当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Obesity and symptoms of depression contribute independently to the poor asthma control of obesity.

Obesity and symptoms of depression contribute independently to the poor asthma control of obesity.

Abstract：

UNLABELLED:Obesity is a major risk factor for poorly controlled asthma, but the reasons for poor asthma control in this patient population are unclear. Symptoms of depression have been associated with poor asthma control, and increase with higher body mass index (BMI). The purpose of this study was to assess whether depressive symptoms underlie poor asthma control in obesity. METHODS:We determined the relationship between BMI, psychological morbidity and asthma control at baseline in a well-characterized patient population participating in a clinical trial conducted by the American Lung Association-Asthma Clinical Research Centers. RESULTS:Obese asthmatic participants had increased symptoms of depression (Center for Epidemiologic Studies Depression Scale score in lean 10.1 ± 8.1, overweight 10.0 ± 8.1, obese 12.4 ± 9.9; p = 0.03), worse asthma control (Juniper Asthma Control Questionnaire score in lean 1.43 ± 0.68, overweight 1.52 ± 0.71, obese 1.76 ± 0.75; p < 0.0001), and worse asthma quality of life (scores in lean 5.21 ± 1.08, overweight 5.08 ± 1.05, obese 4.64 ± 1.09; p < 0.0001). Asthmatics with obesity and those with symptoms of depression both had a higher risk of having poorly controlled asthma (adjusted odds ratio of 1.83 CI 1.23-3.52 for obesity, and 2.08 CI 1.23-3.52 for depression), but there was no interaction between the two. CONCLUSION:Obesity and symptoms of depression are independently associated with poor asthma control. As depression is increased in obese asthmatics it may be an important co-morbidity contributing to poor asthma control in this population, but factors other than depression also contribute to poor asthma control in obesity.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Kapadia SG,Wei C,Bartlett SJ,Lang J,Wise RA,Dixon AE,American Lung Association Asthma Clinical Research Centers.

doi

10.1016/j.rmed.2014.05.012

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1100-7

issue

8

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(14)00199-1

journal_volume

108

pub_type

临床试验,杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • Inspiratory capacity predicts mortality in patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) severity is usually graded upon the FEV(1) reduction and FEV(1) has been considered the most important mortality predictor with age in COPD. Recent studies suggest other factors as more powerfully related to mortality than FEV(1) in COPD patients. AIM:To assess t...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.11.004

    authors： Tantucci C,Donati P,Nicosia F,Bertella E,Redolfi S,De Vecchi M,Corda L,Grassi V,Zulli R

    更新日期：2008-04-01 00:00:00

  • Imaging of pleural masses: which to choose?

    abstract：:The differential diagnosis of pleural masses is limited. Asbestos-related disease and invasive bronchogenic carcinoma make up the majority of cases. The diagnostic yield of biopsies is low, and invasive procedures are often required to achieve diagnosis. A variety of imaging techniques are available to help differenti...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.11.010

    authors： Bruns AS,Mastronarde JG

    更新日期：2008-03-01 00:00:00

  • Methods used in clinical development of novel anti-asthma therapies.

    abstract：:In recent years, it has become increasingly important to get as much as possible information on clinical efficacy already in the early phases of drug development. For proof of concept (POC) studies testing novel anti-inflammatory drugs in asthma, there are several validated exacerbation models, inducing various aspect...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.10.018

    authors： Diamant Z,Boot D,Kamerling I,Bjermer L

    更新日期：2008-03-01 00:00:00

  • Bacterial extracts for the prevention of acute exacerbations in chronic obstructive pulmonary disease: a point of view.

    abstract：:Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2007.11.002

    authors： Cazzola M,Rogliani P,Curradi G

    更新日期：2008-03-01 00:00:00

  • Prevalence of work-related symptoms and serum-specific antibodies to wheat flour in exposed workers in the bakery industry.

    abstract：BACKGROUND:Although baker's asthma (BA) is a common occupational asthma, there have been few reports on this disease in Korean subjects. OBJECTIVES:We evaluated the prevalence of serum-specific IgE, IgG1, and IgG4 antibodies in relation to work-related respiratory symptoms in a single industrial bakery. METHODS:Three...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.11.015

    authors： Hur GY,Koh DH,Kim HA,Park HJ,Ye YM,Kim KS,Park HS

    更新日期：2008-04-01 00:00:00

  • Using laboratory measurements to predict in-flight desaturation in respiratory patients: are current guidelines appropriate?

