Modulite technology: pharmacodynamic and pharmacokinetic implications.

abstract：:Patients with congestive heart failure and Cheyne-Stokes respiration have a low arterial oxygen saturation, especially during sleep, which can be increased by breathing oxygen. Chronic alterations in blood gases are known to modulate the hypercapnic ventilatory response (HCVR). We therefore evaluated whether the HCVR ...

journal_title：Respiratory medicine

authors： Andreas S,von zur Mühlen F,Stevens J,Kreuzer H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial capacitance (PAC) is a strong hemodynamic predictor of outcomes in patients with pulmonary hypertension (PH). Its value across subgroups of race/ethnicity, sex, and PH etiologies is unclear. We hypothesized that the association of PAC with outcomes would not vary across World Health Organi...

journal_title：Respiratory medicine

authors： Mayfield JJ,Papolos A,Vasti E,De Marco T,Tison GH

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:This study evaluated the tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in patients with COPD. METHODS:This double-blind, placebo-controlled study (NCT00629239) randomised patients with moderate to severe COPD to AZD4818 300mug or placebo twice daily via Turbuhaler((R)) for 4 weeks. Safety,...

journal_title：Respiratory medicine

authors： Kerstjens HA,Bjermer L,Eriksson L,Dahlström K,Vestbo J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Traditionally, outpatient visits for COPD are fixed, pre-planned by the pulmonologist. This is not a patient centered method, nor, in times of increasing COPD prevalence and resource constraints, perhaps the optimal method. OBJECTIVES:This pilot study, determined the effect of an on-demand-system, patient i...

journal_title：Respiratory medicine

authors： Berkhof FF,Hesselink AM,Vaessen DL,Uil SM,Kerstjens HA,van den Berg JW

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:According to current GOLD strategy, patients with COPD classified as groups A and B may be treated with inhaled bronchodilators, either long-acting β2-agonist (LABA) or long-acting muscarinic antagonist (LAMA). However, there is little guidance on which class of agent is preferred and a lack of prospective...

journal_title：Respiratory medicine

authors： Mahler DA,Kerstjens HA,Donohue JF,Buhl R,Lawrence D,Altman P

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:This randomized, double-blind, placebo-controlled, cross-over, Phase II dose-ranging study investigated the efficacy and safety of GP MDI (glycopyrronium administered by metered dose inhaler formulated using co-suspension delivery technology) compared with an open-label active comparator, salmeterol dry powd...

journal_title：Respiratory medicine

authors： Kerwin E,Wachtel A,Sher L,Nyberg J,Darken P,Siddiqui S,Duncan EA,Reisner C,Dorinsky P

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Allergic rhino-conjunctivitis is a highly prevalent condition. In moderate to severe cases, allergen immunotherapy (AIT) is a cost-effective therapeutic option. Previous data have reported a large difference in treatment compliance of subcutaneously (SCIT) and sublingually (SLIT) administered AIT. METHODS...

journal_title：Respiratory medicine

authors： Borg M,Løkke A,Hilberg O

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Intermittent ICS treatment with SABA in response to symptoms, is an emerging strategy for control of mild-to-moderate asthma, and recurrent wheezing. This systematic revue compares the efficacy of daily vs. intermittent ICS among preschoolers, children and adults with persistent wheezing and mild to moderate...

journal_title：Respiratory medicine

authors： Rodrigo GJ,Castro-Rodríguez JA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Mortality correlates with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria of airway obstruction. Yet, little data exist concerning the long-term survival of patients presenting with different levels of obstruction. METHODS:We studied the association between all-cause and cause-spe...

journal_title：Respiratory medicine

authors： Mattila T,Vasankari T,Kanervisto M,Laitinen T,Impivaara O,Rissanen H,Knekt P,Jousilahti P,Saarelainen S,Puukka P,Heliövaara M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Recurrent cough can be a clinical manifestation of rhinitis. However, it remains unclear if the association between rhinitis and recurrent cough among children is independent of asthma. OBJECTIVE:The aim of the present study was to determine, in a large longitudinal cohort, whether rhinitis is significantly...

