当前位置： SCI文献检索 > VIRAL IMMUNOLOGY期刊下所有文献 > Expression of leukocyte immunoglobulin-like receptors and natural killer receptors on virus-specific CD8+ T cells during the evolution of Epstein-Barr virus-specific immune responses in vivo.

Expression of leukocyte immunoglobulin-like receptors and natural killer receptors on virus-specific CD8+ T cells during the evolution of Epstein-Barr virus-specific immune responses in vivo.

Abstract：

:Antigen-primed cytotoxic T lymphocytes (CTL) may express leukocyte immunoglobulin-like receptors (LILRs) and natural killer receptors (NKRs). Published work suggests that expression of some of these receptors confers survival advantage, leading to the idea that cells expressing such receptors may accumulate as an antigen-specific response evolves. Here we tested this hypothesis by analyzing expression of CD85j (also known as LILRB1 or ILT2), KIRs, CD94, and CD161 by Epstein- Barr virus (EBV)-specific CTL during the primary and persistent phases of EBV infection in humans. During primary infection, few EBV-specific CTL expressed these receptors and this proportion was equally low in early persistent infection. Thus, expression of these molecules does not influence capacity to survive downregulation of the primary response. However, in donors persistently infected with EBV for many years, a significantly higher proportion of EBV-specific CTL expressed CD85j and NKRs, suggesting that cells expressing these receptors can accumulate with time. Using FACS analysis, we confirmed, at a single cell level, that expression of CD85j, defined by staining with the antibody VMP55, was associated with reduced capacity of EBV-specific CD8+ T cells to respond to antigen. Thus, in the later stages of persistent infection, protective immunity to EBV may be reduced due to the preferential accumulation of hyporesponsive EBV-specific CD8+ T cells.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Poon K,Montamat-Sicotte D,Cumberbatch N,McMichael AJ,Callan MF

doi

10.1089/vim.2005.18.513

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

513-22

issue

3

eissn

0882-8245

issn

1557-8976

journal_volume

18

pub_type

杂志文章

相关文献

VIRAL IMMUNOLOGY文献大全
  • Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

    abstract：:The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns, resulting in the induction of innate immune responses. Viral RNA in...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/vim.2016.0178

    authors： Okamoto M,Tsukamoto H,Kouwaki T,Seya T,Oshiumi H

    更新日期：2017-07-01 00:00:00

  • Immune response to Fc tagged GP5 glycoproteins of porcine reproductive and respiratory syndrome virus.

    abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 5 (GP5) is the most abundant envelope glycoprotein and a key target for neutralizing antibodies. Previous studies have demonstrated that the native GP5 glycoprotein is poorly immunogenic and not able to induce robust protective responses, probabl...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0041

    authors： Wu F,Peng K,Tian J,Xu X,Zhou E,Chen H

    更新日期：2014-09-01 00:00:00

  • Efficacy of modified levamisole adjuvant on inactivated virus vaccine.

    abstract：:To improve efficacy, especially for the cell-mediated response to inactivated viral vaccines, a modified levamisole (LMS) adjuvant formulation, designated LMS+, was evaluated for its efficacy in mice and chickens, using Newcastle Disease Virus (NDV) as a model pathogen. Compared with oil adjuvant, the killed NDV in LM...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.19.525

    authors： Yin J,Jin H,Kang Y,Xiao C,Zhao L,Li X,Ding Z,Yang F,Zhu Q,Wang B

    更新日期：2006-07-01 00:00:00

  • Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus.

    abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be an economically important infectious disease of swine. Mechanisms governing activation of the innate immune response to PRRSV remain to be elucidated. Virulence differences observed between PRRSV isolates have been attributed to replication ab...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2008.0038

    authors： Loving CL,Brockmeier SL,Vincent AL,Lager KM,Sacco RE

    更新日期：2008-09-01 00:00:00

  • Major and minor Kb-restricted epitopes encoded by the endogenous ecotropic murine leukemia virus AKR623 that are recognized by anti-AKR/Gross MuLV CTL.

