当前位置： SCI文献检索 > RESPIRATORY MEDICINE期刊下所有文献 > Medication adherence and persistence in the last year of life in COPD patients.

Medication adherence and persistence in the last year of life in COPD patients.

Abstract：

OBJECTIVE:To examine medication adherence and persistence among COPD patients during their last year of life. DATA SOURCE:National VA databases were used to identify patients who had COPD and died between 1999 and 2003. STUDY DESIGN:We examined use of inhaled corticosteroids (ICS), long acting beta(2) agonists (LABA), methylxanthines (MTX), and anticholinergics (AC), alone and in combination. Medication possession ratios (MPR) were compared between regimens by quarterly periods using General Estimating Equations (GEE). Medication persistence was examined in monotherapy users with Kaplan-Meier survival analysis and extended Cox proportional hazard models. PRINCIPAL FINDINGS:Only half of the identified patients in the COPD cohort (5913 of 11,376) used any medications. Among 5913 patients, overall mean (SD) MPR was 0.44 (0.32) during the last year of life. A positive linear trend in MPR was observed across quarterly periods in AC users (beta=0.014, p<0.0001), and was highest for MTX users (beta=0.11, p<0.0001). Of 3436 on monotherapy only, 40% discontinued medication within 30 days, and 70% discontinued within 90 days. MTX users were less likely to discontinue (HR=0.714, p=0.012) than reference (AC) group. CONCLUSION:COPD patients in their last year of life tended to use respiratory medications sporadically. Further research is needed to qualify whether minor differences in MPR between regimens reflect behavioral differences related to regimen or reflect refill policy and MPR calculation technique.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Jung E,Pickard AS,Salmon JW,Bartle B,Lee TA

doi

10.1016/j.rmed.2008.11.004

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

525-34

issue

4

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(08)00397-1

journal_volume

103

pub_type

杂志文章

相关文献

RESPIRATORY MEDICINE文献大全
  • Measuring lung volumes in advanced asbestosis: comparability of plethysmographic and radiographic versus helium rebreathing and single breath methods.

    abstract：:Total lung capacity was measured in 16 workers with pulmonary asbestosis using four standard methods: body plethysmography, radiographic lung area, helium dilution by multiple breath and by single breath (alveolar volume). All men had irregular opacities of ILO profusion category 2/1 or greater and four had pleural pl...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/0954-6111(93)90138-p

    authors： Kilburn KH,Miller A,Warshaw RH

    更新日期：1993-02-01 00:00:00

  • Chronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review.

    abstract：:Along with the aging population, the public health burden of cerebrovascular disease is increasing. Cerebral small vessel disease and accumulation of brain pathology associate with cognitive decline and can lead to clinical outcomes, such as stroke and dementia. Chronic Obstructive Pulmonary Disease (COPD) is a common...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2015.07.014

    authors： Lahousse L,Tiemeier H,Ikram MA,Brusselle GG

    更新日期：2015-11-01 00:00:00

  • Prognostic significance of hemostatic parameters in patients with lung cancer.

    abstract：:There is a subclinical activation of coagulation and fibrinolysis system in lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In this prospective study, our purpose was to investigate the prognostic significance of hemostatic markers in patients ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2003.07.001

    authors： Unsal E,Atalay F,Atikcan S,Yilmaz A

    更新日期：2004-02-01 00:00:00

  • Decision-making by healthcare payers.

    abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/s0954-6111(02)80032-4

    authors： Levine M,Taylor R,Ryan M,Sculpher M

    更新日期：2002-08-01 00:00:00

  • Identification of individuals with alpha-1-antitrypsin deficiency by a targeted screening program.

    abstract：BACKGROUND:Alpha-1-antitrypsin deficiency (AATD) is significantly underdiagnosed. The early detection of AATD would enable affected persons to make lifestyle changes such as quitting smoking. It was the aim of the study to determine whether the combination of an awareness program with the offer of a cost-free diagnosti...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.02.024

    authors： Bals R,Koczulla R,Kotke V,Andress J,Blackert K,Vogelmeier C

    更新日期：2007-08-01 00:00:00

  • Alveolar haemorrhage revealing epithelioid haemangioendothelioma.

    abstract：:Epithelioid haemangioendothelioma of the pulmonary vessels is a rare neoplasm which usually has a minimal clinical expression. The present case report describes an exceptional case with severe inaugural alveolar haemorrhage which led to death by acute respiratory failure within a few weeks. ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(97)90077-9

    authors： Briens E,Caulet-Maugendre S,Desrues B,Quinquenel ML,Lena H,Turlin B,Delaval P

