Increased angiogenic factors in exhaled breath condensate of children with severe asthma - New markers of disease progression?

abstract：:The 72 kDa matrix metalloproteinase (MMP-2) and the 92 kDa matrix metalloproteinase (MMP-9), are type IV collagenases that have been implicated as important factors in cancer invasion and metastasis formation. We have used quantitative zymography and computer-assisted image analysis to measure the levels of MMP-9 and ...

journal_title：Respiratory medicine

authors： Hrabec E,Strek M,Nowak D,Hrabec Z

更新日期：2001-01-01 00:00:00

abstract：:Several clinical trials have shown that the inhaled beta2-agonists with long-acting properties, formoterol and salmeterol, may be effective in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, there is a great deal of controversy regarding the timing and optimal dose of inhaled beta2-agonis...

journal_title：Respiratory medicine

authors： Cazzola M,Santus P,Matera MG,Carlucci P,Belloli E,Di Marco F,Centanni S

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:To provide optimal care for patients with chronic obstructive pulmonary disease physicians need to understand if their patients benefit from an intervention. The objective of this study was to assess agreement between patients and physicians on health-related quality of life (HRQL) changes in response to r...

journal_title：Respiratory medicine

authors： Puhan MA,Behnke M,Devereaux PJ,Montori VM,Braendli O,Frey M,Schünemann HJ

更新日期：2004-12-01 00:00:00

abstract：:The value of continuous positive airway pressure (CPAP) ventilation via a tight fitting face mask was assessed in eight HIV-1 antibody-positive patients with Pneumocystis carinii pneumonia who were in hypoxaemic respiratory failure. All patients were conscious, able to protect their airway and not hypercapnic. Treatme...

journal_title：Respiratory medicine

authors： Miller RF,Semple SJ

更新日期：1991-03-01 00:00:00

abstract：:Invariant natural killer T (NKT) cells might contribute to the amplified and prolonged T-cell immune response that characterizes sarcoidosis. Therefore, we want to investigate the frequency and distribution of pulmonary invariant NKT cells in corticosteroid-naïve patients with sarcoidosis. We used multi-parameter flow...

journal_title：Respiratory medicine

authors： Korosec P,Rijavec M,Silar M,Kern I,Kosnik M,Osolnik K

更新日期：2010-04-01 00:00:00

abstract：:Systemic inflammation may be present in patients with chronic obstructive pulmonary disease (COPD). Exercise is known to elicit an inflammatory response. We hypothesized that the systemic inflammatory response to exercise might be exaggerated in COPD patients compared to healthy subjects. Sixteen COPD patients and 11 ...

journal_title：Respiratory medicine

authors： van Helvoort HA,van de Pol MH,Heijdra YF,Dekhuijzen PN

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Small fiber neuropathy commonly affects patients with sarcoidosis and is often refractory to standard immunosuppressive therapies used for systemic disease. The clinical features of sarcoidosis-associated small fiber neuropathy (SSFN) and its response to medical therapy have not been described in a large popu...

journal_title：Respiratory medicine

authors： Tavee JO,Karwa K,Ahmed Z,Thompson N,Parambil J,Culver DA

更新日期：2017-05-01 00:00:00

abstract：:Gemcitabine is a newer pyrimidine analog used for the treatment of solid tumors. Though generally considered safe, it can cause pulmonary toxicity, which is generally mild and reversible. The purpose of this publication is to document a case of adult respiratory distress syndrome (ARDS) caused by Gemcitabine administr...

journal_title：Respiratory medicine

authors： Davidoff S,Shah RD,Arunabh T

更新日期：2006-04-01 00:00:00

abstract：:Long-acting bronchodilators in combination with inhaled corticosteroids (ICS) are recommended to decrease the risk of recurrent exacerbations in patients with Global initiative for chronic Obstructive Lung Disease (GOLD) stage 3-4 chronic obstructive pulmonary disease (COPD). There is increasing concern about the clin...

journal_title：Respiratory medicine

authors： Magnussen H,Watz H,Kirsten A,Decramer M,Dahl R,Calverley PM,Towse L,Finnigan H,Tetzlaff K,Disse B

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Multiple criteria have been proposed to define community-acquired pneumonia (CAP) severity and predict ICU admission. Validity studies have found differing results. We tested four models to assess severe CAP built upon the criteria included in the 2007 IDSA/ATS guidelines, hypothesizing that a model providin...

