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Kinetics of Th17 cytokines during telbivudine therapy in patients with chronic hepatitis B.

Abstract：

:Th17 cells and the secreting cytokines play an important role in the immune response and inflammation that is induced by hepatitis B virus (HBV). However, it remains not fully elucidated how the antiviral agents affect Th17 cytokines and signal pathway. Telbivudine therapy has been proved to inhibit HBV replication effectively and to improve clinical outcome of chronic hepatitis B (CHB). Thus, in this study, the effect of decrease in viral load and liver dysfunction resulting from telbivudine treatment on Th17 cells and the related cytokines IL-17, IL-22, and IL-23 were analyzed. Peripheral blood mononuclear cells and serum from twenty-four CHB patients were harvested at 0, 12, 24, 36, and 48 weeks after initiation of telbivudine treatment. In parallel to the reduction of HBV DNA and normalization of serum ALT, significant declines in circulating HBV-specific Th17 cells and IL-22 production were found during antiviral therapy. The expression of serum IL-22 and IL-23, but not IL-17 also decreased during therapy. Our findings suggest that antiviral effect of telbivudine may attribute to both direct virus inhibition and regulation of inflammation, which further improve the understanding of pathogenesis of HBV infection and develop antiviral strategy for controlling viral hepatitis.

journal_name

Viral Immunol

journal_title

Viral immunology

authors

Hao C,Wang J,Kang W,Xie Y,Zhou Y,Ma L,Peng M,Bai X,Lian J,Jia Z

doi

10.1089/vim.2013.0032

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

336-42

issue

5

eissn

0882-8245

issn

1557-8976

journal_volume

26

pub_type

杂志文章

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