当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma.

A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma.

Abstract：

OBJECTIVE:To compare the effects of once-daily ciclesonide and twice-daily fluticasone propionate in patients with moderate persistent asthma. METHODS:Patients aged 12-75 years with moderate bronchial asthma entered a 1-4 week run-in period. For inclusion into the 12-week, randomized, open-label treatment period, patients had to have a forced expiratory volume in 1s (FEV1) of either 60-80% of predicted or 80% of predicted and a defined use of rescue medication and asthma symptoms, depending on previous treatment. Patients received ciclesonide 320 microg once daily (ex-actuator) or fluticasone propionate 200 microg twice daily. Primary efficacy endpoint was change from baseline in FEV1. RESULTS:In total, 474 patients were randomized. FEV1 increased significantly from baseline with ciclesonide and fluticasone propionate in the intention-to-treat (ITT) and per-protocol (PP) analyses (all p < 0.0001). Treatment difference was -31 mL (95% confidence interval [CI]: -121, 59) in the PP analysis, demonstrating non-inferiority of ciclesonide. Similar findings were seen for other measures of lung function. In the ITT population, asthma symptom scores and rescue medication use decreased with both treatments (all p < 0.0001). Improvement in health-related quality of life (HRQoL) from baseline was significantly greater with ciclesonide than fluticasone (p = 0.005; one-sided). There were no cases of oral candidiasis in patients receiving ciclesonide and nine cases (3.8%) in those receiving fluticasone propionate (p = 0.002; one-sided). CONCLUSIONS:Treatment with once-daily ciclesonide and twice-daily fluticasone propionate resulted in similar improvements in lung function in patients with moderate persistent asthma. Ciclesonide showed significant improvements in oral candidiasis and HRQoL over fluticasone.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Boulet LP,Bateman ED,Voves R,Müller T,Wolf S,Engelstätter R

doi

10.1016/j.rmed.2007.03.001

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

1677-86

issue

8

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(07)00104-7

journal_volume

101

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

RESPIRATORY MEDICINE文献大全
  • Patient eligibility for anti-fibrotic therapy in idiopathic pulmonary fibrosis can be altered by use of different sets of reference values for calculation of FVC percent predicted.

    abstract：:Antifibrotic drugs for idiopathic pulmonary fibrosis patients in England and Scotland are only available to those with FVC percent predicted (FVC%pred) less than or equal to 80%. The prescribing guidance does not state which set of reference values should be used and we show that a patient's FVC%pred can change by 4-6...

    journal_title：Respiratory medicine

    pub_type： 信件

    doi：10.1016/j.rmed.2016.10.007

    authors： Ward K,Spurr L,Goldman NR,Margaritopoulos GA,Kokosi M,Renzoni E,Chua F,Maher TM,Ward S,Wells AU

    更新日期：2016-11-01 00:00:00

  • Pathophysiology and treatment of seasonal allergic rhinitis.

    abstract：:Therapeutic approaches to seasonal allergic rhinitis are reviewed in this paper. Pharmacotherapeutic approaches include nonsedative antihistamines, anti-allergic drugs, vasoconstrictors, anticholinergic agents and topical corticosteroids. The choice of treatment depends upon its relative efficacy and safety. Although ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(08)80002-9

    authors： Bousquet J,Chanez P,Michel FB

    更新日期：1990-11-01 00:00:00

  • The impact of inappropriate use of short acting beta agonists in asthma.

    abstract：BACKGROUND:Inappropriate use of short-acting beta-agonists (SABA) has been associated with increased morbidity and mortality in asthma. However, the extent and pattern of SABA use have changed significantly over recent years. The outcomes in patients who are contemporarily receiving inappropriate doses of SABA have not...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.08.014

    authors： FitzGerald JM,Tavakoli H,Lynd LD,Al Efraij K,Sadatsafavi M

    更新日期：2017-10-01 00:00:00

  • Validation of ATS clinical practice guideline cut-points for FeNO in asthma.

    abstract：BACKGROUND:The American Thoracic society (ATS) has suggested using fractional exhaled nitric oxide (FeNO) to monitor the level of eosinophilic (EOS) airway inflammation in asthma, but validation of the proposed cut-points is required in real-life populations. OBJECTIVE:To validate FeNO cut-points suggested by ATS in r...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.09.014

    authors： Jeppegaard M,Veidal S,Sverrild A,Backer V,Porsbjerg C

    更新日期：2018-11-01 00:00:00

  • Assessment and provision of home nebulizers for chronic obstructive pulmonary disease (COPD) in the Yorkshire region of the U.K.