    abstract：:C57BL/6 mice can generate a type-specific and class IH-2Kb-restricted CTL response against histocompatible AKR/Gross murine leukemia virus (MuLV) cell surface antigen positive (GCSA+) tumor cells. These anti-AKR/Gross MuLV CTL are also known to lyse SC.Kb/623 target cells expressing the molecular MuLV clone AKR623 (de...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1994.7.51

    authors： White HD,Roeder DA,Lam T,Green WR

    更新日期：1994-01-01 00:00:00

  • COVID-19: Between Past and Present.

    abstract：:Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2020.0102

    authors： Assaf AM,Haddadin RN,Akour AA

    更新日期：2020-10-05 00:00:00

  • Failure of vaccine or virulent strains of canine parvovirus to induce immunosuppressive effects on the immune system of the dog.

    abstract：:It is generally believed that canine parvovirus (CPV) is immunosuppressive and that immunosuppression plays an important role in the pathogenesis of canine parvovirus disease. However, there is little experimental evidence to support this assertion. The effects of virulent and vaccine strains of CPV on natural effecto...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1987.1.135

    authors： Phillips TR,Schultz RD

    更新日期：1987-01-01 00:00:00

  • Characterization of Anti-HCV Antibodies in IL-10-Treated Patients.

    abstract：:There is limited information on the direct role of the neutralizing antibody responses against hepatitis C virus (HCV) infection or methodologies to study them. Previously we have demonstrated that interleukin-10 (IL-10) administered to chronic hepatitis patients led to a decrease in disease activity, but an increase ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0095

    authors： Eksioglu EA,Bess J,Jones G,Dettloff J,Dangmeon P,Dong HJ,Zhu H,Firpi R,Xu Y,Nelson DR,Liu C

    更新日期：2010-08-01 00:00:00

  • Interleukin-10, interleukin-12, and interferon-gamma levels in the respiratory tract following mycoplasma hyopneumoniae and PRRSV infection in pigs.

    abstract：:The cytokine profile associated with either a T helper 1 (Th1) or Th2 response in a porcine respiratory disease model was assessed by measuring IL-12, IL-10 and IFN-gamma using RT-PCR and ELISA, respectively. IL-10, IL-12, and IFN-gamma levels in pulmonary alveolar macrophages and bronchial lavage fluid were increased...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/088282403322396154

    authors： Thanawongnuwech R,Thacker EL

    更新日期：2003-01-01 00:00:00

  • Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.

    abstract：:Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immuni...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0052

    authors： Hofstetter AR,Evavold BD,Lukacher AE

    更新日期：2013-02-01 00:00:00

  • Varicella zoster virus-specific cytotoxicity following secondary immunization with live or killed vaccine.

    abstract：:Subjects > or = 55 years of age were immunized with attenuated varicella zoster virus (VZV) vaccine (live) or with the same vaccine, which had been heated to 56 degrees C for 7 days (killed). The ability of subjects' blood lymphocytes to lyse target cells infected with VZV was determined before and 3 months after immu...

    journal_title：Viral immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1089/vim.1996.9.241

    authors： Hayward AR,Buda K,Jones M,White CJ,Levin MJ

    更新日期：1996-01-01 00:00:00

  • Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.

    abstract：:Given the continued spread of human immunodeficiency virus (HIV)-1 worldwide, developing efficient vaccine strategies against HIV-1 is a key task. We tested the safety and immunogenicity of a multicomponent, cell-based vaccine that consisted of antigen-expressing apoptotic bodies with or without autologous dendritic c...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2006.0052

    authors： Gruber A,Chalmers AS,Rasmussen RA,Ong H,Popov S,Andersen J,Hu SL,Ruprecht RM

    更新日期：2007-04-01 00:00:00

  • High frequency of variant alleles of the mannose-binding lectin 2 (MBL2) gene are associated with patients infected by hepatitis B virus.

    abstract：:Patients with hepatitis B virus (HBV) infection may develop severe chronic liver disease. Carriers of HBV have an increased risk of developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Worldwide an estimated 350 million people are infected with HBV, and 15-40% will develop serious sequelae in th...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2009.0105

    authors： Filho RM,Carmo RF,Catsman C,Souza C,Silva A,Moura P,Tenorio AL,Vasconcelos LR,Cavalcanti Mdo S,Pereira LM

