exercise induced asthma may symptomatically be difficult to differentiate from exercise related obstruction in the upper airways, sometimes leading to diagnostic confusion and inappropriate treatment. Larynx accounts for a significant fraction of total airway resistance, but its role as a limiting factor for...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.05.024
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE:...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2017.03.017
更新日期：2017-05-01 00:00:00
abstract：:The role of positive end-expiratory pressure (PEEP) in the postoperative course of cardiac surgery patients remains questionable. In this prospective study, we examined the effect of different levels of PEEP on arterial oxygenation, SvO2 and PvO2 values, and on haemodynamic indices, during the early postoperative peri...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(98)90388-2
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Non-invasive ventilation (NIV) is increasingly used in the treatment of patients with chronic hypercapnic respiratory failure (CRF). Residual sleep related respiratory events under NIV such as obstructive or central apnea/hypopnea (AH), or patient-ventilator asynchrony (PVA), may compromise treatment efficac...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2017.10.025
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:The 6-min walk test (6MWT) has prognostic value in various pulmonary disorders including idiopathic pulmonary fibrosis (IPF). We determined the individual prognostic accuracy of distance walked and oxygen saturation during the 6MWT in patients with IPF. We defined a new composite index, the distance-satura...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.02.004
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:The histologic diagnosis of Pulmonary Langerhans cell histiocytosis (PLCH) is invasive and can cause complications. To confirm the diagnosis of PLCH, guidelines therefore recommend measuring CD1a-positive bronchoalveolar lavage fluid (BALF) cells despite its poor sensitivity and specificity. Thus, an improve...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2016.09.004
更新日期：2016-10-01 00:00:00
abstract：:Long-term oxygen therapy (LTOT) in patients with chronic hypoxaemia is an expanding field. Traditional stationary oxygen, with and without portable compressed gas cylinders, and portable liquid oxygen equipment is available today. No official guidelines exist for the prescription of liquid oxygen vs traditional oxygen...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90037-3
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Smoking continues to be a major risk factor for COPD and may impact the efficacy of COPD treatments, with guidelines supporting the crucial importance for current smokers of smoking cessation. A post-hoc analysis of the FLIGHT1 and FLIGHT2 studies assessed the impact of smoking status on the efficacy and saf...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.07.019
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature. AIM:To estimate the prevalence of COPD as defined by British Thoracic Society (BTS) criteria and the recent global initiative for chroni...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2003.1446
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Sarcoidosis (SA) is a multisystem granulomatous disorder of unknown etiology. It seems likely that in genetically different predisposed hosts, the same antigen(s) may cause the development of sarcoid Th1 response. The interaction of the T-cell receptor with the human leukocyte antigen-DQA1*03011 peptide-comp...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2007.06.004
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Although baker's asthma (BA) is a common occupational asthma, there have been few reports on this disease in Korean subjects. OBJECTIVES:We evaluated the prevalence of serum-specific IgE, IgG1, and IgG4 antibodies in relation to work-related respiratory symptoms in a single industrial bakery. METHODS:Three...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2007.11.015
更新日期：2008-04-01 00:00:00
abstract：:The Spacehaler is a new, compact, pressurized aerosol device that uses the same canister as a conventional metered-dose inhaler (MDI). Its design, however, reduces the velocity of the aerosol cloud that emerges from the inhaler, thereby reducing the amount of the non-respirable fraction of the drug delivered to the pa...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(97)90035-4
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:The prevalence of depression in stable COPD patients varies markedly, possibly because of use of different scales. We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically sta...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.11.021
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we ca...
journal_title：Respiratory medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.rmed.2017.06.020
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical feature...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.105982
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The optimal initial management of primary spontaneous pneumothorax (PSP) remains controversial. This study was to evaluate the safety and efficacy of intrapleural minocycline following aspiration for initial treatment of PSP. METHODS:Between January 2004 and November 2006, 64 patients with a first episode o...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.02.006
更新日期：2008-07-01 00:00:00
abstract：:Haemodynamic studies at rest and during exercise together with radionuclide ventriculography, pulmonary function and clinical well-being assessment were evaluated in ten patients with COPD and secondary pulmonary hypertension (mean PAP 25 mm Hg), before and after 6 months therapy with pirbuterol 20 mg thrice daily. De...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/s0954-6111(89)80061-7
更新日期：1989-01-01 00:00:00
abstract：:A 56-year-old female patient, developing ALK-negative anaplastic T cell lymphoma 7 years after the diagnosis of sarcoidosis with clinical and histopathological features of tuberculosis has been presented. We herein present concurrent occurrence of the sarcoidosis, lymphoma and tuberculosis along with the confusing fin...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.09.001
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:Cleaning workers have an increased risk of asthma but the underlying mechanisms are largely unknown. We studied functional and biological characteristics in asthmatic cleaners and compared these to healthy cleaners. METHODS:Forty-two cleaners with a history of asthma and/or recent respiratory symptoms and 5...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2013.01.011
更新日期：2013-05-01 00:00:00
abstract：:Fifty patients with tropical eosinophilia were studied clinically and physiologically, before and after a standard 3-week course of diethylcarbamazine. Before treatment the main physiological abnormality was a reduction in the carbon monoxide transfer factor. One month after the start of treatment most patients had sh...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(06)80205-2
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Combination therapy with inhaled corticosteroids (ICS) and long-acting β(2)-adrenergic agonists (LABA) is reported to have superior effects on controlling asthma symptoms to ICS alone; however, there is no molecular-based evidence to explain the clinical effects. Here, the effect of the ICS/LABA combination ...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2011.08.020
更新日期：2011-12-01 00:00:00