    abstract：:A survey was undertaken to determine the current practice in the Yorkshire Health Region for the assessment and provision of home nebulizers for adults with chronic obstructive pulmonary disease (COPD). A detailed postal questionnaire on assessment methods was sent to each of the 22 consultant physicians in respirator...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(95)90070-5

    authors： Hosker HS,Teale C,Greenstone MA,Muers MF

    更新日期：1995-01-01 00:00:00

  • Severe asthma is related to high societal costs and decreased health related quality of life.

    abstract：BACKGROUND:The aim of the present study was to estimate the societal costs and the key cost drivers for patients with severe asthma in Sweden. In addition, health-related quality of life (HRQOL) and morbidity of patients with severe asthma is described. METHODS:The study population comprised adults with severe asthma ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.105860

    authors： Jansson SA,Backman H,Andersson M,Telg G,Lindberg A,Stridsman C,Lundbäck B,Rönmark E

    更新日期：2020-02-01 00:00:00

  • IL-5, IL-8 and MMP -9 levels in exhaled breath condensate of atopic and nonatopic asthmatic children.

    abstract：RATIONALE:Asthma is a heterogeneous disease, and a great majority of pediatric patients with asthma demonstrate atopic characteristics and develop a Th2 type cytokine response. Nonatopic asthma, on the other hand, is seen more rarely. METHODS:In this study, levels of IL-5, IL-8 and MMP-9 were measured in exhaled breat...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2015.04.004

    authors： Turkeli A,Yilmaz O,Taneli F,Horasan GD,Kanik ET,Kizilkaya M,Gozukara C,Yuksel H

    更新日期：2015-06-01 00:00:00

  • Cyclodextrin as a potential drug carrier in salbutamol dry powder aerosols: the in-vitro deposition and toxicity studies of the complexes.

    abstract：:This research was carried out to develop a new carrier in dry powder aerosols. Two types of cyclodextrin were chosen; gamma cyclodextrin (GCD) and dimethyl-beta-cyclodextrin (DMCD) as carriers in dry powder formulations. Salbutamol was used as a model drug and a control formulation containing lactose and the drug was ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.2001.1079

    authors： Srichana T,Suedee R,Reanmongkol W

    更新日期：2001-06-01 00:00:00

  • Recombinant tissue plasminogen activator in the treatment of pleural infections in adults.

    abstract：BACKGROUND:Intrapleural recombinant tissue plasminogen activator (r-TPA) has been successfully evaluated in pediatric patients with complicated parapneumonic pleural effusion (CPE) and pleural empyema (PE). Yet, there is no data concerning r-TPA in adults with CPE/PE. The aim of our study was to investigate the efficac...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2008.08.012

    authors： Froudarakis ME,Kouliatsis G,Steiropoulos P,Anevlavis S,Pataka A,Popidou M,Mikroulis D,Pneumatikos I,Bouros D

    更新日期：2008-12-01 00:00:00

  • Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects.

    abstract：:Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2015.10.006

    authors： Tao H,Yang JJ,Zhou X,Deng ZY,Shi KH,Li J

    更新日期：2016-01-01 00:00:00

  • A study on infectivity of asymptomatic SARS-CoV-2 carriers.

    abstract：BACKGROUND:An ongoing outbreak of coronavirus disease 2019 (COVID-19) has spread around the world. It is debatable whether asymptomatic COVID-19 virus carriers are contagious. We report here a case of the asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of a...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106026

    authors： Gao M,Yang L,Chen X,Deng Y,Yang S,Xu H,Chen Z,Gao X

    更新日期：2020-08-01 00:00:00

  • Evaluation of bronchoalveolar lavage fluid from ARDS patients with regard to apoptosis.

    abstract：BACKGROUND:Apoptosis is thought to play an important role in the development of acute respiratory distress syndrome (ARDS). We evaluated the bronchoalveolar lavage (BAL) fluid from ARDS patients focusing on apoptosis. METHODS:The study enrolled 31 ARDS patients and 20 healthy controls. BAL fluid levels of caspase-clea...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.10.001

    authors： Lee KS,Choi YH,Kim YS,Baik SH,Oh YJ,Sheen SS,Park JH,Hwang SC,Park KJ

    更新日期：2008-03-01 00:00:00

  • Asthma and COPD in an Italian adult population: role of BMI considering the smoking habit.

    abstract：:Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.04.021

    authors： Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

    更新日期：2013-09-01 00:00:00

  • Exercise-induced bronchospasm in children and adolescents with allergic rhinitis by treadmill and hyperventilation challenges.

