Summing up 100 years of asthma.

abstract：:Myeloperoxidase (MPO) and human neutrophil lipocalin (HNL) are proteins which are stored in neutrophil granulocytes, in the primary and secondary granules, respectively. These granules or their contents of MPO and HNL are secreted upon activation of the cells, and measurement of these soluble markers in biological flu...

journal_title：Respiratory medicine

authors： Schmekel B,Seveus L,Xu SY,Venge P

更新日期：2000-06-01 00:00:00

abstract：:A study assessing the prevalence of respiratory symptoms in two primary schools in Birmingham, U.K. was performed. A questionnaire was delivered to pupils in both schools after which three open days were conducted in one of the schools, where probable asthmatics were identified and referred to their General Practition...

journal_title：Respiratory medicine

authors： Ayres JG,Pansari S,Weller PH,Sykes A,Williams J,Butler N,Low D

更新日期：1992-09-01 00:00:00

abstract：:We studied the effects of chronic nocturnal hypoxaemia due to obstructive sleep apnoea syndrome (OSAS) on the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-testicular axes and on catecholamine and cortisol secretion. We investigated whether hormones other than catecholamines may serve as markers for chroni...

journal_title：Respiratory medicine

authors： Bratel T,Wennlund A,Carlström K

更新日期：1999-01-01 00:00:00

abstract：:The principals of rehabilitation medicine are to prevent muscle atrophy and improve mobility. Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with muscle atrophy and yet many patients do not undergo pulmonary rehabilitation until they have been in stable health for some time. We investigat...

journal_title：Respiratory medicine

authors： Murphy N,Bell C,Costello RW

更新日期：2005-10-01 00:00:00

abstract：:We have recently found that changes in lung sounds correspond well with a 20% fall in the forced expiratory volume in 1 s (FEV1) after methacholine challenge in asthmatic children. Up to now, little was known about the agreement between a 20% fall in FEV1 and a change in lung sounds after repeated bronchial challenge....

journal_title：Respiratory medicine

authors： Sprikkelman AB,Schouten JP,Lourens MS,Heymans HS,van Aalderen WM

更新日期：1999-02-01 00:00:00

abstract：:Previous studies have shown that chronic hypoxia leads to changes in skeletal muscle structure (fibre size and type) and activities of several bioenergetic enzymes. Whether this occurs also in conditions characterised by intermittent hypoxia, such as the obstructive sleep apnoea syndrome (OSAS), is unknown. To explore...

journal_title：Respiratory medicine

authors： Sauleda J,García-Palmer FJ,Tarraga S,Maimó A,Palou A,Agustí AG

更新日期：2003-07-01 00:00:00

abstract：:Pneumocystis carinii colonization was studied in 90 men using the polymerase chain reaction. These comprised ten heterosexual controls; ten HIV-seronegative homosexual controls; 20 HIV-seropositive homosexuals with blood CD4 count > 400 x 10(6) l-1; 20 HIV-seropositive homosexuals with CD4 < 400 x 10(6) l-1; ten HIV-s...

journal_title：Respiratory medicine

authors： Leigh TR,Kangro HO,Gazzard BG,Jeffries DJ,Collins JV

更新日期：1993-10-01 00:00:00

abstract：RATIONALE:Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory approval and can be performed utilizing a simple disposable inhaler in a standardized manner. OBJECTIV...

journal_title：Respiratory medicine

authors： Nurmi HM,Lätti AM,Brannan JD,Koskela HO

更新日期：2019-01-01 00:00:00

abstract：:The first long-term study of sodium cromoglycate, reported in 1972, demonstrated the effectiveness of sodium cromoglycate in controlling asthma. The trial had various limitations, but more recent trials have been designed so that they overcome some of these problems. Results of these trials validate the results obtain...

journal_title：Respiratory medicine

authors： Turner-Warwick M

更新日期：1989-05-01 00:00:00

abstract：INTRODUCTION:Antibodies against mimivirus, a recently discovered giant virus, have been found in patients presenting with pneumonia suggesting a potential role for this virus as a respiratory pathogen. Several bacterial and viral pathogens have been associated with the occurrence of acute exacerbations in COPD. However...

