Abstract：
OBJECTIVES:Cleaning workers have an increased risk of asthma but the underlying mechanisms are largely unknown. We studied functional and biological characteristics in asthmatic cleaners and compared these to healthy cleaners. METHODS:Forty-two cleaners with a history of asthma and/or recent respiratory symptoms and 53 symptom-free controls were identified. Fractional exhaled nitric oxide (FeNO) was measured and forced spirometry with reversibility testing was performed. Total IgE, pulmonary surfactant protein D and the 16 kDa Clara Cell secretory protein were measured in blood serum. Interleukins and other cytokines, growth factors, cys-leukotrienes and 8-isoprostane were measured in exhaled breath condensate. Information on occupational and domestic use of cleaning products was obtained in an interview. Associations between asthma status, specific characteristics and the use of cleaning products were evaluated using multivariable linear and logistic regression analyses. RESULTS:Asthma was associated with an 8% (95% confidence interval (CI) 1-15%) lower postbronchodilator FEV1, a higher prevalence of atopy (42% vs. 10%) and a 2.9 (CI 1.5-5.6) times higher level of total IgE. Asthma status was not associated with the other respiratory biomarkers. Most irritant products and sprays were more often used by asthmatic cleaners. The use of multiuse products, glass cleaners and polishes at work was associated with higher FeNO, particularly in controls. CONCLUSIONS:Asthma in cleaning workers is characterised by non-reversible lung function decrement and increased total IgE. Oxidative stress, altered lung permeability and eosinophilic inflammation are unlikely to play an important underlying role, although the latter may be affected by certain irritant cleaning exposures.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Vizcaya D,Mirabelli MC,Orriols R,Antó JM,Barreiro E,Burgos F,Arjona L,Gomez F,Zock JPdoi
10.1016/j.rmed.2013.01.011subject
Has Abstractpub_date
2013-05-01 00:00:00pages
673-83issue
5eissn
0954-6111issn
1532-3064pii
S0954-6111(13)00037-1journal_volume
107pub_type
杂志文章abstract：:In high-school students, prevalence of smoking is high but few studies analyzed smoking in the student population according to nicotine content of smoked cigarettes and gender. We analyzed the responses to a questionnaire, including the modified Fagerström Tolerance Questionnaire (FTQ), administered to 555 students (3...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.02.006
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Tracheal collapse is a weakness of the tracheal wall leading to expiratory central airway collapse of more than 50% compared to inspiration. It has previously been discussed whether the collapsibility of the greater airways is a stable or a dynamic condition. Indeed, other well-known lung diseases such as as...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.11.018
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVES:This randomized, double-blind, placebo-controlled, cross-over, Phase II dose-ranging study investigated the efficacy and safety of GP MDI (glycopyrronium administered by metered dose inhaler formulated using co-suspension delivery technology) compared with an open-label active comparator, salmeterol dry powd...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2018.04.013
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Although rabbits are becoming popular as pets, data about the characteristics of allergic sensitization to rabbit allergens in patients without professional exposure are scarce. AIMS OF THE STUDY:To determine the characteristics of allergic sensitization to pet rabbits, and the role of direct and indirect e...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.11.008
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND AND AIMS:The total serum IgE level is a marker of immunological activity in allergic bronchopulmonary aspergillosis (ABPA), and a 35% decline beyond six weeks is traditionally taken as criteria for remission. The aim of this study was to evaluate the magnitude and clinical significance of decline in serum Ig...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.09.005
更新日期：2010-02-01 00:00:00
abstract：:Intrapulmonary percussive ventilation (IPV) is a ventilatory technique that delivers bursts of high-flow respiratory gas into the lung at high rates, intended for treating acute respiratory failure and for mobilization of secretions. We performed a study, aimed at assessing the physiological response to IPV, on patien...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2006.01.010
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFE...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2007.09.013
更新日期：2008-02-01 00:00:00
abstract：:Total lung capacity was measured in 16 workers with pulmonary asbestosis using four standard methods: body plethysmography, radiographic lung area, helium dilution by multiple breath and by single breath (alveolar volume). All men had irregular opacities of ILO profusion category 2/1 or greater and four had pleural pl...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/0954-6111(93)90138-p
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate whether smokers with incidental findings of interstitial lung abnormalities have an increased mortality during long-term follow-up, and review the contributing causes of death. METHODS:Baseline CT scans of 1990 participants from the Danish Lung Cancer Screening Trial ...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2018.02.001
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Objective of this study was to validate an activity monitor (DynaPort MoveMonitor [MM], McRoberts, The Hague, The Netherlands) against night-vision video analysis during sleep. METHODS:Twenty patients (65 ± 11 years old, mean body-mass-index: 27 ± 6 kg/m(2)) with different chronic lung diseases were recru...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2014.12.017
更新日期：2015-02-01 00:00:00
abstract：UNLABELLED:Obesity is a major risk factor for poorly controlled asthma, but the reasons for poor asthma control in this patient population are unclear. Symptoms of depression have been associated with poor asthma control, and increase with higher body mass index (BMI). The purpose of this study was to assess whether de...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.rmed.2014.05.012
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.rmed.2016.06.010
更新日期：2016-08-01 00:00:00
abstract：STUDY OBJECTIVES:Community-acquired pneumonia is a frequent event in the course of chronic obstructive pulmonary disease (COPD). The aim of the present study was to provide information on clinical and microbiological characteristics and outcome of community-acquired pneumonia in these patients, in a comparative study w...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2007.05.011