    abstract：BACKGROUND:Respiratory complaints after exercise are common in patients with rhinitis. Exercise-induced bronchospasm (EIB) may be one of the causes. OBJECTIVES:To evaluate EIB prevalence in a group of children and adolescents with allergic rhinitis, to compare the treadmill running (TR) and eucapnic voluntary hyperven...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2018.04.001

    authors： Albuquerque Rodrigues Filho E,Rizzo JÂ,Gonçalves AV,Correia Junior MAV,Sarinho ESC,Medeiros D

    更新日期：2018-05-01 00:00:00

  • Comparison of mannitol and citric acid cough provocation tests.

    abstract：RATIONALE:Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory approval and can be performed utilizing a simple disposable inhaler in a standardized manner. OBJECTIV...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2019.09.011

    authors： Nurmi HM,Lätti AM,Brannan JD,Koskela HO

    更新日期：2019-01-01 00:00:00

  • Electrocardiographic changes in obstructive sleep apnoea syndrome.

    abstract：:Obstructive sleep apnoea syndrome (OSAS) has acute and chronic effects on the cardiovascular system. Both right and left sides of the heart are affected. Electrocardiographic pattern was studied in 190 OSAS patients. One or more of the following were found: persistent deep S in lateral chest leads V5, V6 (79%), left a...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(98)90027-0

    authors： Khalil MM,Rifaie OA

    更新日期：1998-01-01 00:00:00

  • Association between all-cause and cause-specific mortality and the GOLD stages 1-4: A 30-year follow-up among Finnish adults.

    abstract：BACKGROUND:Mortality correlates with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria of airway obstruction. Yet, little data exist concerning the long-term survival of patients presenting with different levels of obstruction. METHODS:We studied the association between all-cause and cause-spe...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2015.06.002

    authors： Mattila T,Vasankari T,Kanervisto M,Laitinen T,Impivaara O,Rissanen H,Knekt P,Jousilahti P,Saarelainen S,Puukka P,Heliövaara M

    更新日期：2015-08-01 00:00:00

  • Asthma from childhood to adulthood: course and outcome of lung function.

    abstract：:Lung function (FEV1 before and after bronchodilatation) was studied prospectively over five visits in 55 asthmatic children (28 boys) from childhood to adulthood (age 30). At the last follow-up recordings were made at rest, after cold air challenge (CACh), and after bronchodilatation. Results were related to clinical ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1053/rmed.1999.0763

    authors： Gustafsson PM,Kjellman B

    更新日期：2000-05-01 00:00:00

  • A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD.

    abstract：BACKGROUND:This study evaluated the dose-response and dosing interval of the novel long-acting muscarinic receptor antagonist (LAMA) GSK573719 in patients with COPD. METHODS:This randomized, double-blind, placebo-controlled, 3-way cross-over, incomplete block study evaluated 5 once-daily doses of GSK573719 (62.5-1000 ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rmed.2012.03.012

    authors： Donohue JF,Anzueto A,Brooks J,Mehta R,Kalberg C,Crater G

    更新日期：2012-07-01 00:00:00

  • Comparison between formoterol 12 microg b.i.d. and on-demand salbutamol in moderate persistent asthma.

    abstract：:Inhalation of on-demand salbutamol (ODS) several times daily is sometimes the only beta2-agonist prescribed in moderate persistent asthma, whereas a long-acting beta2-agonist should be added. This trial aimed to compare the efficacy of formoterol dry-powder capsule 12 microg b.i.d. (Foradil) and ODS in patients with m...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1053/rmed.2000.0972

    authors： Molimard M,Bourcereau J,Le Gros V,Bourdeix I,Leynadier F,Duroux P,French FOR-F-01 Study Group.

    更新日期：2001-01-01 00:00:00

  • COPD care programme can reduce readmissions and in-patient bed days.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a common disease worldwide with significant morbidity and mortality. AIM:To investigate the effect of a comprehensive COPD management programme in decreasing COPD readmissions 1 year before and 1 year after the programme. METHOD:185 (166 males) patients admit...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2014.09.019

    authors： Ko FW,Ngai JC,Ng SS,Chan KP,Cheung R,Leung MY,Pun MC,Hui DS

    更新日期：2014-12-01 00:00:00

  • A proposal for a practical treatment guideline designed for the initial two-hours of the management of patients with acute severe asthma and COPD using the principles of evidence-based medicine.

    abstract：:We have proposed a clinical treatment guideline for the management of acute, severe asthma and chronic obstructive pulmonarydisease (COPD) using the principles of evidence-based medicine. The content is based upon practical clinical issues in need of consensus. A previous study has shown that this particular area is i...

