Abstract:
:Patients with hepatitis B virus (HBV) infection may develop severe chronic liver disease. Carriers of HBV have an increased risk of developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Worldwide an estimated 350 million people are infected with HBV, and 15-40% will develop serious sequelae in their lifetime. In our study we investigated the association of single nucleotide polymorphisms (SNPs) in the first exon and promoter region of the mannose-binding lectin gene 2 (MBL2) situated on chromosome 10, with susceptibility to HBV infection. One-hundred and two patients infected with HBV were included in this study, and 232 uninfected individuals were used as healthy controls. Genotyping of the first exon (alleles A/O) was performed using a melting temperature assay. Genotyping of the promoter region (-550 H/L; -221 Y/X) was performed using the Taqman PCR technique. In the HBV-infected group we found a significantly increased frequency of haplotypes associated with low serum MBL. Our findings may indicate that MBL has a protective role against HBV infection in the studied population.
journal_name
Viral Immunoljournal_title
Viral immunologyauthors
Filho RM,Carmo RF,Catsman C,Souza C,Silva A,Moura P,Tenorio AL,Vasconcelos LR,Cavalcanti Mdo S,Pereira LMdoi
10.1089/vim.2009.0105subject
Has Abstractpub_date
2010-08-01 00:00:00pages
449-53issue
4eissn
0882-8245issn
1557-8976journal_volume
23pub_type
杂志文章相关文献
VIRAL IMMUNOLOGY文献大全abstract::Stage of liver fibrosis is critical for treatment decision and prediction of outcomes in chronic hepatitis C (CHC) patients. We evaluated the diagnostic accuracy of transient elastography (TE)-FibroScan and noninvasive serum markers tests in the assessment of liver fibrosis in CHC patients, in reference to liver biops...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2017.0134
更新日期:2018-05-01 00:00:00
abstract::The purpose of the study was to evaluate pathologically the reproductive system of nonvaccinated and porcine reproductive and respiratory syndrome virus (PRRSV)-vaccinated sows/gilts, as well as the assessment of vaccination impact on their endometrium/myometrium and ovaries. In a farrow-to-finish farm, all sows and g...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0138
更新日期:2015-05-01 00:00:00
abstract::We analyzed T-cell responses to mitogens and antigens and B-cell differentiation in response to T-cell dependent (TCD) and independent stimuli in 22 human immunodeficiency virus (HIV)-infected children (1 to 9 years of age) according to the presence of protective humoral immunity at a mean time of 18 months after vacc...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1997.10.197
更新日期:1997-01-01 00:00:00
abstract::Altered cytokine transcription might play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection in humans. The infection of rhesus macaques with simian immunodeficiency virus (SIV) provides a relevant animal model for HIV infection. Therefore, we evaluated the cyokine transcription of p...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1997.10.65
更新日期:1997-01-01 00:00:00
abstract::Empirically derived vaccines have in the past relied on the isolation and growth of disease-causing microorganisms that are then inactivated or attenuated before being administered. This is often done without prior knowledge of the mechanisms involved in conferring protective immunity. Recent advances in scientific te...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2017.0146
更新日期:2018-03-01 00:00:00
abstract::C57BL/6 mice can generate a type-specific and class IH-2Kb-restricted CTL response against histocompatible AKR/Gross murine leukemia virus (MuLV) cell surface antigen positive (GCSA+) tumor cells. These anti-AKR/Gross MuLV CTL are also known to lyse SC.Kb/623 target cells expressing the molecular MuLV clone AKR623 (de...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1994.7.51
更新日期:1994-01-01 00:00:00
abstract::Dengue virus (DENV) causes a febrile disease, infecting around 50-100 million people annually. The relationship between DENV proteins and host cellular responses during infection is unclear. This study investigated the interaction of host protein disulfide isomerase (PDI) with DENV proteins and role of lipid rafts in ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2014.0095
更新日期:2015-04-01 00:00:00
abstract::In the developing countries, Hepatitis E virus (HEV) is a predominant cause of sporadic acute hepatitis in adults and waterborne epidemics leading to high mortality in pregnant women. Vaccine development mainly focuses on the structural capsid protein open-reading-frame-2 (ORF-2) of the virus. We successfully evaluate...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0024
更新日期:2016-07-01 00:00:00
abstract::Previously, we have shown that bovine herpesvirus 1 (BHV-1) down-regulates the expression of major histocompatibility complex class I molecules by interfering with transport of peptides by the transporter associated with antigen processing (TAP). Further studies revealed that BHV-1 down-regulates the expression of mRN...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282402320914539
更新日期:2002-01-01 00:00:00
abstract::Enterovirus 71 (EV71) infection can cause severe disease and lead to death in children. Recurring outbreaks of EV71 have been reported in several countries. Interferons (IFNs) have been used for decades to treat several types of viral infection, but have a limited ability to inhibit EV71 replication. Herein, we intend...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0127
更新日期:2014-08-01 00:00:00
abstract::California (CAL) serogroup Bunyaviruses are significant agents of arboviral encephalitis in humans. They are maintained and transmitted in nature by mosquitoes to preferred vertebrate amplifying hosts. The G2 envelope glycoprotein of La Crosse virus (LAC) was proposed by Ludwig et al. to be a determinant for virus att...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2000.13.201
更新日期:2000-01-01 00:00:00
abstract::We performed a comprehensive analysis of innate and adaptive immune responses in dual-virus infected pigs to understand whether a pre-existing immunomodulatory respiratory viral infection affects the overall immunity to a subsequent porcine respiratory coronavirus (PRCV) infection in pigs. Pigs were either mock-infect...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0051
更新日期:2010-10-01 00:00:00