更新日期：2007-10-01 00:00:00
abstract：:This multi-centre, randomized, double-blind, double-dummy, parallel-group study was designed to investigate the hypothesis of equivalent efficacy and comparable safety of two inhaled presentations of salmeterol/fluticasone propionate combination product (SALM/FP) 50/100 microg administered twice daily to patients with...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/rmed.2000.1008
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Aspirin desensitization (AD) has been the only available modifying treatment in aspirin-exacerbated respiratory disease (AERD). The mechanisms of AD are nonetheless poorly understood. Though very effective, AD is limited by its risks and side-effects. OBJECTIVE:Moving forward to the targeted biologicals era...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.08.009
更新日期：2018-10-01 00:00:00
abstract：:We compare the adequacy of several titration procedures of oxygen flow in maintaining SpO(2) > 90% during the activities of daily life in patients with very severe COPD. Thirty-one very severe COPD patients undergoing oxygen-therapy were recruited. Three titration methods were randomly performed: (1) 6-min walking tes...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2012.06.021
更新日期：2012-11-01 00:00:00
abstract：:In a double-blind study of 60 patients undergoing fibreoptic bronchoscopy we have compared the local anaesthetic effects of intratracheal injections of cocaine (4 ml, 2.5%) and lignocaine (4 ml, 4%). The two local anaesthetics were equally effective in terms of cough suppression, requirement for extra local anaestheti...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(08)80076-5
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is now the generally preferred surgical treatment for spontaneous pneumothorax but is more difficult once pleural adhesions have developed. To test the hypothesis that VATS is under-used because of prolonged pleural intubation, we have audited the effect of preoper...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90103-2
更新日期：1998-02-01 00:00:00
abstract：:This retrospective study reviews the patterns of P. cepacia pulmonary infection in 75 of a total of 872 mainly adults with cystic fibrosis, registered here during the 4 years 1987-1990; 35 (47%) were female. During this period, 55 patients acquired P. cepacia and the annual incidence and prevalence rates have remained...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/0954-6111(93)90090-m
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:We hypothesized that the peculiar mixed interleukin-4 (IL-4/Th2) and interferon gamma INF-γ (INF-γ/Th1) inflammatory milieu found in the airways of patients with aspirin-exacerbated respiratory disease (AERD) is responsible for the altered regulation of the IL-1β/IL-1RI-/EP2/COX-2 autocrine loop also found i...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.03.008
更新日期：2019-04-01 00:00:00
abstract：:A double-blind, randomized crossover study in 28 asthmatic patients assessed the relative therapeutic index for inhaled formoterol and salbutamol. Pre-drug administration FEV1 (mean 2.08 l) was 49-93% of predicted and reversibility 16-82% after inhalation of salbutamol. Patients inhaled single doses of formoterol (Oxi...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/rmed.2002.1291
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To study whether abnormal spirometric patterns were associated with differential mortality in Chinese adults with and without dyspnea. METHODS:Guangzhou Biobank Cohort Study (GBCS) participants were classified by spirometric patterns and presence of dyspnea into 6 groups: normal spirometry (NS), restriction ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.04.002
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient characteristics associated with all-cause mortality in asthma. METHODS:Asthma patients aged ≥18 years and...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.105919
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Long-term corticosteroid use may increase cataract risk. The Lens Opacities Classification System (LOCS) III ranked lens opacities as Class 1: 0.5-0.9 unit; Class 2: 1.0-1.4 units; or Class 3: ≥1.5 units in clinical trials of combined mometasone furoate and formoterol (MF/F) administered by metered-dose inha...
journal_title：Respiratory medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.rmed.2014.04.015
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Primary spontaneous pneumothorax (PSP) remains a significant global health problem. Despite general agreement, an official algorithm for the management of PSP still does not exist. OBJECTIVES:Evaluating the efficacy of all available treatments in PSP. METHODS:A systematic search of 12 electronic databases ...
journal_title：Respiratory medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.rmed.2018.03.009
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Decreased lung function has health impacts beyond diagnosable lung disease. It is therefore important to understand the factors that may influence even small changes in lung function including obesity, physical fitness and physical activity. The aim of this study was to determine the anthropometric measure m...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2017.08.030
更新日期：2017-10-01 00:00:00
abstract：:Fluticasone propionate pressurized metered dose inhalers (pMDIs) containing the hydrofluoroalkane (HFA) propellant, HFA 134a, are being developed to replace existing chlorofluorocarbon (CFC) pMDIs. This is part of the ongoing worldwide project to limit the damage to the earth's ozone layer. The in vivo performance and...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2000-06-01 00:00:00
abstract：:Oxygen therapy for use in the home can be prescribed in two forms: oxygen concentrators are used to provide long term domiciliary oxygen therapy (LTOT), and oxygen cylinders are used to provide oxygen intermittently for relief of symptoms. In this study prescription and usage of oxygen cylinders in the home were asses...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(05)80201-x
更新日期：1994-11-01 00:00:00
abstract：INTRODUCTION:Current and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respira...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.105820
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Although respiratory muscle weakness (RMW) is known to predict prognosis in patients with heart failure with reduced ejection fraction (HFrEF), RMW prevalence and its prognosis in those with preserved ejection fraction (HFpEF) remain unknown. We aimed to investigate whether the RMW predicted mortality in HFp...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.105834
更新日期：2020-01-01 00:00:00
