当前位置： SCI文献检索 > VIRAL IMMUNOLOGY期刊下所有文献 > Identification of an immunodominant peptide in the parvovirus B19 VP1 unique region able to elicit a long-lasting immune response in humans.

Identification of an immunodominant peptide in the parvovirus B19 VP1 unique region able to elicit a long-lasting immune response in humans.

Abstract：

:The immune response against parvovirus B19 is mainly directed against the two structural proteins, VP1 and VP2. The amino terminal half of the VP1 unique region has been shown to elicit a dominant immune response in humans, more effective than other linear epitopes and also it has been seen to contain significant neutralizing linear epitopes. Three overlapping recombinant peptides corresponding to amino acids 2-40 (VP1-A), amino acids 32-71 (VP1-B), and amino acids 60-100 (VP1-C) of the VP1 unique region were produced by a procaryotic expression system. These peptides were used as antigens in a Western blot assay to detect specific immunoglobulin G (IgG) in serum samples from blood donors of different age groups with documented signs of a past B19 infection. Fragment VP1-C appeared significantly immunodominant over the other peptides, reacting with specific IgG in 86% of serum samples. The fragment VP1-C corresponds to a sequence with a known neutralizing activity and seems able to elicit a long-lasting immune response because specific IgG were present in blood donors of all age groups. VP1-C would therefore appear to be an attractive candidate as a component of a subunit vaccine.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Zuffi E,Manaresi E,Gallinella G,Gentilomi GA,Venturoli S,Zerbini M,Musiani M

doi

10.1089/088282401750234529

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

151-8

issue

2

eissn

0882-8245

issn

1557-8976

journal_volume

14

pub_type

杂志文章

相关文献

VIRAL IMMUNOLOGY文献大全
  • Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.

    abstract：:Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.0052

    authors： Gruber A,Chalmers AS,Rasmussen RA,Ong H,Popov S,Andersen J,Hu SL,Ruprecht RM

    更新日期：2007-04-01 00:00:00

  • Endogenous retroviral gp70 genes of the murine lymphoma L5178Y: analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity.

    abstract：:Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1994.7.155

    authors： Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

    更新日期：1994-01-01 00:00:00

  • Severe acute respiratory syndrome, a pathological immune response to the new coronavirus--implications for understanding of pathogenesis, therapy, design of vaccines, and epidemiology.

    abstract：:Findings coming from autopsies and serum of SARS patients suggest an important immune-inflammatory implication in the evolution to respiratory distress. Conditions such as HIV infection or treatment with immunosuppressors (in cancer or autoimmune diseases) are not among the bad prognosis factors for development of dis...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2004.17.535

    authors： Bermejo JF,Muñoz-Fernandez MA

    更新日期：2004-01-01 00:00:00

  • Immunity and resistance to astrovirus infection.

    abstract：:Astroviruses are one of the leading causes of acute viral enteritis in infants, and are recognized as a clinically important pathogen in the elderly and the immunocompromised. In spite of this, we still know very little about the immune response to astrovirus infection. Clinical observations and human volunteer studie...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2005.18.11

    authors： Koci MD

    更新日期：2005-01-01 00:00:00

  • Major Immunodominant Region of Hepatitis B Virus Core Antigen as a Delivery Vector to Improve the Immunogenicity of the Fusion Antigen ROP2-SAG1 Multiepitope from Toxoplasma gondii in Mice.

    abstract：:To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR),...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0135

    authors： Wang W,Feng F,Lv J,Xie Z,Chen J,Zhang L,Li W

    更新日期：2017-09-01 00:00:00

  • Persistent effect of IFNAR-1 genetic polymorphism on the long-term pathogenesis of chronic HBV infection.

    abstract：:Genetic polymorphism of IFNAR-1 plays a large role in determining the clearance or chronicity after hepatitis B virus (HBV) exposure. However, it is not clear whether type I interferon receptor-1 (IFNAR-1) variations continuously exert their effects to influence the final outcomes following HBV chronicity, including a...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0102

    authors： He XX,Chang Y,Jiang HJ,Tang F,Meng FY,Xie QH,Li PY,Song YH,Lin JS

    更新日期：2010-06-01 00:00:00

  • Mutation of the "a" determinant of HBsAg with discordant HBsAg diagnostic kits.

