当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients.

Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients.

Abstract：

OBJECTIVE:This study evaluated the tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in patients with COPD. METHODS:This double-blind, placebo-controlled study (NCT00629239) randomised patients with moderate to severe COPD to AZD4818 300mug or placebo twice daily via Turbuhaler((R)) for 4 weeks. Safety, lung function, functional capacity and health status measures were measured. Plasma concentrations of AZD4818 were measured after the first dose and after 2 and 4 weeks' treatment. RESULTS:Sixty-five patients (47 male; median age 65.6 years) received AZD4818 (n=33) or placebo (n=32). There was no statistically significant difference between AZD4818 and placebo in change from baseline to endpoint for FEV(1) (AZD4818-placebo: 0.026L, p=0.69), morning PEF (-6L/min, p=0.23), or other lung function measures. There was no difference between treatment groups in the 6-min walk test, MMRC dyspnoea index, BODE index and CCQ scores. Plasma concentrations indicated that patients were exposed to AZD4818 as expected. AZD4818 was well tolerated: 27 treatment-related adverse events (13 with AZD4818, 14 with placebo), 2 serious adverse events (both AZD4818: exacerbation [considered not treatment-related] and deep vein thrombosis [considered treatment-related]) and 11 discontinuations (7 with AZD4818). CONCLUSIONS:Inhaled AZD4818 was well tolerated at 300mug twice daily for 4 weeks in patients with COPD; however, there was no indication of a beneficial treatment effect despite exposure as expected. These findings in COPD are in line with other studies reporting a lack of clinical efficacy with CCR1 antagonists in other therapy areas.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Kerstjens HA,Bjermer L,Eriksson L,Dahlström K,Vestbo J

doi

10.1016/j.rmed.2010.04.010

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

1297-303

issue

9

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(10)00189-7

journal_volume

104

pub_type

杂志文章,随机对照试验

相关文献

RESPIRATORY MEDICINE文献大全
  • Long-term macrolide maintenance therapy in non-CF bronchiectasis: evidence and questions.

    abstract：:Macrolide antibiotics have anti-inflammatory and immunomodulatory properties in addition to antibacterial activity. Until recently, only a small number of studies evaluating macrolides in patients with non-cystic fibrosis (CF) bronchiectasis had been published. These were open-label, uncontrolled, short-duration studi...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2014.09.005

    authors： Haworth CS,Bilton D,Elborn JS

    更新日期：2014-10-01 00:00:00

  • Chronic respiratory symptoms, spirometry and knowledge of COPD among general population.

    abstract：RATIONALE:Infradiagnosis of chronic obstructive pulmonary disease (COPD) may be related to the lack of knowledge about the disease and/or the scarce use of diagnostic procedures. This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of sp...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.02.024

    authors： Miravitlles M,de la Roza C,Morera J,Montemayor T,Gobartt E,Martín A,Alvarez-Sala JL

    更新日期：2006-11-01 00:00:00

  • DQA1*03011 allele: protective or an adverse effect on the development of sarcoidosis; preliminary study.

    abstract：BACKGROUND:Sarcoidosis (SA) is a multisystem granulomatous disorder of unknown etiology. It seems likely that in genetically different predisposed hosts, the same antigen(s) may cause the development of sarcoid Th1 response. The interaction of the T-cell receptor with the human leukocyte antigen-DQA1*03011 peptide-comp...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.06.004

    authors： Dubaniewicz A,Dubaniewicz A,Dubaniewicz A,Moszkowska G

    更新日期：2007-10-01 00:00:00

  • Energy expenditure during daily activities as measured by two motion sensors in patients with COPD.

    abstract：BACKGROUND:In patients with chronic obstructive pulmonary disease (COPD), energy expenditure (EE) assessment during the performance of daily activities is not yet studied in depth. The aim of this study was to determine which daily activities are more demanding to patients with COPD and to compare the accuracy of EE es...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2011.01.004

    authors： Cavalheri V,Donária L,Ferreira T,Finatti M,Camillo CA,Cipulo Ramos EM,Pitta F

    更新日期：2011-06-01 00:00:00

  • Serum and pleural fluid levels of CA50 in malignant and tuberculous effusions.

    abstract：:The measurement of CA50 in serum and pleural fluid by immunoradiometric assay was presented in 45 (27 malignancy and 18 tuberculosis) patients with pleural effusion. The mean CA50 level in malignant effusion (89.26 +/- 122.32 U ml-1) was significantly higher than that in tuberculous effusion (5.18 +/- 8.65 U ml-1) (P ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(94)90170-8

    authors： Yang SZ,Ji SQ

    更新日期：1994-01-01 00:00:00

  • Identifying patients at risk of late recovery (≥ 8 days) from acute exacerbation of chronic bronchitis and COPD.

