Ulcerative colitis responsive to smoking and to nicotine chewing gum in a patient with alpha 1 anti-trypsin deficiency.


:Ulcerative colitis is one of the few diseases in which smoking appears to confer some benefit (1). We report a patient whose ulcerative colitis deteriorated on several occasions on stopping cigarettes, and improved on restarting smoking. As a result, she continued smoking despite developing airflow limitation and severe emphysema. She was subsequently found to have alpha 1 anti-trypsin deficiency. She later noticed that she could get a similar benefit in her colitis with nicotine chewing gum as she had with cigarettes. For patients with smoking-responsive ulcerative colitis, non-tobacco forms of nicotine delivery such as gum or transdermal patches should be considered to avoid the hazards of cigarette smoke.


Respir Med


Respiratory medicine


Watson JP,Lewis RA




Has Abstract


1995-10-01 00:00:00














  • Multiplex PCR for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila in community-acquired pneumonia.

    abstract::A multiplex polymerase chain reaction (PCR) was developed for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. Oligonucleotide primers for the amplification of the DNA of these three organisms were optimized for use in combination in the same reaction. PCR products ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Miyashita N,Saito A,Kohno S,Yamaguchi K,Watanabe A,Oda H,Kazuyama Y,Matsushima T,CAP Study Group.

    更新日期:2004-06-01 00:00:00

  • Identification of individuals with alpha-1-antitrypsin deficiency by a targeted screening program.

    abstract:BACKGROUND:Alpha-1-antitrypsin deficiency (AATD) is significantly underdiagnosed. The early detection of AATD would enable affected persons to make lifestyle changes such as quitting smoking. It was the aim of the study to determine whether the combination of an awareness program with the offer of a cost-free diagnosti...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Bals R,Koczulla R,Kotke V,Andress J,Blackert K,Vogelmeier C

    更新日期:2007-08-01 00:00:00

  • Tuberculosis case-finding in Western Australia.

    abstract::The records of a total of 497 patients notified to have active tuberculosis (TB) in Western Australia from 1986 to 1990 inclusive have been reviewed in relation to case-finding. Of these, 276 (55.5%) were Asian migrants, 92 (18.5%) Europeans and 110 (22.1%) Australians. The disease was confirmed bacteriologically in 2...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Pang SC,Harrison RH,Clayton AS,Mercer J,Brearley J

    更新日期:1994-03-01 00:00:00

  • Measurement validity of an electronic inspiratory loading device during a loaded breathing task in patients with COPD.

    abstract::We studied the validity of a recently introduced, handheld, electronic loading device in providing automatically processed information on external inspiratory work, power and breathing pattern during loaded breathing tasks in patients with COPD. Thirty-five patients with moderate to severe COPD performed an endurance ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Langer D,Jacome C,Charususin N,Scheers H,McConnell A,Decramer M,Gosselink R

    更新日期:2013-04-01 00:00:00

  • Human neutrophil lipocalin (HNL) and myeloperoxidase (MPO). Studies of lung lavage fluid and lung tissue.

    abstract::Myeloperoxidase (MPO) and human neutrophil lipocalin (HNL) are proteins which are stored in neutrophil granulocytes, in the primary and secondary granules, respectively. These granules or their contents of MPO and HNL are secreted upon activation of the cells, and measurement of these soluble markers in biological flu...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Schmekel B,Seveus L,Xu SY,Venge P

    更新日期:2000-06-01 00:00:00

  • One year nationwide evaluation of 24-locus MIRU-VNTR genotyping on Slovenian Mycobacterium tuberculosis isolates.

    abstract:BACKGROUND:Slovenia is one of the few countries where IS6110 RFLP is applied for genotyping M. tuberculosis at a nationwide level, which has been in effect since 2000. Based on S6110 RFLP clustering, typical risk factors and routes of M. tuberculosis transmission were identified, such as alcohol abuse, homelessness, an...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Bidovec-Stojkovic U,Zolnir-Dovc M,Supply P

    更新日期:2011-10-01 00:00:00

  • Utility of blood cultures in community-acquired pneumonia requiring hospitalization: influence of antibiotic treatment before admission.