    abstract：:In an attempt to guide physicians asked by respiratory patients for advice on flight fitness, the British Thoracic Society (BTS) have published guidelines on fitness to fly. The main potential hazard is hypobaric hypoxia, and efforts have focused on the prediction of hypoxia in individuals. The present study examines ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.05.005

    authors： Robson AG,Lenney J,Innes JA

    更新日期：2008-11-01 00:00:00

  • Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis.

    abstract：BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.03.031

    authors： Jacob J,Odink A,Brun AL,Macaluso C,de Lauretis A,Kokosi M,Devaraj A,Desai S,Renzoni E,Wells AU

    更新日期：2018-05-01 00:00:00

  • Effects of inspiratory muscle training on postural stability, pulmonary function and functional capacity in children with cystic fibrosis: A randomised controlled trial.

    abstract：BACKGROUND:Previous research has found conflictive results regarding the benefits of inspiratory muscle training (IMT) for cystic fibrosis (CF) patients. Also, involvement of postural stability is a rising concern in chronic lung diseases but its role in CF patients is poorly understood. Our aim was to investigate the ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2019.01.013

    authors： Zeren M,Cakir E,Gurses HN

    更新日期：2019-03-01 00:00:00

  • Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking.

    abstract：:The imbalance between oxidants and antioxidants is known to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most frequent factor responsible for development of COPD by leading to oxidant overload in the lower airways, due to presence of its own oxida...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0574

    authors： Nowak D,Kasielski M,Antczak A,Pietras T,Bialasiewicz P

    更新日期：1999-06-01 00:00:00

  • Invasive pulmonary aspergillosis complicating allergic bronchopulmonary aspergillosis.

    abstract：:Invasive pulmonary aspergillosis is a frequent complication in immunocompromised patients. The role of the prolonged use of steroids in predisposing to invasive aspergillosis has been recognized, but exceptionally described in asthmatic patients. We report the case of a 59-year-old woman with bronchial asthma treated ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(95)90198-1

    authors： Ganassini A,Cazzadori A

    更新日期：1995-02-01 00:00:00

  • Non-invasive imaging in a rare case of main pulmonary artery aneurysm.

    abstract：:Report of an incidental chest X-ray finding of a large vessel dilation at the root of the ascending aorta in a 65-year-old female patient while pre-operative routine diagnostic. Due to prior allergic reaction to iodine contrast agent, non-invasive imaging was performed with magnetic resonance imaging (MRI), where the ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.10.023

    authors： Ritter CO,Weininger M,Machann M,Beissert M,Hahn D,Kenn W

    更新日期：2008-05-01 00:00:00

  • Measurement validity of an electronic inspiratory loading device during a loaded breathing task in patients with COPD.

    abstract：:We studied the validity of a recently introduced, handheld, electronic loading device in providing automatically processed information on external inspiratory work, power and breathing pattern during loaded breathing tasks in patients with COPD. Thirty-five patients with moderate to severe COPD performed an endurance ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.01.020

    authors： Langer D,Jacome C,Charususin N,Scheers H,McConnell A,Decramer M,Gosselink R

    更新日期：2013-04-01 00:00:00

  • Change in plasma vascular endothelial growth factor during onset and recovery from acute mountain sickness.

    abstract：:There is an increasing body of evidence suggesting that altered vascular permeability may be an important component of the pathogenesis of acute mountain sickness (AMS). Vascular endothelial growth factor (VEGF) is a potent permeability factor subject to hypoxic regulation but its role in the pathogenesis of AMS is ye...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.06.014

    authors： Dorward DA,Thompson AA,Baillie JK,MacDougall M,Hirani N

    更新日期：2007-03-01 00:00:00

  • Exploring the care needs of patients with advanced COPD: an overview of the literature.

    abstract：:Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition worldwide and is associated with significant mortality. This paper gives an overview of the relevant literature regarding care needs in advanced COPD from the perspective of the patient or carer, and aims to explore the appropriateness of a p...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2009.09.007

    authors： Gardiner C,Gott M,Payne S,Small N,Barnes S,Halpin D,Ruse C,Seamark D

    更新日期：2010-02-01 00:00:00

  • Self-reported sleepiness while driving as a risk factor for traffic accidents in patients with obstructive sleep apnoea syndrome and in non-apnoeic snorers.

