Abstract：
BACKGROUND:Apoptosis is thought to play an important role in the development of acute respiratory distress syndrome (ARDS). We evaluated the bronchoalveolar lavage (BAL) fluid from ARDS patients focusing on apoptosis. METHODS:The study enrolled 31 ARDS patients and 20 healthy controls. BAL fluid levels of caspase-cleaved cytokeratin-18 (CK-18) and soluble mediators such as interleukin-8 (IL-8), soluble Fas (sFas), soluble Fas ligand (sFasL), growth-related oncogene-alpha (GRO-alpha), granulocyte colony-stimulating factor (G-CSF), and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS:The BAL fluid caspase-cleaved CK-18 levels in ARDS patients were higher than those in controls, reflecting increased epithelial apoptosis, and were correlated with lung injury scores (rs=0.49). The BAL fluid levels of all mediators were significantly higher in ARDS patients than in controls. In ARDS patients, the BAL fluid IL-8 level was positively correlated with the levels of sFas (rs=0.57), GRO-alpha (rs=0.47), and TRAIL (rs=0.45). The BAL fluid IL-8 (rs=0.61), sFas (rs=0.57), G-CSF (rs=0.44), and TRAIL (rs=0.33) levels were correlated with the BAL fluid neutrophil count. The G-CSF levels were significantly higher in non-surviving than in surviving ARDS patients [median 183.4 pg/mL (interquartile range 76.7-315.9) vs. 63.8 pg/mL (36.2-137.2); p<0.05]. The sFas levels were positively correlated with the PaO2/FiO2 ratio (rs=0.40), and the TRAIL levels were negatively correlated with the multiple organ dysfunction scores (rs=-0.37). CONCLUSIONS:Among the mediators in BAL fluid from ARDS patients, G-CSF had the most significant prognostic implications, and the sFas and TRAIL levels were correlated with clinical severity.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Lee KS,Choi YH,Kim YS,Baik SH,Oh YJ,Sheen SS,Park JH,Hwang SC,Park KJdoi
10.1016/j.rmed.2007.10.001subject
Has Abstractpub_date
2008-03-01 00:00:00pages
464-9issue
3eissn
0954-6111issn
1532-3064pii
S0954-6111(07)00403-9journal_volume
102pub_type
杂志文章abstract：OBJECTIVE:Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical feature...
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2008-03-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To evaluate patient characteristics and practice patterns in the management of acute asthma attack at tertiary care centers across Turkey. METHODS:A total of 294 patients (mean age: 50.4 ± 15.1 years; females: 80.3%) diagnosed with persistent asthma were included in this retrospective study upon their admiss...
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2007.05.011
更新日期：2007-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2006.04.019
更新日期：2007-01-01 00:00:00
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doi：10.1053/rmed.1999.0763
更新日期：2000-05-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2013-06-01 00:00:00
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更新日期：2020-01-01 00:00:00
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doi：10.1016/j.rmed.2004.01.014
更新日期：2004-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2007.11.004
更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2008.09.009
更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2009.11.003
更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2005.03.028
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND AND AIMS:The total serum IgE level is a marker of immunological activity in allergic bronchopulmonary aspergillosis (ABPA), and a 35% decline beyond six weeks is traditionally taken as criteria for remission. The aim of this study was to evaluate the magnitude and clinical significance of decline in serum Ig...
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更新日期：2010-02-01 00:00:00
