Abstract：
BACKGROUND:Non-invasive ventilation (NIV) is increasingly used in the treatment of patients with chronic hypercapnic respiratory failure (CRF). Residual sleep related respiratory events under NIV such as obstructive or central apnea/hypopnea (AH), or patient-ventilator asynchrony (PVA), may compromise treatment efficacy and/or comfort. AIMS OF STUDY:1/to quantify the frequency and describe the types of both AH and PVA in a large group of stable patients with CRF during night-time NIV; 2/to analyze the influence of these events on overnight pulse oximetry and transcutaneous CO2 and 3/to assess interrater agreement in identifying and quantifying AH and PVA. METHODS:We quantified AH and PVA by performing sleep polygraphy in 67 patients during elective follow-up visits. Traces were scored by two trained physicians. RESULTS:Residual AH were frequent: 34% of the patients had an AH Index >5/hour, with obstructive hypopnea being the most frequent event. In addition, 21% of the patients had PVA >10% of total recording time. No correlation was found between respiratory events and overnight hypercapnia. The intraclass correlation coefficients for scoring AHI and time with PVA were 0.97 (0.94-0.98) and 0.85 (0.75-0.91) respectively. CONCLUSIONS:Residual respiratory events are common in patients treated with long term NIV for chronic hypercapnic respiratory failure and can be scored with a very high interobserver agreement. However, these events were not associated with persistent nocturnal hypercapnia; thus, their clinical relevance has yet to be clarified. CLINICALTRIALS.GOV REGISTRATION N°: NCT01845233.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Aarrestad S,Qvarfort M,Kleiven AL,Tollefsen E,Skjønsberg OH,Janssens JPdoi
10.1016/j.rmed.2017.10.025subject
Has Abstractpub_date
2017-11-01 00:00:00pages
210-216eissn
0954-6111issn
1532-3064pii
S0954-6111(17)30364-5journal_volume
132pub_type
杂志文章abstract：:The sick building syndrome has been the subject of research for approximately 10 years. Although it is often suggested that symptoms in office workers are due to circulating micro-organisms or particles, epidemiological studies investigating the relationship between them have been lacking. This cross-sectional study h...
journal_title：Respiratory medicine
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journal_title：Respiratory medicine
pub_type： 杂志文章,meta分析,评审
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pub_type： 杂志文章,多中心研究
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2014-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
