The effect of different bovine viral diarrhea virus genotypes and biotypes on the metabolic activity and activation status of bovine peripheral blood mononuclear cells.

abstract：:We examined whether immunization with a single peptide induces cytotoxic T lymphocytes (CTLs) of heterogeneous specificities in vivo. Immunization of BALB/c mice with the peptide H2:529-537, which corresponded to amino acid residues 529-537 on the HA2 subunit transmembrane region of influenza A/Jap virus (H2N2) and po...

journal_title：Viral immunology

authors： Masaki H,Tamura M,Kurane I

更新日期：2000-01-01 00:00:00

abstract：:To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectiv...

journal_title：Viral immunology

authors： Luo D,Ni B,Zhao G,Jia Z,Zhou L,Pacal M,Zhang L,Zhang S,Xing L,Lin Z,Wang L,Li J,Liang Y,Shi X,Zhao T,Zou L,Wu Y,Wang X

更新日期：2007-09-01 00:00:00

abstract：:The purpose of the study was to evaluate pathologically the reproductive system of nonvaccinated and porcine reproductive and respiratory syndrome virus (PRRSV)-vaccinated sows/gilts, as well as the assessment of vaccination impact on their endometrium/myometrium and ovaries. In a farrow-to-finish farm, all sows and g...

journal_title：Viral immunology

authors： Papatsiros V,Psalla D,Papaioannou D,Tassis P,Tzika E,Papaioannou N

更新日期：2015-05-01 00:00:00

abstract：:In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infec...

journal_title：Viral immunology

authors： Tirado SM,Yoon KJ

更新日期：2003-01-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes an acute, highly contagious disease of livestock. Though FMDV is very sensitive to interferon-alpha (IFN-alpha), IFN-beta, and IFN-gamma, the virus has evolved mechanisms to evade such innate responses. For instance, during acute infection, FMDV suppresses IFN-alpha productio...

journal_title：Viral immunology

authors： Nfon CK,Toka FN,Kenney M,Pacheco JM,Golde WT

更新日期：2010-02-01 00:00:00

abstract：:TransFix(TM) and Cyto-Chex((R)) BCT (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. We evaluated the ability of these blood-stabilizing reagents to preserve HIV-seropositive blood for delayed CD4(+) T-cell quantification utilizing the ...

journal_title：Viral immunology

authors： Plate MM,Louzao R,Steele PM,Greengrass V,Morris LM,Lewis J,Barnett D,Warrino D,Hearps AC,Denny T,Crowe SM

更新日期：2009-10-01 00:00:00

abstract：:Yellow fever is a zoonotic disease caused by the yellow fever virus (YFV) and transmitted by mosquitoes of the family Culicidae. It is well known that cellular and viral microRNAs (miRNAs) are involved in modulation of viral and cellular gene expression, as well as immune response, and are considered by the scientific...

journal_title：Viral immunology

authors： Holanda GM,Casseb SMM,Mello KFL,Vasconcelos PFC,Cruz ACR

更新日期：2017-06-01 00:00:00

abstract：:The ability of porcine reproductive and respiratory syndrome virus (PRRSV) to suppress T cell expression of CD25 (alpha chain of interleukin [IL]-2 receptor), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) was determined by flow cytometry in naive porcine T cells in response to mitogen (conc...

journal_title：Viral immunology

authors： Charerntantanakul W,Platt R,Roth JA

更新日期：2006-01-01 00:00:00

abstract：:Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate...

journal_title：Viral immunology

authors： Yoon KJ,Wu LL,Zimmerman JJ,Hill HT,Platt KB

更新日期：1996-01-01 00:00:00

abstract：:One of the strategies that has been investigated to reduce antiretroviral treatment toxicity in patients infected with human immunodeficiency virus (HIV) is structured treatment interruption (STI). Our aim was to analyze early viral and immune dynamics after interruption of highly active antiretroviral therapy (HAART)...

journal_title：Viral immunology

authors： Vallejo A,Valladares A,De Felipe B,Vivancos J,Gutierrez S,Soriano-Sarabia N,Ruiz-Mateos E,Lissen E,Leal M

更新日期：2005-01-01 00:00:00

abstract：:To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...

journal_title：Viral immunology

authors： Kumar SR,Biswas M,Elankumaran S

更新日期：2014-04-01 00:00:00

abstract：:Patients with hepatitis B virus (HBV) infection may develop severe chronic liver disease. Carriers of HBV have an increased risk of developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Worldwide an estimated 350 million people are infected with HBV, and 15-40% will develop serious sequelae in th...

journal_title：Viral immunology

authors： Filho RM,Carmo RF,Catsman C,Souza C,Silva A,Moura P,Tenorio AL,Vasconcelos LR,Cavalcanti Mdo S,Pereira LM

更新日期：2010-08-01 00:00:00

abstract：:Current treatments for hepatitis C infection have limited efficacy, and there is no vaccine available. The goal of this study was to compare the immune response to several immunization combinations against hepatitis C virus (HCV). Six groups of mice were immunized at weeks 0, 4, and 8 with different combinations of a ...

journal_title：Viral immunology

authors： Ghorbani M,Nass T,Azizi A,Soare C,Aucoin S,Giulivi A,Anderson DE,Diaz-Mitoma F

更新日期：2005-01-01 00:00:00

abstract：:Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...