    abstract：OBJECTIVES:To identify factors associated with late recovery (≥ 8 days from exacerbation start) in patients with acute exacerbations of chronic bronchitis/COPD (AECB/AECOPD). METHODS:An international, observational, non-interventional study in outpatients with AECB/AECOPD who received treatment for their exacerbation ...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.rmed.2012.06.002

    authors： Anzueto A,Miravitlles M,Ewig S,Legnani D,Heldner S,Stauch K

    更新日期：2012-09-01 00:00:00

  • Changes in forced expiratory volume in 1 second over time in patients with controlled asthma at baseline.

    abstract：BACKGROUND:A predominant feature of asthma is an accelerated rate of decline in forced expiratory volume in 1 s (FEV1), but data on the variability and factors associated with this change in patients with controlled asthma are largely unknown. METHODS:140 patients with controlled asthma were enrolled based on the Glob...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.04.014

    authors： Matsunaga K,Ichikawa T,Oka A,Morishita Y,Kanai K,Hiramatsu M,Akamatsu H,Kawabata H,Kikuchi T,Akamatsu K,Hirano T,Kou Y,Nakanishi M,Minakata Y,Yamamoto N

    更新日期：2014-07-01 00:00:00

  • Airway inflammation in obstructive sleep apnea: is leptin the missing link?

    abstract：BACKGROUND:Local and systemic inflammation is implicated in the pathophysiology of Obstructive Sleep Apnea (OSA). Exhaled breath condensate (EBC) is a non-invasive sampling method for the lower airways. However, it is important to consider the potential effect of the systemic origin whereas systemic inflammation is sig...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.04.021

    authors： Antonopoulou S,Loukides S,Papatheodorou G,Roussos C,Alchanatis M

    更新日期：2008-10-01 00:00:00

  • Expression of blood dendritic cell antigens (BDCAs) by CD1a+ human pulmonary cells.

    abstract：BACKGROUND:Myeloid and plasmacytoid dendritic cell (DC) subsets have been recently identified in the human lung based on their differential expression of Blood DC Antigens 1-3 (BDCAs). We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells. METHODS:Using an i...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.02.006

    authors： Tsoumakidou M,Kemp SJ,Thorley AJ,Zhu J,Dewar A,Jeffery PK,Tetley TD

    更新日期：2009-06-01 00:00:00

  • A phase II clinical trial of the Safety Of Simvastatin (SOS) in patients with pulmonary lymphangioleiomyomatosis and with tuberous sclerosis complex.

    abstract：INRODUCTION:The mechanistic target of rapamycin inhibitors (mTORi) sirolimus and everolimus stabilize lung function in patients with pulmonary lymphangioleiomyomatosis (LAM) but do not induce remission. Pre-clinical studies suggest that simvastatin in combination with sirolimus induces LAM cell death. The objective of ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.105898

    authors： Krymskaya VP,Courtwright AM,Fleck V,Dorgan D,Kotloff R,McCormack FX,Kreider M

    更新日期：2020-03-01 00:00:00

  • Comparison between two methods for estimating pneumothorax size from chest X-rays.

    abstract：AIM:To compare the estimated size of spontaneous pneumothoraces using the established Rhea inter-pleural distances method with the CT-derived Collins method. METHOD:Adult patients with spontaneous pneumothorax treated conservatively were identified from the ED databases. X-rays were reviewed independently by two resea...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2005.11.022

    authors： Kelly AM,Weldon D,Tsang AY,Graham CA

    更新日期：2006-08-01 00:00:00

  • Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis.

    abstract：:Primary ciliary dyskinesia (PCD) is a genetic condition resulting in bronchiectasis. Exhaled gas nitric oxide (FE(NO)) is reduced in PCD. A model of pulmonary NO exchange dynamics can be used to demonstrate relative contributions of bronchial (J'aw(NO)) and peripheral airway (Calv(NO)) NO to the final FE(NO) concentra...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.12.004

    authors： Shoemark A,Wilson R

    更新日期：2009-05-01 00:00:00

  • Multiplex PCR for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila in community-acquired pneumonia.

    abstract：:A multiplex polymerase chain reaction (PCR) was developed for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. Oligonucleotide primers for the amplification of the DNA of these three organisms were optimized for use in combination in the same reaction. PCR products ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2003.11.012

    authors： Miyashita N,Saito A,Kohno S,Yamaguchi K,Watanabe A,Oda H,Kazuyama Y,Matsushima T,CAP Study Group.

