Abstract：
BACKGROUND:Gas trapping suggesting small airway disease is observed in adult asthmatic suffering from severe asthma. The aim of the study was to assess whether gas trapping could be evidenced in asthmatic children with/without severe exacerbation and with/without symptoms during the past three months. METHODS AND PATIENTS:Forced expiratory flows (FEV(1), FVC, MEF(25-75%), MEF(50%)), plethysmographic lung volumes (TLC, FRC, RV) before and after bronchodilation (BD) were recorded in asthmatic children with documented airflow reversibility. Three groups were defined according to the presence during the last three months of 1) severe exacerbation (oral steroid: 3 consecutive days) 2) asthma symptoms without severe exacerbation and 3) without any symptom (GINA guidelines). RESULTS:180 children (median 11.3 years, range 6.3-17.6, 57 girls) were included, 24 (13%) had at least one severe exacerbation, 58 (33%) had respiratory symptoms without severe exacerbation and 98 (54%) had no symptom during the past 3 months. Forced expiratory flows did not significantly differ in these three groups, while RV/TLC was significantly higher in the first group before and even after bronchodilation: before BD, 0.27 +/- 0.07, 0.24 +/- 0.05 and 0.23 +/- 0.05, respectively (p = 0.016) and after BD, 0.25 +/- 0.07, 0.21 +/- 0.05, 0.21 +/- 0.05, respectively (p = 0.003). CONCLUSION:In asthmatic children, gas trapping is associated with occurrence of a severe exacerbation during the last three months, suggesting a small airway disease that is not evidenced by forced expiratory flows.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Mahut B,Peiffer C,Bokov P,Beydon N,Delclaux Cdoi
10.1016/j.rmed.2010.05.005subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1230-3issue
8eissn
0954-6111issn
1532-3064pii
S0954-6111(10)00219-2journal_volume
104pub_type
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