Acid and non-acid gastro-esophageal refluxes in children with chronic pulmonary diseases.

abstract：BACKGROUND:The efficacy and safety of extrafine beclomethasone dipropionate 100 μg/formoterol 6 μg (BDP/F HFA) pressurized metered dose inhaler (pMDI) in patients with moderate-to-severe persistent asthma, has been demonstrated in randomised controlled trials (RCTs). The aim of this prospective observational study was ...

journal_title：Respiratory medicine

authors： Brusselle G,Peché R,Van den Brande P,Verhulst A,Hollanders W,Bruhwyler J

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:The efficacy and safety of 750-mg, 5-day levofloxacin was recently shown to be comparable to 500-mg, 10-day levofloxacin in a randomized, double-blind, multicentre clinical trial for mild-to-severe community-acquired pneumonia (CAP). This subgroup analysis attempted to compare the safety and efficacy of a sh...

journal_title：Respiratory medicine

authors： Shorr AF,Khashab MM,Xiang JX,Tennenberg AM,Kahn JB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Having a child with a chronic disease may cause anxiety and depression and impair the sleep quality in the mothers. The aim of this study was to evaluate sleep quality in asthmatic children and their mothers as well as the status of anxiety-depression in the mothers. METHODS:Study group consisted of 75 asth...

journal_title：Respiratory medicine

authors： Yuksel H,Sogut A,Yilmaz O,Demet M,Ergin D,Kirmaz C

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Dipyrone (Novalgin) is an effective analgesic, antipyretic agent also with spasmolytic effects on various types of smooth muscles. It has recently been reported that dipyrone relaxes tracheal smooth muscle of guinea pig. In this present study, we aimed to investigate whether this and previously reported in vi...

journal_title：Respiratory medicine

authors： Gulmez SE,Tulunay FC,Beder S,Kayacan O,Karnak D

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However...

journal_title：Respiratory medicine

authors： Vanspauwen MJ,Franssen FM,Raoult D,Wouters EF,Bruggeman CA,Linssen CF

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:We hypothesized that the peculiar mixed interleukin-4 (IL-4/Th2) and interferon gamma INF-γ (INF-γ/Th1) inflammatory milieu found in the airways of patients with aspirin-exacerbated respiratory disease (AERD) is responsible for the altered regulation of the IL-1β/IL-1RI-/EP2/COX-2 autocrine loop also found i...

journal_title：Respiratory medicine

authors： Machado-Carvalho L,Roca-Ferrer J,Picado C

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Non-invasive positive pressure ventilation (NIPPV) is an effective treatment in respiratory failure. Continuous positive pressure (CPAP) may also be useful in acute hypoxaemic patients. Supplementary oxygen is usually necessary in both systems. However, the inspired oxygen fraction (FiO2) delivered by a NI...

journal_title：Respiratory medicine

authors： Samolski D,Antón A,Güell R,Sanz F,Giner J,Casan P

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) severity is usually graded upon the FEV(1) reduction and FEV(1) has been considered the most important mortality predictor with age in COPD. Recent studies suggest other factors as more powerfully related to mortality than FEV(1) in COPD patients. AIM:To assess t...

journal_title：Respiratory medicine

authors： Tantucci C,Donati P,Nicosia F,Bertella E,Redolfi S,De Vecchi M,Corda L,Grassi V,Zulli R

更新日期：2008-04-01 00:00:00

abstract：:We conducted a large population-based retrospective cross-sectional study for determining the extent of clinically recognized chronic obstructive pulmonary disease (COPD) and asthma, and the prevalence of associated cardiovascular diseases (CVDs), using information obtained from the Health Search Database (HSD) owned ...

journal_title：Respiratory medicine

authors： Cazzola M,Calzetta L,Bettoncelli G,Cricelli C,Romeo F,Matera MG,Rogliani P

更新日期：2012-02-01 00:00:00

abstract：:Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management, and inhaler selection can have a profound impact on drug delivery and medication adherence, as well as on treatment outcomes. Although multiple delivery systems, such as pressurized metered-dose inhalers, dry powder inhalers, slow-...