journal_title：Respiratory medicine

authors： Vanspauwen MJ,Franssen FM,Raoult D,Wouters EF,Bruggeman CA,Linssen CF

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFE...

journal_title：Respiratory medicine

authors： Inui N,Suda T,Chida K

更新日期：2008-02-01 00:00:00

abstract：UNLABELLED:Misdiagnoses are inevitable when working hypotheses of asthma/COPD of General Practitioners (GPs) are not checked by spirometry. To reduce misdiagnoses, Asthma/COPD-support services (AC-services) offer support by performing spirometry assessed together with written medical history by consulting pulmonologist...

journal_title：Respiratory medicine

authors： Lucas AE,Smeenk FJ,Smeele IJ,van Schayck OP

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:IL-4 receptor alpha chain is crucial for the binding and signaling of IL-4, which mediates isotype switching and IgE production. The gene of IL-4 receptor alpha chain is a candidate gene for asthma and atopy. OBJECTIVES:To determine whether Ile50Val and Q576R polymorphisms of IL-4 receptor alpha chain gene ...

journal_title：Respiratory medicine

authors： Zhang W,Zhang X,Qiu D,Sandford A,Tan WC

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to estimate the societal costs and the key cost drivers for patients with severe asthma in Sweden. In addition, health-related quality of life (HRQOL) and morbidity of patients with severe asthma is described. METHODS:The study population comprised adults with severe asthma ...

journal_title：Respiratory medicine

authors： Jansson SA,Backman H,Andersson M,Telg G,Lindberg A,Stridsman C,Lundbäck B,Rönmark E

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Idiopathic bronchiectasis is a poorly defined disease characterised by persistent inflammation, infection and progressive lung damage. Natural killer (NK) cells provide a major defense against infection, through the interaction of their surface receptors, including the activating and inhibitory killer immu...

journal_title：Respiratory medicine

authors： McDonnell MJ,Anwar GA,Rutherford RM,De Soyza A,Worthy S,Corris PA,Lordan JL,Bourke S,Afolabi G,Ward C,Middleton P,Middleton D

更新日期：2014-08-01 00:00:00

abstract：:Inhalation of organic dust from a swine-confinement building leads to an intense inflammatory reaction with an increased number of inflammatory cells and mediators in the upper and lower respiratory tract of previously unexposed subjects. In vitro the dust induces cytokine release from epithelial cells and alveolar ma...

journal_title：Respiratory medicine

authors： Burvall K,Palmberg L,Larsson K

更新日期：2003-01-01 00:00:00

abstract：:Recent developments in intrabronchial administration of insulin raise lung function in patients with type I diabetes as important issue. Several studies in adults report abnormalities of lung function of these patients. The aim of this study was to investigate lung function in children with type I diabetes. Twenty-sev...

journal_title：Respiratory medicine

authors： van Gent R,Brackel HJ,de Vroede M,van der Ent CK

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Having a child with a chronic disease may cause anxiety and depression and impair the sleep quality in the mothers. The aim of this study was to evaluate sleep quality in asthmatic children and their mothers as well as the status of anxiety-depression in the mothers. METHODS:Study group consisted of 75 asth...

journal_title：Respiratory medicine

authors： Yuksel H,Sogut A,Yilmaz O,Demet M,Ergin D,Kirmaz C

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Although theophylline has been shown to have anti-inflammatory effects, the therapeutic use of theophylline before sepsis is unknown. The aim of our study was to determine the effect of theophylline on COPD patients presenting with sepsis. METHODS:This nationwide, population-based, propensity score-matched ...

journal_title：Respiratory medicine

authors： Shih YN,Chen YT,Chu H,Shih CJ,Ou SM,Hsu YT,Chen RC,Quraishi SA,Aisiku IP,Seethala RR,Frendl G,Hou PC

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Recent studies have shown strong evidence that bronchiolitis obliterans is the major long-term sequelae of exposure to sulfur mustard (SM). This study is the first to examine the histopathologic spectrum of changes in a large number of surgical lung biopsies from patients exposed to SM. METHOD:Fifteen patie...