    更新日期：1997-02-01 00:00:00

  • Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.

    abstract：BACKGROUND:Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.11.017

    authors： Horikiri T,Hara H,Saito N,Araya J,Takasaka N,Utsumi H,Yanagisawa H,Hashimoto M,Yoshii Y,Wakui H,Minagawa S,Ishikawa T,Shimizu K,Numata T,Arihiro S,Kaneko Y,Nakayama K,Matsuura T,Matsuura M,Fujiwara M,Okayasu I,I

    更新日期：2017-01-01 00:00:00

  • Smoking, obesity and risk of sarcoidosis: A population-based nested case-control study.

    abstract：BACKGROUND:Smoking and obesity might alter the risk of sarcoidosis. However, the data remained inconclusive. METHODS:A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified based on individual medical record review. For each sarcoidosis su...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.10.003

    authors： Ungprasert P,Crowson CS,Matteson EL

    更新日期：2016-11-01 00:00:00

  • Long-term use of Viozan (sibenadet HCl) in patients with chronic obstructive pulmonary disease: results of a 1-year study.

    abstract：:Viozan (sibenadet HCl, AR-C68397AA) is a novel dual D2 dopamine receptor, beta2-adrenoceptor agonist that has been investigated for efficacy in alleviating the symptoms of chronic obstructive pulmonary disease (COPD). The slowly progressive nature of this disease means that patients will require ongoing therapeutic ma...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Hiller FC,Alderfer V,Goldman M

    更新日期：2003-01-01 00:00:00

  • Association between all-cause and cause-specific mortality and the GOLD stages 1-4: A 30-year follow-up among Finnish adults.

    abstract：BACKGROUND:Mortality correlates with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria of airway obstruction. Yet, little data exist concerning the long-term survival of patients presenting with different levels of obstruction. METHODS:We studied the association between all-cause and cause-spe...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2015.06.002

    authors： Mattila T,Vasankari T,Kanervisto M,Laitinen T,Impivaara O,Rissanen H,Knekt P,Jousilahti P,Saarelainen S,Puukka P,Heliövaara M

    更新日期：2015-08-01 00:00:00

  • Emerging concerns of infectious diseases in lung cancer patients receiving immune checkpoint inhibitor therapy.

    abstract：BACKGROUNDS:Cancer immunotherapy using immune checkpoint inhibitors has received a remarkable amount of attention in patients with non-small cell lung cancer (NSCLC). The unique adverse effects known as immune-related adverse events (irAEs) associated with immune checkpoint inhibitors are not known however, and neither...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.rmed.2018.11.021

    authors： Fujita K,Kim YH,Kanai O,Yoshida H,Mio T,Hirai T

    更新日期：2019-01-01 00:00:00

  • Focus on the pulmonary involvement and genetic patterns in Birt-Hogg-Dubè syndrome: Literature review.

    abstract：INTRODUCTION:Brit-Hogg-Dubé syndrome (BHD) is a rare disorder that is estimated to affects about 600 families in the World. The disease-causing mutations is on FLCN gene which codes for folliculin. This protein has a role in different organs as skin, kidney and lung, thanks to the interaction with type I and II cadheri...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.rmed.2020.105995

    authors： Marziali V,Geropoulos G,Frasca L,Longo F,Patrini D,Panagiotopoulos N,Crucitti P

    更新日期：2020-07-01 00:00:00

  • Chronic respiratory symptoms, spirometry and knowledge of COPD among general population.

    abstract：RATIONALE:Infradiagnosis of chronic obstructive pulmonary disease (COPD) may be related to the lack of knowledge about the disease and/or the scarce use of diagnostic procedures. This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of sp...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2006.02.024

    authors： Miravitlles M,de la Roza C,Morera J,Montemayor T,Gobartt E,Martín A,Alvarez-Sala JL

    更新日期：2006-11-01 00:00:00

  • Economic evaluation studies in respiratory medicine.

    abstract：:The need for efficient use of resources in the provision of health care is now an accepted reality. Despite its economic significance, respiratory disease has been the subject of very few examples of the application of techniques of economic evaluation. There are a number of examples of cost-minimization studies, and ...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(06)80169-1

    authors： Buxton MJ

    更新日期：1991-09-01 00:00:00

  • Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines.