journal_title：Respiratory medicine

authors： Mahler DA

更新日期：2020-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a chronic cardiopulmonary disorder that if left untreated, progresses rapidly and is ultimately fatal. The World Health Organization (WHO) has classified PH into 5 distinct groups according to pathophysiology, hemodynamic characteristics, and clinical presentation. Dysfunction in the nit...

journal_title：Respiratory medicine

authors： Benza R,Mathai S,Nathan SD

更新日期：2017-01-01 00:00:00

abstract：:There is an increasing body of evidence suggesting that altered vascular permeability may be an important component of the pathogenesis of acute mountain sickness (AMS). Vascular endothelial growth factor (VEGF) is a potent permeability factor subject to hypoxic regulation but its role in the pathogenesis of AMS is ye...

journal_title：Respiratory medicine

authors： Dorward DA,Thompson AA,Baillie JK,MacDougall M,Hirani N

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Diagnosing asthma cannot be always easy. It is important to consider the validity of the diagnostic tests, and/or how much more commonly they are positive in patients with asthma compared to healthy subjects and, particularly, to patients with asthma-like symptoms. OBJECTIVE:To evaluate the validity of diag...

journal_title：Respiratory medicine

authors： Di Lorenzo G,Mansueto P,Esposito-Pellitteri M,Ditta V,Castello F,Lo Bianco C,Leto-Barone MS,Di Fede G,Traverso M,Rotolo G,Vigneri S,Rini G

更新日期：2007-07-01 00:00:00

abstract：:Previous studies have shown that chronic hypoxia leads to changes in skeletal muscle structure (fibre size and type) and activities of several bioenergetic enzymes. Whether this occurs also in conditions characterised by intermittent hypoxia, such as the obstructive sleep apnoea syndrome (OSAS), is unknown. To explore...

journal_title：Respiratory medicine

authors： Sauleda J,García-Palmer FJ,Tarraga S,Maimó A,Palou A,Agustí AG

更新日期：2003-07-01 00:00:00

abstract：:Hypoxemic patients with chronic obstructive pulmonary disease (COPD) are at risk of carbon dioxide (CO(2)) retention during oxygen therapy and hypercapnia in COPD is associated with an ominous prognosis. Rebreathing with oxygen mask is possible in practice and possibly affects CO(2) retention due to an increased inspi...

journal_title：Respiratory medicine

authors： Fremault A,Silva M,Beaucage F,Berckmans D,Decramer M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:It is documented that omalizumab treatment reduces the cell surface expression of immunoglobulin E high-affinity receptor (FcɛRI) on several cell types. This has not been investigated in patients with uncontrolled severe persistent allergic asthma. METHODS:In a double-blind, randomized, placebo-controlled s...

journal_title：Respiratory medicine

authors： Chanez P,Contin-Bordes C,Garcia G,Verkindre C,Didier A,De Blay F,de Lara MT,Blanco P,Moreau JF,Robinson P,Bourdeix I,Trunet P,Le Gros V,Humbert M,Molimard M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [<65 versus ≥65 years] and...

journal_title：Respiratory medicine

authors： Chaudhuri R,McSharry C,Heaney LG,Niven R,Brightling CE,Menzies-Gow AN,Bucknall C,Mansur AH,Lee W,Shepherd M,Spears M,Cowan DC,Husi H,Thomson NC,BTS Severe Asthma Network.

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Individuals with chronic respiratory conditions are at-risk for depression and anxiety. In the largest mental health screening study of over 6000 people with cystic fibrosis (CF) and 4000 parent caregivers (TIDES, 2014), rates of symptomatology were two to three times higher than in the general population. I...

journal_title：Respiratory medicine

authors： Graziano S,Spanò B,Majo F,Righelli D,Vincenzina L,Quittner A,Tabarini P

更新日期：2020-10-01 00:00:00

abstract：:Although in the clinic the presence of mucus in the airways is known to be an important factor influencing the sound of coughing in pathological conditions, this observation has not been established experimentally. We have substituted mucus in the airways of anaesthetized cats with 0.5 ml of natural undiluted egg albu...