journal_title：Respiratory medicine

authors： Ghanei M,Tazelaar HD,Chilosi M,Harandi AA,Peyman M,Akbari HM,Shamsaei H,Bahadori M,Aslani J,Mohammadi A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Omalizumab is a recombinant humanized monoclonal anti-IgE antibody approved in adults and adolescents with moderate-to-severe persistent allergic asthma inadequately controlled with inhaled corticosteroids (ICS). EXCELS is an ongoing prospective observational cohort study of approximately 5000 omalizumab-tre...

journal_title：Respiratory medicine

authors： Chen H,Eisner MD,Haselkorn T,Trzaskoma B

更新日期：2013-01-01 00:00:00

abstract：:Intrapulmonary percussive ventilation (IPV) is a ventilatory technique that delivers bursts of high-flow respiratory gas into the lung at high rates, intended for treating acute respiratory failure and for mobilization of secretions. We performed a study, aimed at assessing the physiological response to IPV, on patien...

journal_title：Respiratory medicine

authors： Nava S,Barbarito N,Piaggi G,De Mattia E,Cirio S

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Bacteria expressing phosphorylcholine (ChoP) co-opt host-expressed platelet-activating factor receptor (PAFR) to adhere to lower airway cells. Cigarette smoke and rhinovirus (RV) infection upregulate PAFR-dependent bacterial adhesion to airway cells in vitro, and in healthy adults smoking increases the propo...

journal_title：Respiratory medicine

authors： Suri R,Mallia P,Martin JE,Footitt J,Zhu J,Trujillo-Torralbo MB,Johnston SL,Grigg J

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:In studies of idiopathic pulmonary fibrosis (IPF), whites makeup the vast majority of subjects. Whether ethnic/racial differences in idiopathic pulmonary fibrosis occur in the general population is unknown. METHODS:To compare the presence of IPF between ethnic/racial groups of U.S. decedents from 1989 to 20...

journal_title：Respiratory medicine

authors： Swigris JJ,Olson AL,Huie TJ,Fernandez-Perez ER,Solomon J,Sprunger D,Brown KK

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. ...

journal_title：Respiratory medicine

authors： Jacob J,Odink A,Brun AL,Macaluso C,de Lauretis A,Kokosi M,Devaraj A,Desai S,Renzoni E,Wells AU

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To improve physicians' ability to discriminate tuberculous from malignant pleural effusions through a simple clinical algorithm that avoids pleural biopsy. DESIGN:We retrospectively compared the clinical and pleural fluid features of 238 adults with pleural effusion who satisfied diagnostic criteria for tube...

journal_title：Respiratory medicine

authors： Porcel JM,Alemán C,Bielsa S,Sarrapio J,Fernández de Sevilla T,Esquerda A

更新日期：2008-08-01 00:00:00

abstract：:Aminophylline administration was compared in 43 patients who died from asthma and 43 matched controls who were admitted, suffering from acute asthma, to hospitals in the North East Thames Region. A computer program, which used information about individual characteristics, medical history and drug intake, was employed ...

journal_title：Respiratory medicine

authors： Eason J,Markowe HL

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Asthmatic symptoms usually can be controlled with corticosteroids, but partly asthmatic patients do not respond to corticosteroids, steroid resistance (SR) play a significant role in the poorly responding. However, no approach can accurately predict steroid responsiveness in asthma patients, so prediction of...

journal_title：Respiratory medicine

authors： Jiang H,Chi X,Zhang X,Wang J

更新日期：2016-05-01 00:00:00

abstract：:Patients with congestive heart failure and Cheyne-Stokes respiration have a low arterial oxygen saturation, especially during sleep, which can be increased by breathing oxygen. Chronic alterations in blood gases are known to modulate the hypercapnic ventilatory response (HCVR). We therefore evaluated whether the HCVR ...

journal_title：Respiratory medicine

authors： Andreas S,von zur Mühlen F,Stevens J,Kreuzer H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Exhaled breath condensate (EBC) is simple to collect and as such a non-invasive method that has attracted substantial interest in the last few years. However, several methodological concerns have been raised and it has been difficult to reproduce results between different centres. Because of low concentratio...

journal_title：Respiratory medicine

authors： Tufvesson E,Bjermer L

更新日期：2006-01-01 00:00:00