当前位置： SCI文献检索 > VIRAL IMMUNOLOGY期刊下所有文献 > Persistent effect of IFNAR-1 genetic polymorphism on the long-term pathogenesis of chronic HBV infection.

Persistent effect of IFNAR-1 genetic polymorphism on the long-term pathogenesis of chronic HBV infection.

Abstract：

:Genetic polymorphism of IFNAR-1 plays a large role in determining the clearance or chronicity after hepatitis B virus (HBV) exposure. However, it is not clear whether type I interferon receptor-1 (IFNAR-1) variations continuously exert their effects to influence the final outcomes following HBV chronicity, including acute-on-chronic hepatitis B liver failure (ACLF-HBV), chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Here we report that these four potential outcomes of chronic HBV infection are strongly associated with IFNAR-1 polymorphisms through a hospital-based case-control study of 663 cases. ACLF-HBV and HCC were each compared with CHB+LC. In comparison with the G/G genotype, the C/G and C/C genotypes at both single-nucleotide polymorphism (SNP) sites (rs1012335 and rs2257167) showed significant susceptibility to ACLF-HBV (the highest odds ratio [OR] reached 2.374; 95% CI = 1.488, 3.788; p < 0.001 for the C/G genotype at rs2257167), as well as HCC (OR = 2.475; 95% CI = 1.435, 4.426; p < 0.001 for the C/C genotype at rs1012335). The C allele at both loci was a susceptibility allele for ACLF-HBV and HCC, with the highest ORs reaching 1.653 (95% CI = 1.233, 2.216; p < 0.01 at rs1012335) in the ACLF-HBV group, and 1.659 (95% CI = 1.274, 2.159; p < 0.01 at rs1012335) in the HCC group. A strongly linked disequilibrium was also found within these two alleles (p < 0.001). Our research indicates that genetic polymorphisms of IFNAR-1 not only contribute to the determination of clearance or chronicity in the early stages of HBV exposure, but they also persistently influence pathogenesis over the long-term process of chronic HBV infection.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

He XX,Chang Y,Jiang HJ,Tang F,Meng FY,Xie QH,Li PY,Song YH,Lin JS

doi

10.1089/vim.2009.0102

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

251-7

issue

3

eissn

0882-8245

issn

1557-8976

journal_volume

23

pub_type

杂志文章

相关文献

VIRAL IMMUNOLOGY文献大全
  • Purification and partial characterization of a soluble suppressor factor from papillomavirus-infected patients.

    abstract：:A molecular form of soluble suppressor factor was identified in serum-free supernatant fluid of cultured peripheral blood mononuclear cells (PBMC) from patients with severe forms of papillomavirus infections (epidermodysplasia verruciformis and large treatment-resistant condyloma acuminatum). The papillomavirus-induce...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1991.4.249

    authors： Chopra V,Chopra AK,Tyring S

    更新日期：1991-01-01 00:00:00

  • Endogenous retroviral gp70 genes of the murine lymphoma L5178Y: analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity.

    abstract：:Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1994.7.155

    authors： Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

    更新日期：1994-01-01 00:00:00

  • Antibody-dependent enhancement of virus infection and disease.

    abstract：:In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infec...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/088282403763635465

    authors： Tirado SM,Yoon KJ

    更新日期：2003-01-01 00:00:00

  • Evaluation of the blood stabilizers TransFix and Cyto-Chex BCT for low-cost CD4 T-cell methodologies.

    abstract：:TransFix(TM) and Cyto-Chex((R)) BCT (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. We evaluated the ability of these blood-stabilizing reagents to preserve HIV-seropositive blood for delayed CD4(+) T-cell quantification utilizing the ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0027

    authors： Plate MM,Louzao R,Steele PM,Greengrass V,Morris LM,Lewis J,Barnett D,Warrino D,Hearps AC,Denny T,Crowe SM

    更新日期：2009-10-01 00:00:00

  • Replicon Particle Expressing the E2 Glycoprotein of Bovine Viral Diarrhea Virus Immunization and Evaluation of Antibody Response.

    abstract：:The objective of this study was to develop a new antigen delivery system using an alphavirus replicon particle (RP) to induce humoral antibody responses against bovine viral diarrhea virus (BVDV) recombinant antigen produced from envelope glycoprotein E2. An alphavirus RP expressing the E2 glycoprotein of BVDV was use...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0053

    authors： Hossain MM,Rowland RR

    更新日期：2018-01-01 00:00:00

  • Evidence for Increased Inflammatory Cytokine Profile in Hepatitis E Virus-Infected Obese Patients: Implications for Chronic Liver Disease.

    abstract：:We aimed to characterize the contribution of hepatitis E virus (HEV) in perpetuating the cytokine-mediated inflammatory setting related to liver damage in the context of obesity. Herein, serum samples from patients with liver disease were retrospectively analyzed and categorized as normal-weight patients (NW), overwei...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2020.0064

    authors： Viera-Segura O,Panduro A,Trujillo-Ochoa JL,Copado-Villagrana E,Torres-Valadez R,Sepulveda-Villegas M,Roman S,Fierro NA