    abstract：:The obstructive sleep apnoea syndrome (OSAS) is a condition causing daytime sleepiness and has been related to an increased risk for traffic accidents. However, the evidence linking severity of OSAS to a higher rate of automobile crashes is based on limited data. The aims of this study were to study the traffic accide...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2000.0869

    authors： Lloberes P,Levy G,Descals C,Sampol G,Roca A,Sagales T,de la Calzada MD

    更新日期：2000-10-01 00:00:00

  • The effect of a time delay on the measurement of capillary blood gases.

    abstract：:Patients using domiciliary nasal ventilation, or long-term oxygen, require regular assessment which could be carried out in the home. Blood gas analysis may be regarded as an essential part of the assessment. The present study investigated the effect of a 1-h time delay on the measurement of capillary blood gases. Fou...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(96)90207-3

    authors： Bird CM,Revill SM,Vara DD,Morgan MD

    更新日期：1996-02-01 00:00:00

  • T-cell activation by organic dust in vitro.

    abstract：:Inhalation of swine dust causes intense airway inflammation with a multifold increase of inflammatory cells and lymphocyte activation as assessed by bronchoalveolar lavage. To further investigate the mechanism for lymphocyte activation the present in vitro study focuses on the lymphocyte response to swine dust in whol...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2000.0828

    authors： Müller-Suur C,Larsson PH,Larsson K

    更新日期：2000-08-01 00:00:00

  • Cost-effectiveness analysis of budesonide/formoterol compared with fluticasone in moderate-persistent asthma.

    abstract：:In this economic evaluation, conducted alongside a randomized, double-blind clinical trial, economic data were collected from 339 patients with moderate-persistent asthma randomized to receive twice-daily, double-blind treatment with budesonide/formoterol 160/4.5 microg in a single inhaler (n=166) or fluticasone propi...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2005.09.032

    authors： Ericsson K,Bantje TA,Huber RM,Borg S,Bateman ED

    更新日期：2006-04-01 00:00:00

  • Family clusters of pulmonary tuberculosis in a suburban area of Japan.

    abstract：:A survey was conducted in a metropolitan suburb to examine family clusters of pulmonary tuberculosis patients and related factors. Firstly, a descriptive study was done based on the review of tuberculosis registration cards over a 11-yr period. Of 1106 cases, 109 (9.9%) were found to occur in households which had alre...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(93)90093-f

    authors： Kondo T,Hotta I,Yamanaka K,Sakakibara H,Miyao M,Yamada S

    更新日期：1993-04-01 00:00:00

  • A comprehensive approach to lung function in bronchiectasis.

    abstract：BACKGROUND:International guidelines recommend simple spirometry for bronchiectasis patients. However, pulmonary pathophysiology of bronchiectasis is very complex and still poorly understood. Our objective was to characterize lung function in bronchiectasis and identify specific functional sub-groups. METHODS:This was ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2018.10.031

    authors： Radovanovic D,Santus P,Blasi F,Sotgiu G,D'Arcangelo F,Simonetta E,Contarini M,Franceschi E,Goeminne PC,Chalmers JD,Aliberti S

    更新日期：2018-12-01 00:00:00

  • Stepping down from high dose fluticasone/salmeterol to extrafine BDP/F in asthma is cost-effective.

    abstract：BACKGROUND:GINA guideline recommends stepping down treatment of asthma patients where control is achieved. The aim of this analysis was to estimate the costs and health outcomes associated with step down of controlled patients on high dose fluticasone/salmeterol (FP/S 1000/100 μg daily) to either medium dose FP/S (500/...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2013.07.010

    authors： Paggiaro P,Patel S,Nicolini G,Pradelli L,Zaniolo O,Papi A

    更新日期：2013-10-01 00:00:00

  • Use of combination therapy in asthma: are they prescribed according to guidelines.

    abstract：BACKGROUND:Combination therapy should be prescribed to patients with moderate to severe asthma after daily long-term treatment with inhaled inhaled corticosteroids (ICS) has been tried without obtaining adequate control and it is not indicated to be used as first line treatment in asthma. OBJECTIVES:To describe the us...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.04.017

    authors： Breton MC,Lelorier J,Forget A,Blais L

    更新日期：2007-09-01 00:00:00

  • Once-weekly azithromycin in cystic fibrosis with chronic Pseudomonas aeruginosa infection.