journal_title：Respiratory medicine

authors： Sherrill DL,Guerra S,Minervini MC,Wright AL,Martinez FD

更新日期：2005-11-01 00:00:00

abstract：:The fine particle dose delivered via dry powder inhalers (DPIs) is often affected by the inspiratory flow rate generated during inhalation. This has clinical implications, since the fine particle dose determines the amount of drug reaching the lungs. With Easyhaler DPI the fine particle dose remains relatively constan...

journal_title：Respiratory medicine

authors： Koskela T,Malmström K,Sairanen U,Peltola S,Keski-Karhu J,Silvasti M

更新日期：2000-12-01 00:00:00

abstract：:Smoking cessation is the most effective way to reduce the risk of developing chronic obstructive pulmonary disease (COPD). It prevents or delays the development of airflow limitation and also reduces its progression. The objective of this study was to systematically review the effects of interventions for smoking cess...

journal_title：Respiratory medicine

authors： Wagena EJ,van der Meer RM,Ostelo RJ,Jacobs JE,van Schayck CP

更新日期：2004-09-01 00:00:00

abstract：:The role of short-term tests of reversibility in selecting patients with COAD for long-term nebuliser therapy is uncertain. In a double-blind placebo-controlled crossover study we have examined the correlation between short-term reversibility and response to a home nebuliser. We studied 20 patients with severe COAD (m...

journal_title：Respiratory medicine

authors： Teale C,Morrison JF,Jones PC,Muers MF

更新日期：1991-07-01 00:00:00

abstract：AIM:To assess the effect of intrapleural urokinase, vis-à-vis simple pleural drainage, on residual pleural thickening in a series of patients suffering from loculated tuberculous pleural effusion. PATIENTS AND METHOD:Twenty-nine patients (21 males and 8 females) with loculated pleural effusion were studied. These pati...

journal_title：Respiratory medicine

authors： Cases Viedma E,Lorenzo Dus MJ,González-Molina A,Sanchis Aldás JL

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Physical activity and health status deteriorate early in the course of chronic obstructive pulmonary disease (COPD). This can only partially be explained by the degree of airflow limitation. Changes in (resting and dynamic) lung volumes are known to be associated with functional impairments and thus might in...

journal_title：Respiratory medicine

authors： Lahaije AJ,van Helvoort HA,Dekhuijzen PN,Vercoulen JH,Heijdra YF

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:The Korea Centers for Disease Control & Prevention has implemented a review process for the approval of new drugs used to treat patients with multidrug-resistant tuberculosis (MDR-TB) since September 2016. Therefore, this study aimed to evaluate the efficacy and safety of these new drugs bedaquiline (Bdq) and d...

journal_title：Respiratory medicine

authors： Kang H,Jo KW,Jeon D,Yim JJ,Shim TS

更新日期：2020-06-01 00:00:00

abstract：AIMS:This study tested inhibitory effects of in vitro Montelukast treatment on nasal airway epithelial cells (AEC) cultured from asthmatic patients treated with Montelukast with and without concomitant allergic rhinitis. We further examined the effect of Montelukast withdrawal in these patients on cytokine release from...

journal_title：Respiratory medicine

authors： Scaife A,Miller D,Spiteri-Cornish D,Turner SW,Devereux GS,Walsh GM

更新日期：2013-12-01 00:00:00

abstract：:The Spacehaler is a new, compact, pressurized aerosol device that uses the same canister as a conventional metered-dose inhaler (MDI). Its design, however, reduces the velocity of the aerosol cloud that emerges from the inhaler, thereby reducing the amount of the non-respirable fraction of the drug delivered to the pa...

journal_title：Respiratory medicine

authors： Gunawardena KA,Sohal T,Jones JI,Upchurch FC,Crompton GK

更新日期：1997-05-01 00:00:00

abstract：INTRODUCTION:Primary ciliary dyskinesia (PCD) is a rare genetically heterogeneous disorder of motile cilia, which leads to recurrent and chronic airway infections. Detailed information about infection causing pathogens is scarce. With this study, we aimed to determine the prevalence and susceptibility of the most commo...