    更新日期：2010-08-01 00:00:00

  • Correlation of clinical parameters and immunological function with human immunodeficiency virus plasma viremia in children.

    abstract：:Studies of immune function in human immunodeficiency virus (HIV)-infected children are important, because functional abnormalities can precede CD4+ T-cell loss and are associated with the development of opportunistic and bacterial infections. We sought to correlate clinical parameters and immunological function with H...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1999.12.139

    authors： Peters VB,Mayer L,Sperber KE

    更新日期：1999-01-01 00:00:00

  • Evaluation of NLRC4, NLRP1, and NLRP3, as Components of Inflammasomes, in Chronic Hepatitis B Virus-Infected Patients.

    abstract：:Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0045

    authors： Askari A,Nosratabadi R,Khaleghinia M,Zainodini N,Kennedy D,Shabani Z,Kazemi Arababadi M

    更新日期：2016-11-01 00:00:00

  • Mannan-binding lectin (MBL) serum concentration in relation to propagation of infectious bronchitis virus (IBV) in chickens.

    abstract：:Mannan-binding lectin (MBL) is a collectin that mediates activation of the complement system and is of importance for host defenses. In humans low concentrations of MBL in serum have been associated with susceptibility to several viral diseases. To understand the function of MBL in relation to infectious viral disease...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0036

    authors： Juul-Madsen HR,Norup LR,Handberg KJ,Jørgensen PH

    更新日期：2007-12-01 00:00:00

  • Antibodies against human papillomavirus type 16 and 18 E6 and E7 proteins in cervicovaginal washings and serum of patients with cervical neoplasia.

    abstract：:Serum antibodies against the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18 are associated with cervical cancer. The aim of this study was to investigate the presence of local antibodies against HPV in cervicovaginal washings (CWs). In this study antibodies against the native HPV16 and HPV18 E6/E7 proteins...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/08828240152716655

    authors： Tjiong MY,Zumbach K,Schegget JT,van der Vange N,Out TA,Pawlita M,Struyk L

    更新日期：2001-01-01 00:00:00

  • Loss of RORγt DNA binding activity inhibits IL-17 expression in HIV-1 infected Indian individuals.

    abstract：:Abstract IL-17 producing CD4 T cells have recently been shown to play an important role in mucosal immunity in HIV infection. But its role in peripheral immunity and the molecular mechanism underlying its regulation during HIV-1 infection are ill defined. In this study, we report a significant negative correlation b...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2012.0048

    authors： Singh A,Vajpayee M,Ali SA,Chauhan NK

    更新日期：2013-02-01 00:00:00

  • Cellular gene expression profiles in rhesus macaques challenged mucosally with a pathogenic R5 tropic simian human immunodeficiency virus isolate.

    abstract：:Insights into the host factors that contribute to an effective antiviral immune response may be obtained by examining global gene expression in simian human immunodeficiency virus (SHIV)-infected nonhuman primates that exhibit different virological outcomes. Immune responses and gene expression profiles in peripheral ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2008.0076

    authors： Chung HK,Pise-Masison CA,Radonovich MF,Brady J,Lee JK,Cheon SY,Markham P,Cristillo A,Pal R

    更新日期：2008-12-01 00:00:00

  • High thymic volume is associated with viral replication and immunologic impairment only early after HAART interruption in chronic HIV infection.

    abstract：:One of the strategies that has been investigated to reduce antiretroviral treatment toxicity in patients infected with human immunodeficiency virus (HIV) is structured treatment interruption (STI). Our aim was to analyze early viral and immune dynamics after interruption of highly active antiretroviral therapy (HAART)...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.740

    authors： Vallejo A,Valladares A,De Felipe B,Vivancos J,Gutierrez S,Soriano-Sarabia N,Ruiz-Mateos E,Lissen E,Leal M

    更新日期：2005-01-01 00:00:00

  • Kinetics of Th17 cytokines during telbivudine therapy in patients with chronic hepatitis B.

    abstract：:Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication ef...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2013.0032

    authors： Hao C,Wang J,Kang W,Xie Y,Zhou Y,Ma L,Peng M,Bai X,Lian J,Jia Z

    更新日期：2013-10-01 00:00:00

  • Correlation of in vitro T-cell and B-cell function with responses to childhood vaccines in children with human immunodeficiency virus infection.

