Abstract：
:The fine particle dose delivered via dry powder inhalers (DPIs) is often affected by the inspiratory flow rate generated during inhalation. This has clinical implications, since the fine particle dose determines the amount of drug reaching the lungs. With Easyhaler DPI the fine particle dose remains relatively constant over the range of inspiratory flow rates from 30-60 l min(-1). The aim of this study was to confirm that clinical efficacy is maintained even at low flow rates by comparing the bronchodilating effect of salbutamol (100 microg) delivered via Easyhaler at a target inspiratory flow of 30 l min(-1) with the same dose of salbutamol via pressurised metered-dose inhaler (pMDI) plus spacer. This was a double-blind, randomized, cross-over study with double-dummy technique. Twenty-one paediatric and adult asthmatic patients completed the study, which was conducted over 2 study days. The main outcome parameter was forced expiratory volume in 1 sec (FEV1). The patients were trained to generate a low peak inspiratory flow rate (PIFR) of 30 l min(-1), and the actual PIFR through Easyhaler was recorded. The average PIFR through Easyhaler was 28.7 l min(-1). The difference in the maximum value of FEV1 (FEV1max) between the treatments after drug inhalation was 0.01 l. The mean of FEV1max was 2.67 l after pMDI plus spacer compared to 2.69 l after Easyhaler. Improvements in FEV1 were clinically significant. No significant differences between treatments were found. A reasonably low inspiratory flow rate through Easyhaler produces an equivalent improvement in lung function to a correctly used pMDI plus spacer. Hence, Easyhaler can be used with confidence in patients who may have difficulty in generating a high inspiratory flow rate, such as children and the elderly.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Koskela T,Malmström K,Sairanen U,Peltola S,Keski-Karhu J,Silvasti Mdoi
10.1053/rmed.2000.0959subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1229-33issue
12eissn
0954-6111issn
1532-3064pii
S0954-6111(00)90959-4journal_volume
94pub_type
临床试验,杂志文章,随机对照试验abstract：:Viozan (sibenadet HCl, AR-C68397AA) is a novel dual D2 dopamine receptor, beta2-adrenoceptor agonist that has been investigated for efficacy in alleviating the symptoms of chronic obstructive pulmonary disease (COPD). The slowly progressive nature of this disease means that patients will require ongoing therapeutic ma...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Bacteria expressing phosphorylcholine (ChoP) co-opt host-expressed platelet-activating factor receptor (PAFR) to adhere to lower airway cells. Cigarette smoke and rhinovirus (RV) infection upregulate PAFR-dependent bacterial adhesion to airway cells in vitro, and in healthy adults smoking increases the propo...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2014.03.003
更新日期：2014-06-01 00:00:00
abstract：:Assessment of asthma severity is important for disease management. Analysis of symptoms past and present, and previous and actual lung function measurements (including variability) is the usual method of evaluation and classification of asthma disease severity and activity. However, symptoms and lung function alterati...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0954-6111(97)90003-2
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:Changes in management of COPD in primary care were studied following a training exercise among Spanish general practitioners (GPs). The exercise involved dissemination of the Spanish Society for Pulmonology and Thoracic Surgery (SEPAR) guidelines. The use of a portable device to perform spirometry tests was ...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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abstract：:Ten patients (two male) suffering from acute exacerbations of long-standing chronic obstructive pulmonary disease and admitted in hypoxic, hypercapnic respiratory failure were treated with Nasal Intermittent Positive Pressure Ventilation (NIPPV) plus supplemental oxygen, on a general medical ward. The median (range) p...