    abstract：BACKGROUND:Individuals with chronic respiratory conditions are at-risk for depression and anxiety. In the largest mental health screening study of over 6000 people with cystic fibrosis (CF) and 4000 parent caregivers (TIDES, 2014), rates of symptomatology were two to three times higher than in the general population. I...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106147

    authors： Graziano S,Spanò B,Majo F,Righelli D,Vincenzina L,Quittner A,Tabarini P

    更新日期：2020-10-01 00:00:00

  • Maximal inspiratory and expiratory mouth pressures in sitting and half-lying positions in normal subjects.

    abstract：:Maximal inspiratory (PImax) and expiratory (PEmax) mouth pressures were measured in seven normal adults in both sitting and half-lying positions on 2 days. Analysis of variance did not reveal significant differences between measurements made in the two positions for either PImax or PEmax. Measurements were repeatable ...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(06)80081-8

    authors： Ng GY,Stokes MJ

    更新日期：1991-05-01 00:00:00

  • Use of the QuantiFERON-TB Gold test in Japanese patients with sarcoidosis.

    abstract：BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFE...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.09.013

    authors： Inui N,Suda T,Chida K

    更新日期：2008-02-01 00:00:00

  • Lung deflation and oxygen pulse in COPD: results from the NETT randomized trial.

    abstract：BACKGROUND:In COPD patients, hyperinflation impairs cardiac function. We examined whether lung deflation improves oxygen pulse, a surrogate marker of stroke volume. METHODS:In 129 NETT patients with cardiopulmonary exercise testing (CPET) and arterial blood gases (ABG substudy), hyperinflation was assessed with residu...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2011.07.012

    authors： Come CE,Divo MJ,San José Estépar R,Sciurba FC,Criner GJ,Marchetti N,Scharf SM,Mosenifar Z,Make BJ,Keller CA,Minai OA,Martinez FJ,Han MK,Reilly JJ,Celli BR,Washko GR,NETT Research Group.

    更新日期：2012-01-01 00:00:00

  • Anti-Ro52 antibody is an independent risk factor for interstitial lung disease in dermatomyositis.

    abstract：AIM:Recent studies have shown that anti-Ro52 antibody is associated with both interstitial lung disease (ILD) and the degree of disease severity in juvenile patients with dermatomyositis (DM). We found that more than half of adult patients with DM were positive for anti-Ro52 antibody. In this study, we analysed the cor...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106134

    authors： Xing X,Li A,Li C

    更新日期：2020-10-01 00:00:00

  • Tuberculosis case-finding in Western Australia.

    abstract：:The records of a total of 497 patients notified to have active tuberculosis (TB) in Western Australia from 1986 to 1990 inclusive have been reviewed in relation to case-finding. Of these, 276 (55.5%) were Asian migrants, 92 (18.5%) Europeans and 110 (22.1%) Australians. The disease was confirmed bacteriologically in 2...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/s0954-6111(05)80349-x

    authors： Pang SC,Harrison RH,Clayton AS,Mercer J,Brearley J

    更新日期：1994-03-01 00:00:00

  • Efficacy and safety of rituximab in patients with chronic hypersensitivity pneumonitis (cHP): A retrospective, multicentric, observational study.

    abstract：BACKGROUND:There are chronic forms of hypersensitivity pneumonitis (cHP) that can progress to pulmonary fibrosis. There is no recommended treatment for patients whose respiratory condition continues to deteriorate in spite of antigen avoidance. Whether rituximab may be beneficial to patients with cHP is unknown. The ai...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2020.106146

    authors： Ferreira M,Borie R,Crestani B,Rigaud P,Wemeau L,Israel-Biet D,Leroy S,Quétant S,Plantier L,Dalphin JC,Cottin V,Marchand-Adam S,of the OrphaLung network.

    更新日期：2020-10-01 00:00:00

  • Effects of proportional assisted ventilation on exercise performance in idiopathic pulmonary fibrosis patients.

    abstract：BACKGROUND:Patients with idiopathic pulmonary fibrosis (IPF) present an important ventilatory limitation reducing their exercise capacity. Non-invasive ventilatory support has been shown to improve exercise capacity in patients with obstructive diseases; however, its effect on IPF patients remains unknown. OBJECTIVE:T...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2009.08.001

    authors： Moderno EV,Yamaguti WP,Schettino GP,Kairalla RA,Martins MA,Carvalho CR,Carvalho CR

    更新日期：2010-01-01 00:00:00

  • Costs of asthma in Italy: results of the SIRIO (Social Impact of Respiratory Integrated Outcomes) study.