    abstract::It has been previously shown that antibiotics given before hospitalization significantly reduce the proportion of positive blood cultures in community-acquired pneumonia (CAP). The aim of this prospective study was to compare the utility and cost-benefits of blood cultures in patients, hospitalized for moderate CAP, w...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Glerant JC,Hellmuth D,Schmit JL,Ducroix JP,Jounieaux V

    更新日期:1999-03-01 00:00:00

  • Relative therapeutic index between inhaled formoterol and salbutamol in asthma patients.

    abstract::A double-blind, randomized crossover study in 28 asthmatic patients assessed the relative therapeutic index for inhaled formoterol and salbutamol. Pre-drug administration FEV1 (mean 2.08 l) was 49-93% of predicted and reversibility 16-82% after inhalation of salbutamol. Patients inhaled single doses of formoterol (Oxi...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosenborg J,Larsson R,Rott Z,Böcskei C,Poczi M,Juhász G

    更新日期:2002-06-01 00:00:00

  • Subcutaneous emphysema secondary to pulmonary cavity in absence of pneumothorax or pneumomediastinum.

    abstract::Subcutaneous emphysema is a common condition occurring after chest injury. It may also be observed in association with pneumothorax or pneumomediastinum as a result of pathological changes in the respiratory tract. Spontaneous subcutaneous emphysema in absence of pneumothorax or pneumomediastinum is rare. We report a ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Pandey D,Jaret P,Sharma R,Sharma A,Thakur S

    更新日期:2007-02-01 00:00:00

  • Respiratory syncytial virus prophylaxis--the story so far.

    abstract::Respiratory syncytial virus (RSV) is a common and highly contagious pathogen that infects nearly all children by the age of 2 years. It is responsible for significant morbidity and mortality worldwide among certain high-risk paediatric populations. Therapy is sub-optimal for RSV, thus treatment focuses on ameliorating...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,评审


    authors: Simoes EA,Groothuis JR

    更新日期:2002-04-01 00:00:00

  • Inspired fraction of carbon dioxide in oxygen supply to chronic pulmonary disease.

    abstract::Hypoxemic patients with chronic obstructive pulmonary disease (COPD) are at risk of carbon dioxide (CO(2)) retention during oxygen therapy and hypercapnia in COPD is associated with an ominous prognosis. Rebreathing with oxygen mask is possible in practice and possibly affects CO(2) retention due to an increased inspi...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Fremault A,Silva M,Beaucage F,Berckmans D,Decramer M

    更新日期:2008-12-01 00:00:00

  • Advanced cryptogenic fibrosing alveolitis: preliminary report on treatment with cyclosporin A.

    abstract::Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the tre...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Alton EW,Johnson M,Turner-Warwick M

    更新日期:1989-07-01 00:00:00

  • Immunological consequences of three doses of heat-killed Mycobacterium vaccae in the immunotherapy of tuberculosis.

    abstract::We report the first study of triple-dose immunotherapy with heat-killed Mycobacterium vaccae (SRL 172) combined with short-course, directly observed chemotherapy in newly diagnosed pulmonary tuberculosis patients. The study was carried out in Rosario, Argentina, where single-dose immunotherapy with M. vaccae has previ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,随机对照试验


    authors: Dlugovitzky D,Fiorenza G,Farroni M,Bogue C,Stanford C,Stanford J

    更新日期:2006-06-01 00:00:00

  • Nocturnal oxygen and hypercapnic ventilatory response in patients with congestive heart failure.

    abstract::Patients with congestive heart failure and Cheyne-Stokes respiration have a low arterial oxygen saturation, especially during sleep, which can be increased by breathing oxygen. Chronic alterations in blood gases are known to modulate the hypercapnic ventilatory response (HCVR). We therefore evaluated whether the HCVR ...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Andreas S,von zur Mühlen F,Stevens J,Kreuzer H

    更新日期:1998-03-01 00:00:00

  • HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody.

    abstract:BACKGROUND:Anti-CADM-140 antibody (anti-CADM-140), also referred to as anti-melanoma differentiation-associated gene 5 (MDA5) antibody, is a myositis-specific antibody identified in the sera of patients with clinically amyopathic dermatomyositis (C-ADM) and is associated with a worse prognosis in dermatomyositis-associ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Tanizawa K,Handa T,Nakashima R,Kubo T,Hosono Y,Watanabe K,Aihara K,Oga T,Chin K,Nagai S,Mimori T,Mishima M