journal_title：Respiratory medicine

authors： Gearhart AM,Furmanek S,English C,Ramirez J,Cavallazzi R

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate the efficacy and safety of ciclesonide compared with budesonide in adolescents with severe asthma. METHODS:In this randomized, double-blind, double-dummy, parallel-group study, patients aged 12-17 years with severe asthma were treated with budesonide 400 microg once d...

journal_title：Respiratory medicine

authors： Vermeulen JH,Gyurkovits K,Rauer H,Engelstätter R

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Intermittent ICS treatment with SABA in response to symptoms, is an emerging strategy for control of mild-to-moderate asthma, and recurrent wheezing. This systematic revue compares the efficacy of daily vs. intermittent ICS among preschoolers, children and adults with persistent wheezing and mild to moderate...

journal_title：Respiratory medicine

authors： Rodrigo GJ,Castro-Rodríguez JA

更新日期：2013-08-01 00:00:00

abstract：:The objective of this study was to describe asthma exacerbation self-management in children and adolescents. We used a cross-sectional study population enrolled in the International Study of Asthma and Allergies in Childhood (ISAAC) in Bordeaux. Subjects answered an additional questionnaire on utilization of health se...

journal_title：Respiratory medicine

authors： Raherison C,Tunon-de-Lara JM,Vernejoux JM,Taytard A

更新日期：2000-11-01 00:00:00

abstract：:This study aimed to evaluate the utility of the pleural fluid lactate dehydrogenase (LDH) isoenzyme algorithm for the differential diagnosis of pleural fluid in patients with haematological malignancies. Twenty consecutive haemato-oncological patients with pleural effusion, hospitalized in the Haematology Department d...

journal_title：Respiratory medicine

authors： Lossos IS,Intrator O,Berkman N,Breuer R

更新日期：1999-05-01 00:00:00

abstract：:Long-term oxygen therapy (LTOT) in patients with chronic hypoxaemia is an expanding field. Traditional stationary oxygen, with and without portable compressed gas cylinders, and portable liquid oxygen equipment is available today. No official guidelines exist for the prescription of liquid oxygen vs traditional oxygen...

journal_title：Respiratory medicine

authors： Schaanning J,Strøm K,Boe J

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Myeloid and plasmacytoid dendritic cell (DC) subsets have been recently identified in the human lung based on their differential expression of Blood DC Antigens 1-3 (BDCAs). We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells. METHODS:Using an i...

journal_title：Respiratory medicine

authors： Tsoumakidou M,Kemp SJ,Thorley AJ,Zhu J,Dewar A,Jeffery PK,Tetley TD

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To investigate impact of distribution of computed tomography (CT) emphysema on severity of airflow limitation and gas exchange impairment in current and former heavy smokers participating in a lung cancer screening trial. MATERIALS AND METHODS:In total 875 current and former heavy smokers underwent baseline lo...

journal_title：Respiratory medicine

authors： Gietema HA,Zanen P,Schilham A,van Ginneken B,van Klaveren RJ,Prokop M,Lammers JW

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical feature...

journal_title：Respiratory medicine

authors： Varone F,Friello L,Di Blasi C,Sgalla G,Luigetti M,Iovene B,Richeldi L,Della Marca G,Brunetti V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Combination therapy should be prescribed to patients with moderate to severe asthma after daily long-term treatment with inhaled inhaled corticosteroids (ICS) has been tried without obtaining adequate control and it is not indicated to be used as first line treatment in asthma. OBJECTIVES:To describe the us...

journal_title：Respiratory medicine

authors： Breton MC,Lelorier J,Forget A,Blais L

更新日期：2007-09-01 00:00:00

abstract：:The aim of the study was to investigate which features predict favourable response to omeprazole therapy in asthmatics with gastro-oesophageal reflux (GER). The study population consisted of 52 outpatient asthmatics with GER who had completed an intervention where they were randomized to receive omeprazole 40 mg once ...

journal_title：Respiratory medicine

authors： Kiljander T,Salomaa ER,Hietanen E,Helenius H,Liippo K,Terho EO

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to estimate the societal costs and the key cost drivers for patients with severe asthma in Sweden. In addition, health-related quality of life (HRQOL) and morbidity of patients with severe asthma is described. METHODS:The study population comprised adults with severe asthma ...