    abstract：:Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclon...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2004.17.440

    authors： Louisirirotchanakul S,Kanoksinsombat C,Theamboonlert A,Puthavatana P,Wasi C,Poovorawan Y

    更新日期：2004-01-01 00:00:00

  • Effects of virion host shut-off activity of bovine herpesvirus 1 on MHC class I expression.

    abstract：:Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282402320914539

    authors： Gopinath RS,Ambagala AP,Hinkley S,Srikumaran S

    更新日期：2002-01-01 00:00:00

  • Effects of interferon-gamma on neuronal infections.

    abstract：:IFN-gamma is released in the brain, not only during acute infectious diseases or immunological reactions, but also for extended periods of time after clearance of infectious virus and during viral latency. In this review, we focus on the role of IFN-gamma in the interaction between a neuron and a pathogen, that is, th...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/08828240260066206

    authors： Rottenberg M,Kristensson K

    更新日期：2002-01-01 00:00:00

  • Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.

    abstract：:CD8(+) T-cell-mediated pulmonary immunopathology in respiratory virus infection is mediated in large part by antigen-specific TNF-α expression by antiviral effector T cells, which results in epithelial chemokine expression and inflammatory infiltration of the lung. To further define the signaling events leading to lun...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2010.0076

    authors： Srikiatkhachorn A,Chintapalli J,Liu J,Jamaluddin M,Harrod KS,Whitsett JA,Enelow RI,Ramana CV

    更新日期：2010-12-01 00:00:00

  • IFN-γ Attenuates Spontaneous Lymphocyte Proliferation by Fuelling Regulatory T Cells in HIV-1-Infected Patients.

    abstract：:HIV infection is characterized by a high degree of immune activation. It has an impact on CD4 cell count and populations' distribution and function. T regulatory cells (Tregs) were found to play a controversial role in the course of infection because of their beneficial effect on the degree of immune activation and un...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0075

    authors： Terzieva VI,Popova DN,Elenkov II

    更新日期：2017-04-01 00:00:00

  • PyNTTTTGT prototype oligonucleotide IMT504, a novel effective adjuvant of the FMDV DNA vaccine.

    abstract：:Synthetic oligodeoxynucleotides (ODNs) such as CpG can stimulate B and plasmacytoid dendritic cells in vertebrate immune systems. Several studies showed that non-CpG ODNs could also induce strong stimulation of B and T cells. PyNTTTTGT ODNs, non-CpG ODNs, can activate and cause immunoglobulin secretion by B cells and ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2008.0073

    authors： Zhao G,Jin H,Li J,Su B,Du X,Kang Y,Wang X,Wang B

    更新日期：2009-04-01 00:00:00

  • CD8+ CD11+ suppressor cells in HIV-infected asymptomatic patients: effect on HIV-specific cytotoxicity.

    abstract：:CD3+CD8+CD11+ cells were present in the peripheral blood of patients infected with asymptomatic human immunodeficiency virus (HIV) in higher percentage (10-20%) than in normal individuals (3-5%) in this study. These cells, through the release of soluble factors, significantly suppressed the effector phase of anti-HIV ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1992.5.15

    authors： Kundu SK,Merigan TC

    更新日期：1992-04-01 00:00:00

  • Protein A-based ELISA: its evaluation in the diagnosis of herpes simplex encephalitis.

    abstract：:Herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, early rapid and reliable diagnosis has become important. The objective of the present study was to develop a sensitive enzyme-linked immunosorbent assay (EL...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2010.0129

    authors： Bhullar SS,Kashyap RS,Chandak NH,Purohit HJ,Taori GM,Daginawala HF

    更新日期：2011-08-01 00:00:00

  • What Targets Somatic Hypermutation to the Immunoglobulin Loci?