    更新日期：2004-06-01 00:00:00

  • Efficacy of treatments in primary spontaneous pneumothorax: A systematic review and network meta-analysis of randomized clinical trials.

    abstract：BACKGROUND:Primary spontaneous pneumothorax (PSP) remains a significant global health problem. Despite general agreement, an official algorithm for the management of PSP still does not exist. OBJECTIVES:Evaluating the efficacy of all available treatments in PSP. METHODS:A systematic search of 12 electronic databases ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rmed.2018.03.009

    authors： Vuong NL,Elshafay A,Thao LP,Abdalla AR,Mohyeldin IA,Elsabaa K,Omran ES,Yu F,Hirayama K,Huy NT

    更新日期：2018-04-01 00:00:00

  • Should we consider paranasal and chest computed tomography in severe asthma patients?

    abstract：BACKGROUND:It is essential to recognize and treat findings that can simulate or worsen symptoms to improve asthma control and thereby to reduce costs. Guidelines highlight a paranasal (PS) and chest computed tomography (CT) scan as a tool for disease evaluation and, although they suggest its indication in patients whom...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106013

    authors： Zamarron E,Romero D,Fernández-Lahera J,Villasante C,Pinilla I,Barranco P,Dominguez-Ortega J,Álvarez-Sala Walther R R

    更新日期：2020-08-01 00:00:00

  • Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis.

    abstract：BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.03.031

    authors： Jacob J,Odink A,Brun AL,Macaluso C,de Lauretis A,Kokosi M,Devaraj A,Desai S,Renzoni E,Wells AU

    更新日期：2018-05-01 00:00:00

  • Prescribing of nebulized bronchodilators--can we change bad habits?

    abstract：:The accuracy of prescriptions for bronchodilator drugs was monitored before and after an educational circular to the medical staff of five medical wards. The circular contained model prescriptions for beta-agonists alone and combined with ipratropium bromide. There was a significant improvement overall in the accuracy...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(89)80207-0

    authors： Craig IR,Riley MR,Cooke NJ

    更新日期：1989-07-01 00:00:00

  • The relation of rhinitis to recurrent cough and wheezing: a longitudinal study.

    abstract：BACKGROUND:Recurrent cough can be a clinical manifestation of rhinitis. However, it remains unclear if the association between rhinitis and recurrent cough among children is independent of asthma. OBJECTIVE:The aim of the present study was to determine, in a large longitudinal cohort, whether rhinitis is significantly...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.03.025

    authors： Sherrill DL,Guerra S,Minervini MC,Wright AL,Martinez FD

    更新日期：2005-11-01 00:00:00

  • Randomized comparison of the efficacy and safety of ciclesonide and budesonide in adolescents with severe asthma.

    abstract：BACKGROUND:The aim of the study was to investigate the efficacy and safety of ciclesonide compared with budesonide in adolescents with severe asthma. METHODS:In this randomized, double-blind, double-dummy, parallel-group study, patients aged 12-17 years with severe asthma were treated with budesonide 400 microg once d...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2007.05.006

    authors： Vermeulen JH,Gyurkovits K,Rauer H,Engelstätter R

    更新日期：2007-10-01 00:00:00

  • Impact of patient education and self-management on morbidity in asthmatics and patients with chronic obstructive pulmonary disease.

    abstract：:The effect of patient education on morbidity in asthmatics and COPD patients has not previously been investigated in a single study. We randomized 78 asthmatics and 62 COPD patients after ordinary outpatient management. Intervention consisted of educational group sessions and individual sessions administered by a trai...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/rmed.1999.0749

    authors： Gallefoss F,Bakke PS

    更新日期：2000-03-01 00:00:00

  • Domiciliary oxygen cylinders: indications, prescription and usage.

    abstract：:Oxygen therapy for use in the home can be prescribed in two forms: oxygen concentrators are used to provide long term domiciliary oxygen therapy (LTOT), and oxygen cylinders are used to provide oxygen intermittently for relief of symptoms. In this study prescription and usage of oxygen cylinders in the home were asses...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(05)80201-x

    authors： Okubadejo AA,Paul EA,Wedzicha JA

    更新日期：1994-11-01 00:00:00

  • Reversibility tests in chronic obstructive airways disease: their predictive value with reference to benefit from domiciliary nebuliser therapy.