    abstract：BACKGROUND:Data on the effects of long-term treatment with azithromycin (AZM) on inflammatory markers in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa are scarce. So far there is no pharmacokinetic and clinical data on once-weekly dosage of AZM in CF patients. METHODS:In a randomised double...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2008.03.009

    authors： Steinkamp G,Schmitt-Grohe S,Döring G,Staab D,Pfründer D,Beck G,Schubert R,Zielen S

    更新日期：2008-11-01 00:00:00

  • Clinical features of primary ciliary dyskinesia in Cyprus with emphasis on lobectomized patients.

    abstract：BACKGROUND:Despite the manifestations of primary ciliary dyskinesia (PCD) in early life, the diagnosis is often much delayed. Since 1998 in Cyprus, we have established the only national diagnostic and clinical referral center for PCD. OBJECTIVE:To review the phenotypic features at presentation of PCD patients in Cypru...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2015.01.015

    authors： Yiallouros PK,Kouis P,Middleton N,Nearchou M,Adamidi T,Georgiou A,Eleftheriou A,Ioannou P,Hadjisavvas A,Kyriacou K

    更新日期：2015-03-01 00:00:00

  • Stepping down from combination asthma therapy: The predictors of outcome.

    abstract：BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.rmed.2016.06.010

    authors： Koskela HO,Purokivi MK,Kokkarinen J

    更新日期：2016-08-01 00:00:00

  • High levels of PEEP may improve survival in acute respiratory distress syndrome: A meta-analysis.

    abstract：OBJECTIVE:Positive end-expiratory pressure (PEEP) has been viewed as an essential component of mechanical ventilation in acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). However, clinical trials have not yet convincingly demonstrated that high PEEP levels improve survival. The object of this stud...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rmed.2009.02.008

    authors： Oba Y,Thameem DM,Zaza T

    更新日期：2009-08-01 00:00:00

  • Prophylactic use of noninvasive ventilation in patients undergoing lung resectional surgery.

    abstract：QUESTION OF THE STUDY:We studied whether prophylactic use of noninvasive pressure support ventilation (NIPSV) administered pre- and postoperatively may reduce the postoperative pulmonary function impairment. PATIENTS AND METHODS:Prospective randomized clinical trial. Thirty-nine patients with a preoperative FEV(1) <70...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2006.12.002

    authors： Perrin C,Jullien V,Vénissac N,Berthier F,Padovani B,Guillot F,Coussement A,Mouroux J

    更新日期：2007-07-01 00:00:00

  • Local anaesthesia for fibreoptic bronchoscopy: comparison between intratracheal cocaine and lignocaine.

    abstract：:In a double-blind study of 60 patients undergoing fibreoptic bronchoscopy we have compared the local anaesthetic effects of intratracheal injections of cocaine (4 ml, 2.5%) and lignocaine (4 ml, 4%). The two local anaesthetics were equally effective in terms of cough suppression, requirement for extra local anaestheti...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(08)80076-5

    authors： Teale C,Gomes PJ,Muers MF,Pearson SB

    更新日期：1990-09-01 00:00:00

  • Recombinant tissue plasminogen activator in the treatment of pleural infections in adults.

    abstract：BACKGROUND:Intrapleural recombinant tissue plasminogen activator (r-TPA) has been successfully evaluated in pediatric patients with complicated parapneumonic pleural effusion (CPE) and pleural empyema (PE). Yet, there is no data concerning r-TPA in adults with CPE/PE. The aim of our study was to investigate the efficac...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.08.012

    authors： Froudarakis ME,Kouliatsis G,Steiropoulos P,Anevlavis S,Pataka A,Popidou M,Mikroulis D,Pneumatikos I,Bouros D

    更新日期：2008-12-01 00:00:00

  • Predicting airway hyperreactivity to mannitol using exhaled nitric oxide in an unselected sample of adolescents and young adults.

    abstract：:Increased levels of exhaled nitric oxide (FeNO) and airway hyperresponsiveness (AHR) to inhaled mannitol are related to allergic inflammation characterized by eosinophil infiltration and a clinical response to treatment with anti-inflammatory agents in subjects with asthma. This study determines the diagnostic accurac...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2012.09.004

    authors： Sverrild A,Malinovschi A,Porsbjerg C,Backer V,Alving K

    更新日期：2013-01-01 00:00:00