    更新日期：2020-11-01 00:00:00

  • Early replication in pulmonary B cells after infection with Marek's disease herpesvirus by the respiratory route.

    abstract：:Abstract Natural infection with Marek's disease virus occurs through the respiratory mucosa after chickens inhale dander shed from infected chickens. The early events in the lung following exposure to the feather and squamous epithelial cell debris containing the viral particles remain unclear. In order to elucidate t...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0047

    authors： Baaten BJ,Staines KA,Smith LP,Skinner H,Davison TF,Butter C

    更新日期：2009-12-01 00:00:00

  • Loss of RORγt DNA binding activity inhibits IL-17 expression in HIV-1 infected Indian individuals.

    abstract：:Abstract IL-17 producing CD4 T cells have recently been shown to play an important role in mucosal immunity in HIV infection. But its role in peripheral immunity and the molecular mechanism underlying its regulation during HIV-1 infection are ill defined. In this study, we report a significant negative correlation b...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0048

    authors： Singh A,Vajpayee M,Ali SA,Chauhan NK

    更新日期：2013-02-01 00:00:00

  • Immune responses to measles and measles vaccine: challenges for measles control.

    abstract：:Most strategies for reducing global measles morbidity and mortality and eliminating measles are based on the ability to enhance immune responses to measles virus. Challenges to measles elimination and eradication are based in part on the need to sustain high levels of population immunity to interrupt transmission of m...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/08828240152716556

    authors： Moss WJ,Polack FP

    更新日期：2001-01-01 00:00:00

  • CD8+ CD11+ suppressor cells in HIV-infected asymptomatic patients: effect on HIV-specific cytotoxicity.

    abstract：:CD3+CD8+CD11+ cells were present in the peripheral blood of patients infected with asymptomatic human immunodeficiency virus (HIV) in higher percentage (10-20%) than in normal individuals (3-5%) in this study. These cells, through the release of soluble factors, significantly suppressed the effector phase of anti-HIV ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1992.5.15

    authors： Kundu SK,Merigan TC

    更新日期：1992-04-01 00:00:00

  • Induction of immunity in the respiratory tract and protection from bovine herpesvirus type 1 infection by different routes of immunization with recombinant adenovirus.

    abstract：:To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1998.11.79

    authors： Papp Z,Babiuk LA,Baca-Estrada ME

    更新日期：1998-01-01 00:00:00

  • Immunity and resistance to astrovirus infection.

    abstract：:Astroviruses are one of the leading causes of acute viral enteritis in infants, and are recognized as a clinically important pathogen in the elderly and the immunocompromised. In spite of this, we still know very little about the immune response to astrovirus infection. Clinical observations and human volunteer studie...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2005.18.11

    authors： Koci MD

    更新日期：2005-01-01 00:00:00

  • A Novel Recombinant Canine Adenovirus Type 1 Detected from Acute Lethal Cases of Infectious Canine Hepatitis.

    abstract：:In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centril...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0041

    authors： Wong M,Woolford L,Hasan NH,Hemmatzadeh F

    更新日期：2017-05-01 00:00:00

  • Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T cell activation and antiviral cytokine production.

    abstract：:The ability of porcine reproductive and respiratory syndrome virus (PRRSV) to suppress T cell expression of CD25 (alpha chain of interleukin [IL]-2 receptor), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) was determined by flow cytometry in naive porcine T cells in response to mitogen (conc...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.646

    authors： Charerntantanakul W,Platt R,Roth JA

    更新日期：2006-01-01 00:00:00

  • Identification of an immunodominant peptide in the parvovirus B19 VP1 unique region able to elicit a long-lasting immune response in humans.

    abstract：:The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282401750234529

    authors： Zuffi E,Manaresi E,Gallinella G,Gentilomi GA,Venturoli S,Zerbini M,Musiani M

    更新日期：2001-01-01 00:00:00

  • Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27.

    abstract：:Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1995.8.53

    authors： Manickan E,Yu Z,Rouse RJ,Wire WS,Rouse BT

    更新日期：1995-01-01 00:00:00

  • HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of naïve CD8(+) T cells.

    abstract：:Naïve CD8(+) T cells differentiate into effectors secreting various cytokines that modulate immune functions. A striking finding for most HIV-1-infected patients is that they accumulate CD8(+) T cells belonging to early and intermediate differentiated elements. Structural HIV-1 proteins, and among these the matrix pro...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0095

    authors： Avolio M,Caracciolo S,Tosti G,Vollero L,Fiorentini S,Caruso A

    更新日期：2008-06-01 00:00:00

  • A lower viral set point but little immunological impact after early treatment during primary HIV infection.

    abstract：:The Primo-SHM trial, a multicenter randomized trial comparing no treatment with 24 or 60 weeks of combination antiretroviral therapy (cART) during primary human immunodeficiency virus (HIV) infection (PHI), recently demonstrated that temporary early cART lowered the viral set point and deferred the need for re-initiat...

