Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.

Abstract:

:Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2(b) haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2(s) and H-2(g7) strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Hofstetter AR,Evavold BD,Lukacher AE

doi

10.1089/vim.2012.0052

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

109-13

issue

1

eissn

0882-8245

issn

1557-8976

journal_volume

26

pub_type

杂志文章
  • Opinion: Making Inactivated and Subunit-Based Vaccines Work.

    abstract::Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2017.0146

    authors: Chua BY,Sekiya T,Jackson DC

    更新日期:2018-03-01 00:00:00

  • Endogenous retroviral gp70 genes of the murine lymphoma L5178Y: analysis of restriction fragment polymorphism upon induction of drug-mediated immunogenicity.

    abstract::Highly immunogenic ("xenogenized") tumor variants appear after treatment of murine lymphoma L5178Y with the triazene derivative DTIC, this phenomenon being associated with the appearance of structurally abnormal gp70 env proteins in the cell variants. In the present study, we have isolated and sequenced several PCR-am...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.1994.7.155

    authors: Grohmann U,Belladonna ML,Allegrucci M,Silla S,Schiaffella E,Fioretti MC,Puccetti P

    更新日期:1994-01-01 00:00:00

  • Ricin toxin B subunit enhancement of rotavirus NSP4 immunogenicity in mice.

    abstract::A 90-amino acid peptide from the simian rotavirus SA-11 nonstructural protein, NSP4 was linked to the N-terminus of the Ricinus communis A-B toxin B subunit protein (RTB) and synthesized in Escherichia coli. Recombinant RTB and the NSP4(90)::RTB fusion protein bound artificial receptor glycoprotein asialofetuin in an ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2006.19.54

    authors: Choi NW,Estes MK,Langridge WH

    更新日期:2006-04-01 00:00:00

  • Evaluation of NLRC4, NLRP1, and NLRP3, as Components of Inflammasomes, in Chronic Hepatitis B Virus-Infected Patients.

    abstract::Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2016.0045

    authors: Askari A,Nosratabadi R,Khaleghinia M,Zainodini N,Kennedy D,Shabani Z,Kazemi Arababadi M

    更新日期:2016-11-01 00:00:00

  • Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy.

    abstract::Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2018.0014

    authors: Ariyanto IA,Estiasari R,Waters S,Wulandari EAT,Fernandez S,Lee S,Price P

    更新日期:2018-07-01 00:00:00

  • Immunological characterization of respiratory syncytial virus N protein epitopes recognized by human cytotoxic T lymphocytes.

    abstract::Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N protein for HLA-A 0201-binding amino acid consensus motifs, identifying t...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2007.0041

    authors: Terrosi C,Di Genova G,Savellini GG,Correale P,Blardi P,Cusi MG

    更新日期:2007-09-01 00:00:00

  • Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2.

    abstract::The JHM strain of mouse hepatitis virus (JHMV) is rapidly cleared from the central nervous system (CNS) by CD8(+) T cells. In the absence of CD4(+) T cells, fewer CD8(+) T cells are found within the CNS in association with a coordinate increase in apoptotic lymphocytes. Previous data suggested that CD4(+) T cells may ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2005.18.162

    authors: Zhou J,Hinton DR,Stohlman SA,Liu CP,Zhong L,Marten NW

    更新日期:2005-01-01 00:00:00

  • A Novel Recombinant Canine Adenovirus Type 1 Detected from Acute Lethal Cases of Infectious Canine Hepatitis.

    abstract::In this study, canine adenoviruses (CAdVs) from two acute fatal cases of infectious canine hepatitis (ICH) were analyzed using molecular detection and sequencing of the pVIII, E3, and fiber protein genes. Pathological findings in affected dogs were typical for CAdV-1 associated disease, characterized by severe centril...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2016.0041

    authors: Wong M,Woolford L,Hasan NH,Hemmatzadeh F

    更新日期:2017-05-01 00:00:00

  • Induction of protective immunity against herpes simplex virus with DNA encoding the immediate early protein ICP 27.

    abstract::Using a mouse zosteriform model that mimics human herpes simplex virus (HSV) infection in several aspects, the effectiveness of plasmid DNA encoding the immediate early protein ICP 27 was evaluated as a vaccine. Animals were immunized intramuscularly twice with DNA, then either challenged with virus or killed, and the...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.1995.8.53

    authors: Manickan E,Yu Z,Rouse RJ,Wire WS,Rouse BT

    更新日期:1995-01-01 00:00:00

  • Differential Immune Responses in Mice Immunized with Recombinant Neutralizing Epitope Protein of Hepatitis E Virus Formulated with Liposome and Alum Adjuvants.

