Abstract：
BACKGROUND:Recurrent cough can be a clinical manifestation of rhinitis. However, it remains unclear if the association between rhinitis and recurrent cough among children is independent of asthma. OBJECTIVE:The aim of the present study was to determine, in a large longitudinal cohort, whether rhinitis is significantly associated with recurrent cough alone, wheezing alone, or the combination of both symptoms during childhood. METHODS:We investigated determinants of recurrent cough, with or without wheezing, using longitudinal data from the Tucson Children's Respiratory Study. Among the 1246 subjects originally enrolled, 1024 children completed at least one questionnaire between the ages of 6 and 18 years and were included in the present study. In any survey, wheezing was defined as at least one wheezing episode during the past year and recurrent cough as two or more coughing episodes lasting at least 1 week without a cold during the past year. Generalized estimating equations were used to determine significant risk factors. RESULTS:After adjusting for sex, skin test reactivity and parental asthma, both rhinitis (OR = 2.47 CI = 1.84, 3.30) and sinusitis (OR = 1.54 CI = 1.11, 2.14) were associated with an increased risk of recurrent cough plus wheezing. The OR associated with rhinitis were significantly reduced for subjects reporting only recurrent cough or only wheezing (OR = 1.43, CI = 1.03, 1.99; and OR = 1.30, CI = 1.07, 1.58, respectively). Recurrent cough and wheezing, when examined independently, showed different patterns of risk factors. CONCLUSION:We found rhinitis to be an independent risk factor for both recurrent cough and wheezing during childhood. Different pathways may be involved in the association of rhinitis with recurrent cough and wheezing.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Sherrill DL,Guerra S,Minervini MC,Wright AL,Martinez FDdoi
10.1016/j.rmed.2005.03.025subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1377-85issue
11eissn
0954-6111issn
1532-3064pii
S0954-6111(05)00112-5journal_volume
99pub_type
杂志文章abstract：:Ten patients (two male) suffering from acute exacerbations of long-standing chronic obstructive pulmonary disease and admitted in hypoxic, hypercapnic respiratory failure were treated with Nasal Intermittent Positive Pressure Ventilation (NIPPV) plus supplemental oxygen, on a general medical ward. The median (range) p...
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pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.rmed.2008.04.006
更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章,meta分析
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,多中心研究
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2005-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2015.04.014
更新日期：2015-08-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-03-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
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更新日期：2001-03-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2018-04-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2001-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2006-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.2001.1035
更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2006-09-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2014.05.011
更新日期：2014-08-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
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更新日期：1997-09-01 00:00:00