    abstract：:One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the swit...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2019.0149

    authors： Heltzel JMH,Gearhart PJ

    更新日期：2020-05-01 00:00:00

  • Replicon Particle Expressing the E2 Glycoprotein of Bovine Viral Diarrhea Virus Immunization and Evaluation of Antibody Response.

    abstract：:The objective of this study was to develop a new antigen delivery system using an alphavirus replicon particle (RP) to induce humoral antibody responses against bovine viral diarrhea virus (BVDV) recombinant antigen produced from envelope glycoprotein E2. An alphavirus RP expressing the E2 glycoprotein of BVDV was use...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0053

    authors： Hossain MM,Rowland RR

    更新日期：2018-01-01 00:00:00

  • Major and minor Kb-restricted epitopes encoded by the endogenous ecotropic murine leukemia virus AKR623 that are recognized by anti-AKR/Gross MuLV CTL.

    abstract：:C57BL/6 mice can generate a type-specific and class IH-2Kb-restricted CTL response against histocompatible AKR/Gross murine leukemia virus (MuLV) cell surface antigen positive (GCSA+) tumor cells. These anti-AKR/Gross MuLV CTL are also known to lyse SC.Kb/623 target cells expressing the molecular MuLV clone AKR623 (de...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1994.7.51

    authors： White HD,Roeder DA,Lam T,Green WR

    更新日期：1994-01-01 00:00:00

  • Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection.

    abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease with significant mortality. Two testing methods are currently used for MERS-CoV diagnostics: nucleic acid detection (the gold standard) and serological analysis. In this study, we evaluated the detection of MERS-CoV-IgG in suspec...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0091

    authors： Alhetheel A,Altalhi H,Albarrag A,Shakoor Z,Mohamed D,El-Hazmi M,Somily A,Barry M,Bakhrebah M,Nassar M

    更新日期：2017-11-01 00:00:00

  • Enhanced CD103 Expression and Reduced Frequencies of Virus-Specific CD8+ T Cells Among Airway Lymphocytes After Influenza Vaccination of Mice Deficient in Vitamins A + D.

    abstract：:Previous research has evaluated antibody responses toward an influenza virus vaccine in the context of deficiencies for vitamins A and D (VAD+VDD). Results showed that antibodies and antibody-forming cells in the respiratory tract were reduced in VAD+VDD mice. However, effectors were recovered when oral supplements of...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0086

    authors： Surman SL,Jones BG,Woodland DL,Hurwitz JL

    更新日期：2017-12-01 00:00:00

  • Opinion: Making Inactivated and Subunit-Based Vaccines Work.

    abstract：:Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2017.0146

    authors： Chua BY,Sekiya T,Jackson DC

    更新日期：2018-03-01 00:00:00

  • Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe.

    abstract：:This study aimed to investigate the seroprevalence of cytomegalovirus (CMV) infection and risk factors associated with CMV acquisition among pregnant women in Zimbabwe. In a cross-sectional study, pregnant women were recruited in late gestation, seeking antenatal care at council clinics in three high-density suburbs i...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2019.0024

    authors： Mhandire D,Duri K,Kaba M,Mhandire K,Musarurwa C,Chimusa E,Munjoma P,Mazengera L,Stray-Pedersen B,Dandara C

    更新日期：2019-09-01 00:00:00

  • Development of a Time and Cost Benefit Antibody Binding Test-Based Method for Determination of Rabies Vaccine Potency.

    abstract：:This study is an improvement on the antibody binding test, known as ABT method, to develop a simple and fast method in comparison with NIH for determination of rabies vaccine potency. In the current study, several commercial human and veterinary vaccines were tested using both modified ABT and NIH methods. The ED50 wa...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0105

    authors： Asgary V,Mojtabavi N,Janani A,Mousavi T,Hadjati J,Khosravy MS,Ahangari Cohan R

    更新日期：2017-04-01 00:00:00

  • Evaluation of the blood stabilizers TransFix and Cyto-Chex BCT for low-cost CD4 T-cell methodologies.