journal_title：Respiratory medicine

authors： Korpás J,Widdicombe JG,Vrabec M

更新日期：1993-01-01 00:00:00

abstract：:The fraction of the emitted dose from an inhaler that has the potential to be deposited into the lungs is known as the fine particle dose (also the respirable dose). During inhalation all dry powder inhalers require a 'force' to be created inside the device so that a fine particle dose is generated from the formulatio...

journal_title：Respiratory medicine

authors： Chrystyn H

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:There are no validated patient diaries for evaluating respiratory symptoms in idiopathic pulmonary fibrosis (IPF). PURPOSE:To evaluate the performance properties of the chronic obstructive pulmonary disease (COPD) Evaluating Respiratory Symptoms™ (E-RS™: COPD) measure in patients with IPF. METHODS:Concept ...

journal_title：Respiratory medicine

authors： Bacci ED,O'Quinn S,Leidy NK,Murray L,Vernon M

更新日期：2018-01-01 00:00:00

abstract：:Smoking cessation is the most effective way to reduce the risk of developing chronic obstructive pulmonary disease (COPD). It prevents or delays the development of airflow limitation and also reduces its progression. The objective of this study was to systematically review the effects of interventions for smoking cess...

journal_title：Respiratory medicine

authors： Wagena EJ,van der Meer RM,Ostelo RJ,Jacobs JE,van Schayck CP

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Posturally induced changes in minute ventilation in patients may be autonomically driven. This study aimed to test whether changes in autonomic tone with posture differed between normal and asthmatic subjects and whether this related to changes in indices of ventilation. METHODS:Ten patients with type 1 bri...

journal_title：Respiratory medicine

authors： Mukhopadhyay J,Bates R,Manney S,Ayres JG

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The 6-min walk test (6MWT) is a submaximal exercise test used to assess functional status in patients with cardiopulmonary diseases. Regression equations have previously been published as a normal reference for 6-min walk distance (6MWD) in healthy Caucasian adults. However, a recent study showed that the no...

journal_title：Respiratory medicine

authors： Alameri H,Al-Majed S,Al-Howaikan A

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To investigate impact of distribution of computed tomography (CT) emphysema on severity of airflow limitation and gas exchange impairment in current and former heavy smokers participating in a lung cancer screening trial. MATERIALS AND METHODS:In total 875 current and former heavy smokers underwent baseline lo...

journal_title：Respiratory medicine

authors： Gietema HA,Zanen P,Schilham A,van Ginneken B,van Klaveren RJ,Prokop M,Lammers JW

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND AIM:Vocal Cord Dysfunction (VCD) and chronic cough (CC) are challenging conditions which lead to significant quality of life impairment. The underlying mechanisms are poorly understood, but laryngeal dysfunction may be common to both conditions. The aim of this study was to determine the characteristics ...

journal_title：Respiratory medicine

authors： Vertigan AE,Kapela SL,Gibson PG

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:COPD is a prevalent disease that generates high use of resources. The objective of this study was to quantify the economic consequences of non-adherence to GOLD guidelines for the management of COPD patients. METHOD:An economic model was generated to compare different scenarios of observed vs. expected cost...

journal_title：Respiratory medicine

authors： Miravitlles M,Brosa M,Velasco M,Crespo C,Gobartt E,Diaz S,González-Rojas N

更新日期：2009-05-01 00:00:00

abstract：:We studied the validity of a recently introduced, handheld, electronic loading device in providing automatically processed information on external inspiratory work, power and breathing pattern during loaded breathing tasks in patients with COPD. Thirty-five patients with moderate to severe COPD performed an endurance ...

journal_title：Respiratory medicine

authors： Langer D,Jacome C,Charususin N,Scheers H,McConnell A,Decramer M,Gosselink R

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we ca...

journal_title：Respiratory medicine

authors： Calzetta L,Ora J,Cavalli F,Rogliani P,O'Donnell DE,Cazzola M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE:...

journal_title：Respiratory medicine

authors： Schor D,Rizzo JÂ,Medeiros D,Dela Bianca AC,Silva AR,Nunes C,Morais-Almeida M,Sarinho E

更新日期：2017-05-01 00:00:00