    journal_title：Respiratory medicine

    pub_type： 指南,杂志文章,实务指引

    doi：10.1053/rmed.2002.1332

    authors： Phanareth K,Hansen LS,Christensen LK,Laursen LC

    更新日期：2002-09-01 00:00:00

  • Post-9/11 sarcoidosis in WTC-exposed firefighters and emergency medical service workers.

    abstract：INTRODUCTION:The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested "greater than expected" numbers of post-9/11 cases in some workers. We undertook this study to estimate t...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.06.004

    authors： Webber MP,Yip J,Zeig-Owens R,Moir W,Ungprasert P,Crowson CS,Hall CB,Jaber N,Weiden MD,Matteson EL,Prezant DJ

    更新日期：2017-11-01 00:00:00

  • Skeletal muscle changes in patients with obstructive sleep apnoea syndrome.

    abstract：:Previous studies have shown that chronic hypoxia leads to changes in skeletal muscle structure (fibre size and type) and activities of several bioenergetic enzymes. Whether this occurs also in conditions characterised by intermittent hypoxia, such as the obstructive sleep apnoea syndrome (OSAS), is unknown. To explore...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(03)00034-9

    authors： Sauleda J,García-Palmer FJ,Tarraga S,Maimó A,Palou A,Agustí AG

    更新日期：2003-07-01 00:00:00

  • Factors related to tobacco use among teenagers.

    abstract：AIM:To examine tobacco use among teenagers, identify factors related to tobacco use, as well as evaluate the outcome of a smoking prevention program. METHODS:From age 7/8 to 14/15, annual questionnaires about asthma and allergy have been completed in the OLIN paediatric study in Northern Sweden. From 12/13 years, ques...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.07.001

    authors： Hedman L,Bjerg A,Perzanowski M,Sundberg S,Rönmark E

    更新日期：2007-03-01 00:00:00

  • Does the 'oxygen cost diagram' reflect changes in six minute walking distance in follow up studies?

    abstract：:The oxygen cost diagram (OCD) is a simple scale for quantifying a patient's evaluation of his tolerance to exercise frequently used in clinical trials; it has been shown to be well correlated with objective measures of capacity of ambulation such as the 6 min walk test (6' W). This study aimed to determine whether the...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(99)90266-4

    authors： Janssens JP,Breitenstein E,Rochat T,Fitting JW

    更新日期：1999-11-01 00:00:00

  • Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey.

    abstract：BACKGROUND:Given the high incidence of confirmed infection by SARS-CoV-2 and mortality by COVID-19 in the Spanish population, its impact was analysed among persons with Cystic Fibrosis (CF) as a group at risk of a worse evolution. The possible causes of the incidence observed in them are explained and how CF Units have...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106062

    authors： Mondejar-Lopez P,Quintana-Gallego E,Giron-Moreno RM,Cortell-Aznar I,Ruiz de Valbuena-Maiz M,Diab-Caceres L,Prados-Sanchez C,Alvarez-Fernandez A,Garcia-Marcos PW,Peñalver-Mellado C,Pastor-Vivero MD,Olveira C,Lopez-Neyra A,Castil

    更新日期：2020-01-01 00:00:00

  • The association between anthropometric measures and lung function in a population-based study of Canadian adults.

    abstract：BACKGROUND:Decreased lung function has health impacts beyond diagnosable lung disease. It is therefore important to understand the factors that may influence even small changes in lung function including obesity, physical fitness and physical activity. The aim of this study was to determine the anthropometric measure m...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2017.08.030

    authors： Rowe A,Hernandez P,Kuhle S,Kirkland S

    更新日期：2017-10-01 00:00:00

  • How to investigate a suspected immune deficiency in adults.

    abstract：:Patients with immune deficiencies can present with variable clinical phenotypes. This often translates into a significant delay in their diagnosis, and resultant patient morbidity. This review summarises the most common types of immunodeficiency disorders, primary and secondary, along with their key features. It provi...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106100

    authors： Grammatikos A,Bright P,Bhatnagar R,Johnston S

    更新日期：2020-09-01 00:00:00

  • Higher prevalence of breathlessness in elderly exposed to indoor aldehydes and VOCs in a representative sample of French dwellings.

    abstract：:The purpose of this study was to explore respiratory health effects of indoor exposures to aldehydes and volatile organic compounds (VOCs) in elderly living in a population-based representative sample of French dwellings and to compare them to the rest of the occupants of the dwellings. Twenty VOCs were objectively me...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.07.015

    authors： Bentayeb M,Billionnet C,Baiz N,Derbez M,Kirchner S,Annesi-Maesano I

    更新日期：2013-10-01 00:00:00