    更新日期:2011-09-01 00:00:00

  • Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer - a retrospective single institution analysis.

    abstract:PURPOSE:The aim of this retrospective study is to present data on clinical significance of lactate dehydrogenase (LDH) serum levels in an unselected contemporary patient population with small cell lung cancer (SCLC) in limited disease (LD) and extensive disease stage (ED). PATIENTS AND METHODS:From June 2004 to June 2...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Hermes A,Gatzemeier U,Waschki B,Reck M

    更新日期:2010-12-01 00:00:00

  • Direct medical costs of chronic obstructive pulmonary disease: chronic bronchitis and emphysema.

    abstract::In this study we aimed to estimate direct medical costs of Chronic Obstructive Pulmonary Disease (COPD) by disease type; chronic bronchitis and emphysema. This study estimates direct costs in 1996 dollars using a prevalence approach and both aggregate and microcosting. A societal perspective is taken using prevalence,...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Wilson L,Devine EB,So K

    更新日期:2000-03-01 00:00:00

  • Identifying patients at risk of late recovery (≥ 8 days) from acute exacerbation of chronic bronchitis and COPD.

    abstract:OBJECTIVES:To identify factors associated with late recovery (≥ 8 days from exacerbation start) in patients with acute exacerbations of chronic bronchitis/COPD (AECB/AECOPD). METHODS:An international, observational, non-interventional study in outpatients with AECB/AECOPD who received treatment for their exacerbation ...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Anzueto A,Miravitlles M,Ewig S,Legnani D,Heldner S,Stauch K

    更新日期:2012-09-01 00:00:00

  • Clara cell 16 protein in COPD sputum: a marker of small airways damage?

    abstract:RATIONALE:The development of chronic obstructive pulmonary disease (COPD) in smokers and their susceptibility to infections is not fully understood. Recent evidences suggest that Clara cells play a part in host defense, immunomodulatory response and airways remodelling through the production of specific factors such as...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Braido F,Riccio AM,Guerra L,Gamalero C,Zolezzi A,Tarantini F,De Giovanni B,Folli C,Descalzi D,Canonica GW

    更新日期:2007-10-01 00:00:00

  • Endobronchial metastasis from rectal adenocarcinoma.

    abstract::A case of endobronchial metastasis 2 yr following treatment of rectal carcinoma is presented. Endobronchial metastases from extrathoracic primary malignancies are uncommon, the estimated frequency and possible mechanisms underlying this complication are discussed. The importance of recognizing possible endobronchial m...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Lee YC,Wong CS,Jeffery GM

    更新日期:1997-04-01 00:00:00

  • A single high dose of formoterol is as effective as the same dose administered in a cumulative manner in patients with acute exacerbation of COPD.

    abstract::Several clinical trials have shown that the inhaled beta2-agonists with long-acting properties, formoterol and salmeterol, may be effective in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, there is a great deal of controversy regarding the timing and optimal dose of inhaled beta2-agonis...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cazzola M,Santus P,Matera MG,Carlucci P,Belloli E,Di Marco F,Centanni S

    更新日期:2003-05-01 00:00:00

  • The prevalence of asthma and wheezing illnesses amongst 10-year-old schoolchildren.

    abstract::Asthma and wheezing illnesses carry a significant burden of disease during childhood. Prevalence studies have the capacity to provide invaluable insights into the nature of these common conditions. As part of the Isle of Wight Whole Population Birth Cohort Study (n=1456) we have examined wheezing and asthma developmen...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Kurukulaaratchy RJ,Fenn M,Twiselton R,Matthews S,Arshad SH

    更新日期:2002-03-01 00:00:00

  • Exhaled hydrogen peroxide correlates with the release of reactive oxygen species by blood phagocytes in healthy subjects.

