Abstract：
:Patients with congestive heart failure and Cheyne-Stokes respiration have a low arterial oxygen saturation, especially during sleep, which can be increased by breathing oxygen. Chronic alterations in blood gases are known to modulate the hypercapnic ventilatory response (HCVR). We therefore evaluated whether the HCVR is influenced by nocturnal nasal oxygen in patients with heart failure and Cheyne-Stokes respiration. Twenty patients with chronic congestive heart failure and a left ventricular ejection fraction < or = 35% (mean 18.3% +/- SD 6.0%) as well as 25 healthy control subjects were studied. The patients were assigned to 1 week each of nocturnal nasal oxygen and room air with a flow of 41 min-1 in a randomized cross-over fashion. After each week resting ventilation and HCVR were evaluated by the rebreathing technique. Breathing oxygen during the night for 1 week increased the basal nocturnal oxygen saturation from 92.5% +/- 1.6% to 96.5% +/- 0.9% (P < 0.000,01) and reduced Cheyne-Stokes respiration. HCVR was 1.22 +/- 0.90 l min-1 mmHg-1 after nocturnal room air and did not differ from that in the control subjects (1.31 +/- 0.62 l min-1 mmHg-1). In the patients HCVR decreased to 0.91 +/- 0.52 l min-1 mmHg-1 after nocturnal oxygen (P = 0.019). There were no significant changes with nocturnal oxygen in resting minute ventilation, respiratory rate or end-tidal PCO2. We conclude that nocturnal nasal oxygen reduces HCVR in patients with congestive heart failure and Cheyne-Stokes respiration.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Andreas S,von zur Mühlen F,Stevens J,Kreuzer Hdoi
10.1016/s0954-6111(98)90286-4subject
Has Abstractpub_date
1998-03-01 00:00:00pages
426-31issue
3eissn
0954-6111issn
1532-3064pii
S0954-6111(98)90286-4journal_volume
92pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Interleukin-32(IL-32)γ is a pro-inflammatory cytokine involved in the development and severity of chronic inflammatory diseases, but its role in asthma is unclear. OBJECTIVE:This study was conducted to evaluate the relationship of IL-32γ levels in sputum with the severity of asthma. METHODS:IL-32γ levels i...
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2018-03-01 00:00:00
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