Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects.

Abstract:

BACKGROUND:The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS:We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. RESULTS:Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0.001 and P < 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41-20.23; P < 0.00001). CONCLUSIONS:Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Öcal S,Portakal O,Öcal A,Demir AU,Topeli A,Çöplü L

doi

10.1016/j.rmed.2016.08.027

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

109-114

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(16)30222-0

journal_volume

119

pub_type

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