High thymic volume is associated with viral replication and immunologic impairment only early after HAART interruption in chronic HIV infection.

abstract：:The effects of cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) on the cellular metabolic activity and activation status of bovine peripheral blood mononuclear cells (PBMC) were investigated. Cellular DNA and protein synthesis was determined by [3H]thymidine and [3H]valine incorporation, res...

journal_title：Viral immunology

authors： Hou L,Wilkerson M,Kapil S,Mosier D,Shuman W,Reddy JR,Loughin T,Minocha HC

更新日期：1998-01-01 00:00:00

abstract：:Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism against infectious agents, specifically viruses. In the present investigation we employed a mouse assay system we previously developed, for rapid induction of CTLs by synthetic peptides from E6 and E7 oncoproteins of human papillomav...

journal_title：Viral immunology

authors： Sarkar AK,Tortolero-Luna G,Nehete PN,Arlinghaus RB,Mitchell MF,Sastry KJ

更新日期：1995-01-01 00:00:00

abstract：:Serial virus specimens rescued from rabbits, experimentally infected with bovine immunodeficiency (BIV) strain R29, were monitored for changes in quasispecies population, using the single-strand conformation polymorphism (SSCP) analysis. The generation of characteristic SSCP patterns enables the rapid differentiation ...

journal_title：Viral immunology

authors： Kalvatchev Z,Walder R,Garzaro D,Barrios M

更新日期：2000-01-01 00:00:00

abstract：:The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neut...

journal_title：Viral immunology

authors： Zuffi E,Manaresi E,Gallinella G,Gentilomi GA,Venturoli S,Zerbini M,Musiani M

更新日期：2001-01-01 00:00:00

abstract：:Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...

journal_title：Viral immunology

authors： Askari A,Nosratabadi R,Khaleghinia M,Zainodini N,Kennedy D,Shabani Z,Kazemi Arababadi M

更新日期：2016-11-01 00:00:00

abstract：:Subjects > or = 55 years of age were immunized with attenuated varicella zoster virus (VZV) vaccine (live) or with the same vaccine, which had been heated to 56 degrees C for 7 days (killed). The ability of subjects' blood lymphocytes to lyse target cells infected with VZV was determined before and 3 months after immu...

journal_title：Viral immunology

authors： Hayward AR,Buda K,Jones M,White CJ,Levin MJ

更新日期：1996-01-01 00:00:00

abstract：:HIV-1 p17 is a viral cytokine that acts on preactivated, but not on resting, human T cells promoting proliferation, proinflammatory cytokines release and HIV-1 replication, after binding to a cellular receptor (p17R). Here, we demonstrate that p17Rs are expressed on activated murine T cells, which respond to p17 stimu...

journal_title：Viral immunology

authors： Fiorentini S,Becker PD,Marini E,Marconi P,Avolio M,Tosti G,Link C,Manservigi R,Guzman CA,Caruso A

更新日期：2006-07-01 00:00:00

abstract：:Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...

journal_title：Viral immunology

authors： Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

更新日期：2007-09-01 00:00:00

abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

journal_title：Viral immunology

authors： Phillips TR,Schultz RD

更新日期：1987-01-01 00:00:00

abstract：:Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically s...

journal_title：Viral immunology

authors： Yager EJ,Szaba FM,Kummer LW,Lanzer KG,Burkum CE,Smiley ST,Blackman MA

更新日期：2009-02-01 00:00:00

abstract：:To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...

journal_title：Viral immunology

authors： Yin J,Jin H,Kang Y,Xiao C,Zhao L,Li X,Ding Z,Yang F,Zhu Q,Wang B

更新日期：2006-07-01 00:00:00

abstract：:Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in...

journal_title：Viral immunology

authors： Ariyanto IA,Estiasari R,Waters S,Wulandari EAT,Fernandez S,Lee S,Price P

更新日期：2018-07-01 00:00:00

abstract：:The ability of porcine reproductive and respiratory syndrome virus (PRRSV) to suppress T cell expression of CD25 (alpha chain of interleukin [IL]-2 receptor), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) was determined by flow cytometry in naive porcine T cells in response to mitogen (conc...

journal_title：Viral immunology

authors： Charerntantanakul W,Platt R,Roth JA

更新日期：2006-01-01 00:00:00

abstract：:Sudan virus (SUDV) is a member of the Filoviridae family that has been associated with sporadic outbreaks of human disease in sub-Saharan Africa. The filoviruses are notable for the high frequencies with which they cause both hemorrhagic manifestations and death in infected individuals. Recently, we reported an extens...

journal_title：Viral immunology

authors： McElroy AK,Erickson BR,Flietstra TD,Rollin PE,Towner JS,Nichol ST,Spiropoulou CF

更新日期：2015-02-01 00:00:00

abstract：:Serum antibodies against the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18 are associated with cervical cancer. The aim of this study was to investigate the presence of local antibodies against HPV in cervicovaginal washings (CWs). In this study antibodies against the native HPV16 and HPV18 E6/E7 proteins...

journal_title：Viral immunology

authors： Tjiong MY,Zumbach K,Schegget JT,van der Vange N,Out TA,Pawlita M,Struyk L

更新日期：2001-01-01 00:00:00

abstract：:Persistent cervicovaginal infection with high-risk types of HPV is the major risk factor for subsequent cervical neoplasia. HPV53, part of the alpha 6 species group along with HPV types 30, 56, and 66, is one of the most prevalent high risk-related HPV types, yet little is known about the molecular basis of its benign...