    abstract：:Bronchial asthma is a costly disease and the correlated social impact is ever increasing. The aim of the Social Impact of Respiratory Integrated Outcomes (SIRIO) study was to measure the health resources consumption and the costs generated in 1 year by asthmatic patients investigated in a real-life setting. This botto...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2007.07.011

    authors： Dal Negro RW,Micheletto C,Tosatto R,Dionisi M,Turco P,Donner CF

    更新日期：2007-12-01 00:00:00

  • Appraisal of lens opacity with mometasone furoate/formoterol fumarate combination in patients with COPD or asthma.

    abstract：BACKGROUND:Long-term corticosteroid use may increase cataract risk. The Lens Opacities Classification System (LOCS) III ranked lens opacities as Class 1: 0.5-0.9 unit; Class 2: 1.0-1.4 units; or Class 3: ≥1.5 units in clinical trials of combined mometasone furoate and formoterol (MF/F) administered by metered-dose inha...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.rmed.2014.04.015

    authors： Maspero J,Cherrez I,Doherty DE,Tashkin DP,Kuna P,Kuo WL,Gates D,Nolte H,Chylack LT Jr

    更新日期：2014-09-01 00:00:00

  • Comparison of supplemental oxygen delivery by continuous versus demand based flow systems in hypoxemic COPD patients - A randomized, single-blinded cross-over study.

    abstract：BACKGROUND:Supplemental oxygen is a recommended therapy option in stable hypoxemic COPD patients. Often, supplemental oxygen is provided by continuous flow (CF). However, demand oxygen delivery systems (DODS) that provide an oxygen bolus only during inspiration have gained increasing use as they prolong oxygen cylinder...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rmed.2019.08.001

    authors： Gloeckl R,Jarosch I,Schneeberger T,Fiedler C,Lausen M,Weingaertner J,Hitzl W,Kenn K,Koczulla AR

    更新日期：2019-09-01 00:00:00

  • Asthma and COPD in an Italian adult population: role of BMI considering the smoking habit.

    abstract：:Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2013.04.021

    authors： Cazzola M,Calzetta L,Lauro D,Bettoncelli G,Cricelli C,Di Daniele N,Rogliani P

    更新日期：2013-09-01 00:00:00

  • Relationship between blood eosinophils and clinical characteristics in a cross-sectional study of a US population-based COPD cohort.

    abstract：BACKGROUND:Current evidence suggests that blood eosinophil levels (Eos) are associated with chronic obstructive pulmonary disease (COPD) treatment response and natural history. This analysis investigated the relationship between Eos levels and clinical characteristics in a representative cohort of US subjects with spir...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2016.01.013

    authors： DiSantostefano RL,Hinds D,Le HV,Barnes NC

    更新日期：2016-03-01 00:00:00

  • Chronic obstructive lung disease and respiratory muscle function: the role of nutrition and exercise training in cystic fibrosis.

    abstract：:Malnutrition may be an extremely important complicating factor in patients with a variety of chronic lung diseases. The impact of malnutrition on lung disease and respiratory muscle function has been extensively studied in patients with chronic lung disease due to cystic fibrosis (CF). In patients with CF it appears t...

    journal_title：Respiratory medicine

    pub_type： 杂志文章,评审

    doi：10.1016/0954-6111(93)90127-l

    authors： Heijerman HG

    更新日期：1993-08-01 00:00:00

  • Cytokine levels in the sera of patients with idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder. Cytokines contribute an important but yet undefined role to its pathogenesis. OBJECTIVES:The present study aims to compare serum levels of cytokines involved in Th-1 and Th-2 immunity, such as interleukins (IL) IL-2, IL-4, IL-8, IL-10, in...

    journal_title：Respiratory medicine

    pub_type： 杂志文章

    doi：10.1016/j.rmed.2005.06.016

    authors： Tsoutsou PG,Gourgoulianis KI,Petinaki E,Germenis A,Tsoutsou AG,Mpaka M,Efremidou S,Molyvdas PA

    更新日期：2006-05-01 00:00:00

  • Inhaled nedocromil sodium in symptomatic young children born prematurely.

    abstract：:The efficacy of a non-steroidal anti-inflammatory agent (nedocromil sodium, NS) has been assessed in young children born prematurely who had recurrent respiratory symptoms at follow-up. In a randomized, double-blind cross-over trial, either two puffs of NS (2 mg puff-1) or placebo were administered three times a day v...

    journal_title：Respiratory medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0954-6111(96)90173-0

    authors： Yüksel B,Greenough A

    更新日期：1996-09-01 00:00:00