    journal_title：Viral immunology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1089/vim.2014.0094

    authors： Spits HB,Grijsen ML,Steingrover R,Nanlohy NM,Kootstra N,Borghans JA,van Baarle D,Prins JM,Schellens IM

    更新日期：2015-04-01 00:00:00

  • Adaptive B Cell Responses to Influenza Virus Infection in the Lung.

    abstract：:Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To ac...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2017.0025

    authors： Takahashi Y,Onodera T,Adachi Y,Ato M

    更新日期：2017-07-01 00:00:00

  • Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions.

    abstract：:Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 c...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0017

    authors： Rizzo R,Gentili V,Rotola A,Bortolotti D,Cassai E,Di Luca D

    更新日期：2014-11-01 00:00:00

  • A small animal model for mother-to-fetus transmission of ts1, a murine retrovirus.

    abstract：:Infection with a murine retrovirus, MoMuLV-TB, ts1 in BALB/c mice has been established as a small animal model for retroviral neurodegenerative disease as shown with infections such as HIV. However, mother-to-pup transmission has never been demonstrated in this model. The current investigation examines vertical transm...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282403322017929

    authors： Chakraborty J,Clark S,Okonta H,Duggan J

    更新日期：2003-01-01 00:00:00

  • HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens.

    abstract：:HIV-1 p17 is a viral cytokine that acts on preactivated, but not on resting, human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication, after binding to a cellular receptor (p17R). Here, we demonstrate that p17Rs are expressed on activated murine T cells, which respond to p17 stimu...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.177

    authors： Fiorentini S,Becker PD,Marini E,Marconi P,Avolio M,Tosti G,Link C,Manservigi R,Guzman CA,Caruso A

    更新日期：2006-07-01 00:00:00

  • ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway.

    abstract：:Hepatitis E virus (HEV) is one of the primary causative agents of acute hepatitis. It is noteworthy that HEV can develop chronic infection and even lead to liver cirrhosis; however, the mechanism has not been revealed. In this study, the ELISA assay was used to detect protein levels, and we found that HEV open reading...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2015.0107

    authors： Lei Q,Li L,Cai J,Huang W,Qin B,Zhang S

    更新日期：2016-03-01 00:00:00

  • Failure of vaccine or virulent strains of canine parvovirus to induce immunosuppressive effects on the immune system of the dog.

    abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1987.1.135

    authors： Phillips TR,Schultz RD

    更新日期：1987-01-01 00:00:00

  • Effects of different immunization protocols and adjuvant on antibody responses to inactivated SARS-CoV vaccine.

    abstract：:Severe acute respiratory syndrome (SARS) is a deadly and highly infectious disease caused by SARS Coronavirus (SARS-CoV). Inactivated SARS-CoV has been explored as a vaccine against SARS-CoV; however, current knowledge of inactivated SARS-CoV vaccine is quite limited. We attempted to investigate the effects of differe...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0079

    authors： Gai W,Zou W,Lei L,Luo J,Tu H,Zhang Y,Wang K,Tien P,Yan H

    更新日期：2008-03-01 00:00:00

  • Clonal analysis of the cytotoxic T-lymphocyte response to reovirus.

    abstract：:Reovirus has previously been classified into three serotypes based on hemagglutination inhibition assays. In the present study, the specificity of cytotoxic T lymphocytes (CTL) generated in reovirus type 3-infected C3H/HeN mice was investigated at the population and clonal levels. Short-term CTL lines generated in res...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1991.4.167

    authors： Hogan KT,Cashdollar LW

    更新日期：1991-10-01 00:00:00

  • Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression.

    abstract：:Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282402320914539

    authors： Gopinath RS,Ambagala AP,Hinkley S,Srikumaran S

    更新日期：2002-01-01 00:00:00

  • Autoantibody idiotypy and neonatal B cell repertoire.

    abstract：:During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.1989.2.263

    authors： Sollazzo M,Glotz D,Castiglia D,Zanetti M

    更新日期：1989-01-01 00:00:00

  • Von Willebrand factor is elevated in individuals infected with Sudan virus and is associated with adverse clinical outcomes.

    abstract：:Sudan virus (SUDV) is a member of the Filoviridae family that has been associated with sporadic outbreaks of human disease in sub-Saharan Africa. The filoviruses are notable for the high frequencies with which they cause both hemorrhagic manifestations and death in infected individuals. Recently, we reported an extens...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0072

    authors： McElroy AK,Erickson BR,Flietstra TD,Rollin PE,Towner JS,Nichol ST,Spiropoulou CF

    更新日期：2015-02-01 00:00:00

  • Antibody-binding epitope differences in the nucleoprotein of avian and mammalian influenza A viruses.

    abstract：:Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2010.0088

    authors： Varich NL,Sadykova GK,Prilipov AG,Kochergin-Nikitsky KS,Kushch AA,Masalova OV,Klimova RR,Gitelman AK,Kaverin NV

    更新日期：2011-04-01 00:00:00