abstract::This study was aimed at investigating the genes that control host responses to Marek's disease virus (MDV). Spleen tissues from infected and age-matched uninfected control chickens were examined 4, 7, 14, and 21 d postinfection for gene expression differences, using both microarray and quantitative real-time polymeras...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2006.19.747
更新日期:2006-01-01 00:00:00
abstract::Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2020.0102
更新日期:2020-10-05 00:00:00
abstract::Infusion of interleukin-12 (IL-12) enhances recovery from lethal experimental vesicular stomatitis virus (VSV) infection of the central nervous system (CNS). Interleukin-12 treatment resulted in: 1) increased survival frequency; 2) faster recovery from weight loss; 3) substantially decreased VSV titers in brain homoge...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1997.10.35
更新日期:1997-01-01 00:00:00
abstract::Abstract Influenza virus nucleoprotein (NP) binds to the viral genome RNA and forms the internal ribonucleoprotein complex of the virus particle. Avian and human influenza virus NP have characteristic differences at several amino acid positions. It is not known whether any of these differences can be recognized by ant...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2010.0088
更新日期:2011-04-01 00:00:00
abstract::One of the strategies that has been investigated to reduce antiretroviral treatment toxicity in patients infected with human immunodeficiency virus (HIV) is structured treatment interruption (STI). Our aim was to analyze early viral and immune dynamics after interruption of highly active antiretroviral therapy (HAART)...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2005.18.740
更新日期:2005-01-01 00:00:00
abstract::During ontogeny, antibody variable (V) regions are subjected to selection events at the level of B-cell clones bearing on their surfaces Ig molecules useful to the developing organism. Antigenic determinants of immunoglobulin V regions (idiotypes) are believed to play an essential role in molecular recognition and imm...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.1989.2.263
更新日期:1989-01-01 00:00:00
abstract::Nucleotide-binding domain leucine repeats (NLRs) are required for the recognition of various molecules that are expressed within microbes and are able to actuate appropriate immune responses via activation of cytokines. The current study evaluates the expression levels of NLRP1 and NLRC4, which are components of infla...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0045
更新日期:2016-11-01 00:00:00
abstract::Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to mi...
journal_title:Viral immunology
pub_type: 杂志文章,评审
doi:10.1089/vim.2005.18.411
更新日期:2005-01-01 00:00:00
abstract::The cytokine profile associated with either a T helper 1 (Th1) or Th2 response in a porcine respiratory disease model was assessed by measuring IL-12, IL-10 and IFN-gamma using RT-PCR and ELISA, respectively. IL-10, IL-12, and IFN-gamma levels in pulmonary alveolar macrophages and bronchial lavage fluid were increased...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/088282403322396154
更新日期:2003-01-01 00:00:00
abstract::HIV infection is characterized by a high degree of immune activation. It has an impact on CD4 cell count and populations' distribution and function. T regulatory cells (Tregs) were found to play a controversial role in the course of infection because of their beneficial effect on the degree of immune activation and un...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0075
更新日期:2017-04-01 00:00:00
abstract::The implications of sequential prime and challenge with mismatched influenza A viruses is a concern in mammals, including humans. We evaluated the ability of pigs affected with vaccine-associated enhanced respiratory disease (VAERD) to generate a humoral immune response against the heterologous challenge virus incitin...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0018
更新日期:2013-10-01 00:00:00
abstract::We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturat...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2011.0091
更新日期:2012-06-01 00:00:00
abstract::To understand the mechanistic basis for the reported outcomes of influenza A virus (IAV) infection during pregnancy, the effects of mouse adapted and pandemic (pdm) IAV infection in human choriocarcinoma cells were examined. Both viruses were able to infect and replicate in human placental cells, with pdm IAV being mo...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2013.0093
更新日期:2014-04-01 00:00:00
abstract::Persistent cervicovaginal infection with high-risk types of HPV is the major risk factor for subsequent cervical neoplasia. HPV53, part of the alpha 6 species group along with HPV types 30, 56, and 66, is one of the most prevalent high risk-related HPV types, yet little is known about the molecular basis of its benign...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0019
更新日期:2008-09-01 00:00:00
abstract::Insights into the host factors that contribute to an effective antiviral immune response may be obtained by examining global gene expression in simian human immunodeficiency virus (SHIV)-infected nonhuman primates that exhibit different virological outcomes. Immune responses and gene expression profiles in peripheral ...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2008.0076
更新日期:2008-12-01 00:00:00
abstract::Sera from 1003 in- and out-patients were investigated for hepatitis B surface antigen (HBsAg) mutation at Siriraj Hospital, Bangkok, Thailand. Individual samples were screened using two commercial HBsAg kits on automatic machine-based assays set up in parallel. The first kit was a sandwich ELISA kit that used monoclon...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2004.17.440
更新日期:2004-01-01 00:00:00
abstract::Infection with helper-free, defective MAIDS murine leukemia virus (MuLV) caused a rapid polyclonal activation of B cells in 0.75-, 2-, and 6-month-old C57L/J mice (H-2b, Fv-1n/n), similar to that in C57BL/6 mice (H-2b, Fv-1b/b), which was recognized by elevated plasma immunoglobulin concentrations. However, changes in...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.1992.5.39
更新日期:1992-04-01 00:00:00
abstract::Yellow fever is a zoonotic disease caused by the yellow fever virus (YFV) and transmitted by mosquitoes of the family Culicidae. It is well known that cellular and viral microRNAs (miRNAs) are involved in modulation of viral and cellular gene expression, as well as immune response, and are considered by the scientific...
journal_title:Viral immunology
pub_type: 杂志文章
doi:10.1089/vim.2016.0149
更新日期:2017-06-01 00:00:00