Abstract：
STUDY OBJECTIVES:Surgical lung biopsy (SLB) plays an important role in the diagnosis of interstitial pneumonia, however, the occurrence of acute respiratory failure following SLB remains largely unreported. We evaluated the incidence, clinical features, therapy and prognosis of acute exacerbation of interstitial pneumonia following SLB. DESIGN:Retrospective study of consecutive patients who underwent SLB to establish a diagnosis of diffuse lung disease between May 1989 and April 2000. Patients with an acute exacerbation following lung biopsy were studied, and the HRCT images of the chest before and after surgery were reviewed. MEASUREMENTS AND RESULTS:Among the 236 consecutive patients with interstitial pneumonia who underwent a surgical lung biopsy, five (2.1%) (IPF, 3; NSIP, 1; COP, 1) developed acute exacerbation of the diffuse lung disease in the course of 1-18 days after SLB. The extent of parenchymal involvement on HRCT before surgery was not significantly different between operated and contralateral nonoperated lung. Significantly increased regions of parenchymal involvement on HRCT were seen postoperatively compared with the preoperative CT in both the operated (20.7+/-12.5% versus 38.2+/-10.8%, P = 0.0431) and nonoperated lung (22.7+/-13.8% versus 70.5+/-24.4%, P = 0.0431), but the extent of the parenchymal involvement was significantly greater on the nonoperated side (P = 0.0251). Two of the 3 IPF patients died from the acute exacerbation. CONCLUSIONS:It is important to be aware of the possibility of acute exacerbation of interstitial pneumonia following SLB even after an apparently uneventful immediate postoperative course. The asymmetric image findings suggest that intraoperative respiratory management is a possible etiologic factor.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Kondoh Y,Taniguchi H,Kitaichi M,Yokoi T,Johkoh T,Oishi T,Kimura T,Nishiyama O,Kato K,du Bois RMdoi
10.1016/j.rmed.2006.02.002subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1753-9issue
10eissn
0954-6111issn
1532-3064pii
S0954-6111(06)00063-1journal_volume
100pub_type
杂志文章abstract：OBJECTIVE:To assess the incidence and determinants of the triple inhaled therapy in chronic obstructive pulmonary disease (COPD) primary care patients. METHODS:Data derived from the Health Search Database (HSD) gathering information on 700 Italian general practitioners. A cohort of COPD patients, prescribed for the fi...
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2008.11.004
更新日期：2009-04-01 00:00:00
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更新日期：2014-03-01 00:00:00
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更新日期：2016-06-01 00:00:00
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更新日期：2017-02-01 00:00:00
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更新日期：2011-06-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1999-07-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