    abstract::In the developing countries, Hepatitis E virus (HEV) is a predominant cause of sporadic acute hepatitis in adults and waterborne epidemics leading to high mortality in pregnant women. Vaccine development mainly focuses on the structural capsid protein open-reading-frame-2 (ORF-2) of the virus. We successfully evaluate...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2016.0024

    authors: Joshi SS,Arankalle VA

    更新日期:2016-07-01 00:00:00

  • The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

    abstract::We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2011.0091

    authors: Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

    更新日期:2012-06-01 00:00:00

  • Antibody to dengue 1 detected more than 60 years after infection.

    abstract::We investigated the duration of humoral responses to dengue virus infection in individuals who recalled experiencing dengue fever-like illnesses at the time of the Second World War, when dengue fever epidemics occurred throughout the Pacific and Southeast Asia. In July 1943 dengue fever reappeared in Hawaii following ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2007.0050

    authors: Imrie A,Meeks J,Gurary A,Sukhbaatar M,Truong TT,Cropp CB,Effler P

    更新日期:2007-12-01 00:00:00

  • Association of a TANK gene polymorphism with outcomes of hepatitis B virus infection in a Chinese Han population.

    abstract::The host genetic compound plays a vital role in determining clinical outcomes of hepatitis B virus (HBV) infection. The tumor necrosis factor receptor-associated factor family member-associated nuclear factor-κB (NF-κB) activator (TANK) takes part in the tumor necrosis factor-α (TNF-α)-mediated NF-κB signaling pathway...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2011.0053

    authors: Song QL,He XX,Yang H,Li J,Chen M,Wang MY,Liu Q,Yu JL,Yao JJ,Liu LF,Sun SZ,Lin JS

    更新日期:2012-02-01 00:00:00

  • Antibodies against human papillomavirus type 16 and 18 E6 and E7 proteins in cervicovaginal washings and serum of patients with cervical neoplasia.

    abstract::Serum antibodies against the E6 and E7 proteins of human papillomavirus (HPV) 16 and 18 are associated with cervical cancer. The aim of this study was to investigate the presence of local antibodies against HPV in cervicovaginal washings (CWs). In this study antibodies against the native HPV16 and HPV18 E6/E7 proteins...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/08828240152716655

    authors: Tjiong MY,Zumbach K,Schegget JT,van der Vange N,Out TA,Pawlita M,Struyk L

    更新日期:2001-01-01 00:00:00

  • Correlation of in vitro T-cell and B-cell function with responses to childhood vaccines in children with human immunodeficiency virus infection.

    abstract::We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.1997.10.197

    authors: Peters VB,Mayer LF,Sperber KE

    更新日期:1997-01-01 00:00:00

  • Cellular gene expression profiles in rhesus macaques challenged mucosally with a pathogenic R5 tropic simian human immunodeficiency virus isolate.

    abstract::Insights into the host factors that contribute to an effective antiviral immune response may be obtained by examining global gene expression in simian human immunodeficiency virus (SHIV)-infected nonhuman primates that exhibit different virological outcomes. Immune responses and gene expression profiles in peripheral ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2008.0076

    authors: Chung HK,Pise-Masison CA,Radonovich MF,Brady J,Lee JK,Cheon SY,Markham P,Cristillo A,Pal R

    更新日期:2008-12-01 00:00:00

  • gamma-Herpesvirus-induced protection against bacterial infection is transient.

    abstract::Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically s...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2008.0086

    authors: Yager EJ,Szaba FM,Kummer LW,Lanzer KG,Burkum CE,Smiley ST,Blackman MA

    更新日期:2009-02-01 00:00:00

  • Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin.

    abstract::Highly pathogenic avian influenza (HPAI) H5N1 virus emerged in 1997 as a zoonotic disease in Hong Kong. It has since spread to Asia and Europe and is a serious threat to both the poultry industry and human health. For effective surveillance and possible prevention/control of HPAI H5N1 viruses, it is necessary to under...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2017.0020

    authors: Daidoji T,Watanabe Y,Arai Y,Kajikawa J,Hirose R,Nakaya T

    更新日期:2017-07-01 00:00:00

  • Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling.

    abstract::Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/0882824041310568

    authors: Rodriguez JJ,Horvath CM

    更新日期:2004-01-01 00:00:00

  • Eradicating HPV-Associated Cancer Through Immunization: A Glass Half Full….

    abstract::The human papillomavirus (HPV) is an important causal agent of premalignant cervical epithelial changes and cervical cancers. These cancers account for ∼5% of all cancers globally and kill more than a quarter million women annually. HPV infections also associate with certain anogenital and oropharyngeal cancers. Event...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2017.0119

    authors: Frazer IH

    更新日期:2018-03-01 00:00:00

  • To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

    abstract::As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/088282402317340260

    authors: He Y,Katze MG

    更新日期:2002-01-01 00:00:00

  • High frequency of variant alleles of the mannose-binding lectin 2 (MBL2) gene are associated with patients infected by hepatitis B virus.