    abstract：:TransFix(TM) and Cyto-Chex((R)) BCT (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. We evaluated the ability of these blood-stabilizing reagents to preserve HIV-seropositive blood for delayed CD4(+) T-cell quantification utilizing the ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0027

    authors： Plate MM,Louzao R,Steele PM,Greengrass V,Morris LM,Lewis J,Barnett D,Warrino D,Hearps AC,Denny T,Crowe SM

    更新日期：2009-10-01 00:00:00

  • Antibodies against p24 of HIV-1 in patients with systemic lupus erythematosus?

    abstract：:The involvement of retroviruses in the etiopathogenesis of autoimmunity is discussed. Recently antibodies against p24 of HIV-1 were described in patients from Texas with SLE. Therefore we investigated the presence of these antibodies in our SLE collective (German caucasians and blacks from Michigan) employing ELISA an...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1992.5.229

    authors： Herrmann M,Baur A,Nebel-Schickel H,Vornhagen R,Jahn G,Krapf FE,Kalden JR

    更新日期：1992-10-01 00:00:00

  • Fowl Aviadenovirus 9 dUTPase Plays a Role in Regulation of the Host Immune Response.

    abstract：:Fowl aviadenoviruses (FAdVs) are distributed worldwide in poultry farms. Some FAdVs are the causative agents of inclusion body hepatitis and hydropericardium syndrome that cause significant economic losses to the poultry industry. In contrast with human adenovirus, the study of the molecular biology of FAdV is still f...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2017.0068

    authors： Deng L,Griffin BD,Pei Y,Leishman D,McBey BA,Sharif S,Nagy É

    更新日期：2017-11-01 00:00:00

  • A truncated plasmid-encoded HIV-1 reverse transcriptase displays strong immunogenicity.

    abstract：:Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. In this study, we explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy fo...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0083

    authors： Hallengärd D,Wahren B,Bråve A

    更新日期：2013-04-01 00:00:00

  • Failure of vaccine or virulent strains of canine parvovirus to induce immunosuppressive effects on the immune system of the dog.

    abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1987.1.135

    authors： Phillips TR,Schultz RD

    更新日期：1987-01-01 00:00:00

  • Effects of different immunization protocols and adjuvant on antibody responses to inactivated SARS-CoV vaccine.

    abstract：:Severe acute respiratory syndrome (SARS) is a deadly and highly infectious disease caused by SARS Coronavirus (SARS-CoV). Inactivated SARS-CoV has been explored as a vaccine against SARS-CoV; however, current knowledge of inactivated SARS-CoV vaccine is quite limited. We attempted to investigate the effects of differe...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0079

    authors： Gai W,Zou W,Lei L,Luo J,Tu H,Zhang Y,Wang K,Tien P,Yan H

    更新日期：2008-03-01 00:00:00

  • Induction of immunity in the respiratory tract and protection from bovine herpesvirus type 1 infection by different routes of immunization with recombinant adenovirus.

    abstract：:To investigate the capability of different routes of immunization with replication-competent recombinant adenovirus to induce antigen-specific antibody responses, we immunized cotton rats with a human adenovirus type 5 (HAd5) vector expressing the glycoprotein D (gD) of bovine herpesvirus type 1 (BHV-1) (gD-dE3). Diff...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1998.11.79

    authors： Papp Z,Babiuk LA,Baca-Estrada ME

    更新日期：1998-01-01 00:00:00

  • Adaptive B Cell Responses to Influenza Virus Infection in the Lung.

    abstract：:Adaptive B cell response is a key arm of protective immunity against influenza viruses. Owing to the acutely infectious and cytopathic nature of these viruses, efficient containment of viral spread relies on the prompt provision of protective antibodies to the site of virus infection, the respiratory tract (RT). To ac...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2017.0025

    authors： Takahashi Y,Onodera T,Adachi Y,Ato M

    更新日期：2017-07-01 00:00:00