journal_title：Viral immunology

authors： Komatsu T,Barna M,Reiss CS

更新日期：1997-01-01 00:00:00

abstract：:Anogenital warts are a common clinical manifestation of genital infection with human papillomavirus type 6b (HPV-6b). Accumulating data indicate that an effective cellular immune response is required for the control of HPV infections. However, in a minority of patients there is a high rate of recurrence of wart lesion...

journal_title：Viral immunology

authors： Blanchet JS,Sonnex C,Gough GW,Warren AP

更新日期：2007-04-01 00:00:00

abstract：:Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to mi...

journal_title：Viral immunology

authors： Suvas S,Rouse BT

更新日期：2005-01-01 00:00:00

abstract：:Expression of the high-affinity interleukin 2 receptor alpha chain (CD25) was used to monitor antigen-specific activation of T lymphocyte subsets (CD4+, CD8+, and gammadelta T cells) from cattle immunized with modified live bovine herpesvirus-1 (BHV-1). Calves seronegative for BHV-1 were either vaccinated with one dos...

journal_title：Viral immunology

authors： Endsley JJ,Quade MJ,Terhaar B,Roth JA

更新日期：2002-01-01 00:00:00

abstract：:Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...

journal_title：Viral immunology

authors： Liang SH,Rieber P,Prewett M,Riethmüller G,Pletcher C,Hoxie J,Koprowski H,Herlyn D

更新日期：1991-07-01 00:00:00

abstract：:Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...

journal_title：Viral immunology

authors： Manickan E,Yu Z,Rouse RJ,Wire WS,Rouse BT

更新日期：1995-01-01 00:00:00

abstract：:Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

journal_title：Viral immunology

authors： Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

更新日期：2018-05-01 00:00:00

abstract：:Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...

journal_title：Viral immunology

authors： Park EH,Song BM,Yum J,Kim JA,Oh SK,Kim HS,Cho GJ,Seo SH

更新日期：2014-11-01 00:00:00

abstract：:Toll-like receptor (TLR)3 signaling pathway is known to induce type 1 interferons (IFNs) and proinflammatory mediators leading to antiviral response against many viral infections. Double-stranded ribonucleic acid (dsRNA) has been shown to act as a ligand for TLR3 and, as such, has been a focus as a potential antiviral...

journal_title：Viral immunology

authors： Ahmed-Hassan H,Abdul-Cader MS,Ahmed Sabry M,Hamza E,Sharif S,Nagy E,Abdul-Careem MF

更新日期：2018-07-01 00:00:00

abstract：:The resolution revolution of cryo-electron microscopy (cryo-EM) has made a significant impact on the structural analysis of the Pneumoviridae multifunctional RNA polymerases. In recent months, several high-resolution structures of apo RNA polymerases of Pneumoviridae, which includes the human respiratory syncytial vir...

journal_title：Viral immunology

authors： Cao D,Liang B

更新日期：2021-01-01 00:00:00

abstract：:In this study we investigated the efficacy of a multigenic DNA prime/modified vaccinia Ankara (MVA)boost vaccine approach, followed by mucosal challenge with highly pathogenic simian-human immunodeficiency virus (SHIV) 89.6P, using different routes for vaccine delivery. After three times of DNA priming (SIVmac239, Gag...

journal_title：Viral immunology

authors： Stolte-Leeb N,Bieler K,Kostler J,Heeney J,Haaft PT,Suh YS,Hunsmann G,Stahl-Hennig C,Wagner R

更新日期：2008-06-01 00:00:00

abstract：:The human papillomavirus (HPV) is an important causal agent of premalignant cervical epithelial changes and cervical cancers. These cancers account for ∼5% of all cancers globally and kill more than a quarter million women annually. HPV infections also associate with certain anogenital and oropharyngeal cancers. Event...

journal_title：Viral immunology

authors： Frazer IH

更新日期：2018-03-01 00:00:00

abstract：:Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...

journal_title：Viral immunology

authors： Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

更新日期：2007-09-01 00:00:00

abstract：:Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

journal_title：Viral immunology

authors： Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

更新日期：1994-01-01 00:00:00

abstract：:Infection of mice with murine gammaherpesvirus-68 (γHV-68) serves as a model to understand the pathogenesis of persistent viral infections, including the potential for co-infections to modulate viral latency. We have previously found that infection of neonates (8-day-old mice) with γHV-68 resulted in a high level of p...

journal_title：Viral immunology

authors： Ptaschinski C,Wilmore J,Fiore N,Rochford R

更新日期：2010-12-01 00:00:00

abstract：:Pretreatment of mice iv with syngeneic spleen cells modified with soluble HSV envelope antigens induced an anti-HSV antibody hyporesponsiveness following challenge with infectious virus. The epitope density on the HSV-modified spleen cells was quantitated using a photon-counting spectrofluorimeter so that observed imm...

journal_title：Viral immunology

authors： Wilson LA,Thompson JJ,Ohkawa S,Scott DW

更新日期：1992-07-01 00:00:00

abstract：:BALB/c mice, preimmunized with a protective dose of native herpes simplex virus type 1 glycoprotein D (ngD1) vaccine, were depleted of selected immunocyte populations in vivo using monoclonal antibodies directed at Thy1+, L3T4+, or Lyt2+ cells. Following immunization and depletion, animals were inoculated with varied ...

journal_title：Viral immunology

authors： Mishkin EM,Blasiak M,Giorgio D,Ishizaka ST

更新日期：1992-07-01 00:00:00