    abstract：:The role of short-term tests of reversibility in selecting patients with COAD for long-term nebuliser therapy is uncertain. In a double-blind placebo-controlled crossover study we have examined the correlation between short-term reversibility and response to a home nebuliser. We studied 20 patients with severe COAD (m...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(06)80097-1

    authors： Teale C,Morrison JF,Jones PC,Muers MF

    更新日期：1991-07-01 00:00:00

  • Evaluation of multidimensional COPD-related subjective fatigue following a pulmonary rehabilitation programme.

    abstract：INTRODUCTION:Subjective fatigue has been recognised as an important, multi-component symptom in COPD. Pulmonary Rehabilitation (PR) improves fatigue component of the Chronic Respiratory Questionnaire, a quality of life (QoL) measure. However, it is not clear if all fatigue dimensions are affected equally. This study ai...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.09.003

    authors： Lewko A,Bidgood PL,Jewell A,Garrod R

    更新日期：2014-01-01 00:00:00

  • Relationship between blood eosinophils and clinical characteristics in a cross-sectional study of a US population-based COPD cohort.

    abstract：BACKGROUND:Current evidence suggests that blood eosinophil levels (Eos) are associated with chronic obstructive pulmonary disease (COPD) treatment response and natural history. This analysis investigated the relationship between Eos levels and clinical characteristics in a representative cohort of US subjects with spir...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.01.013

    authors： DiSantostefano RL,Hinds D,Le HV,Barnes NC

    更新日期：2016-03-01 00:00:00

  • Long-term non-invasive ventilation in COPD after acute-on-chronic respiratory failure.

    abstract：BACKGROUND:COPD patients who remain hypercapnic after acute respiratory failure requiring mechanical ventilation have a poor prognosis. Long-term nocturnal non-invasive ventilation (NIV) may be beneficial for these patients. We hypothesized that stable patients on long-term NIV would experience clinical worsening after...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2010.09.005

    authors： Funk GC,Breyer MK,Burghuber OC,Kink E,Kirchheiner K,Kohansal R,Schmidt I,Hartl S

    更新日期：2011-03-01 00:00:00

  • Changes in airway hyperresponsiveness following smoking cessation: comparisons between Mch and AMP.

    abstract：BACKGROUND:Given the observed association between smoking, inflammation and airway hyperresponsiveness (AHR) one may predict that smoking cessation may improve AHR. However, only a few studies have investigated the effect of smoking on AHR and their results appear to be conflicting depending on the stimulus used in the...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.09.004

    authors： Piccillo G,Caponnetto P,Barton S,Russo C,Origlio A,Bonaccorsi A,Di Maria A,Oliveri C,Polosa R

    更新日期：2008-02-01 00:00:00

  • Helicobacter pylori seroprevalence in patients with chronic bronchitis.

    abstract：AIM:A high rate of seropositivity for antibodies against Helicobacter pylori has been found in many extra-gastrointestinal diseases. In addition, it has been reported that the risk of chronic bronchitis may be increased in subjects infected with H. pylori. This study was designed to determine the H. pylori seroprevalen...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2005.02.036

    authors： Kanbay M,Gur G,Akcay S,Yilmaz U

    更新日期：2005-10-01 00:00:00

  • What characterizes patients who are unable to tolerate continuous positive airway pressure (CPAP) treatment?

    abstract：:Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnoea syndrome (OSAS), but many patients find this treatment intolerable. The aim of this study was to characterize patients who were unable to tolerate CPAP treatment (non-complaint) as opposed to those who continued using CP...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0703

    authors： Janson C,Nöges E,Svedberg-Randt S,Lindberg E

    更新日期：2000-02-01 00:00:00

  • Factors influencing the compliance of patients using oxygen concentrators for long-term home oxygen therapy.

    abstract：:A previous study in the Liverpool district on patients receiving long term oxygen treatment using a domiciliary oxygen concentrator showed that only 55% were both using oxygen therapy correctly and had stopped smoking. To try and identify which factors influence patient behaviour, all 55 patients in this district rece...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(08)80062-5

    authors： Walshaw MJ,Lim R,Evans CC,Hind CR

    更新日期：1990-07-01 00:00:00

  • Effects of inspiratory muscle training on postural stability, pulmonary function and functional capacity in children with cystic fibrosis: A randomised controlled trial.

    abstract：BACKGROUND:Previous research has found conflictive results regarding the benefits of inspiratory muscle training (IMT) for cystic fibrosis (CF) patients. Also, involvement of postural stability is a rising concern in chronic lung diseases but its role in CF patients is poorly understood. Our aim was to investigate the ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2019.01.013

    authors： Zeren M,Cakir E,Gurses HN

    更新日期：2019-03-01 00:00:00