Abstract:
:Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To accelerate the protective antibody response, B cell responses can be ectopically induced, maintained, and reactivated in the lungs after primary and secondary infection, thereby providing an anatomical advantage in supplying neutralizing antibodies against reinfecting viruses with faster kinetics. However, the prompt supply of protective antibodies may be insufficient to protect against reinfection because influenza viruses can easily change their antigenic profiles to escape antibody surveillance. B cell responses have multiple strategies for adjusting antibody repertoires according to viral fitness, one of which is the formation of local germinal centers capable of selecting B cell repertoires for antigenically subdominant, but conserved, epitopes. In this review, we discuss several unique aspects of B cell responses that take place at local sites to combat acutely infectious and rapidly mutating influenza viruses.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Takahashi Y,Onodera T,Adachi Y,Ato Mdoi
10.1089/vim.2017.0025subject
Has Abstractpub_date
2017-07-01 00:00:00pages
431-437issue
6eissn
0882-8245issn
1557-8976journal_volume
30pub_type
杂志文章,评审相关文献
VIRAL IMMUNOLOGY文献大全abstract::Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication ef...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0032
更新日期:2013-10-01 00:00:00
abstract::Virus-based influenza vaccines induce less protection in old compared to young subjects due, in part, to age-associated alterations in the immune response. This study shows that old mice produce a less diverse HI antibody response after immunization than adult mice. However, immunization of old and young mice with pla...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1999.12.217
更新日期:1999-01-01 00:00:00
abstract::Hepatitis B and C infections can be either acute or chronic. The chronic infection can culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic makeup on conversion of acute to chronic infection, development of cirrhosis, and hepatocellular carcinoma is an interesting area of research. ...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2016.0062
更新日期:2016-12-01 00:00:00
abstract::Expression of the high-affinity interleukin 2 receptor alpha chain (CD25) was used to monitor antigen-specific activation of T lymphocyte subsets (CD4+, CD8+, and gammadelta T cells) from cattle immunized with modified live bovine herpesvirus-1 (BHV-1). Calves seronegative for BHV-1 were either vaccinated with one dos...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240260066305
更新日期:2002-01-01 00:00:00
abstract::Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0091
更新日期:2017-11-01 00:00:00
abstract::Cholangiocarcinoma is a malignancy of the biliary duct system. Presently, these malignant biliary tract diseases are common among the people in Southeast Asia, with the world's highest prevalence in northeastern Thailand and Laos. This carcinoma tends to grow slowly and to infiltrate the walls of the ducts, dissecting...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402320914593
更新日期:2002-01-01 00:00:00
abstract::Subjects > or = 55 years of age were immunized with attenuated varicella zoster virus (VZV) vaccine (live) or with the same vaccine, which had been heated to 56 degrees C for 7 days (killed). The ability of subjects' blood lymphocytes to lyse target cells infected with VZV was determined before and 3 months after immu...
journal_title:Viral immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1089/vim.1996.9.241
更新日期:1996-01-01 00:00:00
abstract::The purpose of the study was to evaluate pathologically the reproductive system of nonvaccinated and porcine reproductive and respiratory syndrome virus (PRRSV)-vaccinated sows/gilts, as well as the assessment of vaccination impact on their endometrium/myometrium and ovaries. In a farrow-to-finish farm, all sows and g...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0138
更新日期:2015-05-01 00:00:00
abstract::CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0076
更新日期:2010-12-01 00:00:00
abstract::Astroviruses are one of the leading causes of acute viral enteritis in infants, and are recognized as a clinically important pathogen in the elderly and the immunocompromised. In spite of this, we still know very little about the immune response to astrovirus infection. Clinical observations and human volunteer studie...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.11
更新日期:2005-01-01 00:00:00
abstract::It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1987.1.135
更新日期:1987-01-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 5 (GP5) is the most abundant envelope glycoprotein and a key target for neutralizing antibodies. Previous studies have demonstrated that the native GP5 glycoprotein is poorly immunogenic and not able to induce robust protective responses, probabl...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0041
更新日期:2014-09-01 00:00:00
