Abstract:
:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effector (NE) cell activity, antibody-dependent cell-mediated cytotoxicity (ADCC), chemiluminescence (CL) of neutrophils, lymphocyte response to mitogen, specific antibody response to CPV, and dermal reaction to phytohemagglutinin (PHA) were examined. Neither a virulent nor a vaccine strain of CPV significantly suppressed the immune system. The only potential effect noted was that dogs infected with the virulent strain of CPV developed a transient peripheral blood leukopenia. It was concluded that CPV does not cause immunosuppression and that immunosuppression does not play a significant role in the pathogenesis of canine parvovirus disease.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Phillips TR,Schultz RDdoi
10.1089/vim.1987.1.135subject
Has Abstractpub_date
1987-01-01 00:00:00pages
135-44issue
2eissn
0882-8245issn
1557-8976journal_volume
1pub_type
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