    abstract：:We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1997.10.197

    authors： Peters VB,Mayer LF,Sperber KE

    更新日期：1997-01-01 00:00:00

  • The effect of different bovine viral diarrhea virus genotypes and biotypes on the metabolic activity and activation status of bovine peripheral blood mononuclear cells.

    abstract：:The effects of cytopathic (cp) and non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) on the cellular metabolic activity and activation status of bovine peripheral blood mononuclear cells (PBMC) were investigated. Cellular DNA and protein synthesis was determined by [3H]thymidine and [3H]valine incorporation, res...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1998.11.233

    authors： Hou L,Wilkerson M,Kapil S,Mosier D,Shuman W,Reddy JR,Loughin T,Minocha HC

    更新日期：1998-01-01 00:00:00

  • Major Immunodominant Region of Hepatitis B Virus Core Antigen as a Delivery Vector to Improve the Immunogenicity of the Fusion Antigen ROP2-SAG1 Multiepitope from Toxoplasma gondii in Mice.

    abstract：:To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR),...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2016.0135

    authors： Wang W,Feng F,Lv J,Xie Z,Chen J,Zhang L,Li W

    更新日期：2017-09-01 00:00:00

  • Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression.

    abstract：:Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2013.0127

    authors： Liu Y,Zhang Z,Zhao X,Yu R,Zhang X,Wu S,Liu J,Chi X,Song X,Fu L,Yu Y,Hou L,Chen W

    更新日期：2014-08-01 00:00:00

  • Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions.

    abstract：:Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 c...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2014.0017

    authors： Rizzo R,Gentili V,Rotola A,Bortolotti D,Cassai E,Di Luca D

    更新日期：2014-11-01 00:00:00

  • Better protective effects in rhesus macaques by combining systemic and mucosal application of a dual component vector vaccine after rectal SHIV89.6P challenge compared to systemic vaccination alone.

    abstract：:In this study we investigated the efficacy of a multigenic DNA prime/modified vaccinia Ankara (MVA)boost vaccine approach, followed by mucosal challenge with highly pathogenic simian-human immunodeficiency virus (SHIV) 89.6P, using different routes for vaccine delivery. After three times of DNA priming (SIVmac239, Gag...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2007.0103

    authors： Stolte-Leeb N,Bieler K,Kostler J,Heeney J,Haaft PT,Suh YS,Hunsmann G,Stahl-Hennig C,Wagner R

    更新日期：2008-06-01 00:00:00

  • Effects of interferon-gamma on neuronal infections.

    abstract：:IFN-gamma is released in the brain, not only during acute infectious diseases or immunological reactions, but also for extended periods of time after clearance of infectious virus and during viral latency. In this review, we focus on the role of IFN-gamma in the interaction between a neuron and a pathogen, that is, th...

    journal_title：Viral immunology

    pub_type： 杂志文章,评审

    doi：10.1089/08828240260066206

    authors： Rottenberg M,Kristensson K

    更新日期：2002-01-01 00:00:00

  • Anti-idiotypic antibodies against anti-CD4 antibodies MT151 and OKT4A.

    abstract：:Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of other antibodies may functionally and even structurally mimic antigen. Ab2 to antibodies directed against the lymphocyte CD4 receptor for human immunodeficiency virus type 1 (HIV-1) may mimic the receptor and therefore inhibit viral infectivity. ...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.1991.4.83

    authors： Liang SH,Rieber P,Prewett M,Riethmüller G,Pletcher C,Hoxie J,Koprowski H,Herlyn D

    更新日期：1991-07-01 00:00:00

  • Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge.

    abstract：:We have previously demonstrated the formation and release of influenza virus-like particles (VLPs) from the surface of Sf9 cells infected with either a quadruple baculovirus recombinant that simultaneously expresses the influenza structural proteins hemagglutinin (HA), neuraminidase (NA), matrix 1 (M1) and M2, or a co...

    journal_title：Viral immunology

    pub_type： 杂志文章

    doi：10.1089/vim.2005.18.244

    authors： Galarza JM,Latham T,Cupo A

    更新日期：2005-01-01 00:00:00