    abstract::Patients with hepatitis B virus (HBV) infection may develop severe chronic liver disease. Carriers of HBV have an increased risk of developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Worldwide an estimated 350 million people are infected with HBV, and 15-40% will develop serious sequelae in th...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2009.0105

    authors: Filho RM,Carmo RF,Catsman C,Souza C,Silva A,Moura P,Tenorio AL,Vasconcelos LR,Cavalcanti Mdo S,Pereira LM

    更新日期:2010-08-01 00:00:00

  • Environmental toxins as modulators of antiviral immune responses.

    abstract::Exposure to environmental contaminants has a profound effect on immune function, yet mechanistic understanding of how pollutants deregulate immune responses has, for many chemicals, remained elusive. Available data suggest that certain pollutants alter host immune responses and increase susceptibility to viral infecti...

    journal_title:Viral immunology

    pub_type: 杂志文章,评审

    doi:10.1089/vim.2007.0013

    authors: Lawrence BP

    更新日期:2007-07-01 00:00:00

  • Immunization with a Recombinant Expression Vector Encoding NS3/NS4A of Hepatitis C Virus Genotype 3a Elicits Cell-Mediated Immune Responses in C57BL/6 Mice.

    abstract::Today, hepatitis C virus (HCV) infection is considered as one of the most significant international health concerns. Although novel therapeutic regimens against the infection have shown satisfactory results, no approved vaccine exists yet. This study aimed to evaluate the immunogenicity of a DNA vaccine candidate for ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2015.0085

    authors: Behzadi MA,Alborzi A,Kalani M,Pouladfar G,Dianatpour M,Ziyaeyan M

    更新日期:2016-04-01 00:00:00

  • Highly active antiretroviral therapy in patients infected with human immunodeficiency virus increases CD40 ligand expression and IL-12 production in cells ex vivo.

    abstract::Highly active anti-retroviral therapy (HAART) restores CD4(+) T-cell numbers in the periphery; however, its efficacy in restoring functional immunity is not fully elucidated. Here we evaluated longitudinal changes in the expression of several key markers of T-cell activation, namely CD40 ligand (CD154), OX40 (CD134), ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2010.0142

    authors: Nyakeriga AM,Ying J,Shire NJ,Fichtenbaum CJ,Chougnet CA

    更新日期:2011-08-01 00:00:00

  • PyNTTTTGT prototype oligonucleotide IMT504, a novel effective adjuvant of the FMDV DNA vaccine.

    abstract::Synthetic oligodeoxynucleotides (ODNs) such as CpG can stimulate B and plasmacytoid dendritic cells in vertebrate immune systems. Several studies showed that non-CpG ODNs could also induce strong stimulation of B and T cells. PyNTTTTGT ODNs, non-CpG ODNs, can activate and cause immunoglobulin secretion by B cells and ...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2008.0073

    authors: Zhao G,Jin H,Li J,Su B,Du X,Kang Y,Wang X,Wang B

    更新日期:2009-04-01 00:00:00

  • What Targets Somatic Hypermutation to the Immunoglobulin Loci?

    abstract::One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the swit...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2019.0149

    authors: Heltzel JMH,Gearhart PJ

    更新日期:2020-05-01 00:00:00

  • Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells.

    abstract::The objective of this study was to investigate the immune responses elicited by either a modified-live (MLV) or a killed virus (KV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Specifically, we investigated the effects of multiple vaccinations on antigen-specific cellular and antibody responses...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/088282404322875430

    authors: Bassaganya-Riera J,Thacker BJ,Yu S,Strait E,Wannemuehler MJ,Thacker EL

    更新日期:2004-01-01 00:00:00

  • Protective efficacy of a single dose of baculovirus hemagglutinin-based vaccine in chickens and ducks against homologous and heterologous H5N1 virus infections.

    abstract::Outbreaks of the highly pathogenic H5N1 virus in poultry and humans are ongoing. Vaccination is an efficient method for prevention of H5N1 infection. Using chickens and ducks, we assessed the efficacy of a vaccine comprising H5N1 hemagglutinin (HA) protein produced in a baculovirus expression system. The immunized chi...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2014.0029

    authors: Park EH,Song BM,Yum J,Kim JA,Oh SK,Kim HS,Cho GJ,Seo SH

    更新日期:2014-11-01 00:00:00

  • Cytokine expression in the cervical stroma of HIV-positive and HIV-negative women with cervical intraepithelial neoplasia.

    abstract::Cervical intraepithelial neoplasias (CINs) are a major public health issue. The prevalence of CINs is higher in women with the human immunodeficiency virus (HIV). The objective of this study was to determine whether there are differences in the immune responses in the cervical stroma of HIV-infected and -uninfected wo...

    journal_title:Viral immunology

    pub_type: 杂志文章

    doi:10.1089/vim.2014.0032

    authors: Guimarães MV,Michelin MA,Lucena AA,Lodi CT,Lima MI,Murta EF,Melo VH

    更新日期:2014-09-01 00:00:00