Abstract:
BACKGROUND:The efficacy and safety of extrafine beclomethasone dipropionate 100 μg/formoterol 6 μg (BDP/F HFA) pressurized metered dose inhaler (pMDI) in patients with moderate-to-severe persistent asthma, has been demonstrated in randomised controlled trials (RCTs). The aim of this prospective observational study was to assess real-life effectiveness in terms of asthma control in smoking (most of the time excluded from RCTs) and non-smoking asthmatics. METHODS:Adult patients with persistent asthma, in whom treatment with an inhaled corticosteroid/long-acting β(2)-agonist (ICS/LABA) combination is indicated, were included. Pulmonary function (FEV1%pred or PEF absolute value), Asthma Control Questionnaire (ACQ) and asthma control according to GINA criteria were measured at baseline as well as 2-8 months and >8-14 months after treatment initiation with BDP/F HFA. RESULTS:Overall, 619 patients were enrolled by 97 investigators. In the effectiveness cohort (N = 568), at baseline, smoking asthmatics (N = 123) had higher ACQ6 (p < 0.0001) and lower asthma control (p = 0.021) than non-smoking asthmatics. Treatment with BDP/F HFA pMDI was associated with significant (p < 0.0001) improvements in pulmonary function (+7.1% in FEV1% pred), ACQ6 (-1.32) and GINA asthma control (improvement of control in 49.8% of patients). Importantly, the same treatment benefits were observed in former or current smokers compared with non-smoking asthmatics. There was a reduction in the dose of ICS from 489 ± 192 μg BDP extrafine equivalents at baseline to 265 ± 125 μg after one year. The drug was well-tolerated. CONCLUSION:This prospective cohort study demonstrates the real-life effectiveness and safety of BDP/F HFA in adult asthma patients, including smokers, in normal clinical practice.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Brusselle G,Peché R,Van den Brande P,Verhulst A,Hollanders W,Bruhwyler Jdoi
10.1016/j.rmed.2012.01.010subject
Has Abstractpub_date
2012-06-01 00:00:00pages
811-9issue
6eissn
0954-6111issn
1532-3064pii
S0954-6111(12)00044-3journal_volume
106pub_type
杂志文章,多中心研究abstract::A case of endobronchial metastasis 2 yr following treatment of rectal carcinoma is presented. Endobronchial metastases from extrathoracic primary malignancies are uncommon, the estimated frequency and possible mechanisms underlying this complication are discussed. The importance of recognizing possible endobronchial m...
journal_title:Respiratory medicine
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pub_type: 杂志文章,随机对照试验
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abstract:BACKGOUND AND OBJECTIVES:The disadvantages of custom-made mandibular advancement devices (MAD) for obstructive sleep apnoea (OSA) therapy are the cost and delay required to manufacture the device. This study aimed to evaluate the efficacy of a titrable, thermoplastic MAD compared to a custom-made MAD for OSA therapy. ...
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Respiratory medicine
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更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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