    abstract::Various cells including polymorphonuclear leukocytes, alveolar macrophages and type-II pneumocytes may be a source of exhaled hydrogen peroxide (H2O2) in airways of humans. H2O2 can convert into hydroxyl radicals leading to peroxidative damage of airways structures and formation of volatile thiobarbituric acid-reactiv...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Szkudlarek U,Maria L,Kasielski M,Kaucka S,Nowak D

    更新日期:2003-06-01 00:00:00

  • Trends in the prevalence of asthma, rhinitis, and eczema in 15 year old adolescents over an 8 year period.

    abstract:BACKGROUND:Trends in prevalence of asthma and allergic diseases are still controversial, and rarely studied among adolescents at midpoint of puberty. METHODS:In 2000, a questionnaire was mailed to adolescents (n = 18,158) attending 9th grade at school and living in Västra Götaland County, Sweden. Eight years later, th...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Kim JL,Brisman J,Aberg MA,Forslund HB,Winkvist A,Torén K

    更新日期:2014-05-01 00:00:00

  • Anti-endothelial cell antibodies in patients with interstitial lung diseases.

    abstract:BACKGROUND:Anti-endothelial cell antibodies (AECA) are circulating antibodies that bind to endothelial antigens and induce endothelial cell damage. AECA have been detected in patients with collagen vascular disease (CVD) and their presence is associated with interstitial lung disease (ILD) in cases of CVD. However, the...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Matsui T,Inui N,Suda T,Chida K

    更新日期:2008-01-01 00:00:00

  • Assessment of patient performance of the HandiHaler compared with the metered dose inhaler four weeks after instruction.

    abstract::The HandiHaler is a novel breath-actuated dry powder system designed for the delivery of tiotropium 18microg daily in the treatment of COPD. We compared patient ability to use the HandiHaler or metered dose inhaler (MDI) device correctly 4 weeks after receiving brief instructions and device demonstration. A single-bli...

    journal_title:Respiratory medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Dahl R,Backer V,Ollgaard B,Gerken F,Kesten S

    更新日期:2003-10-01 00:00:00

  • Prospective evaluation of pneumonia severity index in hospitalised patients with community-acquired pneumonia.

    abstract::The aim of the present study was to investigate whether the pneumonia severity index (PSI) could adequately predict the severity of community-acquired pneumonia (CAP) and could be used as a severity of illness classification system. Furthermore, reasons that may influence the decision to admit low risk patients were a...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: van der Eerden MM,de Graaff CS,Bronsveld W,Jansen HM,Boersma WG

    更新日期:2004-09-01 00:00:00

  • Inspiratory capacity predicts mortality in patients with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) severity is usually graded upon the FEV(1) reduction and FEV(1) has been considered the most important mortality predictor with age in COPD. Recent studies suggest other factors as more powerfully related to mortality than FEV(1) in COPD patients. AIM:To assess t...

    journal_title:Respiratory medicine

    pub_type: 杂志文章


    authors: Tantucci C,Donati P,Nicosia F,Bertella E,Redolfi S,De Vecchi M,Corda L,Grassi V,Zulli R

    更新日期:2008-04-01 00:00:00

  • Influence of salmeterol/fluticasone via single versus separate inhalers on exacerbations in severe/very severe COPD.

    abstract:BACKGROUND:Patients with severe or very severe chronic obstructive pulmonary disease (COPD) frequently suffer repeated exacerbations generating high health care utilization costs. Combined corticosteroid and bronchodilator treatment using a single inhaler might - via improved compliance - reduce exacerbation rates. OB...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hagedorn C,Kässner F,Banik N,Ntampakas P,Fielder K

    更新日期:2013-04-01 00:00:00

  • A comprehensive approach to lung function in bronchiectasis.

    abstract:BACKGROUND:International guidelines recommend simple spirometry for bronchiectasis patients. However, pulmonary pathophysiology of bronchiectasis is very complex and still poorly understood. Our objective was to characterize lung function in bronchiectasis and identify specific functional sub-groups. METHODS:This was ...

    journal_title:Respiratory medicine

    pub_type: 杂志文章,多中心研究


    authors: Radovanovic D,Santus P,Blasi F,Sotgiu G,D'Arcangelo F,Simonetta E,Contarini M,Franceschi E,Goeminne PC,Chalmers JD,Aliberti S

    更新日期:2018-12-01 00:00:00