abstract::This study is an improvement on the antibody binding test, known as ABT method, to develop a simple and fast method in comparison with NIH for determination of rabies vaccine potency. In the current study, several commercial human and veterinary vaccines were tested using both modified ABT and NIH methods. The ED50 wa...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0105
更新日期:2017-04-01 00:00:00
abstract::We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1997.10.197
更新日期:1997-01-01 00:00:00
abstract::As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/088282402317340260
更新日期:2002-01-01 00:00:00
abstract::Infection of mice with murine gammaherpesvirus-68 (γHV-68) serves as a model to understand the pathogenesis of persistent viral infections, including the potential for co-infections to modulate viral latency. We have previously found that infection of neonates (8-day-old mice) with γHV-68 resulted in a high level of p...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0055
更新日期:2010-12-01 00:00:00
abstract::Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/08828240050144680
更新日期:2000-01-01 00:00:00
abstract::Persistent cervicovaginal infection with high-risk types of HPV is the major risk factor for subsequent cervical neoplasia. HPV53, part of the alpha 6 species group along with HPV types 30, 56, and 66, is one of the most prevalent high risk-related HPV types, yet little is known about the molecular basis of its benign...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0019
更新日期:2008-09-01 00:00:00
abstract::Pretreatment of mice iv with syngeneic spleen cells modified with soluble HSV envelope antigens induced an anti-HSV antibody hyporesponsiveness following challenge with infectious virus. The epitope density on the HSV-modified spleen cells was quantitated using a photon-counting spectrofluorimeter so that observed imm...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1992.5.113
更新日期:1992-07-01 00:00:00
abstract::Previous research has evaluated antibody responses toward an influenza virus vaccine in the context of deficiencies for vitamins A and D (VAD+VDD). Results showed that antibodies and antibody-forming cells in the respiratory tract were reduced in VAD+VDD mice. However, effectors were recovered when oral supplements of...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0086
更新日期:2017-12-01 00:00:00
abstract::Hantavirus nucleocapsid protein (N) has been proven to induce highly protective immune responses in animal models. The knowledge on the mechanisms behind N-induced protection is still limited, although recent data suggest that both cellular and humoral immune responses are of importance. For a detailed B-cell epitope ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402317340323
更新日期:2002-01-01 00:00:00
abstract::Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclon...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2004.17.440
更新日期:2004-01-01 00:00:00
abstract::Antigen-primed cytotoxic T lymphocytes (CTL) may express leukocyte immunoglobulin-like receptors (LILRs) and natural killer receptors (NKRs). Published work suggests that expression of some of these receptors confers survival advantage, leading to the idea that cells expressing such receptors may accumulate as an anti...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.513
更新日期:2005-01-01 00:00:00
abstract::The effects of cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) on the cellular metabolic activity and activation status of bovine peripheral blood mononuclear cells (PBMC) were investigated. Cellular DNA and protein synthesis was determined by [3H]thymidine and [3H]valine incorporation, res...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1998.11.233
更新日期:1998-01-01 00:00:00
abstract::Infectious bursal disease (IBD) is an acute, highly contagious, immunosuppressive disease of young chickens that causes considerable economic loss in the poultry industry worldwide. Vaccination with live attenuated vaccines is still the most important method used for the control and prevention of IBD in chickens. Here...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0204
更新日期:2021-01-28 00:00:00
abstract::We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0064
更新日期:2020-11-01 00:00:00
abstract::Genetic polymorphism of IFNAR-1 plays a large role in determining the clearance or chronicity after hepatitis B virus (HBV) exposure. However, it is not clear whether type I interferon receptor-1 (IFNAR-1) variations continuously exert their effects to influence the final outcomes following HBV chronicity, including a...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2009.0102
更新日期:2010-06-01 00:00:00
abstract::Synthetic oligodeoxynucleotides (ODNs) such as CpG can stimulate B and plasmacytoid dendritic cells in vertebrate immune systems. Several studies showed that non-CpG ODNs could also induce strong stimulation of B and T cells. PyNTTTTGT ODNs, non-CpG ODNs, can activate and cause immunoglobulin secretion by B cells and ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0073
更新日期:2009-04-01 00:00:00
abstract::The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.162
更新日期:2005-01-01 00:00:00
abstract::To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR),...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0135
更新日期:2017-09-01 00:00:00