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Effects of positive end-expiratory pressure (PEEP) in cardiac surgery patients.

Abstract：

:The role of positive end-expiratory pressure (PEEP) in the postoperative course of cardiac surgery patients remains questionable. In this prospective study, we examined the effect of different levels of PEEP on arterial oxygenation, SvO2 and PvO2 values, and on haemodynamic indices, during the early postoperative period in cardiac surgery patients. Upon transfer to the ICU, 67 adult patients with normal preoperative respiratory status were randomly assigned to receive zero PEEP (Group A), 5 cmH2O (Group B), or 10 cmH2O PEEP (Group C) during mechanical ventilatory support. PaO2/FIO2 ratio, mixed venous PvO2 and SvO2, and cardiac index, were measured 30 min, 4 h and 8 h after application of mechanical ventilation in the ICU, just prior to extubation, half an hour after extubation, and 4 h post-extubation. We found no statistically significant differences (P = n.s.) in arterial oxygenation expressed by PaO2/FIO2 ratio, SvO2 and PvO2 values, and in cardiac index among the three groups at any study interval. We conclude that low levels of PEEP have no advantage over zero PEEP in improving gas exchange in the early postoperative course of patients following open heart surgery.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Michalopoulos A,Anthi A,Rellos K,Geroulanos S

doi

10.1016/s0954-6111(98)90388-2

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

858-62

issue

6

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(98)90388-2

journal_volume

92

pub_type

临床试验,杂志文章,随机对照试验

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