Abstract：
:Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The model simulates a population longitudinally throughout their lifetimes, providing projections of future COPD prevalence and evaluation of the effects of changes in risk factor prevalence such as smoking. Sensitivity analysis provides information on the most influential model parameters. The model-predicted prevalence of COPD in 2040 was 17% in males over the age of 35 years (13% amongst non-smokers and 22% amongst smokers), and a modest decline over the next 25 years due to recent trends in smoking rates. The simulation model provides us with valuable information on current and future trends in COPD in Great Britain. It was developed primarily to enable easy extension to evaluate the effects of occupational and environmental exposures on lung function and the prevalence of COPD and to allow evaluation of interventions, such as introducing health surveillance or policy changes. As longitudinal studies for investigating COPD are difficult due to the lengthy follow-up time required and the potentially large number of drop-outs, we anticipate that the model will provide a valuable tool for health impact assessment. An extended model for occupational exposures is under development and will be presented in a subsequent paper.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Tan E,Boessen R,Fishwick D,Klein Entink R,Meijster T,Pronk A,van Duuren-Stuurman B,Warren Ndoi
10.1016/j.rmed.2015.09.011subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1521-31issue
12eissn
0954-6111issn
1532-3064pii
S0954-6111(15)30058-5journal_volume
109pub_type
杂志文章abstract：BACKGROUND:Fluticasone propionate and formoterol fumarate have been combined in a single inhaler (fluticasone/formoterol; flutiform(®)) for the maintenance treatment of asthma. This pooled analysis assessed the efficacy of fluticasone/formoterol versus fluticasone in patients who previously received inhaled corticoster...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2015-02-01 00:00:00
abstract：:In developing countries, many sputum-negative suspects of pulmonary tuberculosis (PTB) are given antituberculous medication just because tuberculosis (TB) could not be excluded in them. Many studies have shown that BCG test is nearly 100% sensitive, except in those with severe malnutrition, steroid therapy and other c...
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更新日期：2003-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.rmed.2010.07.011
更新日期：2010-11-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2019-02-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
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更新日期：1997-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1053/rmed.2001.1178
更新日期：2001-10-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2013.06.003
更新日期：2013-11-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(89)80196-9
更新日期：1989-07-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.rmed.2016.08.027
更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0954-6111(03)00119-7
更新日期：2003-08-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.03.021
更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.rmed.2017.10.025
更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
abstract：:The pathophysiology of corticosteroid-induced osteoporosis is complex, but centres around a primary inhibition of osteoblastic activity compounded by the effects of secondary hyperparathyroidism. The preservation of the microanatomy of bone in the early stages of the disease, coupled with strategies to prevent the eme...
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pub_type： 杂志文章,评审
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更新日期：1993-02-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
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更新日期：2012-06-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2007.07.024
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Bacteria expressing phosphorylcholine (ChoP) co-opt host-expressed platelet-activating factor receptor (PAFR) to adhere to lower airway cells. Cigarette smoke and rhinovirus (RV) infection upregulate PAFR-dependent bacterial adhesion to airway cells in vitro, and in healthy adults smoking increases the propo...
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更新日期：2014-06-01 00:00:00
