Abstract:
:Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2(s) and H-2(g7) strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Hofstetter AR,Evavold BD,Lukacher AEdoi
10.1089/vim.2012.0052subject
Has Abstractpub_date
2013-02-01 00:00:00pages
109-13issue
1eissn
0882-8245issn
1557-8976journal_volume
26pub_type
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