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pub_type： 杂志文章
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abstract：BACKGROUND:An ongoing outbreak of coronavirus disease 2019 (COVID-19) has spread around the world. It is debatable whether asymptomatic COVID-19 virus carriers are contagious. We report here a case of the asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of a...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2020.106026
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2013.10.004
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:In patients with chronic obstructive pulmonary disease (COPD), energy expenditure (EE) assessment during the performance of daily activities is not yet studied in depth. The aim of this study was to determine which daily activities are more demanding to patients with COPD and to compare the accuracy of EE es...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2011.01.004
更新日期：2011-06-01 00:00:00
abstract：:We conducted a large population-based retrospective cross-sectional study for determining the extent of clinically recognized chronic obstructive pulmonary disease (COPD) and asthma, and the prevalence of associated cardiovascular diseases (CVDs), using information obtained from the Health Search Database (HSD) owned ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2011.07.021
更新日期：2012-02-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.1999.0746
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:The effect of pro-inflammatory stimuli on bronchoconstrictor-induced air trapping has not been studied. OBJECTIVE:To determine the effect of natural allergen exposure, a pro-inflammatory stimulus, on methacholine- and adenosine 5'-monophospate (AMP)-induced air trapping. METHODS:Airway responsiveness to me...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2010.11.023
更新日期：2011-06-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic seronegative spondyloarthritis with the major histocompatibility antigen HLA B27. Pulmonary involvement in AS is rare and is usually in the form of upper lobe fibrocavitary disease. Herein, we present a case with recurrent pleural and pericardial effusion without apical fibrobu...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2006.04.028
更新日期：2007-02-01 00:00:00
abstract：AIM:To describe how patients with COPD, heart failure, dementia and cancer differ in frequency and timing of referral to palliative care services. METHODS:We performed a population-based study with the Sentinel Network of General Practitioners in Belgium. Of 2405 registered deaths respectively 5%, 4% and 28% were iden...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2013.06.003
更新日期：2013-11-01 00:00:00
abstract：:Fifty patients with tropical eosinophilia were studied clinically and physiologically, before and after a standard 3-week course of diethylcarbamazine. Before treatment the main physiological abnormality was a reduction in the carbon monoxide transfer factor. One month after the start of treatment most patients had sh...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(06)80205-2
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:To evaluate whether elevated levels of cardiac troponin increases the risk of mortality in patients with acute PE. METHODS:We conducted a systematic review and meta-analysis with rigorous statistical evaluation using publications (2000-2018) from Cochrane Library, MEDLINE, PubMed, Scopus, Cochrane Central R...
journal_title：Respiratory medicine
pub_type： 杂志文章,meta分析
doi：10.1016/j.rmed.2019.08.011
更新日期：2019-10-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.09.037
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:To analyse the relationship between symptoms at different times during the 24-hour day and outcomes in COPD. METHODS:Observational cross-sectional study in a patients from 7 Latin American countries. The frequency of symptoms in the morning, at night and during the day was explored by means of standardised ...
journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmed.2017.11.018
更新日期：2018-01-01 00:00:00
abstract：:Lung function (FEV1 before and after bronchodilatation) was studied prospectively over five visits in 55 asthmatic children (28 boys) from childhood to adulthood (age 30). At the last follow-up recordings were made at rest, after cold air challenge (CACh), and after bronchodilatation. Results were related to clinical ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1053/rmed.1999.0763
更新日期：2000-05-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.12.008
更新日期：2006-09-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2005.06.011
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Combination therapy with inhaled corticosteroids (ICS) and long-acting β(2)-adrenergic agonists (LABA) is reported to have superior effects on controlling asthma symptoms to ICS alone; however, there is no molecular-based evidence to explain the clinical effects. Here, the effect of the ICS/LABA combination ...
journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2011.08.020
更新日期：2011-12-01 00:00:00
abstract：:Thirteen soldiers (11 men and two women) were exposed to zinc chloride smoke (ZCS) during a combat exercise. Even though their initial symptoms were modest, a prolonged follow up with lung function testing and blood samples was undertaken due to previous cases with fatal outcome after exposure to ZCS. Four weeks after...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(99)90054-9
更新日期：1999-12-01 00:00:00
abstract：:Snoring and obstructive sleep apnoea/hypopnoea syndrome (OSAHS) are often treated with mandibular repositioning splints (MRS), but the efficacy and satisfaction of them has not been comprehensively addressed. A survey on the use of and satisfaction with MRS was posted to 177 patients referred by a hospital orthodontic...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.07.007
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is an inflammatory condition characterized by oxidative stress and the formation of volatile organic compounds (VOCs) secreted via the lungs. We recently developed a methodological approach able to identify profiles of VOCs in breath unique for patient groups. Her...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.10.018
更新日期：2010-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2019.02.007
更新日期：2019-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.08.008
更新日期：2010-01-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2015.09.011
更新日期：2015-12-01 00:00:00
abstract：:A previous study in the Liverpool district on patients receiving long term oxygen treatment using a domiciliary oxygen concentrator showed that only 55% were both using oxygen therapy correctly and had stopped smoking. To try and identify which factors influence patient behaviour, all 55 patients in this district rece...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(08)80062-5
更新日期：1990-07-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2018.07.001
更新日期：2018-08-01 00:00:00
abstract：:The first long-term study of sodium cromoglycate, reported in 1972, demonstrated the effectiveness of sodium cromoglycate in controlling asthma. The trial had various limitations, but more recent trials have been designed so that they overcome some of these problems. Results of these trials validate the results obtain...
journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章
doi：10.1016/s0954-6111(89)80244-6
更新日期：1989-05-01 00:00:00