journal_title：Respiratory medicine

authors： Roden L,Görlich D,Omran H,Peters G,Große-Onnebrink J,Kahl BC

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The 6 min walk test (6MWT) provides prognostic information in various respiratory diseases, but limited data exist in cystic fibrosis (CF) adults. METHODS:Consecutive CF adults who performed 6MWT at Cochin Hospital (Paris, France) over 12 years were analyzed. The cut-off 6 min walking distance (6MWD) value ...

journal_title：Respiratory medicine

authors： Martin C,Chapron J,Hubert D,Kanaan R,Honoré I,Paillasseur JL,Aubourg F,Dinh-Xuan AT,Dusser D,Fajac I,Burgel PR

更新日期：2013-12-01 00:00:00

abstract：:The aim of the present investigation was to evaluate the predictive value of a symptom-limited exercise test in predicting postoperative morbidity and mortality in patients submitted to pneumonectomy. The study was conducted in 150 patients (mean age, 57.1). Forty-four patients (29.3%) had postoperative complications....

journal_title：Respiratory medicine

authors： Villani F,De Maria P,Busia A

更新日期：2003-12-01 00:00:00

abstract：:Nasal mucociliary system is the first line of defense of the upper airways and may be affected acutely by exposure to particulate matter (PM) from biomass burning. Several epidemiologic studies have demonstrated a consistent association between levels of air pollution from biomass burning with increases in hospitaliza...

journal_title：Respiratory medicine

authors： Ferreira-Ceccato AD,Ramos EM,de Carvalho LC Jr,Xavier RF,Teixeira MF,Raymundo-Pereira PA,Proença Cdos A,de Toledo AC,Ramos D

更新日期：2011-11-01 00:00:00

abstract：:A survey was conducted in a metropolitan suburb to examine family clusters of pulmonary tuberculosis patients and related factors. Firstly, a descriptive study was done based on the review of tuberculosis registration cards over a 11-yr period. Of 1106 cases, 109 (9.9%) were found to occur in households which had alre...

journal_title：Respiratory medicine

authors： Kondo T,Hotta I,Yamanaka K,Sakakibara H,Miyao M,Yamada S

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...

journal_title：Respiratory medicine

authors： Bhushan B,Guleria R,Misra A,Luthra K,Vikram NK

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Current and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respira...

journal_title：Respiratory medicine

authors： Parekh TM,Bhatia S,Cherrington A,Kim YI,Lambert A,Iyer A,Regan EA,DeMeo DL,Han M,Dransfield MT

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:There are no validated patient diaries for evaluating respiratory symptoms in idiopathic pulmonary fibrosis (IPF). PURPOSE:To evaluate the performance properties of the chronic obstructive pulmonary disease (COPD) Evaluating Respiratory Symptoms™ (E-RS™: COPD) measure in patients with IPF. METHODS:Concept ...

journal_title：Respiratory medicine

authors： Bacci ED,O'Quinn S,Leidy NK,Murray L,Vernon M

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of...

journal_title：Respiratory medicine

authors： Morimoto K,Janssen WJ,Terada M

更新日期：2012-12-01 00:00:00

abstract：:The objective of this study was to describe asthma exacerbation self-management in children and adolescents. We used a cross-sectional study population enrolled in the International Study of Asthma and Allergies in Childhood (ISAAC) in Bordeaux. Subjects answered an additional questionnaire on utilization of health se...

journal_title：Respiratory medicine

authors： Raherison C,Tunon-de-Lara JM,Vernejoux JM,Taytard A

更新日期：2000-11-01 00:00:00

abstract：:Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction (EIB). It has been shown that an in vitro hyperosmolar stimulation of basophils and mast cells with mannitol can induce the release of histamine and leukotrienes. The aim of thi...

journal_title：Respiratory medicine

authors： Moloney ED,Griffin S,Burke CM,Poulter LW,O'Sullivan S

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Patients with amyopathic dermatomyositis (ADM) sometimes develop rapidly progressive interstitial lung disease (ILD) predominantly in Asia. Although anti-CADM-140/MDA5 antibody titer could correlate with disease activity and predict the course of ILD associated with ADM, it is not clear how this antibody is ...

journal_title：Respiratory medicine

authors： Takada T,Aoki A,Asakawa K,Sakagami T,Moriyama H,Narita I,Sato S

更新日期：2015-09-01 00:00:00