Abstract：
:Primary ciliary dyskinesia (PCD) is a genetic condition resulting in bronchiectasis. Exhaled gas nitric oxide (FE(NO)) is reduced in PCD. A model of pulmonary NO exchange dynamics can be used to demonstrate relative contributions of bronchial (J'aw(NO)) and peripheral airway (Calv(NO)) NO to the final FE(NO) concentration. The aim of this study was to compare bronchial and peripheral airway contribution to FE(NO) in patients with PCD, non-PCD bronchiectasis and healthy controls in order to establish the source of present FE(NO) in these conditions and to compare these with severity of disease. NO was measured at 50, 100, and 200 ml/s using an NO analyser (NiOx Sweden). J'aw(NO) and Calv(NO) were calculated according to a model of pulmonary exchange dynamics. PCD patients had reduced levels of J'aw(NO) compared to healthy controls whereas patients with non-PCD bronchiectasis had elevated J'aw(NO) levels. There was no difference in Calv(NO) between the three groups. In the disease groups Calv(NO) correlated negatively with FEV(1). In conclusion patients with PCD had significantly reduced FE(NO) at all expiratory flow rates. This was due to a significantly low bronchial NO. In contrast, peripheral airway NO was increased with more severe disease.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Shoemark A,Wilson Rdoi
10.1016/j.rmed.2008.12.004subject
Has Abstractpub_date
2009-05-01 00:00:00pages
700-6issue
5eissn
0954-6111issn
1532-3064pii
S0954-6111(08)00423-Xjournal_volume
103pub_type
杂志文章abstract：:Haemodynamic studies at rest and during exercise together with radionuclide ventriculography, pulmonary function and clinical well-being assessment were evaluated in ten patients with COPD and secondary pulmonary hypertension (mean PAP 25 mm Hg), before and after 6 months therapy with pirbuterol 20 mg thrice daily. De...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
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更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.10.001
更新日期：2009-03-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.03.028
更新日期：2005-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2003.10.009
更新日期：2004-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.04.004
更新日期：2007-01-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2009.01.006
更新日期：2009-05-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2007.07.011
更新日期：2007-12-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.04.028
更新日期：2007-02-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2000-06-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2006.11.010
更新日期：2007-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2020.105915
更新日期：2020-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2007-02-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Patients with chronic obstructive pulmonary disease (COPD) are often characterised by a range of characteristic co-morbidities that interfere with their pulmonary disease. In addition to a mere association with co-morbidities, a complex pathophysiological interaction and mutual augmentation occurs between COPD and its...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/S0954-6111(11)70005-1
更新日期：2011-10-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/rmed.2002.1456
更新日期：2003-05-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.01.011
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS:We prospectively evaluated 23 bronch...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2016.08.027
更新日期：2016-10-01 00:00:00
abstract：:The oxygen cost diagram (OCD) is a simple scale for quantifying a patient's evaluation of his tolerance to exercise frequently used in clinical trials; it has been shown to be well correlated with objective measures of capacity of ambulation such as the 6 min walk test (6' W). This study aimed to determine whether the...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(99)90266-4
更新日期：1999-11-01 00:00:00
abstract：:Surfactant protein-A enhances the phagocytosis and killing of many pathogens, although studying this effect in an assortment of models and different experimental protocols has sometimes yielded conflicting results. In this report, using the human THP-1 cell line as the primary phagocytic cell, we systematically examin...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2003.12.018
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To compare the effects of once-daily ciclesonide and twice-daily fluticasone propionate in patients with moderate persistent asthma. METHODS:Patients aged 12-75 years with moderate bronchial asthma entered a 1-4 week run-in period. For inclusion into the 12-week, randomized, open-label treatment period, pati...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.rmed.2007.03.001
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Previous investigations have suggested that genetic variations are associated with reduced lung function in early childhood. This study was conducted to evaluate the association between IL13+2044G-->A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function i...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.08.009
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Lung fibrosis is attributed to derangements in extracellular matrix remodeling, a process driven by collagen turnover. We examined the association of two collagen biomarkers, carboxy-terminal telopeptide of collagen type I (ICTP) and amino-terminal propeptide of type III procollagen (PIIINP), with subclinica...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmed.2018.06.001
更新日期：2018-07-01 00:00:00
abstract：BACKGOUND AND OBJECTIVES:The disadvantages of custom-made mandibular advancement devices (MAD) for obstructive sleep apnoea (OSA) therapy are the cost and delay required to manufacture the device. This study aimed to evaluate the efficacy of a titrable, thermoplastic MAD compared to a custom-made MAD for OSA therapy. ...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.rmed.2017.08.004
更新日期：2017-10-01 00:00:00
abstract：:The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case cont...
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pub_type： 杂志文章
doi：10.1016/j.rmed.2003.10.005
更新日期：2004-03-01 00:00:00
abstract：:In response to the introduction of ethnic monitoring within the U.K. hospital inpatient data set, this study investigates the variations in secondary healthcare utilization by Black and minority ethnic communities whose cause of admission is related to asthma. The study examines all residents of the West Midlands: ove...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90511-x
更新日期：1998-04-01 00:00:00
abstract：:Pulmonary hypertension (PH) is a chronic cardiopulmonary disorder that if left untreated, progresses rapidly and is ultimately fatal. The World Health Organization (WHO) has classified PH into 5 distinct groups according to pathophysiology, hemodynamic characteristics, and clinical presentation. Dysfunction in the nit...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2016.11.010
更新日期：2017-01-01 00:00:00
abstract：:Despite the growing field of interest in the role of pulmonary oxidative stress in chronic obstructive pulmonary disease (COPD), barely any data are available with respect to antioxidant capacity in the peripheral musculature of these patients. The main objective of this study was to assess in detail the antioxidant s...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.05.018
更新日期：2005-01-01 00:00:00
abstract：:In recent years, it has become increasingly important to get as much as possible information on clinical efficacy already in the early phases of drug development. For proof of concept (POC) studies testing novel anti-inflammatory drugs in asthma, there are several validated exacerbation models, inducing various aspect...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2007.10.018
更新日期：2008-03-01 00:00:00
abstract：:This study aimed to evaluate the utility of the pleural fluid lactate dehydrogenase (LDH) isoenzyme algorithm for the differential diagnosis of pleural fluid in patients with haematological malignancies. Twenty consecutive haemato-oncological patients with pleural effusion, hospitalized in the Haematology Department d...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(99)90315-3
更新日期：1999-05-01 00:00:00
abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0954-6111(02)80032-4
更新日期：2002-08-01 00:00:00
