Abstract:
:Gemcitabine is a newer pyrimidine analog used for the treatment of solid tumors. Though generally considered safe, it can cause pulmonary toxicity, which is generally mild and reversible. The purpose of this publication is to document a case of adult respiratory distress syndrome (ARDS) caused by Gemcitabine administration. The patient was noticed to have the extreme elevation of erythrocyte sedimentation rate (ESR) (> 100 mm/h) at the time of diagnosis. We observed excellent response to the corticosteroids. The ESR trended back to normal after the resolution of her symptoms thereby suggesting the utility of monitoring ESR in the diagnosis and management of Gemcitabine-induced pulmonary toxicity.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Davidoff S,Shah RD,Arunabh Tdoi
10.1016/j.rmed.2005.08.002subject
Has Abstractpub_date
2006-04-01 00:00:00pages
760-3issue
4eissn
0954-6111issn
1532-3064pii
S0954-6111(05)00325-2journal_volume
100pub_type
杂志文章abstract:BACKGROUND:Treatment with an inhaled corticosteroid (ICS) and long-acting bronchodilator is recommended for severe/very severe chronic obstructive pulmonary disease (COPD) patients with repeated exacerbations. This randomized, double-blind, double-dummy, parallel-group, 12-month multicenter study evaluated the effect o...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rmed.2011.07.020
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Klotho is an 'anti-ageing' hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smokers including emphysema and muscle wasting. The objective of this study was to evaluate skeletal muscle and circulating Klotho protein in smokers and COPD patients and to relate Kloth...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2016.02.004
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Stepping down from combination asthma therapy (inhaled corticosteroids (ICS) + long-acting β2 agonists (LABA)) is often avoided due to fear of exacerbations, which may lead to overmedication in well-controlled asthma. A better knowledge about the predictors of outcome might encourage clinicians to start step...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章
doi:10.1016/j.rmed.2016.06.010
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:The possible effect of the various meteorological variables on the incidence of upper and lower respiratory tract infections (RTIs) has intrigued the scientific community for decades. METHODS:We performed a retrospective analysis regarding the association between meteorological variables and clinical data fo...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.12.010
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Given the observed association between smoking, inflammation and airway hyperresponsiveness (AHR) one may predict that smoking cessation may improve AHR. However, only a few studies have investigated the effect of smoking on AHR and their results appear to be conflicting depending on the stimulus used in the...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.09.004
更新日期:2008-02-01 00:00:00
abstract::We have proposed a clinical treatment guideline for the management of acute, severe asthma and chronic obstructive pulmonarydisease (COPD) using the principles of evidence-based medicine. The content is based upon practical clinical issues in need of consensus. A previous study has shown that this particular area is i...
journal_title:Respiratory medicine
pub_type: 指南,杂志文章,实务指引
doi:10.1053/rmed.2002.1332
更新日期:2002-09-01 00:00:00
abstract::Maximal inspiratory (PImax) and expiratory (PEmax) mouth pressures were measured in seven normal adults in both sitting and half-lying positions on 2 days. Analysis of variance did not reveal significant differences between measurements made in the two positions for either PImax or PEmax. Measurements were repeatable ...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0954-6111(06)80081-8
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Tracheal collapse is a weakness of the tracheal wall leading to expiratory central airway collapse of more than 50% compared to inspiration. It has previously been discussed whether the collapsibility of the greater airways is a stable or a dynamic condition. Indeed, other well-known lung diseases such as as...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2018.11.018
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:For patients with idiopathic pulmonary fibrosis (IPF), there is limited real-world data on patient journey and treatment patterns. AIM:To explore predictors of early diagnosis and treatment initiation, and treatment patterns in IPF patients using linked data from Swedish registers and electronic medical rec...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2019.06.001
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Asthma treatment per Global Initiative for Asthma (GINA) guidelines targets airway remodeling and achievement of normal lung function. OBJECTIVE:To study inhaled steroid therapy on airway remodeling and achievement of normal lung function. SUBJECTS AND SET UP: Asthmatic patients were followed over 5 years ....
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2005.06.011
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Supplemental oxygen is a recommended therapy option in stable hypoxemic COPD patients. Often, supplemental oxygen is provided by continuous flow (CF). However, demand oxygen delivery systems (DODS) that provide an oxygen bolus only during inspiration have gained increasing use as they prolong oxygen cylinder...
journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2019.08.001
更新日期:2019-09-01 00:00:00
abstract::Measurement of exhaled nitric oxide is widely used in respiratory research and clinical practice, especially in patients with asthma. However, interpretation is often difficult, due to common interfering factors, and little is known about interactions between factors. We assessed the influences and interactions of fac...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2008.02.012
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:The choice of inhaler device for asthma patients depends upon multiple attributes. We investigated factors that may drive general practitioners (GPs) and respiratory specialists in the prescription of inhaler devices for asthma patients who initiated inhalation therapy. METHODS:We retrospectively analysed p...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2020.105937
更新日期:2020-05-01 00:00:00
abstract::The prevalence of preferential nasal breathing was studied in an awake adult population. One hundred and ninety-four people consented to gentle manual compression of the nostrils. They were advised to 'breathe in and out', but no further information regarding breathing was given to avoid influencing the patient. One h...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/0954-6111(93)90026-v
更新日期:1993-05-01 00:00:00
abstract::Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rmed.2007.11.002
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:In patients with chronic obstructive pulmonary disease (COPD), energy expenditure (EE) assessment during the performance of daily activities is not yet studied in depth. The aim of this study was to determine which daily activities are more demanding to patients with COPD and to compare the accuracy of EE es...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2011.01.004
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:Older patients are the most prevalent age cohort requiring bronchoscopy. Prior sedation should be offered to improve patient comfort and operator technical ease. Older patients have increased sensitivity to centrally acting drugs increasing the procedural risk. This perceived risk may limit access to bronc...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rmed.2004.06.002
更新日期:2005-02-01 00:00:00
abstract::Fluticasone propionate pressurized metered dose inhalers (pMDIs) containing the hydrofluoroalkane (HFA) propellant, HFA 134a, are being developed to replace existing chlorofluorocarbon (CFC) pMDIs. This is part of the ongoing worldwide project to limit the damage to the earth's ozone layer. The in vivo performance and...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) are responsible for a high utilisation of the health care resources, and the cost is expected to increase. Physiological measures of lung function often fail to describe the impact the symptoms have on exacerbations, days of hospitalisation, and on a...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.09.020
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma. MATERIAL AND METHODS:Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohort...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2017.10.010
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:To analyse the relationship between symptoms at different times during the 24-hour day and outcomes in COPD. METHODS:Observational cross-sectional study in a patients from 7 Latin American countries. The frequency of symptoms in the morning, at night and during the day was explored by means of standardised ...
journal_title:Respiratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rmed.2017.11.018
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:We aimed to investigate the results of anti-tumor necrosis factor (TNF) therapy in patients with a previous history of tuberculosis (TB). METHODS:A total of 101 patients with a previous history of TB receiving TNF antagonists between December 2004 and September 2012 at the Asan Medical Center in South Korea...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.08.011
更新日期:2013-11-01 00:00:00
abstract::Several clinical trials have shown that the inhaled beta2-agonists with long-acting properties, formoterol and salmeterol, may be effective in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, there is a great deal of controversy regarding the timing and optimal dose of inhaled beta2-agonis...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/rmed.2002.1456
更新日期:2003-05-01 00:00:00
abstract::Smoking and body mass index (BMI) are well-documented risk factors that contribute substantially to chronic obstructive pulmonary disease (COPD) and asthma. However, the relations among smoking, obesity, and COPD or asthma remain to be clarified. We conducted a population-based cross-sectional epidemiologic study to e...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2013.04.021
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Slovenia is one of the few countries where IS6110 RFLP is applied for genotyping M. tuberculosis at a nationwide level, which has been in effect since 2000. Based on S6110 RFLP clustering, typical risk factors and routes of M. tuberculosis transmission were identified, such as alcohol abuse, homelessness, an...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/S0954-6111(11)70014-2
更新日期:2011-10-01 00:00:00
abstract::Inhalation of dust in swine confinement buildings causes airway inflammation and systemic symptoms. The proinflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) increase in bronchoalveolar and nasal lavage fluid, and in serum. The aim of this investigation was to study changes in the...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/s0954-6111(98)90349-3
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:There is little information available on the features of initial presentation of bronchiectasis and documentation of the onset and progress of symptoms leading up to this. Therefore a study was performed on a large cohort of adult patients presenting to Monash Medical Centre (MMC) to survey the course of the...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.03.012
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Bronchiectasis is a common disabling but rarely fatal disease. However the long-term prognosis and risk factors for mortality are not well known. OBJECTIVE:The aim of this study was to determine prospectively the survival and predictive factors of mortality in patients with bronchiectasis, during 4-year fol...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.02.002
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To assess the incidence and determinants of the triple inhaled therapy in chronic obstructive pulmonary disease (COPD) primary care patients. METHODS:Data derived from the Health Search Database (HSD) gathering information on 700 Italian general practitioners. A cohort of COPD patients, prescribed for the fi...
journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2019.05.022
更新日期:2019-01-01 00:00:00
abstract::This multi-centre, randomized, double-blind, double-dummy, parallel-group study was designed to investigate the hypothesis of equivalent efficacy and comparable safety of two inhaled presentations of salmeterol/fluticasone propionate combination product (SALM/FP) 50/100 microg administered twice daily to patients with...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/rmed.2000.1008
更新日期:2001-02-01 00:00:00