journal_title：Viral immunology

authors： Malik ZA,Hailpern SM,Burk RD

更新日期：2008-09-01 00:00:00

abstract：:To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR),...

journal_title：Viral immunology

authors： Wang W,Feng F,Lv J,Xie Z,Chen J,Zhang L,Li W

更新日期：2017-09-01 00:00:00

abstract：:Expression of the high-affinity interleukin 2 receptor alpha chain (CD25) was used to monitor antigen-specific activation of T lymphocyte subsets (CD4+, CD8+, and gammadelta T cells) from cattle immunized with modified live bovine herpesvirus-1 (BHV-1). Calves seronegative for BHV-1 were either vaccinated with one dos...

journal_title：Viral immunology

authors： Endsley JJ,Quade MJ,Terhaar B,Roth JA

更新日期：2002-01-01 00:00:00

abstract：:Chemokine receptors CXCR4 and CCR5 play a key role in Human Immunodeficiency Virus (HIV) entry into CD4+ monocytic cells. Alteration in the expression levels of these receptors by immunoregulatory cytokines may influence viral entry and hence susceptibility to HIV infection, viral tropism, and disease progression. Hel...

journal_title：Viral immunology

authors： Creery D,Weiss W,Graziani-Bowering G,Kumar R,Aziz Z,Angel JB,Kumar A

更新日期：2006-07-01 00:00:00

abstract：:Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

journal_title：Viral immunology

authors： Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

更新日期：1994-01-01 00:00:00

abstract：:During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...

journal_title：Viral immunology

authors： Sollazzo M,Glotz D,Castiglia D,Zanetti M

更新日期：1989-01-01 00:00:00

abstract：:Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the FcγRIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC fu...

journal_title：Viral immunology

authors： Johansson SE,Rollman E,Chung AW,Center RJ,Hejdeman B,Stratov I,Hinkula J,Wahren B,Kärre K,Kent SJ,Berg L

更新日期：2011-10-01 00:00:00

abstract：:Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...

journal_title：Viral immunology

authors： Chua BY,Sekiya T,Jackson DC

更新日期：2018-03-01 00:00:00

abstract：:California (CAL) serogroup Bunyaviruses are significant agents of arboviral encephalitis in humans. They are maintained and transmitted in nature by mosquitoes to preferred vertebrate amplifying hosts. The G2 envelope glycoprotein of La Crosse virus (LAC) was proposed by Ludwig et al. to be a determinant for virus att...

journal_title：Viral immunology

authors： Cheng LL,Schultz KT,Yuill TM,Israel BA

更新日期：2000-01-01 00:00:00

abstract：:This study aimed to investigate the seroprevalence of cytomegalovirus (CMV) infection and risk factors associated with CMV acquisition among pregnant women in Zimbabwe. In a cross-sectional study, pregnant women were recruited in late gestation, seeking antenatal care at council clinics in three high-density suburbs i...

journal_title：Viral immunology

authors： Mhandire D,Duri K,Kaba M,Mhandire K,Musarurwa C,Chimusa E,Munjoma P,Mazengera L,Stray-Pedersen B,Dandara C

更新日期：2019-09-01 00:00:00

abstract：:Toll-like receptor (TLR)3 signaling pathway is known to induce type 1 interferons (IFNs) and proinflammatory mediators leading to antiviral response against many viral infections. Double-stranded ribonucleic acid (dsRNA) has been shown to act as a ligand for TLR3 and, as such, has been a focus as a potential antiviral...

journal_title：Viral immunology

authors： Ahmed-Hassan H,Abdul-Cader MS,Ahmed Sabry M,Hamza E,Sharif S,Nagy E,Abdul-Careem MF

更新日期：2018-07-01 00:00:00

abstract：:Highly active anti-retroviral therapy (HAART) restores CD4(+) T-cell numbers in the periphery; however, its efficacy in restoring functional immunity is not fully elucidated. Here we evaluated longitudinal changes in the expression of several key markers of T-cell activation, namely CD40 ligand (CD154), OX40 (CD134), ...

journal_title：Viral immunology

authors： Nyakeriga AM,Ying J,Shire NJ,Fichtenbaum CJ,Chougnet CA

更新日期：2011-08-01 00:00:00

abstract：:Endocannabinoid system plays an important role in pathophysiologic processes such as immune functions and impacts on disease severity. Our previous study showed that cannabinoid receptor 2 (CB2) affects clinical course of respiratory syncytial virus (RSV) infection. In this study, we investigated the role of cannabino...

journal_title：Viral immunology

authors： Tahamtan A,Tavakoli-Yaraki M,Shadab A,Rezaei F,Marashi SM,Shokri F,Mokhatri-Azad T,Salimi V

更新日期：2018-05-01 00:00:00

abstract：:To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectiv...

journal_title：Viral immunology

authors： Luo D,Ni B,Zhao G,Jia Z,Zhou L,Pacal M,Zhang L,Zhang S,Xing L,Lin Z,Wang L,Li J,Liang Y,Shi X,Zhao T,Zou L,Wu Y,Wang X

更新日期：2007-09-01 00:00:00

abstract：:Highly pathogenic avian influenza (HPAI) H5N1 virus emerged in 1997 as a zoonotic disease in Hong Kong. It has since spread to Asia and Europe and is a serious threat to both the poultry industry and human health. For effective surveillance and possible prevention/control of HPAI H5N1 viruses, it is necessary to under...

journal_title：Viral immunology

authors： Daidoji T,Watanabe Y,Arai Y,Kajikawa J,Hirose R,Nakaya T

更新日期：2017-07-01 00:00:00