journal_title：Respiratory medicine

authors： Jansson SA,Backman H,Andersson M,Telg G,Lindberg A,Stridsman C,Lundbäck B,Rönmark E

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:An Expert Forum was held at the 2014 European Respiratory Society International Congress to address issues involved in the management of Pseudomonas aeruginosa infection in patients with non-cystic fibrosis bronchiectasis (NCFB). Multiple studies have found that chronic P. aeruginosa infection is associated ...

journal_title：Respiratory medicine

authors： Wilson R,Aksamit T,Aliberti S,De Soyza A,Elborn JS,Goeminne P,Hill AT,Menendez R,Polverino E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:During military service young men (age 19-21 years) are exposed to many predisposing factors for asthma. We aimed to study the short-term prognosis of asthma after the military service. METHODS:All 216 men with verified asthma in 2004-2005 from the register of the Central Military Hospital were included in ...

journal_title：Respiratory medicine

authors： Lindström I,Koponen P,Luukkonen R,Pallasaho P,Kauppi P,Latvala J,Karjalainen A,Lauerma A

更新日期：2009-12-01 00:00:00

abstract：:The aim of the present study was to investigate whether the pneumonia severity index (PSI) could adequately predict the severity of community-acquired pneumonia (CAP) and could be used as a severity of illness classification system. Furthermore, reasons that may influence the decision to admit low risk patients were a...

journal_title：Respiratory medicine

authors： van der Eerden MM,de Graaff CS,Bronsveld W,Jansen HM,Boersma WG

更新日期：2004-09-01 00:00:00

abstract：:Metered dose inhalers (MDIs) are the mainstay of inhaled steroid therapy for asthma. With the phasing out of traditional chlorofluorocarbon (CFC) propellants and their replacement with a new generation of CFC-free products, it is becoming clear that formulation and inhaler characteristics can markedly affect the drug ...

journal_title：Respiratory medicine

authors： Shaw RJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature. AIM:To estimate the prevalence of COPD as defined by British Thoracic Society (BTS) criteria and the recent global initiative for chroni...

journal_title：Respiratory medicine

authors： Lundbäck B,Lindberg A,Lindström M,Rönmark E,Jonsson AC,Jönsson E,Larsson LG,Andersson S,Sandström T,Larsson K,Obstructive Lung Disease in Northern Sweden Studies.

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Severe asthma is a heterogeneous disease. Patients with both eosinophilic and allergic asthma phenotypes may be eligible for treatment with mepolizumab and omalizumab. Evidence on the relative effectiveness of these treatments in this 'overlap' population would be informative for clinical and payer decision ...

journal_title：Respiratory medicine

authors： Cockle SM,Stynes G,Gunsoy NB,Parks D,Alfonso-Cristancho R,Wex J,Bradford ES,Albers FC,Willson J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The choice of inhaler device for asthma patients depends upon multiple attributes. We investigated factors that may drive general practitioners (GPs) and respiratory specialists in the prescription of inhaler devices for asthma patients who initiated inhalation therapy. METHODS:We retrospectively analysed p...

journal_title：Respiratory medicine

authors： Lavorini F,Bianco A,Blasi F,Braido F,Corsico AG,Di Marco F,Gentile A,Paggiaro PL,Pegoraro V,Pelaia G,Rogliani P,Santus P,Scichilone N,Soldi A,Canonica GW

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Continuous, non-invasive assessment of alveolar ventilation achieved by transcutaneous PCO(2) (PtcCO(2)) monitoring is clearly superior to intermittent, invasive blood gas analyses in patients receiving nocturnal non-invasive positive pressure ventilation (NPPV), but the reliability and accuracy of PtcCO(2)-...

journal_title：Respiratory medicine

authors： Storre JH,Magnet FS,Dreher M,Windisch W

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Almost all international guidelines recommend corticosteroids for management of exacerbations of chronic obstructive pulmonary disease (COPD), because it leads to improved outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Nevertheless, due to its side effects, there are still...

journal_title：Respiratory medicine

authors： Ding Z,Li X,Lu Y,Rong G,Yang R,Zhang R,Wang G,Wei X,Ye Y,Qian Z,Liu H,Zhu D,Zhou R,Zhu K,Ni R,Xia K,Luo N,Pei C

更新日期：2016-12-01 00:00:00